Abstract：
:The alpha-actinin-3 (ACTN3) gene encodes a Z-disc structural protein which is found only in fast glycolytic muscle fibers. A common nonsense polymorphism in codon 577 of the ACTN3 gene (R577X) results in alpha-actinin-3 deficiency in XX homozygotes. Previous reports have shown a lower proportion of the ACTN3 XX genotype in power-oriented athletes compared to the general population. In the present study we tested whether XX genotype was under-represented in Russian power-oriented athletes. The study involved 486 Russian power-oriented athletes of regional or national competitive standard. ACTN3 genotype and allele frequencies were compared to 1,197 controls. The frequencies of the ACTN3 XX genotype (6.4 vs. 14.2%; P < 0.0001) and X allele (33.3 vs. 38.7%; P = 0.004) were significantly lower in power-oriented athletes compared to controls. Furthermore, the lowest (3.4%) frequency of the ACTN3 XX genotype was found in a group of highly elite athletes, supporting the hypothesis that the presence of alpha-actinin-3 has a beneficial effect on the function of skeletal muscle in generating forceful contractions at high velocity. In conclusion, ACTN3 R577X polymorphism was associated with power athlete status in Russians.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Druzhevskaya AM,Ahmetov II,Astratenkova IV,Rogozkin VAdoi
10.1007/s00421-008-0763-1subject
Has Abstractpub_date
2008-08-01 00:00:00pages
631-4issue
6eissn
1439-6319issn
1439-6327journal_volume
103pub_type
杂志文章,多中心研究abstract：:An intermittent exposure to artificial hypergravity with physical exercise by a human centrifuge may provide a countermeasure against various physiological problems after space flight. To test the effects of hypergravity with ergometric exercise on dynamic regulation of heart rate during weightlessness, we quantified ...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-004-1308-x
更新日期：2005-06-01 00:00:00
abstract：:This study contrasted the effects of load characteristics on coordinative strategies between postural holding and position tracking. Fifteen healthy adults conducted postural holding and sinusoidal tracking with the index finger while manipulated loads (0, 50, and 100 g) were superimposed on an outstretched arm. Oscil...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2009-04-01 00:00:00
abstract：:The purpose of this study was to determine whether the onset kinetics of muscle oxygenation in localized working muscle (mOxy) was affected by differences in exercise intensity. Five healthy male subjects exercised for 6 min at 125 W, 150 W, and 175 W, and 1 min at 300 W on a cycle ergometer. mOxy was estimated by nea...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：PURPOSE:Muscular strength is suggested to be dependent upon muscle characteristics. Yet, sex-specific relationships of muscle characteristics to strength in the resistance-trained require investigation. Therefore, the purpose was to evaluate sex differences in muscle characteristics and isometric strength in the elbow ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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abstract：PURPOSE:This study aimed at investigating how prior knowledge of drop heights affects proactive and reactive motor control in drop jumps (DJ). METHODS:In 22 subjects, the effect of knowledge of three different drop heights (20, 30, 40 cm) during DJs was evaluated in seven conditions: three different drop heights were ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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abstract：PURPOSE:The purpose of this research is to determine the pacing and nutrition strategies which minimize completion time and carbohydrate intake for athletes competing in ultramarathon races. METHODS:We present the formulation of a two-phase optimization model. The first-phase mixed-integer nonlinear program (MINLP) de...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
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更新日期：2008-05-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,评审
doi：10.1007/s00421-002-0610-8
更新日期：2002-07-01 00:00:00
abstract：:Fifteen healthy men performed a 5-week training program comprising four sets of seven unilateral, coupled concentric-eccentric knee extensions 2-3 times weekly. While eight men were assigned to training using a weight stack (WS) machine, seven men trained using a flywheel (FW) device, which inherently provides variabl...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0583-8
更新日期：2008-02-01 00:00:00
abstract：:Whole-body vibration (WBV) is being promoted as an efficient complement to resistance training. The aim of this study was to investigate the effects of an 8-week program of WBV in combination with resistance training on knee extensors muscular performance. A group of 29 young adults (25 men, 4 women; age 21.8 ± 1.5) p...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
abstract：:Cold-induced vasodilatation (CIVD) is proposed to be a protective response to prevent cold injuries in the extremities during cold exposure, but the laboratory-based trainability of CIVD responses in the hand remains equivocal. Therefore, we investigated the thermal response across the fingers with repeated local cold...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0727-5
更新日期：2008-09-01 00:00:00
abstract：:Sixteen male students exercised for 14 days (1 h/day) in the heat for heat acclimation (HA). During deacclimation (DA) one group exercised in the cold (EXG, n=8) for 60 min/day (morning) and was exposed to the cold for another hour (afternoon) for 14 days. The other group was exposed to the cold (EPG, n=8) for 1 h eac...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-005-0012-9
更新日期：2005-10-01 00:00:00
abstract：:A hypoxic model was used to investigate changes in localized cerebral and muscle haemodynamics during knee extension (KE) in healthy individuals. Thirty-one young healthy volunteers performed one set of KE until failure under hypoxia (14 % O(2)) or normoxia (21 % O(2)) at 50, 75 or 100 % of 1 repetition maximum, in ra...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-012-2408-7
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:This study examined the mechanisms for force and power reduction during and up to 48 h after maximal eccentric contractions of the knee extensor muscles in young men and women. METHODS:13 men (22.8 ± 2.6 years) and 13 women (21.6 ± 2.2 years) performed 150 maximal effort eccentric contractions (5 sets of 30) w...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-017-3599-8
