Abstract:
OBJECTIVE:Corticotropin-releasing hormone (CRH) is one of the most potent vasodilatory factors in the human feto-placental circulation. The expression of CRH was significantly down-regulated in patients with intrahepatic cholestasis of pregnancy (ICP). METHODS:One hundred pregnant women diagnosed with ICP at 34-34(+6) weeks of gestation agreed to participate in this prospective nested case-control study. Thirty ICP patients were finally recruited in this study, with 16 cases in the ursodeoxycholic acid (UDCA) group (UDCA 750 mg/d) and 14 cases in the control group (Transmetil 1000 mg/d or Essentiale 1368 mg/d). Maternal serum samples were obtained in diagnosis and at 37-37(+6) weeks of gestation. Placental tissues were obtained from participants after delivery. ELISA, enzymatic colorimetric and Western blotting were used to evaluate the concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acid (TBA) and CRH in maternal serum and expression of CRH in placenta tissues. RESULTS:The UDCA group had greater reduction in maternal serum ALT, AST and TBA levels in ICP patients (all p < 0.01). Maternal serum CRH concentrations in the UDCA group after treatment (122.10 ± 44.20) pg/ml was significantly higher than pretreatment (95.45 ± 26.47) pg/ml (p < 0.01). After treatment, maternal serum CRH concentrations of the UDCA group (122.10 ± 44.20) pg/ml was significantly higher than in the control group (80.71 ± 41.10) pg/ml (p < 0.01). Placental CRH expression in the UDCA group (2.79 ± 1.72) was significantly higher than in the control group (0.69 ± 0.36) (p < 0.01). CONCLUSIONS:Maternal serum and placental CRH expression in ICP patients were up-regulated after treatment of UDCA. The up-regulation of CRH expression after UDCA treatment may play an important role in the therapeutic mechanism of ICP. All patients recruited in this study had severe cholestasis (TBA ≥ 40 µmol/L). Further studies are warranted in different gestational weeks and TBA levels to provide more evidence for the correlation between UDCA treatment and CRH expression in ICP patients.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Zhou F,Zhang L,He MM,Liu ZF,Gao BX,Wang XDdoi
10.1185/03007995.2014.907560subject
Has Abstractpub_date
2014-08-01 00:00:00pages
1529-35issue
8eissn
0300-7995issn
1473-4877journal_volume
30pub_type
杂志文章abstract:OBJECTIVE:Bariatric surgery is an effective treatment for the reduction of weight in obese patients (BMI ≥ 40 kg/m(2) or 30 kg/m(2) with ≥1 comorbidities), who are refractory to behavioral and medical therapies. This study examined the effect of the adjustable gastric band (AGB) system on changes in gastroesophageal re...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,meta分析
doi:10.1185/03007995.2012.666962
更新日期:2012-04-01 00:00:00
abstract::Objective: Health utility estimates for children and adolescents are critical for cost-utility analyses informing health technology assessment (HTA) authorities' decisions governing access to pediatric treatments. However, in a recent review, only 29% of published pediatric cost-utility models used a utility measure v...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1762553
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079906X148481
更新日期:2006-12-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/030079908x253870
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether healthy men would prefer either luteinizing hormone releasing hormone analogues (LHRHa) or non-steroidal anti-androgen therapy (NSAA) should they hypothetically develop locally advanced prostate cancer. PARTICIPANTS AND METHODS:A representative sample of 180 men...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X59058
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abstract:OBJECTIVES:Epidemiological data support an association between age-related macular degeneration (AMD) and cataract surgery that may be attributed to post-operative blue light exposure. By limiting the retina's blue light exposure, new blue-light filtering intraocular lenses (BLF IOLs) have the potential to reduce the d...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079906X115586
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/030079908x280635
更新日期:2008-04-01 00:00:00
abstract::Objective: The aim of this study was to investigate the impact of methodological choices in a meta-analysis of real-world evidence (RWE) comparing three non-vitamin-K antagonist oral anticoagulants with vitamin K antagonists (VKAs) for the treatment of patients with non-valvular atrial fibrillation (NVAF). Methods: Th...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1080/03007995.2019.1647020
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2015.1105202
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079908x301857
更新日期:2008-05-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1832058
