When to consider "mixed pain"? The right questions can make a difference!

abstract：:The glomerular and tubular function of 7 patients with a spectrum of renal impairment was measured before, during and after 4-days' treatment with cefuroxime and gentamicin. Neither the mean plasma urea nor creatinine concentrations of the group increased after combined treatment, nor was the excretion of cefuroxime s...

journal_title：Current medical research and opinion

authors： Cockram CS,Richards P,Bax RP

更新日期：1980-01-01 00:00:00

abstract：:Objectives Real-world patient outcomes data is scarce concerning the high disease burden of IBS-C. The aim of this study was to compare patient-reported symptom control, health-related quality of life (HRQoL), resource utilization, and treatment satisfaction of lubiprostone vs non-lubiprostone treatment for irritable ...

journal_title：Current medical research and opinion

authors： Solem CT,Patel H,Mehta S,Mody R,Macahilig C,Gao X

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Lowering intraocular pressure (IOP) is currently the only therapeutic approach that preserves visual function in primary open-angle glaucoma. In making treatment decisions for first- and second-line therapy, the clinician needs to provide an appropriate balance of efficacy and tolerability. Prostaglandin ana...

journal_title：Current medical research and opinion

authors： Aptel F,Denis P

更新日期：2011-10-01 00:00:00

abstract：:Objective: The purpose of this study was to examine surgical and survival outcomes in the elderly (65-79 years of age) and the very elderly (≥80 years of age) who received surgery for gastric cancer.Methods: This study retrospectively reviewed the records of patients ≥65 years old who received a gastrectomy for gastri...

journal_title：Current medical research and opinion

authors： Wong JU,Tai FC,Huang CC

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To determine the economic impact of sustained non-remission of depression on the total annual all-cause healthcare costs of patients with a history of depression. METHODS:Adults with ≥2 claims with depression diagnosis codes from the HealthCore Integrated Research Database were invited to participate in this...

journal_title：Current medical research and opinion

authors： Dennehy EB,Robinson RL,Stephenson JJ,Faries D,Grabner M,Palli SR,Stauffer VL,Marangell LB

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:We recently reported the efficacy of rofecoxib in two randomized controlled trials in chronic low back pain (CLBP). The objectives of this report are to present data regarding the onset of efficacy of rofecoxib from these trials and propose methods for reporting onset. RESEARCH DESIGN AND METHODS:Patients we...

journal_title：Current medical research and opinion

authors： Katz N,Rodgers DB,Krupa D,Reicin A

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:Epidemiological data support an association between age-related macular degeneration (AMD) and cataract surgery that may be attributed to post-operative blue light exposure. By limiting the retina's blue light exposure, new blue-light filtering intraocular lenses (BLF IOLs) have the potential to reduce the d...

journal_title：Current medical research and opinion

authors： Reddy P,Gao X,Barnes R,Fairchild C,Boci K,Waycaster C,Pashos C

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to quantify the incidence of thromboembolic events (specifically, deep vein thromboses [DVT] and pulmonary embolism [PE]) in patients with cancer, and to examine the effects of a major clinical trial design and execution factors on those incidence rates. RESEARCH DESIGN AND ME...

journal_title：Current medical research and opinion

authors： Reynolds MW,Shibata A,Zhao S,Jones N,Fahrbach K,Goodnough LT

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of rosuvastatin in postmenopausal women with hypercholesterolemia who are receiving hormone replacement therapy (HRT) in a randomized, double-blind, placebo-controlled trial. METHODS:After a 6-week dietary lead-in period, 135 postmenopausal women who had been taking a stab...

journal_title：Current medical research and opinion

authors： Shepherd J,Packard C,Littlejohn TW 3rd,Walker J,Stein EA,Smith K,Kallend D,Blasetto JW

更新日期：2004-10-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVE:As evidence grows about the management of hyponatremia, a number of different international and national recommendations/guidelines from professional organizations have recently been published that offer guidance on decision-making. However, they include several important differences that cou...

