Abstract:
:Sildenafil and epoprostenol are effective therapies in pulmonary arterial hypertension (PAH). Both drugs increase cardiac output, which has been in part attributed to improved right ventricular (RV) contractility. We therefore used tissue Doppler imaging (TDI) to test whether sildenafil and epoprostenol might differently affect RV function in normal subjects before and after induction of acute hypoxic pulmonary hypertension. Ten healthy volunteers underwent this randomized, double-blind, placebo-controlled cross-over study. Echocardiographic measurements were obtained 60 min after the intake of a placebo or 50 mg sildenafil or under 8 ng/kg/min iv epoprostenol, in normoxia or after 60 min of hypoxic breathing (FIO(2) of 0.12). Right ventricular systolic function was assessed by systolic strain (ε), strain rate (SR), isovolumic contraction acceleration (IVA) and tricuspid annulus plane systolic excursion (TAPSE), and diastolic function by tricuspid annulus E/A ratio and isovolumic relaxation time related to RR interval (IRT/RR). Pulmonary artery pressure was calculated from the acceleration time of pulmonary flow and cardiac output from the left ventricular outflow tract flow-velocity. Hypoxia increased pulmonary vascular resistance (PVR) by 78%, did not affect indices of RV systolic function, decreased E/A and increased IRT/RR. Epoprostenol more than sildenafil increased cardiac output, apical ε and TAPSE, the latter in proportion to decreased PVR. In addition, apical SR was increased only by epoprostenol. None of the drugs affected IVA, basal SR, E/A and IRT/RR. These results are not suggestive of intrinsic positive inotropic effects of either sildenafil or epoprostenol at maximal doses tolerated by normal subjects.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Pavelescu A,Naeije Rdoi
10.1007/s00421-011-2085-ysubject
Has Abstractpub_date
2012-04-01 00:00:00pages
1285-94issue
4eissn
1439-6319issn
1439-6327journal_volume
112pub_type
杂志文章,随机对照试验abstract::This study compared the first and second exercise bouts consisting of electrically evoked isometric contractions for muscle damage profile. Nine healthy men (31 +/- 4 years) had two electrical muscle stimulation (EMS) bouts separated by 2 weeks. The knee extensors of one leg were stimulated by biphasic rectangular pul...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00421-009-1278-0
更新日期:2010-03-01 00:00:00
abstract::The purpose of this study was to assess the effect of a soccer match on the cardiac autonomic control of heart rate (HR) in soccer referees. Sixteen Spanish regional and third division referees (11 males: 26 ± 7 years, 74.4 ± 4.1 kg, 178 ± 3 cm, Yo-Yo IR1 ~600-1,560 m; 5 females: 22 ± 3 years, 59.3 ± 4.8 kg, 158 ± 8 c...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-011-2202-y
更新日期:2012-06-01 00:00:00
abstract::The alpha-actinin-3 (ACTN3) gene encodes a Z-disc structural protein which is found only in fast glycolytic muscle fibers. A common nonsense polymorphism in codon 577 of the ACTN3 gene (R577X) results in alpha-actinin-3 deficiency in XX homozygotes. Previous reports have shown a lower proportion of the ACTN3 XX genoty...
journal_title:European journal of applied physiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00421-008-0763-1
更新日期:2008-08-01 00:00:00
abstract::The cardiovascular benefits of exercise are well known. In contrast, the impact of lifelong endurance exercise is less well understood. Long-term high-intensity endurance exercise is associated with changes in cardiac morphology together with electrocardiographic alterations that are believed to be physiologic in natu...