更新日期:2020-12-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1185/03007999109111519
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:To describe the impact of migraine on psychological well-being of young women and to evaluate their communication with physicians about migraine. RESEARCH DESIGN AND METHODS:This cross-sectional telephone survey was conducted in Israel and eight European countries (Finland, Germany, Greece, Italy, Norway, Sp...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X56394
更新日期:2005-08-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/030079906X148319
更新日期:2006-11-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1080/03007995.2019.1703665
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Chronic obstructive pulmonary disease (COPD) is becoming a leading cause of morbidity and mortality in China. In the IMPACT trial, fluticasone furoate[FF]/umeclidinium[UMEC]/vilanterol[VI] single-inhaler triple therapy demonstrated lower rates of moderate/severe exacerbations than dual therapy with FF/VI or ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1844646
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abstract:OBJECTIVE:We recently reported the efficacy of rofecoxib in two randomized controlled trials in chronic low back pain (CLBP). The objectives of this report are to present data regarding the onset of efficacy of rofecoxib from these trials and propose methods for reporting onset. RESEARCH DESIGN AND METHODS:Patients we...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/030079904125003160
更新日期:2004-05-01 00:00:00
abstract::Objective To assess the efficacy of a mixed intervention, educational, and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods This was a prospective, longitudinal, multi-center study, carried out in 110 speci...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1080/03007995.2018.1435519
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abstract::A long-term follow-up study was carried out in 44 Type II diabetic patients to confirm the lack of effect of gliclazide on body weight as well as its hypoglycaemic efficacy and tolerance. Patients were assessed for up to 51 months. The results showed no overall significant change in body weight, 21 patients gaining we...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998409109552
更新日期:1984-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
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更新日期:2020-03-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1178108
更新日期:2016-08-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998609111090
更新日期:1986-01-01 00:00:00
abstract::A single-blind, open-label controlled study was carried out in 30 healthy male volunteers to compare gastro-intestinal blood loss before, during and after treatment with a new, sustained-release formulation of the non-steroidal anti-inflammatory agent etodolac (etodolac SR) or with naproxen. Subjects remained at the s...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007999209115217
更新日期:1992-01-01 00:00:00
abstract::Evidence is needed to guide therapeutic decisions on patients who had ischaemic cerebral events. The recently published European/Australasian Stroke Prevention in Reversible Ischaemia Trial (ESPRIT), an open-label randomised controlled study, compared long-term treatment of patients randomised to aspirin 30-325 mg dai...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/030079906X167291
更新日期:2007-02-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007997809111903
更新日期:1978-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2010.517718
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:Schizophrenia is one of the most debilitating diseases in the United Arab Emirates. Oral antipsychotics (OA) are commonly used in terms of pharmacotherapy; however, these treatments can be rendered ineffective by poor patient adherence. Paliperidone palmitate once monthly (PP1M) is a long acting antipsychotic...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2017.1417246
更新日期:2018-04-01 00:00:00
abstract::A randomized study was performed on 24 patients with ankylosing spondylitis to compare the efficacy and tolerability of 20 mg tenoxicam daily with 50 mg diclofenac twice daily. There were 6 withdrawals from the group taking tenoxicam and 4 from the diclofenac group. Depression in 1 patient taking tenoxicam was the onl...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007999009112691
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:To evaluate effectiveness and safety information of transdermal fentanyl (TDF) (Duragesic/Durogesic) and sustained-release oral morphine (SRM) in cancer pain (CP) and chronic non-cancer pain (NCP), a pooled analysis was conducted on datasets of published, open label, uncontrolled (no comparator group) and rando...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/030079904X2114
更新日期:2004-09-01 00:00:00