更新日期：2017-06-01 00:00:00
abstract：:Early effects of a resistance training program include neural adaptations at multiple levels of the neuraxis, but direct evidence of central changes is lacking. Plasticity exhibited by multiple supraspinal centers following training may alter slow negative electroencephalographic activity, referred to as movement-rela...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1432-8
更新日期：2010-07-01 00:00:00
abstract：PURPOSE:Walking is a complex locomotor process that involves both spinal cord reflexes and cortical integration of peripheral nerve input. Maintaining an upright body position requires not only neuromuscular activity but also cardiovascular regulation. We postulated that plantar mechanical stimulation might modulate au...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-016-3479-7
更新日期：2016-12-01 00:00:00
abstract：:The purpose of the current investigation was to determine whether sodium citrate enhances endurance cycling performance and, if so, what dosage(s) produces this effect. Eight trained [peak power output: 362 (48) W; power:weight: 5.1 (0.4) W x kg(-1), mean (SD)] male cyclists were requested to complete four, 40-km time...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s004210000264
更新日期：2000-11-01 00:00:00
abstract：PURPOSE:To examine and compare the acute effects of moderate-intensity continuous and accumulated exercise in three bouts with different intervals on arterial stiffness. METHOD:Nineteen healthy young males (mean age = 24.7 years) were randomized to no-exercise control (CON), continuous exercise (CE, 30-min cycling), a...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-015-3195-8
更新日期：2015-10-01 00:00:00
abstract：:This study examined the effects of a 6-week stretching program on the dynamic passive elastic properties of the calf muscle-tendon unit (MTU) of unconditioned younger women. After random assignment of 12 women (age 18-31 years) to a stretching group (SG) or to a control group (CG), six subjects in the SG and four subj...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-006-0366-7
更新日期：2007-03-01 00:00:00
abstract：:The purpose of the present article is to identify the most appropriate method of scaling VO2max for differences in body mass when assessing the energy cost of time-trial cycling. The data from three time-trial cycling studies were analysed (N = 79) using a proportional power-function ANCOVA model. The maximum oxygen u...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-005-1321-8
更新日期：2005-08-01 00:00:00
abstract：:Maximal exercise elicits systemic acidosis where venous pH can drop to 6.74 and here we assessed how much lower the intracellular value (pH(i)) might be. The wrist flexor muscles are intensively involved in rowing and (31)P-magnetic resonance spectroscopy allows for calculation of forearm pH(i) and energy metabolites ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1451-5
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:This study aimed to evaluate the accuracy of a novel approach for predicting the one-repetition maximum (1RM). The prediction is based on the force-velocity and load-velocity relationships determined from measured force and velocity data collected during resistance-training exercises with incremental submaximal...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-016-3457-0
更新日期：2016-10-01 00:00:00
abstract：:The aim of this study was to examine the influence of the performance level of athletes on pacing strategy during a simulated 10-km running race, and the relationship between physiological variables and pacing strategy. Twenty-four male runners performed an incremental exercise test on a treadmill, three 6-min bouts o...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-009-1300-6
更新日期：2010-03-01 00:00:00
abstract：:Heart rate recovery (HRR) after submaximal exercise improves after training. However, it is unknown if this also occurs in already well-trained cyclists. Therefore, 14 well-trained cyclists (VO(2max) 60.3 +/- 7.2 ml kg(-1) min(-1); relative peak power output 5.2 +/- 0.6 W kg(-1)) participated in a high-intensity train...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
abstract：PURPOSE:To examine the accuracy of practical indirect methods (i.e., recreational football match and estimation equations) in assessing individual maximal heart rate (HRmax) in recreational football players. Sixty-two untrained male participants engaged in a recreational football intervention (age 39.3 ± 5.8 years, VO2...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
abstract：:The aims of this study were (1) to evaluate changes in muscle activity associated with physiological fatigue and decreased swimming velocity (SV) during 200 m of front crawl swimming, and (2) to examine the relationship between the decreased SV and changes in kinematic or electromyogram parameters. Twenty swimmers par...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04442-1
更新日期：2020-10-01 00:00:00
abstract：:In classic concentric/eccentric exercise, the same absolute load is applied in concentric and eccentric actions, which infers a smaller relative eccentric load. We compared the effects of 6 weeks of classic concentric/eccentric quadriceps strength training (CON/ECC, 11 subjects) to eccentric overload training (CON/ECC...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-009-1292-2
更新日期：2010-03-01 00:00:00
abstract：:This study was undertaken to determine the cell adhesion molecule profile of CD4+, CD8hi and CD56+ lymphocytes, which are mobilised to and from the peripheral blood during and after prolonged aerobic exercise. Ten healthy males (21-35 years old) were tested on two occasions, separated by at least 14 days. On the first...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210000374
更新日期：2001-04-01 00:00:00
abstract：:The recently reported static stretching impairments found in adults have not been studied in youth. Furthermore, stretch-training effects on sprint performance are equivocal, hence the purpose of this study was to examine the effect of stretch and sprint training on the acute effects of static stretching in 13-15 year...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0799-2
更新日期：2008-10-01 00:00:00
