Abstract：
:In rodents, endurance training increases leptin sensitivity in skeletal muscle; however, little is known about the effects of exercise on the leptin signalling system in human skeletal muscle. Thus, to determine whether chronic muscle loading increases leptin receptor (OB-R170) protein expression, body composition dual-energy X-ray absorptiometry was assessed in nine professional male tennis players (24 +/- 4 years old) and muscle biopsies were obtained from the dominant (DTB) and non-dominant (NDTB) arm triceps brachii (TB), and also from the right vastus lateralis (VL). In each biopsy, the protein content of OB-R170, perilipin A, suppressor of cytokine signalling 3 (SOCS3), protein tyrosine phosphatase 1B (PTP1B) and signal transducer and activator of transcription 3 (STAT3) phosphorylation were determined by western blot. The DTB had 15% greater lean mass (P < 0.05) and 62% greater OB-R170 protein expression (P < 0.05) than the NDTB. SOCS3 and PTP1B protein expression was similar in both arms, while STAT3 phosphorylation was reduced in the NDTB. OB-R170 protein content was also higher in DTB than in VL (P < 0.05). In summary, this study shows that the functional isoform of the leptin receptor is up-regulated in the hypertrophied TB. The latter combined with the fact that both SOCS3 and PTP1B protein expression were unaltered is compatible with increased leptin sensitivity in this muscle. Our findings are also consistent with a role of leptin signalling in muscle hypertrophy in healthy humans.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Olmedillas H,Sanchis-Moysi J,Fuentes T,Guadalupe-Grau A,Ponce-González JG,Morales-Alamo D,Santana A,Dorado C,Calbet JA,Guerra Bdoi
10.1007/s00421-009-1281-5subject
Has Abstractpub_date
2010-03-01 00:00:00pages
749-58issue
4eissn
1439-6319issn
1439-6327journal_volume
108pub_type
杂志文章abstract：:Although pacing-related research is widely reported, no studies have described the consistency of pacing strategies or their associated energetic contributions. This study aimed to investigate the consistency of pacing and energetic outlay by establishing the typical within and between trial variations during simulate...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-010-1818-7
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:23Na MRI demonstrated increased tissue sodium concentrations in a number of pathologies. Acute atrophy results in muscle fibre volume shrinking that may result in a relative increase of extracellular volume and might affect sodium concentration. Thus, we hypothesized that local unloading of the calf muscles wou...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3647-4
更新日期：2017-08-01 00:00:00
abstract：:The purpose of this study was to investigate the effects of 20 days bed-rest on the elastic properties of tendon structures of the human knee extensor muscles in vivo. Six healthy men carried out a 6 degrees head-down bed-rest for 20 days. Muscle volume and maximal voluntary contraction (MVC) torque of the quadriceps ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210000309
更新日期：2000-12-01 00:00:00
abstract：PURPOSE:We tested the hypothesis that exposure to a short-term (1 h) increase in intraluminal pressure and shear stress (SS), to mimic two mechanical signals associated with a bout of exercise, improves nitric oxide (NO)-mediated endothelium-dependent dilation in aged soleus muscle feed arteries (SFA). In addition, we ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-016-3388-9
更新日期：2016-07-01 00:00:00
abstract：:Fifteen healthy men performed a 5-week training program comprising four sets of seven unilateral, coupled concentric-eccentric knee extensions 2-3 times weekly. While eight men were assigned to training using a weight stack (WS) machine, seven men trained using a flywheel (FW) device, which inherently provides variabl...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0583-8
更新日期：2008-02-01 00:00:00
abstract：:Microdialysis presents the unique possibility to measure metabolite concentrations in human interstitial fluid. During exercise, the recovery of these metabolites should be precisely monitored since it is known to increase greatly with muscle blood flow. The loss of ethanol, perfused at low concentration, can be accur...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-004-1099-0
