A cost-effectiveness analysis of calcipotriol plus betamethasone dipropionate aerosol foam versus gel for the topical treatment of plaque psoriasis.

Abstract:

BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD foam compared with Cal/BD gel from the Australian perspective. METHODS:A Markov model was developed to evaluate the cost-effectiveness of topical Cal/BD foam and gel for the treatment of people with plaque psoriasis. Treatment effectiveness, safety, and utilities were based on a randomized control trial, resource use was informed by expert opinion, and unit costs were obtained from public sources. Outcomes were reported in terms of 1-year costs, quality-adjusted life years, and incremental cost-effectiveness ratios. All costs were reported in 2017 Australian Dollars. RESULTS:The model showed that patients using Cal/BD foam had more QALYs and higher costs over 1 year compared with patients using Cal/BD gel, resulting in a cost of $13,609 per QALY gained at 4-weeks. When 4 weeks of Cal/BD foam was compared with 8 weeks of Cal/BD gel treatment, Cal/BD foam was $8 less expensive and resulted in 0.006 more QALYs gained. Sensitivity analyses showed that, compared with Cal/BD ointment, Cal/BD foam was associated with an incremental cost of $15,091 per QALY gained. CONCLUSION:Cal/BD foam is the most cost-effective Cal/BD formulation for the topical treatment of patients with plaque psoriasis.

journal_name

Curr Med Res Opin

authors

Foley P,Garrett S,Ryttig L

doi

10.1080/03007995.2018.1428542

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

1277-1283

issue

7

eissn

0300-7995

issn

1473-4877

journal_volume

34

pub_type

杂志文章
  • Critical thinking about three meta-analyses: can vitamin D alone or with calcium prevent fractures?

    abstract::Critical thinking is crucially important in both research and practice. This article demonstrates that a lack of critical thinking in two meta-analyses resulted in a conclusion that contradicts another meta-analysis and popular opinions. Kahwati et al. and Zhao et al. drew a conclusion that "Vitamin D supplementation ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2019.1687432

    authors: Fan H,Xiao J

    更新日期:2020-03-01 00:00:00

  • Temazepam 'Planpak', a fixed-dose reduction regimen for withdrawing benzodiazepine hypnotics: results of a general practice survey.

    abstract::In a general practice survey of the use of Temazepam 'Planpak' ('Planpak'), 31 participating doctors completed questionnaires on 250 patients. Of these, 228 patients had been taking a variety of 8 benzodiazepine hypnotics prior to 'Planpak' therapy while 22 (8.8%) patients received 'Planpak' as a short course, without...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007999109111510

    authors: Drake J

    更新日期:1991-01-01 00:00:00

  • Stratum corneum pharmacokinetics of the anti-fungal drug, terbinafine, in a novel topical formulation, for single-dose application in dermatophytoses.

    abstract:OBJECTIVE:The stratum corneum (SC) pharmacokinetics of terbinafine following single-dose administration of a novel cutaneous solution (film-forming solution, FFS) containing terbinafine hydrochloride and a film-forming agent, was investigated in three studies. Terbinafine 1% cream (Lamisil) was included as a benchmark ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,meta分析

    doi:10.1185/030079907X199664

    authors: Kienzler JL,Queille-Roussel C,Mugglestone C,Ortonne JP,Larnier C

    更新日期:2007-06-01 00:00:00

  • The effect of carvedilol on mortality risk in heart failure patients with diabetes: results of a meta-analysis.

    abstract:BACKGROUND:Although beta-blocker therapy has been shown to improve survival in patients with chronic heart failure, this class of drugs tends to be underutilized in diabetic patients due to concerns about adverse metabolic effects, especially on glycemic control. No randomized clinical trial has specifically evaluated ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,meta分析

    doi:10.1185/030079906X80459

    authors: Bell DS,Lukas MA,Holdbrook FK,Fowler MB

    更新日期:2006-02-01 00:00:00

  • Lipid-lowering effects of colesevelam HCl in combination with ezetimibe.

    abstract:OBJECTIVE:The primary aim of this study was to compare the effect of colesevelam HCl in combination with ezetimibe to ezetimibe monotherapy on low-density lipoprotein cholesterol (LDL-C) levels in subjects with primary hypercholesterolemia. METHODS:Subjects with primary hypercholesterolemia (N = 86) were enrolled in a...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1185/030079906X148436

    authors: Bays H,Rhyne J,Abby S,Lai YL,Jones M

    更新日期:2006-11-01 00:00:00

  • Putting evidence-based medicine into clinical practice: comparing anti-resorptive agents for the treatment of osteoporosis.

    abstract:OBJECTIVE:To compare the effectiveness of antiresorptive agents in reducing the risk of vertebral and non-vertebral fractures using data from published meta-analyses and the technique of adjusted indirect comparisons. RESEARCH DESIGN AND METHODS:Pairs of agents were compared by adjusted indirect comparison of 0.56 [0....