journal_title：Current medical research and opinion

authors： Verbalis JG,Grossman A,Höybye C,Runkle I

更新日期：2014-07-01 00:00:00

abstract：:Oesophageal mucosa has well established protective mechanisms, which operate within pre-epithelial, epithelial and post-epithelial compartments. Since refluxed acid and pepsin always act from the luminal side of the mucosa, protective factors like EGF, operating as a part of pre-epithelial defence, are thought to be p...

journal_title：Current medical research and opinion

authors： Marcinkiewicz M,Grabowska SZ,Czyzewska E

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:The efficacy of antihistamines in perennial allergic rhinitis in children has been evaluated in studies using active comparators, whereas placebo-controlled studies are very few. A randomized, multicenter, double-blind, parallel-group clinical study was carried out to evaluate the dose-response relationship a...

journal_title：Current medical research and opinion

authors： Okubo K,Okuda M,Magara H,Kaneko K

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Although beta-blocker therapy has been shown to improve survival in patients with chronic heart failure, this class of drugs tends to be underutilized in diabetic patients due to concerns about adverse metabolic effects, especially on glycemic control. No randomized clinical trial has specifically evaluated ...

journal_title：Current medical research and opinion

authors： Bell DS,Lukas MA,Holdbrook FK,Fowler MB

更新日期：2006-02-01 00:00:00

abstract：:An open, multi-centre study was carried out in 804 patients complaining of sleep disorders to assess the effectiveness and acceptance of temazepam as a hypnotic. Patients received between 10 mg and 30 mg (mean 16.4 mg) temazepam each night for a week. Subjective assessments using a self-administered questionnaire were...

journal_title：Current medical research and opinion

authors： Harry TV,Johnson PA

更新日期：1978-01-01 00:00:00

abstract：:Filgrastim prophylaxis, both primary and secondary, was rapidly incorporated into clinical practice in the 1990s. When pegfilgrastim became available in 2002, it quickly replaced filgrastim as the colony-stimulating factor (CSF) of choice for prophylaxis. Use of prophylaxis increased markedly in the first decade of th...

journal_title：Current medical research and opinion

authors： Edelsberg J,Weycker D,Bensink M,Bowers C,Lyman GH

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Fibromyalgia (FM) is characterized by persistent and widespread pain and often associated with other symptoms and comorbidities. Thus, FM patients seek care from multiple physician specialties. This study compared prescribing patterns, patient-reported outcomes (PROs), healthcare resource use (HRU), and dire...

journal_title：Current medical research and opinion

authors： McNett M,Goldenberg D,Schaefer C,Hufstader M,Baik R,Chandran A,Zlateva G

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the influence of age, sex, and previous opioid experience on the likelihood of successfully titrating opioid-naive and experienced patients with chronic low back pain (CLBP) to an effective and well-tolerated dose of oxymorphone extended release (ER). METHODS:Post hoc analysis of open-label titra...

journal_title：Current medical research and opinion

authors： Peniston JH,Xiang Q,Gould EM

更新日期：2010-08-01 00:00:00

abstract：:The efficacy of trimetazidine, an anti-ischaemic agent, has been largely assessed and presented in the international literature through its metabolic effects, selective and specific fatty acid oxidation inhibition and lack of haemodynamic effects in stable angina pectoris. As such, trimetazidine has opened up a new cl...

journal_title：Current medical research and opinion

authors： Marzilli M

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Insulin resistance alone does not result in the development of type 2 diabetes; progressive dysfunction of pancreatic islet alpha and beta cells, which results in inadequate control of hyperglycemia, must be present for the disease to develop. Because of these defects, meal-stimulated insulin secretion from ...

journal_title：Current medical research and opinion

authors： Meece J

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the positive predictive value of claims-based V85 codes for identifying individuals with varying degrees of BMI relative to their measured BMI obtained from medical record abstraction. METHODS:This was a retrospective validation study utilizing administrative claims and medical chart data from 1 ...

journal_title：Current medical research and opinion

authors： Caplan EO,Kamble PS,Harvey RA,Smolarz BG,Renda A,Bouchard JR,Huang JC

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Deriving preference scores for the Medical Outcomes Study (MOS) Sleep Scale would enable its use in cost-utility analyses. The objective of this study was to map scores of the MOS Sleep Scale to a preference-based health-state utility index (SF-6D) scored from the SF-36 Health Survey (SF-36). RESEARCH DESIGN...