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:Vascular dysfunction has been demonstrated in patients with Alzheimer's disease (AD). Exercise is known to positively affect vascular function. Thus, the aim of our study was to investigate exercise-induced effects on vascular function in AD. METHODS:Thirty-nine patients with AD (79 ± 8 years) were recruited a...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04447-w
更新日期：2020-10-01 00:00:00
abstract：:Dynamic stretching has gained popularity, due to a number of studies showing an increase in high intensity performance compared to static stretch modalities. Twenty-four males (age mean 21 +/- 0.3 years) performed a standardised 10 min jogging warm-up followed by either; no stretching (NS), slow dynamic stretching at ...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-010-1386-x
更新日期：2010-06-01 00:00:00
abstract：:Cardiovascular autonomic function is associated with physical performance and exercise training adaptation. The association between physical performance and sympathetic regulation is not well known. We hypothesized that sympathetic nervous system activity is associated with physical performance among male runners. The...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0618-1
更新日期：2008-03-01 00:00:00
abstract：:The influence of fatigue on the stretch reflex evoked in ankle extensor muscles by hopping was investigated in six healthy men. The men hopped on a force platform, at spontaneous frequency and amplitude, until they were unable to maintain the initial frequency or amplitude of the jumps. This task was done with the kne...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210000324
更新日期：2001-01-01 00:00:00
abstract：:The alpha-actinin-3 (ACTN3) gene encodes a Z-disc structural protein which is found only in fast glycolytic muscle fibers. A common nonsense polymorphism in codon 577 of the ACTN3 gene (R577X) results in alpha-actinin-3 deficiency in XX homozygotes. Previous reports have shown a lower proportion of the ACTN3 XX genoty...
journal_title：European journal of applied physiology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00421-008-0763-1
更新日期：2008-08-01 00:00:00
abstract：:SCUBA diving is regularly associated with asymptomatic changes in cardiac, pulmonary and vascular function. The aim of this study was to evaluate the changes in vascular/endothelial function following SCUBA diving and to assess the potential difference between two breathing gases: air and nitrox 36 (36% oxygen and 64%...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2187-6
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:To examine and compare systemic arterial stiffness responses in humans to acute continuous and interval low-intensity exercise. METHODS:Fifteen healthy young men (21.2 ± 0.4 years) underwent non-exercise control (CON), continuous exercise (CE), and interval exercise trial (IE) in a randomized balanced self-con...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-014-2869-y
更新日期：2014-01-01 00:00:00
abstract：:Through our recent studies on heart rate variability (Oida et al. J Appl Physiol 82:1794-1801, 1997; J Gerontol 54A:M219-M224, 1999a; Acta Physiol Scand 165:129-134, 1999b; Acta Physiol Scand 165:421-422, 1999c), we discover that autonomic functions could be assessed quantitatively in time domain by the tone-entropy (...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-005-1364-x
更新日期：2005-08-01 00:00:00
abstract：:One of the possible risks incurred while diving is inert gas narcosis (IGN), yet its mechanism of action remains a matter of controversy. Although providing insights in the basic mechanisms of IGN, research has been primarily limited to animal studies. A human study, in real diving conditions, was needed. Twenty volun...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-012-2391-z
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:Electro-induced (EI) muscle actions are largely used in healthy subjects to improve motor performance, in frail/older subjects to limit sarcopenia and mobility loss, and in pathological subjects to restore functional abilities after injury and/or surgical operation. Their effects on motor output (e.g., muscle s...