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/030079904125003269

    authors: Wehren LE,Hosking D,Hochberg MC

    更新日期:2004-04-01 00:00:00

  • Effect of low-fat dairy products fortified with 1500IU nano encapsulated vitamin D3 on cardiometabolic indicators in adults with abdominal obesity: A total blinded randomized controlled trial.

    abstract:: Background & aims: Vitamin D deficiency is widespread worldwide. In this study, we aimed to evaluate the effect of a nano encapsulated form of vitamin D used for fortifying low-fat dairy products (milk and yogurt) on anthropometric indices, glycemic status, and lipid profi...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2021.1874324

    authors: Sharifan P,Ziaee A,Darroudi S,Rezaie M,Safarian M,Eslami S,Khadem-Rezaiyan M,Tayefi M,Mohammadi M,Ghazizadeh H,Khorasanchi Z,Bagherniya M,Sardar MA,Ferns G,Vatanparast H,Ghayour Mobarhan M

    更新日期:2021-01-12 00:00:00

  • Effects of pirazolac on arachidonic acid metabolism in the human synovial system.

    abstract::Six patients suffering from rheumatoid arthritis with massive knee joint effusions were treated with single daily doses of 600 mg pirazolac, a novel non-steroidal anti-inflammatory drug, for 3 days. Before the first dose, 3 hours after the second and the third dose, specimens of plasma and synovial fluid were drawn si...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007998709112409

    authors: Kurowski M,Dunky A,Geddawi M

    更新日期:1987-01-01 00:00:00

  • Efficacy and tolerability of lumiracoxib 100 mg once daily in knee osteoarthritis: a 13-week, randomized, double-blind study vs. placebo and celecoxib.

    abstract:OBJECTIVE:To determine the efficacy and safety of lumiracoxib for knee osteoarthritis (OA). METHODS:This was a 13-week, multicentre, randomized, double-blind, double-dummy, placebo-controlled study. Males or females aged >/= 18 years with primary knee OA received lumiracoxib 100 mg od, lumiracoxib 100 mg od with a loa...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1185/030079905x38196

    authors: Lehmann R,Brzosko M,Kopsa P,Nischik R,Kreisse A,Thurston H,Litschig S,Sloan VS

    更新日期:2005-04-01 00:00:00

  • Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review.

    abstract:BACKGROUND:The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines development group examined the properties of oral H(1)-antihistamines and made proposals about an 'optimal' drug. Several criteria should be met by oral H(1)-antihistamines in terms of their pharmacological, and clinical efficacy and safety pro...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007995.2011.648263

    authors: Bousquet J,Ansótegui I,Canonica GW,Zuberbier T,Baena-Cagnani CE,Bachert C,Cruz AA,González SN,Kuna P,Morais-Almeida M,Mullol J,Ryan DP,Sánchez-Borges M,Valiente R,Church MK

    更新日期:2012-01-01 00:00:00

  • A comparison of etodolac (Ultradol) with acetaminophen plus codeine (Tylenol #3) in controlling post-surgical pain in vasectomy patients.

    abstract::The efficacy and safety of etodolac (Ultradol) and acetaminophen plus codeine [A + C (Tylenol #3)] in controlling post-surgical pain were compared in an open-label, randomized, parallel-group outpatient study. Patients who were voluntarily having a vasectomy performed for sterilization were assigned to receive either ...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007999709113329

    authors: Casey R,Zadra J,Khonsari H

    更新日期:1997-01-01 00:00:00

  • Prophylaxis of febrile neutropenia with colony-stimulating factors: the first 25 years.

    abstract::Filgrastim prophylaxis, both primary and secondary, was rapidly incorporated into clinical practice in the 1990s. When pegfilgrastim became available in 2002, it quickly replaced filgrastim as the colony-stimulating factor (CSF) of choice for prophylaxis. Use of prophylaxis increased markedly in the first decade of th...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1080/03007995.2019.1703665

    authors: Edelsberg J,Weycker D,Bensink M,Bowers C,Lyman GH

    更新日期:2020-03-01 00:00:00

  • Nutritional status and well being. Is there a relationship between body mass index and the well-being of older people?

    abstract::Poor nutritional status may impair well being indirectly as a consequence of increased morbidity and decline in functional status. The aim of this study was to examine the independent effect of body mass index on the well being of older people. Thirty one hospital-based patients over 65 years of age were studied. Well...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:

    authors: Balcombe NR,Ferry PG,Saweirs WM

    更新日期:2001-01-01 00:00:00

  • Effects of oral posaconazole on the pharmacokinetics of sirolimus.

