B7 molecule mRNA expression in colorectal carcinoma.

Abstract:

AIM:To observe the status of tumor-associated B(7) molecule mRNA expression in human colorectal cancer tissue by in situ hybridization. METHODS:The mRNA expression patterns of cancer-associated B(7-1),B(7)H(1),B(7)H(2),ICOS in 22 specimens of human colorectal cancer tissue were monitored by in situ hybridization (ISH) with digoxin-labeled oligonucleotide probes. RESULTS:B(7-1),B(7)H(1),B(7)H(2),ICOS mRNA were detected in both cancer cells and tumor infiltrating lymphocytes (TIL). The mRNA expression level of these molecules in tumor cells was higher than that in TIL (0.76+/-0.54 - 1.62+/-0.82 vs 0.38+/-0.19 - 0.65+/-0.33, P<0.001). There was no relationship between expression level of tested B(7) family molecules and patients' sex, age, differentiation status of cancer and regional lymph node metastasis. CONCLUSION:Th2 cytokine predominant in tumor microenvironment might be related to the expression of B(7)H(1),B(7)H(2) co-signal molecules in tumor cells and TIL.

journal_name

World J Gastroenterol

authors

Xiao JX,Bai PS,Lai BC,Li L,Zhu J,Wang YL

doi

10.3748/wjg.v11.i36.5655

keywords:

subject

Has Abstract

pub_date

2005-09-28 00:00:00

pages

5655-8

issue

36

eissn

1007-9327

issn

2219-2840

journal_volume

11

pub_type

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