Abstract:
OBJECTIVES:The objective of this study was to analyze the characteristics and costs of exogenous endoscopy-related infections, pseudo-infections, and toxic reactions in the US. METHODS:A systematic review of the scientific literature published between 1966 and 2005 was conducted in Medline. Data collection was based on a prospective protocol developed by the authors. RESULTS:The literature review included 70 outbreaks described in 64 scientific articles. Bronchoscopy accounted for half of all reported outbreaks. Inadequate decontamination practices were the leading cause of contamination; equipment malfunction became the second leading cause of contamination during the period 1990-2004. More than 91% of the infections identified could be prevented by health care providers if quality control systems are improved and implemented. The available economic information concerning exogenous endoscope related events is very limited. A model for the analysis of the economic burden of exogenous endoscopy-related events is proposed. CONCLUSIONS:Proper decontamination practices, the use of protective sheaths, and the improvement of surveillance systems could reduce the clinical and economic burdens associated with exogenous endoscopy-related events.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Seoane-Vazquez E,Rodriguez-Monguio R,Visaria J,Carlson Adoi
10.1185/030079906X121048subject
Has Abstractpub_date
2006-10-01 00:00:00pages
2007-21issue
10eissn
0300-7995issn
1473-4877journal_volume
22pub_type
杂志文章,评审abstract:OBJECTIVES:High-sensitivity C-reactive protein (hs-CRP) has been explored for use in predicting cardiovascular risk. The recent Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study found that statin therapy reduced cardiovascular events in those with ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2010.516994
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Tumor necrosis factor (TNF) antagonists, most frequently prescribed biologics for moderate to severe rheumatoid arthritis (RA), are subject to dose escalation. Even though different methods have been employed to estimate the timing and magnitude of dose escalation, there is no consensus on which method is op...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2010.483127
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:As evidence grows about the management of hyponatremia, a number of different international and national recommendations/guidelines from professional organizations have recently been published that offer guidance on decision-making. However, they include several important differences that cou...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2014.920314
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:Statins are hypothesized to have beneficial effects in asthma management through their pleiotropic anti-inflammatory effects. Several studies have examined this relationship, but have yielded conflicting results. This study investigates the effect of statin use on asthma-related hospitalizations and/or emerge...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2013.865599
更新日期:2014-04-01 00:00:00
abstract::Three methods for the determination of azapropazone were studied for the analysis of blood plasma samples taken after oral administration of azapropazone. A gas chromatographic method was compared with two simple spectrophotometric assay methods and the effect of metabolites of the drug on each method is described. It...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997609109279
更新日期:1976-01-01 00:00:00
abstract::In this narrative review, we will discuss some of the significant risks and dramatic consequences that are associated with epilepsy: depression, suicide, seizure-related injuries, and mortality, both in adults and in children. Considering the high prevalence of depression among people with epilepsy (PWE), routine and ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1776234
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy and safety of lumiracoxib for knee osteoarthritis (OA). METHODS:This was a 13-week, multicentre, randomized, double-blind, double-dummy, placebo-controlled study. Males or females aged >/= 18 years with primary knee OA received lumiracoxib 100 mg od, lumiracoxib 100 mg od with a loa...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1185/030079905x38196
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Proton pump inhibitors (PPIs) are the most commonly used pharmacological treatment for gastroesophageal reflux disease (GERD). OBJECTIVE:To examine the utilization patterns of PPIs and other GERD-related medications, satisfaction with PPI treatment and presence of GERD symptoms. PATIENTS AND METHODS:GERD p...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990903035745
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to estimate utility values for hypothetical health states that describe differences in weight and quality of life associated with type 2 diabetes mellitus (DM) from Canadians with type 2 DM. The impact on utility values was examined separately for participants with a body mass ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2014.899207
更新日期:2014-07-01 00:00:00
abstract::A double-blind, crossover study was carried out in 31 patients with rheumatoid arthritis or osteoarthritis who suffered from insomnia which was considered to be caused primarily by their disease. Patients received 7-day courses of 400 mg chlormezanone, 200 mg chlormezanone and placebo in a pre-determined random order....
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998309109782
更新日期:1983-01-01 00:00:00
abstract::This commentary critically evaluates the limitations of genetic risk predictions in multifactorial disease, with specific reference to age-related macular degeneration (AMD). AMD is a common blinding disease with 33 million people worldwide experiencing vision impairment. Although gene polymorphism combinations infer ...