    abstract:OBJECTIVES:Azole antifungal agents are often coadministered with immunosuppressants to recipients of solid organ and hematopoietic stem cell transplants. Posaconazole, an extended-spectrum triazole, is an inhibitor of the cytochrome P450 (CYP) isoenzyme CYP3A4, and sirolimus, an immunosuppressant, is a substrate of the...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007990802644209

    authors: Moton A,Ma L,Krishna G,Martinho M,Seiberling M,McLeod J

    更新日期:2009-03-01 00:00:00

  • The clinical diagnosis of influenza.

    abstract::Effective management of influenza depends on early recognition of influenza in the community and on rapid diagnosis. Early recognition is achieved by integrated clinical and laboratory based surveillance programmes in representative populations. The recent introduction of 'near patient tests' for influenza provide inc...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/030079902125000921

    authors: Fleming D,Wood M

    更新日期:2002-01-01 00:00:00

  • Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs.

    abstract:BACKGROUND:Low-dose acetylsalicylic acid (ASA; aspirin; 75-325 mg/day) is effective for the prevention of cardiovascular events, and its use in this indication is rapidly increasing. However, the use of ASA and, indeed, other non-steroidal anti-inflammatory drugs (NSAIDs) is limited by the incidence of adverse gastrodu...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007990903212682

    authors: Yeomans ND,Hawkey CJ,Brailsford W,Naesdal J

    更新日期:2009-11-01 00:00:00

  • Influence of a genomic classifier on post-operative treatment decisions in high-risk prostate cancer patients: results from the PRO-ACT study.

    abstract:OBJECTIVE:To assess the effect of an individualized genomic classifier (GC) test, for predicting metastasis following radical prostatectomy (RP), on urologists' adjuvant treatment decisions when caring for high-risk patients. PATIENTS AND METHODS:Data were submitted by US board-certified urologists in community practi...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究

    doi:10.1185/03007995.2014.919908

    authors: Michalopoulos SN,Kella N,Payne R,Yohannes P,Singh A,Hettinger C,Yousefi K,Hornberger J,PRO-ACT Study Group.

    更新日期:2014-08-01 00:00:00

  • Strategies for improving dabigatran adherence for stroke prevention in patients with non-valvular atrial fibrillation: education and drug intake reminders (FACILITA study).

    abstract::Objective To assess the efficacy of a mixed intervention, educational, and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods This was a prospective, longitudinal, multi-center study, carried out in 110 speci...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究

    doi:10.1080/03007995.2018.1435519

    authors: Márquez-Contreras E,Martell-Claros N,Márquez-Rivero S,Hermida-Campa E,Gracia-Diez C,Sanchez-López E,Gil-Guillén V,Compliance and Inertia Working Group, Spanish Society of Hypertension (SEH-LELHA).

    更新日期:2018-07-01 00:00:00

  • Effect of prophylactic bisoprolol plus magnesium on the incidence of atrial fibrillation after coronary bypass surgery: results of a randomized controlled trial.

    abstract:OBJECTIVE:Bisoprolol, a highly cardioselective beta(1)-blocker, is widely used to treat elderly patients with hypertension, coronary artery disease and heart failure. The current literature lacks evidence regarding its potency to prevent atrial fibrillation (AF) following cardiac surgery. Therefore the aim of this stud...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,随机对照试验

    doi:10.1185/030079906X115649

    authors: Behmanesh S,Tossios P,Homedan H,Hekmat K,Hellmich M,Müller-Ehmsen J,Schwinger RH,Mehlhorn U

    更新日期:2006-08-01 00:00:00

  • Surveying general practitioners: a new avenue.

    abstract:BACKGROUND:The validity of opinions expressed in questionnaire surveys diminishes with lower response rates. Recent research suggests that general practitioners (GPs) are more likely to respond to questionnaire surveys if they are motivated to do so because the subject of the survey is perceived as relevant to the prac...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/030079903125002900

    authors: Jiwa M,Coker AE,Bagley J,Freeman J,Coleman M

    更新日期:2004-03-01 00:00:00

  • The management of phenylketonuria in adult patients in Italy: a survey of six specialist metabolic centers.

    abstract:INTRODUCTION:Phenylketonuria (PKU) is a rare autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase (PAH). Its prevalence is estimated to be 1:10,000 in Europe. PKU is the commonest congenital inborn error of metabolism. The aim of our study was to investigate the characteristics of clinical p...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2020.1847717

    authors: Burlina A,Leuzzi V,Spada M,Carbone MT,Paci S,Tummolo A

    更新日期:2020-11-23 00:00:00

  • Exogenous endoscopy-related infections, pseudo-infections, and toxic reactions: clinical and economic burden.

