Abstract：
:This study was performed to examine the effect of diurnal normobaric hypoxia on hematological parameters. Eleven healthy male volunteers were randomly selected to be in either the hypoxic group (n=6) or the control group (n=5). The hypoxic group was exposed to 8 h of normobaric hypoxia in hypoxic tent systems that elicited a target peripheral O(2) saturation of 81+/-2% on three consecutive days. The control group spent three consecutive 8-h days in modified tent systems that delivered normoxic air into the tent. Venous blood samples were collected before the exposure (days -5, 0), after each day of the exposure (days 1, 2, 3), and for 3 weeks after the exposure (days 7, 10, 13, 17, 24). Serum erythropoietin concentration significantly increased from 9.1+/-3.3 U.L(-1) to 30.7+/-8.6 U.L(-1) in the hypoxic group. Although there were significant increases in hematocrit (4%), hemoglobin concentration (5%), red blood cell count (4%) on day 7 in the hypoxic group, these observations were likely due to dehydration or biological variation over time. There was no significant change in early erythropoietic markers (reticulocyte counts or serum ferritin concentration), which provided inconclusive evidence of accelerated erythroid differentiation and proliferation. The results suggest that the degree of hypoxia was sufficient to stimulate increased erythropoietin production and release. However, the duration of hypoxic exposure was insufficient to propagate the erythropoietic cascade.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
McLean SR,Kolb JC,Norris SR,Smith DJdoi
10.1007/s00421-005-0125-1keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
651-8issue
6eissn
1439-6319issn
1439-6327journal_volume
96pub_type
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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更新日期：2014-09-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2010-02-01 00:00:00
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