Abstract：
OBJECTIVE:To analyze the construct validity of the EQ-5D in patients with acute coronary syndromes (ACS). METHODS:All ACS-diagnosed patients discharged from a university-affiliated hospital during a 3-year period were mailed a questionnaire that included the EQ-5D and the SF-8. The EQ-5D includes a visual analogue scale (EQ VAS) to measure self-reported current health-status (0-100) and a five-item descriptive system measuring mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Also included were disease severity measures [Duke Activity Status Index (DASI), cardiac symptom count (SC), patient-perceived cardiac disease severity], comorbidity measures (Charlson comorbidity index, total medication count), and other demographic and disease-related items. RESULTS:Of 1217 patients, 490 (40.3%) responded. Patients averaged 65.2 (SD 11.3) years of age; 71.0% male; 91.9% Caucasian; 64.3% history of MI. Only 0.2%-0.4% of EQ-5D items and 8% of the EQ VAS were left unanswered by respondents. The nine most common health states were identified based on the five EQ-5D item scores. Levels of responses to EQ-5D items and the EQ VAS score were significantly better for patients with very mild/mild perceived disease severity compared to severe/very severe, for patients with lower comorbidity, for patients with lower symptom responses, and for patients with a higher cardiac-related functioning. EQ VAS score and SF-8 subscale score correlation coefficients ranged from 0.527 to 0.798 (all p < 0.0001). Significant differences were observed between the response level of individual EQ-5D items and scores of comparable SF-8 subscales. CONCLUSIONS:This study demonstrated the construct validity of the EQ-5D in a population-based sample of patients with a history of ACS.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Ellis JJ,Eagle KA,Kline-Rogers EM,Erickson SRdoi
10.1185/030079905X56349keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
1209-16issue
8eissn
0300-7995issn
1473-4877journal_volume
21pub_type
杂志文章abstract：BACKGROUND:A double-blind randomized trial evaluated the efficacy and tolerability of rivastigmine and donepezil in patients with Alzheimer's disease (AD) over 2 years. Baseline data indicated that some patients had symptoms suggestive of concomitant Lewy body disease. This retrospective analysis investigated whether A...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
doi：10.1185/030079906x80279
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:Based on the clear neuroanatomical delineation of many neuropathic pain (NP) symptoms, a simple tool for performing a short structured clinical encounter based on the IASP diagnostic criteria was developed to identify NP. This study evaluated its accuracy and usefulness. METHODS:A case-control study was perf...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2018.1465905
更新日期：2018-08-01 00:00:00
abstract：:The therapeutic efficacy of cimetidine given as 400 mg twice daily was compared to that of cimetidine given as 1.0 g daily in 4 divided doses (200 mg 3-times daily and 400 mg at night) in two groups of 25 patients (total 50 patients) with active duodenal ulceration. After 4 weeks, healing rates of 72% and 76%, respect...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007998509109626
更新日期：1985-01-01 00:00:00
abstract：AIM:To assess the efficacy of a strategy to improve vascular risk management in patients with type 2 diabetes mellitus (T2DM). METHODS:This was a pilot best practice implementation enhancement programme that enrolled 578 patients with T2DM. A baseline visit was followed by a concerted effort from previously trained ph...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007990903073035
更新日期：2009-08-01 00:00:00
abstract：:A double-blind, multi-centre trial was carried out in 191 patients with acute musculoskeletal conditions to compare the efficacy of naproxen and indomethacin. Patients were randomly allocated to receive either 250 mg naproxen or 50 mg indomethacin twice daily. Treatment was for 7 or 14 days. The results, assessed by t...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007997609109332
更新日期：1976-01-01 00:00:00
abstract：:Objective: To assess real-world costs for patients with hemophilia A treated with bypassing agents versus factor VIII (FVIII) replacement. Methods: Claims data from a large US health insurer during 1 January 2006-30 September 2014 were used for analysis. Treated patients with hemophilia A were identified based on ≥1 m...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2019.1596437
更新日期：2019-08-01 00:00:00
abstract：:Although the statistical strength of direct comparative randomized controlled trials is generally acknowledged, the particular demands of therapeutic decision making will often require indirect comparisons to be made, based on pooled data from multiple trials. As for all post-hoc analyses, the process of indirect comp...