    abstract:OBJECTIVES:The objective of this study was to analyze the characteristics and costs of exogenous endoscopy-related infections, pseudo-infections, and toxic reactions in the US. METHODS:A systematic review of the scientific literature published between 1966 and 2005 was conducted in Medline. Data collection was based o...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/030079906X121048

    authors: Seoane-Vazquez E,Rodriguez-Monguio R,Visaria J,Carlson A

    更新日期:2006-10-01 00:00:00

  • Multimodal analgesia in moderate-to-severe pain: a role for a new fixed combination of dexketoprofen and tramadol.

    abstract:BACKGROUND:Untreated and under-treated pain represent one of the most pervasive health problems, which is worsening as the population ages and accrues risk for pain. Multiple treatment options are available, most of which have one mechanism of action, and cannot be prescribed at unlimited doses due to the ceiling of ef...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1080/03007995.2017.1310092

    authors: Varrassi G,Hanna M,Macheras G,Montero A,Montes Perez A,Meissner W,Perrot S,Scarpignato C

    更新日期:2017-06-01 00:00:00

  • GOAL: multicenter, open-label, post-marketing study of flavocoxid, a novel dual pathway inhibitor anti-inflammatory agent of botanical origin.

    abstract:OBJECTIVES:GOAL (Gauging Osteoarthritis [OA] with Limbrel*), an open-label, post-marketing study was performed to determine the overall efficacy and gastrointestinal (GI) tolerability of flavocoxid, a novel, plant-based, anti-inflammatory medication, in a 'real world' clinical practice setting. To this end, the study e...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究

    doi:10.1185/03007991003694522

    authors: Pillai L,Burnett BP,Levy RM,GOAL Study Cooperative Group.

    更新日期:2010-05-01 00:00:00

  • Antihypertensive efficacy of olmesartan medoxomil or valsartan in combination with amlodipine: a review of factorial-design studies.

    abstract:BACKGROUND:Most patients with hypertension require more than one drug to attain recommended blood pressure (BP) targets. Initiating therapy with two agents is recommended for patients at high risk of a cardiovascular event or with a BP > 20/10 mmHg above goal. Combination therapy is effective when comprised of agents w...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007990802597456

    authors: Ram CV

    更新日期:2009-01-01 00:00:00

  • A prescription for clinical immunology: the pills are available and ready for testing. A review.

    abstract:OBJECTIVE:Modern immunology has been extremely successful in elucidating many features of the immune system, but not in stemming pandemics of non-infectious, immune-related disease associated with industrialized populations. These pandemics involve a broad range of allergic, autoimmune, and inflammatory diseases, poten...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007995.2012.695731

    authors: Parker W,Perkins SE,Harker M,Muehlenbein MP

    更新日期:2012-07-01 00:00:00

  • A clinical and health economic review of a prefilled insulin pen.

    abstract:OBJECTIVE:Several different durable or disposable insulin pen delivery devices are currently available, and newer, improved devices are being introduced. One prefilled insulin device, FlexPen (FP), has recently been improved (known as the Next Generation FlexPen (NGFP) in Europe or the improved FlexPen in the United St...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007995.2010.512447

    authors: Niskanen L

    更新日期:2010-10-01 00:00:00

  • Ways to increase adherence to allergen immunotherapy.

    abstract::Adherence to allergen immunotherapy (AIT) is crucial for its efficacy. Subcutaneous AIT requires monthly visits (or more extended in the case of venom immunotherapy), while sublingual AIT is performed with a daily intake of allergen drops. Non-adherence to an AIT schedule and premature discontinuation are common probl...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1080/03007995.2018.1552044

    authors: Pitsios C,Dietis N

    更新日期:2019-06-01 00:00:00

  • Treatment of osteoarthritis: a 3-month comparison between tiaprofenic acid and indomethacin.

    abstract::A double-blind trial was carried out in 60 elderly patients with osteoarthritis of the knee or hip to compare the efficacy and tolerability of treatment with tiaprofenic acid and indomethacin. Patients received either 600 mg tiaprofenic acid or 100 mg indomethacin daily for 3 months. The results of assessments made ev...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007998309112387

    authors: Meurice J

    更新日期:1983-01-01 00:00:00

  • Efficacy and tolerability of cefuroxime axetil in patients with upper respiratory tract infections.

    abstract::A study was carried out in general practice to assess the clinical effectiveness and tolerability of the oral cephalosporin, cefuroxime axetil, in the treatment of 369 patients presenting with acute infections of the upper respiratory tract. The main diagnoses were tonsillitis, pharyngitis, sinusitis and otitis media....

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007998709108965

    authors: Griffiths GK,VandenBurg MJ,Wight LJ,Gudgeon AC,Kelsey M

    更新日期:1987-01-01 00:00:00