Abstract:
BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD foam compared with Cal/BD gel from the Australian perspective. METHODS:A Markov model was developed to evaluate the cost-effectiveness of topical Cal/BD foam and gel for the treatment of people with plaque psoriasis. Treatment effectiveness, safety, and utilities were based on a randomized control trial, resource use was informed by expert opinion, and unit costs were obtained from public sources. Outcomes were reported in terms of 1-year costs, quality-adjusted life years, and incremental cost-effectiveness ratios. All costs were reported in 2017 Australian Dollars. RESULTS:The model showed that patients using Cal/BD foam had more QALYs and higher costs over 1 year compared with patients using Cal/BD gel, resulting in a cost of $13,609 per QALY gained at 4-weeks. When 4 weeks of Cal/BD foam was compared with 8 weeks of Cal/BD gel treatment, Cal/BD foam was $8 less expensive and resulted in 0.006 more QALYs gained. Sensitivity analyses showed that, compared with Cal/BD ointment, Cal/BD foam was associated with an incremental cost of $15,091 per QALY gained. CONCLUSION:Cal/BD foam is the most cost-effective Cal/BD formulation for the topical treatment of patients with plaque psoriasis.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Foley P,Garrett S,Ryttig Ldoi
10.1080/03007995.2018.1428542subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1277-1283issue
7eissn
0300-7995issn
1473-4877journal_volume
34pub_type
杂志文章abstract::Critical thinking is crucially important in both research and practice. This article demonstrates that a lack of critical thinking in two meta-analyses resulted in a conclusion that contradicts another meta-analysis and popular opinions. Kahwati et al. and Zhao et al. drew a conclusion that "Vitamin D supplementation ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2019.1687432
更新日期:2020-03-01 00:00:00
abstract::In a general practice survey of the use of Temazepam 'Planpak' ('Planpak'), 31 participating doctors completed questionnaires on 250 patients. Of these, 228 patients had been taking a variety of 8 benzodiazepine hypnotics prior to 'Planpak' therapy while 22 (8.8%) patients received 'Planpak' as a short course, without...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007999109111510
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:The stratum corneum (SC) pharmacokinetics of terbinafine following single-dose administration of a novel cutaneous solution (film-forming solution, FFS) containing terbinafine hydrochloride and a film-forming agent, was investigated in three studies. Terbinafine 1% cream (Lamisil) was included as a benchmark ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/030079907X199664
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Although beta-blocker therapy has been shown to improve survival in patients with chronic heart failure, this class of drugs tends to be underutilized in diabetic patients due to concerns about adverse metabolic effects, especially on glycemic control. No randomized clinical trial has specifically evaluated ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/030079906X80459
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:The primary aim of this study was to compare the effect of colesevelam HCl in combination with ezetimibe to ezetimibe monotherapy on low-density lipoprotein cholesterol (LDL-C) levels in subjects with primary hypercholesterolemia. METHODS:Subjects with primary hypercholesterolemia (N = 86) were enrolled in a...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/030079906X148436
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To compare the effectiveness of antiresorptive agents in reducing the risk of vertebral and non-vertebral fractures using data from published meta-analyses and the technique of adjusted indirect comparisons. RESEARCH DESIGN AND METHODS:Pairs of agents were compared by adjusted indirect comparison of 0.56 [0....
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079904125003269
更新日期:2004-04-01 00:00:00
abstract:: Background & aims: Vitamin D deficiency is widespread worldwide. In this study, we aimed to evaluate the effect of a nano encapsulated form of vitamin D used for fortifying low-fat dairy products (milk and yogurt) on anthropometric indices, glycemic status, and lipid profi...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2021.1874324
更新日期:2021-01-12 00:00:00
abstract::Six patients suffering from rheumatoid arthritis with massive knee joint effusions were treated with single daily doses of 600 mg pirazolac, a novel non-steroidal anti-inflammatory drug, for 3 days. Before the first dose, 3 hours after the second and the third dose, specimens of plasma and synovial fluid were drawn si...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998709112409
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy and safety of lumiracoxib for knee osteoarthritis (OA). METHODS:This was a 13-week, multicentre, randomized, double-blind, double-dummy, placebo-controlled study. Males or females aged >/= 18 years with primary knee OA received lumiracoxib 100 mg od, lumiracoxib 100 mg od with a loa...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1185/030079905x38196
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines development group examined the properties of oral H(1)-antihistamines and made proposals about an 'optimal' drug. Several criteria should be met by oral H(1)-antihistamines in terms of their pharmacological, and clinical efficacy and safety pro...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2011.648263
更新日期:2012-01-01 00:00:00
abstract::The efficacy and safety of etodolac (Ultradol) and acetaminophen plus codeine [A + C (Tylenol #3)] in controlling post-surgical pain were compared in an open-label, randomized, parallel-group outpatient study. Patients who were voluntarily having a vasectomy performed for sterilization were assigned to receive either ...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007999709113329
更新日期:1997-01-01 00:00:00
abstract::Filgrastim prophylaxis, both primary and secondary, was rapidly incorporated into clinical practice in the 1990s. When pegfilgrastim became available in 2002, it quickly replaced filgrastim as the colony-stimulating factor (CSF) of choice for prophylaxis. Use of prophylaxis increased markedly in the first decade of th...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1080/03007995.2019.1703665
更新日期:2020-03-01 00:00:00
abstract::Poor nutritional status may impair well being indirectly as a consequence of increased morbidity and decline in functional status. The aim of this study was to examine the independent effect of body mass index on the well being of older people. Thirty one hospital-based patients over 65 years of age were studied. Well...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:Azole antifungal agents are often coadministered with immunosuppressants to recipients of solid organ and hematopoietic stem cell transplants. Posaconazole, an extended-spectrum triazole, is an inhibitor of the cytochrome P450 (CYP) isoenzyme CYP3A4, and sirolimus, an immunosuppressant, is a substrate of the...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802644209