journal_title:Current medical research and opinion
pub_type: 社论
doi:10.1185/03007995.2011.603301
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension (PAH) in real-world clinical practice. METHODS:This prospective, multicenter, noninterventional, post-marketing surveillance included patients with PAH who were observed for up to 2 years after in...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1080/03007995.2017.1297931
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To quantify changes in clinical and cost outcomes associated with increasing levels of body mass index (BMI) in a US setting. RESEARCH METHODS AND PROCEDURES:A semi-Markov model was developed to project and compare life expectancy (LE), quality-adjusted life expectancy (QALE) and direct medical costs associa...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079906X96227
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:As results from an increasing number of clinical trials with disease-modifying drugs (DMDs) in multiple sclerosis (MS) become available, the challenge for the treating neurologist is how to decide on the appropriate therapy for an individual patient. OBJECTIVE:An International Working Group for Treatment Op...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007x233007
更新日期:2007-11-01 00:00:00
abstract::A trial to compare the therapeutic potential of 1200 mg. azapropazone daily with 3.9 g. aspirin daily was carried out in 108 out-patients with rheumatoid arthritis over a 14-day period. Analysis of results from the 85 patients with completed assessment data (49 on azapropazone; 36 on aspirin) showed that azapropazone ...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007997609109281
更新日期:1976-01-01 00:00:00
abstract::A double-blind crossover trial was undertaken to compare the efficacy of sustained-release clonidine and long-acting propranolol in the treatment of 20 patients (8 males and 12 females) with sustained hypertension. Each patient was stabilized with metoprolol with or without diuretic therapy prior to admission to the t...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998209109778
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:To investigate the predictive factors associated with physical impairment among older patients with type 2 diabetes mellitus (T2DM) in Japan and to examine the potential impact of physical impairment on patient-reported health outcomes in this population. METHODS:A cross-sectional analysis was conducted usin...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1846170
更新日期:2020-11-23 00:00:00
abstract:OBJECTIVE:Neuropathic pain is often difficult to treat due to a complex pathophysiology. This study evaluated the efficacy, tolerability and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin for neuropathic pain in patients with post-herpetic neuralgia (PHN) or painful diabetic polyneurop...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990903048078
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:The pattern of renal transplantation has never been described since the introduction of the technique. The purpose of this study was therefore to characterise the pattern of renal transplantation from 1967 to 2000, focusing on renal graft function as a predictor of survival. METHODS:This study was a retrosp...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X65574
更新日期:2005-11-01 00:00:00
abstract::A study was carried out to compare a new, unique chemical strip test for the measurement of urine specific gravity with the traditional methods of hydrometry and refractometry, during water concentration/dilution tests in 12 normal subjects. The pattern of specific gravity results during these serial measurements was ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998309111742
更新日期:1983-01-01 00:00:00
abstract::A clinical study was carried out to evaluate the usefulness of intravenous lorazepam, given for sedation instead of opiate narcotics or diazepam, in 25 seriously-ill patients being treated in a respiratory and intensive care unit. All but 3 patients were on assisted ventilation. Standard doses of 4 mg lorazepam were g...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997609109320
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:Corticotropin-releasing hormone (CRH) is one of the most potent vasodilatory factors in the human feto-placental circulation. The expression of CRH was significantly down-regulated in patients with intrahepatic cholestasis of pregnancy (ICP). METHODS:One hundred pregnant women diagnosed with ICP at 34-34(+6)...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2014.907560
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:The Physician Payments Sunshine Act, enacted in 2010, is intended to increase the transparency of relationships between US physicians and teaching hospitals and manufacturers of drugs, biologics, and medical devices. We examined current opinion regarding the impact of the Sunshine Act on peer-reviewed medical...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2015.1131151
更新日期:2016-01-01 00:00:00
abstract::Understanding of the damaging effects of significance testing has steadily grown. Reporting p values without dichotomizing the result to be significant or not, is not the solution. Confidence intervals are better, but are troubled by a non-intuitive interpretation, and are often misused just to see whether the null va...
journal_title:Current medical research and opinion
pub_type: 信件
doi:10.1185/03007995.2011.618493
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To assess whether maintenance of labor epidural analgesia using programmed intermittent epidural bolus (PIEB) is associated with reduced local anesthetic (LA) consumption, patient-controlled epidural analgesia (PCEA) use, and rescue analgesia requirements compared to continuous epidural infusion (CEI). RESEA...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1181619
更新日期:2016-08-01 00:00:00
abstract::Filgrastim prophylaxis, both primary and secondary, was rapidly incorporated into clinical practice in the 1990s. When pegfilgrastim became available in 2002, it quickly replaced filgrastim as the colony-stimulating factor (CSF) of choice for prophylaxis. Use of prophylaxis increased markedly in the first decade of th...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1080/03007995.2019.1703665
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To further assess the clinically active dose range of etoricoxib, a COX-2 selective inhibitor, in rheumatoid arthritis (RA). METHODS:RA patients were randomized to etoricoxib 10, 30, 60, or 90 mg or placebo in a double-blind, 12-week study. DMARDs (methotrexate, biologics) or low-dose corticosteroids were al...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007995.2011.614935
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To identify determinants of non-compliance with bisphosphonates in women with postmenopausal osteoporosis. By considering the year of the introduction of weekly bisphosphonates important additional information is obtained. METHODS:New female users of daily or weekly alendronate or risedronate between 1999 an...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079908x297358
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:For the prevention of chemotherapy-induced febrile aplasia, a single injection of pegfilgrastim per cycle has the same efficacy as six to ten injections of conventional granulocyte colony-stimulating factor (G-CSF). However, there are few data on the economic impact of pegfilgrastim use, especially in the co...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007990902918156
更新日期:2009-06-01 00:00:00
abstract::An open study was carried out in 40 elderly patients suffering from osteoarthrosis of the hip to assess the effectiveness of 200 mg flurbiprofen daily, fiven either in tablet or liquid suspension form, over a period of 4 weeks. Statistical evaluation of the results in the 19 patients admitted to analysis showed that f...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007997709108988
更新日期:1977-01-01 00:00:00