journal_title:European journal of applied physiology
pub_type: 杂志文章,评审
doi:10.1007/s00421-010-1534-3
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To examine and compare the acute effects of moderate-intensity continuous and accumulated exercise in three bouts with different intervals on arterial stiffness. METHOD:Nineteen healthy young males (mean age = 24.7 years) were randomized to no-exercise control (CON), continuous exercise (CE, 30-min cycling), a...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-015-3195-8
更新日期:2015-10-01 00:00:00
abstract::Differences in physiological functioning in the hypothalamus-pituitary-adrenal cortex axis and the autonomic nervous system have been suggested to contribute to many of the health differences that may be observed between men and women as well as being relevant for the development of musculoskeletal pain. To clarify wh...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-008-0939-8
更新日期:2009-03-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-011-1906-3
更新日期:2011-11-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-013-2590-2
更新日期:2013-06-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00421-002-0747-5
更新日期:2003-01-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-018-3834-y
更新日期:2018-05-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s004210100460
更新日期:2001-08-01 00:00:00
abstract::Acute physical exercise may affect cardiac autonomic modulation hours or even days during the recovery phase. Although sleep is an essential recovery period, the information on nocturnal autonomic modulation indicated by heart rate variability (HRV) after different exercises is mostly lacking. Therefore, this study in...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-011-2034-9
更新日期:2012-03-01 00:00:00
abstract::The purpose of this study was to investigate the effects of 20 days bed-rest on the elastic properties of tendon structures of the human knee extensor muscles in vivo. Six healthy men carried out a 6 degrees head-down bed-rest for 20 days. Muscle volume and maximal voluntary contraction (MVC) torque of the quadriceps ...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s004210000309
更新日期:2000-12-01 00:00:00
abstract::The purpose of the present article is to identify the most appropriate method of scaling VO2max for differences in body mass when assessing the energy cost of time-trial cycling. The data from three time-trial cycling studies were analysed (N = 79) using a proportional power-function ANCOVA model. The maximum oxygen u...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00421-005-1321-8
更新日期:2005-08-01 00:00:00
abstract::The aim of the present study was to determine whether glutamine ingestion, which has been shown to enhance the exercise-induced increase in the tricarboxylic acid intermediate (TCAi) pool size, resulted in augmentation of the rate of increase in oxidative metabolism at the onset of exercise. In addition, the potential...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-006-0324-4
更新日期:2007-01-01 00:00:00
abstract::The measurement of human muscle size is essential when assessing the effects of training, disuse and ageing. The considered 'gold standard' for cross-sectional area measurements of muscle size is magnetic resonance imaging (MRI). However, MRI is costly and often inaccessible. The aim of the present study was to test t...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-003-0961-9
更新日期:2004-01-01 00:00:00
abstract::The purpose of this study was to determine the effects of 8 weeks of norsteroid supplementation on body composition and athletic performance in previously weight-trained males. Subjects were weight and percent body fat matched and randomly assigned to receive either 100 mg of 19-nor-4-androstene-3,17-dione (N-dione) a...
journal_title:European journal of applied physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s004210100395
更新日期:2001-05-01 00:00:00
abstract::The insertion (I) variant of the angiotensin-1 converting enzyme (ACE) I/D genetic polymorphism is associated with lower circulating and tissue ACE activity. Some studies have also suggested associations of ACE I/D genotype with endurance phenotypes. This study assessed the relationships between circulating ACE activi...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-006-0309-3
更新日期:2007-01-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-015-3113-0
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Arterial blood pressure variations are an independent risk factor for end organ failure. Respiratory sinus arrhythmia (RSA) is a sign of a healthy cardiovascular system. However, whether RSA counteracts arterial blood pressure variations during the respiratory cycle remains controversial. We restricted normal R...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-014-3042-3
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:Locomotor muscle fatigue impairs exercise performance during time to exhaustion tests. However, its effect on self-regulation of power output (pacing) is unknown. The primary aim of this study was to investigate the effects of locomotor muscle fatigue on pacing and time trial performance. METHODS:Ten healthy r...
journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-013-2673-0
更新日期:2013-09-01 00:00:00
abstract::A hypoxic model was used to investigate changes in localized cerebral and muscle haemodynamics during knee extension (KE) in healthy individuals. Thirty-one young healthy volunteers performed one set of KE until failure under hypoxia (14 % O(2)) or normoxia (21 % O(2)) at 50, 75 or 100 % of 1 repetition maximum, in ra...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-012-2408-7
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare the muscle oxygenation between trained and untrained subjects during heavy exercise until exhaustion at two extreme pedaling cadences using a NIRS system. METHODS:Nine untrained male subjects and nine male competitive triathletes cycled until exhaustion at an intensity corr...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-015-3235-4
更新日期:2015-12-01 00:00:00
abstract::In order to quantify the seasonal variability of haemoglobin mass (Hb(mass)) in cyclists during a competitive season, and investigate whether variability is associated with changes in training load or performance, Hb(mass) was measured in 10 internationally competitive female road cyclists approximately once per month...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-009-1349-2
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:The purpose of this research is to determine the pacing and nutrition strategies which minimize completion time and carbohydrate intake for athletes competing in ultramarathon races. METHODS:We present the formulation of a two-phase optimization model. The first-phase mixed-integer nonlinear program (MINLP) de...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-017-3741-7
更新日期:2017-12-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00421-015-3284-8
更新日期:2016-02-01 00:00:00
abstract::Whole-body vibration (WBV) leads to a rapid increase in intra-muscular temperature and enhances muscle power. The power-enhancing effects by WBV can, at least in part, be explained by intra-muscular temperature. However, this does not exclude possible neural effects of WBV occurring at the spinal level. The aim of thi...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-009-1215-2
更新日期:2010-01-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章,评审
doi:10.1007/s00421-011-1879-2
更新日期:2011-11-01 00:00:00
abstract::Whole-Body vibration (WBV) may lead to muscle contractions via reflex activation of the primary muscle spindle (Ia) fibres. WBV has been reported to increase muscle power in the short term by improved muscle activation. The present study set out to investigate the acute effects of a standard WBV training session on vo...
journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-002-0723-0
更新日期:2003-01-01 00:00:00
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journal_title:European journal of applied physiology
pub_type: 杂志文章
doi:10.1007/s00421-007-0500-1
更新日期:2007-10-01 00:00:00