更新日期:2009-03-01 00:00:00
abstract::Effective management of influenza depends on early recognition of influenza in the community and on rapid diagnosis. Early recognition is achieved by integrated clinical and laboratory based surveillance programmes in representative populations. The recent introduction of 'near patient tests' for influenza provide inc...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079902125000921
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Low-dose acetylsalicylic acid (ASA; aspirin; 75-325 mg/day) is effective for the prevention of cardiovascular events, and its use in this indication is rapidly increasing. However, the use of ASA and, indeed, other non-steroidal anti-inflammatory drugs (NSAIDs) is limited by the incidence of adverse gastrodu...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990903212682
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To assess the effect of an individualized genomic classifier (GC) test, for predicting metastasis following radical prostatectomy (RP), on urologists' adjuvant treatment decisions when caring for high-risk patients. PATIENTS AND METHODS:Data were submitted by US board-certified urologists in community practi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007995.2014.919908
更新日期:2014-08-01 00:00:00
abstract::Objective To assess the efficacy of a mixed intervention, educational, and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods This was a prospective, longitudinal, multi-center study, carried out in 110 speci...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1080/03007995.2018.1435519
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Bisoprolol, a highly cardioselective beta(1)-blocker, is widely used to treat elderly patients with hypertension, coronary artery disease and heart failure. The current literature lacks evidence regarding its potency to prevent atrial fibrillation (AF) following cardiac surgery. Therefore the aim of this stud...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/030079906X115649
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:The validity of opinions expressed in questionnaire surveys diminishes with lower response rates. Recent research suggests that general practitioners (GPs) are more likely to respond to questionnaire surveys if they are motivated to do so because the subject of the survey is perceived as relevant to the prac...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079903125002900
更新日期:2004-03-01 00:00:00
abstract:INTRODUCTION:Phenylketonuria (PKU) is a rare autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase (PAH). Its prevalence is estimated to be 1:10,000 in Europe. PKU is the commonest congenital inborn error of metabolism. The aim of our study was to investigate the characteristics of clinical p...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1847717
更新日期:2020-11-23 00:00:00
abstract:OBJECTIVES:The objective of this study was to analyze the characteristics and costs of exogenous endoscopy-related infections, pseudo-infections, and toxic reactions in the US. METHODS:A systematic review of the scientific literature published between 1966 and 2005 was conducted in Medline. Data collection was based o...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079906X121048
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Untreated and under-treated pain represent one of the most pervasive health problems, which is worsening as the population ages and accrues risk for pain. Multiple treatment options are available, most of which have one mechanism of action, and cannot be prescribed at unlimited doses due to the ceiling of ef...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1080/03007995.2017.1310092
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:GOAL (Gauging Osteoarthritis [OA] with Limbrel*), an open-label, post-marketing study was performed to determine the overall efficacy and gastrointestinal (GI) tolerability of flavocoxid, a novel, plant-based, anti-inflammatory medication, in a 'real world' clinical practice setting. To this end, the study e...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007991003694522
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Most patients with hypertension require more than one drug to attain recommended blood pressure (BP) targets. Initiating therapy with two agents is recommended for patients at high risk of a cardiovascular event or with a BP > 20/10 mmHg above goal. Combination therapy is effective when comprised of agents w...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990802597456
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Modern immunology has been extremely successful in elucidating many features of the immune system, but not in stemming pandemics of non-infectious, immune-related disease associated with industrialized populations. These pandemics involve a broad range of allergic, autoimmune, and inflammatory diseases, poten...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2012.695731
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Several different durable or disposable insulin pen delivery devices are currently available, and newer, improved devices are being introduced. One prefilled insulin device, FlexPen (FP), has recently been improved (known as the Next Generation FlexPen (NGFP) in Europe or the improved FlexPen in the United St...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2010.512447
更新日期:2010-10-01 00:00:00
abstract::Adherence to allergen immunotherapy (AIT) is crucial for its efficacy. Subcutaneous AIT requires monthly visits (or more extended in the case of venom immunotherapy), while sublingual AIT is performed with a daily intake of allergen drops. Non-adherence to an AIT schedule and premature discontinuation are common probl...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1080/03007995.2018.1552044
更新日期:2019-06-01 00:00:00
abstract::A double-blind trial was carried out in 60 elderly patients with osteoarthritis of the knee or hip to compare the efficacy and tolerability of treatment with tiaprofenic acid and indomethacin. Patients received either 600 mg tiaprofenic acid or 100 mg indomethacin daily for 3 months. The results of assessments made ev...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998309112387
更新日期:1983-01-01 00:00:00
abstract::A study was carried out in general practice to assess the clinical effectiveness and tolerability of the oral cephalosporin, cefuroxime axetil, in the treatment of 369 patients presenting with acute infections of the upper respiratory tract. The main diagnoses were tonsillitis, pharyngitis, sinusitis and otitis media....
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998709108965
更新日期:1987-01-01 00:00:00