journal_title：Current medical research and opinion
pub_type： 社论
doi：10.1185/03007995.2014.1002559
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Niacin is currently the most effective approved agent for raising high-density lipoprotein cholesterol. However, niacin-induced cutaneous flushing (redness, warmth, tingling and/or itching) significantly limits patient acceptance. To further characterize flushing, a patient-reported Flushing Symptom Question...
journal_title：Current medical research and opinion
pub_type： 杂志文章,随机对照试验
doi：10.1185/030079907x199637
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:Pharmaceutical preparations of human menopausal gonadotrophin (hMG), urine-derived follicle-stimulating hormone (u-FSH) and highly purified u-FSH (u-FSH-HP) have been available since the early 1960s and the mid 1980s and 1990s, respectively. Another commercial preparation of u-FSH-HP, Folyrmon P, was launched...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079905X48410
更新日期：2005-06-01 00:00:00
abstract：:Two clinical trials were carried out in order to study adrenal suppression in 6 patients with psoriatic erythroderma and in 28 patients with psoriasis treated with topical glucocorticosteroids. Betamethasone-17-valerate (0.1%), betamethasone-17,21-dipropionate (0.05%) and budesonide (0.025%) ointments were studied in ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007998309109785
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:To quantify changes in clinical and cost outcomes associated with increasing levels of body mass index (BMI) in a US setting. RESEARCH METHODS AND PROCEDURES:A semi-Markov model was developed to project and compare life expectancy (LE), quality-adjusted life expectancy (QALE) and direct medical costs associa...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079906X96227
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:To assess the safety, tolerability and pharmacokinetics of an interleukin (IL)-12/23 monoclonal antibody (mAb) in subjects with a relapsing form of multiple sclerosis (MS). METHODS:A phase I, double-blind, placebo-controlled, sequential dose escalation study was conducted in 20 subjects with MS. Subjects wer...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/030079906X120931
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:Recent survey data have reported the incidence rate of needlestick injuries (NIs) and NIs which draw blood sustained by nurses caring for patients with diabetes in an in-patient hospital setting. The purpose of this study was to deduce the potential short-term annual economic impact resulting from such NI, and ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079905X65286
更新日期：2005-12-01 00:00:00
abstract：:One hundred and eight patients who had been taking phenytoin for a year or more, either alone or in combination with other drugs, were examined for gum hypertrophy by three observers independently. Approximately 90% of the patients showed either mild or no gum hypertrophy and severe swelling occurred in only 1%. The o...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007998809111114
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:In epidural analgesia, synthetic opioids increase the potency of amide local anesthetics by modifying their analgesic properties. The purpose of this systematic review and meta-analysis is to compare the efficacy and safety of bupivacaine with ropivacaine and levobupivacaine in combination with sufentanil (B...
journal_title：Current medical research and opinion
pub_type： 杂志文章,meta分析,评审
doi：10.1185/03007995.2014.946127
更新日期：2014-11-01 00:00:00
abstract：:A trial to compare the therapeutic potential of 1200 mg. azapropazone daily with 3.9 g. aspirin daily was carried out in 108 out-patients with rheumatoid arthritis over a 14-day period. Analysis of results from the 85 patients with completed assessment data (49 on azapropazone; 36 on aspirin) showed that azapropazone ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007997609109281
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVE:To compare the effectiveness of antiresorptive agents in reducing the risk of vertebral and non-vertebral fractures using data from published meta-analyses and the technique of adjusted indirect comparisons. RESEARCH DESIGN AND METHODS:Pairs of agents were compared by adjusted indirect comparison of 0.56 [0....