journal_title：European journal of applied physiology
pub_type： 杂志文章,评审
doi：10.1007/s00421-020-04383-9
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:This study investigated whether muscle cooling and its associated effects on skeletal muscle oxidative responses, blood gases, and hormonal concentrations influenced energy metabolism during cycling. METHODS:Twelve healthy participants (Males: seven; Females: five) performed two steady-state exercise sessions ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04407-4
更新日期：2020-08-01 00:00:00
abstract：:The purpose of this article was to establish whether previously reported oxygen-to-mass ratios, used to predict flat and hill-climbing cycling performance, extend to similar power-to-mass ratios incorporating other, often quick and convenient measures of power output recorded in the laboratory [maximum aerobic power (...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-006-0189-6
更新日期：2006-07-01 00:00:00
abstract：:Prolonged, strenuous exercise may lead to suppressive effects on the immune system, which might be responsible for a greater susceptibility to opportunistic infections. The aim of this study was to examine the influence of carbohydrate substitution (CHS) during prolonged, strenuous exercise on neutrophil granulocytes ...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-002-0642-0
更新日期：2002-10-01 00:00:00
abstract：:A model that describes the blood lactate concentration (BLC) dynamics [BLC(t)] of a Wingate Anaerobic Test (WAnT) as a function of (a) BLC at the start of exercise (BLC(0)), (b) extra-vascular increase in lactate (A), (c) two corresponding velocity constants of appearance (k (1)) and disappearance (k (2)) of lactate i...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1481-z
更新日期：2010-09-01 00:00:00
abstract：:The purpose of this study was to investigate the differences in the viscoelastic properties of human tendon structures (tendon and aponeurosis) in the medial gastrocnemius muscle between men (n=16) and women (n=13). The elongation of the tendon and aponeurosis of the medial gastrocnemius muscle was measured directly b...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-002-0744-8
更新日期：2003-02-01 00:00:00
abstract：:While there is some controversy whether anaerobic capacity might be improved after altitude training little is known about changes in anaerobic capacity during hypoxic exposure in highly trained athletes. In order to analyze the effects of acute moderate normobaric hypoxia on anaerobic capacity, 18 male competitive tr...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0473-0
更新日期：2007-09-01 00:00:00
abstract：:This study contrasted the effects of load characteristics on coordinative strategies between postural holding and position tracking. Fifteen healthy adults conducted postural holding and sinusoidal tracking with the index finger while manipulated loads (0, 50, and 100 g) were superimposed on an outstretched arm. Oscil...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-009-0981-1
更新日期：2009-04-01 00:00:00
abstract：:The object of this study was to assess the effects of magnitopuncture applied to Dazhui (DU14) point and Neiguan (PC6) points on sympathetic and parasympathetic nerve activities by power spectrum analysis of heart rate variability in healthy drivers during simulated driving. Using power spectrum analysis, the low freq...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00421-002-0747-5
更新日期：2003-01-01 00:00:00
abstract：:The effects of physical exercise stress on the endocannabinoid system in humans are almost unexplored. In this prospective study, we investigated in a crossover design and under field conditions at different altitudes the effects of physical exercise on the endocannabinoid system (ECS) in 12 trained healthy volunteers...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2237-0
更新日期：2012-07-01 00:00:00
abstract：PURPOSE:To compare the increases in upper- and lower-body muscle strength in premenopausal women performing resistance training (RT) alone or alongside concurrent high-intensity interval training (CT). METHODS:Sixteen women (26-40 years) were randomly assigned into two groups that performed either RT or CT. Both group...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3614-0
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine the effects of high-intensity aerobic interval training (AIT) on exercise hemodynamics in metabolic syndrome (MetS) volunteers. METHODS:Thirty-eight, MetS participants were randomly assigned to a training (TRAIN) or to a non-training control (CONT) group. TRAIN consisted ...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3697-7
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:This study aimed to determine whether men and women display a different magnitude of muscle fatigue in response to high-load (HL) and low-load blood flow-restricted (LLBFR) elbow-flexion exercise. We also explored to which extent both exercise protocols induce similar levels of muscle fatigue (i.e., torque decr...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-018-3940-x
更新日期：2018-10-01 00:00:00
abstract：:The recently reported static stretching impairments found in adults have not been studied in youth. Furthermore, stretch-training effects on sprint performance are equivocal, hence the purpose of this study was to examine the effect of stretch and sprint training on the acute effects of static stretching in 13-15 year...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0799-2
更新日期：2008-10-01 00:00:00
abstract：:This study was undertaken to elucidate the impact of long-term physical training on the modulation of stretch reflex excitability. To this end, electromyographic activities of the soleus muscle in response to quick toe-up rotation were compared between highly trained endurance runners (n = 8) and non-trained control s...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-012-2351-7
更新日期：2012-10-01 00:00:00
