Abstract:
AIM:To observe the status of tumor-associated B(7) molecule mRNA expression in human colorectal cancer tissue by in situ hybridization. METHODS:The mRNA expression patterns of cancer-associated B(7-1),B(7)H(1),B(7)H(2),ICOS in 22 specimens of human colorectal cancer tissue were monitored by in situ hybridization (ISH) with digoxin-labeled oligonucleotide probes. RESULTS:B(7-1),B(7)H(1),B(7)H(2),ICOS mRNA were detected in both cancer cells and tumor infiltrating lymphocytes (TIL). The mRNA expression level of these molecules in tumor cells was higher than that in TIL (0.76+/-0.54 - 1.62+/-0.82 vs 0.38+/-0.19 - 0.65+/-0.33, P<0.001). There was no relationship between expression level of tested B(7) family molecules and patients' sex, age, differentiation status of cancer and regional lymph node metastasis. CONCLUSION:Th2 cytokine predominant in tumor microenvironment might be related to the expression of B(7)H(1),B(7)H(2) co-signal molecules in tumor cells and TIL.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Xiao JX,Bai PS,Lai BC,Li L,Zhu J,Wang YLdoi
10.3748/wjg.v11.i36.5655keywords:
subject
Has Abstractpub_date
2005-09-28 00:00:00pages
5655-8issue
36eissn
1007-9327issn
2219-2840journal_volume
11pub_type
杂志文章abstract:AIM:To evaluate the clinical characteristics of nonvariceal upper gastrointestinal hemorrhage (NGIH) in patients with chronic kidney disease (CKD). METHODS:From 2003 to 2010, a total of 72 CKD patients (male n = 52, 72.2%; female n = 20, 27.8%) who had undergone endoscopic treatments for NGIH were retrospectively iden...
journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v19.i43.7719
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.15.583
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journal_title:World journal of gastroenterology
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doi:10.3748/wjg.v11.i20.3118
更新日期:2005-05-28 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v19.i48.9334
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pub_type: 杂志文章
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更新日期:2017-12-14 00:00:00
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更新日期:2014-07-28 00:00:00
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更新日期:2014-11-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v22.i19.4781
更新日期:2016-05-21 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v21.i20.6252
更新日期:2015-05-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i10.1567
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v22.i32.7226
更新日期:2016-08-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v13.i34.4586
更新日期:2007-09-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v21.i33.9736
更新日期:2015-09-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 信件
doi:10.3748/wjg.v19.i3.426
更新日期:2013-01-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v13.i25.3513
更新日期:2007-07-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 社论
doi:10.3748/wjg.v16.i5.538
更新日期:2010-02-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v13.i20.2889
更新日期:2007-05-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.14.1370
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journal_title:World journal of gastroenterology
pub_type: 社论
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更新日期:2008-12-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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journal_title:World journal of gastroenterology
pub_type: 社论,评审
doi:10.3748/wjg.v22.i2.467
更新日期:2016-01-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v9.i6.1374
更新日期:2003-06-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v25.i42.6289
更新日期:2019-11-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,meta分析,评审
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更新日期:2013-02-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v12.i2.280
更新日期:2006-01-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i43.6871
更新日期:2005-11-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v10.i15.2174
更新日期:2004-08-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v20.i26.8638
更新日期:2014-07-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v18.i16.1975
更新日期:2012-04-28 00:00:00