Glycogen reduction in non-exercising muscle depends on blood lactate concentration.

Abstract:

:The purpose of this study was to determine for the first time by repeated non-invasive 13C-NMR spectrometry whether blood lactate concentration affects glycogen reduction in non-exercising muscle during prolonged (6 h) physical exercise in healthy adult males. Such an effect would indirectly show that glycogenolysis independent of nervous activation occurs in non-exercising muscle. After an overnight fast, 12 subjects performed alternating one-leg cycle exercise and arm cranking exercise at an average work load of 106 (SD 26) W [63 (9)% maximum oxygen consumption for one-leg exercise] and 69 (13) W [61 (10)% maximum oxygen consumption for arm cranking exercise], respectively. During the 6-h exercise test, glycogen concentration of the non-exercising calf muscle decreased by 17 (7)% while the glycogen concentration in the exercising calf muscle decreased by 45 (8)%. In a resting control group (n=6), the glycogen concentration did not decrease significantly. The higher the exercise intensity and therefore blood lactate concentration, the smaller was the glycogen reduction in the non-exercising calf muscles. We conclude that during prolonged physical exercise glycogenolysis in non-exercising human muscles decreases as exercise intensity increase contrary to exercising muscles. This observation might be an indirect evidence for a non-exercise induced glycogenolysis in inactive muscles.

journal_name

Eur J Appl Physiol

authors

Kohler G,Boutellier U

doi

10.1007/s00421-004-1109-2

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

548-54

issue

4-5

eissn

1439-6319

issn

1439-6327

journal_volume

92

pub_type

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