Abstract:
OBJECTIVE:Acute postprandial hyperglycemia (aPPHG) is often symptomatic and can be associated with behavioral changes such as impaired working memory and attention. However, there is little evidence of the impact of aPPHG on the daily lives of patients. The aim of this study was to explore the frequency and severity of aPPHG episodes and their impact on daily functioning in people with insulin-treated diabetes. METHODS:Adults (n = 1200) with insulin-treated diabetes mellitus type 1 (T1DM) or 2 (T2DM), most of whom experienced aPPHG, were recruited to complete an online cross-sectional survey in the USA and UK. The survey captured self-reported severity and frequency of aPPHG episodes and included a newly developed questionnaire (aPPHG-Q) assessing the impact of aPPHG episodes on patients' daily lives. Data was analyzed separately according to diabetes type and country. Regression analyses were used to assess the relationship between severity or frequency and scores on the aPPHG-Q. RESULTS:Between 70% and 86% of USA, and 87% and 88% of UK participants reported experiencing aPPHG episodes. Increasing frequency and severity of aPPHG episodes were associated with worse scores on the aPPHG-Q in patients with both T1DM and T2DM in both countries (p < .014) on all subscale scores (excluding the worry and concerns scores for T1DM in the UK), although the magnitude of the association was smaller for aPPHG frequency. CONCLUSIONS:Increased severity and frequency of aPPHG episodes in patients with insulin-treated diabetes is associated with greater burden and experience of symptoms, and can negatively impact daily functioning.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Heller S,Meneghini L,Nikolajsen A,Kragh N,Lewis HB,Saretsky T,Kosmas CE,Lloyd Adoi
10.1080/03007995.2018.1525344subject
Has Abstractpub_date
2019-03-01 00:00:00pages
525-533issue
3eissn
0300-7995issn
1473-4877journal_volume
35pub_type
杂志文章abstract:BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD f...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1428542
更新日期:2018-07-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997709109336
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007995.2014.975338
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2011.573546
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X40472
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abstract:OBJECTIVE:Most registration studies for new osteoporosis drugs have used a combination of quantitative morphometry (QM) and visual semiquantitative reading (SQ) to define vertebral fractures. However, in the pivotal teriparatide Fracture Prevention Trial (ClinicalTrials.gov Identifier: NCT00670501), vertebral fractures...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990902790993
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079906X132523
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079906X112516
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079903125002810
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X56349
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
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journal_title:Current medical research and opinion
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doi:10.1185/03007990802594941
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journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1080/03007995.2018.1520694
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
pub_type: 评论,社论
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Current medical research and opinion
pub_type: 杂志文章
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
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journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
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更新日期:2000-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997709115283
更新日期:1977-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
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更新日期:2009-04-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-11-01 00:00:00