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079904125003269
更新日期：2004-04-01 00:00:00
abstract：:Recombinant human erythropoietin (epoetin) is a highly active molecule and as such is used at very low therapeutic concentrations that require stabilisation. Commercially available epoetins differ in the stabilisers used in their formulations, which result in variations between epoetin preparations in storage and hand...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079903125002063
更新日期：2003-01-01 00:00:00
abstract：:Twenty-five acutely disturbed psychotic patients were treated in an open study with a single injection of zuclopenthixol acetate 5% in 'Viscoleo, a thin vegetable oil. Patients were assessed post-injection for 3 days using the BPRS, CGI, and a specially designed behaviour/activity scale. Doses of 50 to 150 mg proved e...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007999009111492
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Alternaria alternata (AA) sensitisation is a common cause of respiratory allergies such as rhinitis and asthma. So far there are no controlled double-blind trials evaluating the efficacy and safety of specific sublingual immunotherapy (SLIT) in AA allergies. OBJECTIVE:To evaluate the efficacy of SLIT treatm...
journal_title：Current medical research and opinion
pub_type： 杂志文章,随机对照试验
doi：10.1185/03007995.2010.532201
更新日期：2010-12-01 00:00:00
abstract：:The results of recent clinical trials with rivastigmine show that in the approved indication of mild to moderate Alzheimer's disease (AD), the drug is effective in the long term. Rivastigmine produces a significant delay in the decline of the three components of AD that have been identified by European guidelines as e...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/0300799039117029
更新日期：2003-01-01 00:00:00
abstract：:Objective To assess the efficacy of a mixed intervention, educational, and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods This was a prospective, longitudinal, multi-center study, carried out in 110 speci...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
doi：10.1080/03007995.2018.1435519
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score <19 as a threshold for moderate to severe dry eye disease (DED). METHODS:A phase III, randomized, controlled...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1080/03007995.2018.1434496
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:Acute postprandial hyperglycemia (aPPHG) is often symptomatic and can be associated with behavioral changes such as impaired working memory and attention. However, there is little evidence of the impact of aPPHG on the daily lives of patients. The aim of this study was to explore the frequency and severity of...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2018.1525344
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is mostly seen in adult populations. It is known that increased levels of several inflammatory mediators play roles in OSAS and related comorbidities. Calprotectin is an inflammatory mediator that increases in some diseases such as Behçet's syndrome, bowel diseases and...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2017.1383890
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVES:The primary objective of this study was to quantify how many publications retracted because of misconduct involved declared medical writers (i.e., not ghostwriters) or declared pharmaceutical industry support. The secondary objective was to investigate factors associated with misconduct retractions. DESIGN:...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2011.573546
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:The objectives of this survey were to understand (1) the effects of overactive bladder (OAB) and urinary incontinence (UI) on women's lives and to understand (2) women's needs and expectations of health care providers and treatment related to these disorders. METHODS:Women (N = 1046) with self-reported sympt...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079905X59076
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVE:The dopamine agonist rotigotine has shown efficacy and safety for the treatment of early and advanced Parkinson's disease (PD) in controlled clinical trials. This observational study evaluated rotigotine administration in combination with other antiparkinsonian medication in routine clinical practice. METHOD...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1185/03007995.2011.611630
更新日期：2011-10-01 00:00:00
abstract：:A trial was carried out in 3 clinics to test the efficacy of and cycle control obtained with a very low dosage oral contraceptive combination of lynesternol (0.75 mg) and ethinyl oestradiol (0.0375 mg). A total of 134 healthy, fertile women, ages ranging from under 19 years to over 40 years, participated and completed...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007997609109328
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVE:To review clinical trial evidence supporting treatment of patients to a near-normal HbA(1c) target level and outline therapeutic strategies that optimize glycemic control. RESEARCH DESIGN AND METHODS:The current MEDLINE database and bibliographies were searched for literature relevant to diabetic complicatio...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079904X6291
更新日期：2004-12-01 00:00:00
