Abstract：
:A routine method to determine total haemoglobin mass (tHb) in clinical practice and sports medicine is non-existent. Radioactive tracers or other dilution procedures like the common CO-rebreathing method (Proc(com)) are impractical, the latter in particular because of the relatively long time of respiration. According to the multicompartment model of Bruce and Bruce (J Appl Physiol 95:1235-1247, 2003) the respiration time can be considerably reduced by inhaling a CO-bolus instead of the commonly used gas mixture. The aim of this study was to evaluate this theoretical concept in practice. The kinetics of the HbCO formation were compared in arterialised blood sampled from an hyperaemic earlobe after inhaling a CO-bolus (Proc(new)) for 2 min and a CO-O(2) mixture (Proc(com)) for approximately 10 min. The reliability of Proc(new) was checked in three consecutive tests, and phlebotomy was used to determine the validity. VO(2max) was determined with and without previous application of Proc(new) and the half-time of HbCO was registered also in arterialised blood after resting quietly and after the VO(2max) test. Proc(new) yielded virtual identical tHb values compared to Proc(com) when HbCO determined 5 min after starting CO-rebreathing was used for calculation. The typical error of Proc(new) was 1.7%, corresponding to a limit of agreement (95%) of 3.3%. The loss of 95 g (19) haemoglobin was detected with an accuracy of 9 g (12). After application of Proc(new) VO(2max) was reduced by 3.0% (3.7) (P=0.022) and half-time was lowered from 132 min (77) to 89 min (23) after the VO(2max) test. Inhaling a CO-bolus markedly simplifies the CO-rebreathing method without reducing validity and reliability and can be used for routine determination of tHb for various indications.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Schmidt W,Prommer Ndoi
10.1007/s00421-005-0050-3keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
486-95issue
5-6eissn
1439-6319issn
1439-6327journal_volume
95pub_type
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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pub_type： 临床试验,杂志文章
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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更新日期：2012-03-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,随机对照试验
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
abstract：:In this study we investigated force loss and recovery after eccentric exercise, and further characterized profound losses in muscle function (n = 192 subjects--98 males, 94 females; population A). Maximal voluntary contractile force (MVC) was assessed before, immediately after, and at 36 and 132 h after eccentric exer...
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pub_type： 杂志文章
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