journal_title：Current medical research and opinion

authors： Yang M,Dubois D,Kosinski M,Sun X,Gajria K

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:To compare compliance/persistence, health care resource utilization, and costs associated with single-pill combination (SPC) vs. free-combination (FC) therapies among adult hypertension patients at the national and state level. Combination therapies with angiotensin receptor blocker (ARB) + calcium channel b...

journal_title：Current medical research and opinion

authors： Yang W,Chang J,Kahler KH,Fellers T,Orloff J,Wu EQ,Bensimon AG

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the effect of gliclazide modified release (MR) treatment on adiponectin, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) plasma concentrations in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:24 randomly selected type 2 diabetic patients, aged 61...

journal_title：Current medical research and opinion

authors： Drzewoski J,Zurawska-Klis M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To compare safety and efficacy of biphasic insulin aspart 70/30 (BIAsp 30) with exenatide in subjects with type 2 diabetes mellitus (T2DM) not achieving glycemic targets with metformin and sulfonylurea in a randomized, open-label, 24-week trial. RESEARCH DESIGN AND METHODS:Subjects (N = 372, T2DM > 6 months,...

journal_title：Current medical research and opinion

authors： Bergenstal R,Lewin A,Bailey T,Chang D,Gylvin T,Roberts V,NovoLog Mix-vs.-Exenatide Study Group.

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of epoetin theta and epoetin beta in anaemic patients with chronic kidney disease, undergoing haemodialysis and previously on stable maintenance therapy with epoetin beta. METHODS:In this multicentre, randomised, controlled, double-blind study 270 haemodialysis patients wer...

journal_title：Current medical research and opinion

authors： Gertz B,Kohler E,Kes P,Essaian A,Bias P,Buchner A,Elsässer R

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:In addition to direct weight reduction, there may be other benefits of obesity treatment including improved insulin sensitivity. The purpose of this study was to characterise concomitant diabetes drug use and the related costs in patients with diabetes treated with orlistat (Xenical) in the first 6 months of ...

journal_title：Current medical research and opinion

authors： Rowe R,Cowx M,Poole C,McEwan P,Morgan C,Walker M

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:To evaluate intraocular pressure (IOP)-lowering efficacy, tolerability, and safety of the fixed combination of bimatoprost 0.03% and timolol 0.5% (Ganfort) among German patients. METHODS:Multicenter, observational, open-label study of patients with primary open angle glaucoma or ocular hypertension (n = 606)...

journal_title：Current medical research and opinion

authors： Feuerhake C,Buchholz P,Kimmich F

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Acute postprandial hyperglycemia (aPPHG) is often symptomatic and can be associated with behavioral changes such as impaired working memory and attention. However, there is little evidence of the impact of aPPHG on the daily lives of patients. The aim of this study was to explore the frequency and severity of...

journal_title：Current medical research and opinion

authors： Heller S,Meneghini L,Nikolajsen A,Kragh N,Lewis HB,Saretsky T,Kosmas CE,Lloyd A

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:In May 2018, the US Food and Drug Administration approved pegvaliase-pqpz (Palynziq*), the first enzyme substitution therapy for the treatment of phenylketonuria (PKU). This article provides an overview of the mechanism of action, pharmacokinetic properties, clinical efficacy, and the safety and tolerability ...

journal_title：Current medical research and opinion

authors： Mahan KC,Gandhi MA,Anand S

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of selective laser trabeculoplasty (SLT) on the intraocular pressure (IOP) of untreated fellow eyes in patients with open-angle glaucoma. STUDY DESIGN:Retrospective chart review. PATIENTS AND METHODS:Charts of all patients who underwent SLT at the University of Texas Southwestern M...

journal_title：Current medical research and opinion

authors： Rhodes KM,Weinstein R,Saltzmann RM,Aggarwal N,Kooner KS,Petroll WM,Whitson JT

更新日期：2009-03-01 00:00:00