The safety of cefuroxime and gentamicin in patients with reduced renal function.

abstract：OBJECTIVE:We recently reported the efficacy of rofecoxib in two randomized controlled trials in chronic low back pain (CLBP). The objectives of this report are to present data regarding the onset of efficacy of rofecoxib from these trials and propose methods for reporting onset. RESEARCH DESIGN AND METHODS:Patients we...

journal_title：Current medical research and opinion

authors： Katz N,Rodgers DB,Krupa D,Reicin A

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Rhizophora mangle aqueous bark extract (RMABE) (CIKRON-H), has been used as antiseptic and skin wound healing promoter. The present study was a randomised, single-blinded, placebo control trial conducted to asses the efficacy of RMABE in treating oral aphthous ulcers. RESEARCH DESIGN AND METHODS:Patients (n ...

journal_title：Current medical research and opinion

authors： de Armas E,Sarracent Y,Marrero E,Fernández O,Branford-White C

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:Gastro-oesophageal reflux disease (GORD) is a recurring condition with many patients requiring long-term maintenance therapy. Therefore initial choice of treatment has long-term cost implications. The aim was to compare the costs and effectiveness of treatment of GORD the (unconfirmed by endoscopy) with seven...

journal_title：Current medical research and opinion

authors： Remák E,Brown RE,Yuen C,Robinson A

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of rosuvastatin in postmenopausal women with hypercholesterolemia who are receiving hormone replacement therapy (HRT) in a randomized, double-blind, placebo-controlled trial. METHODS:After a 6-week dietary lead-in period, 135 postmenopausal women who had been taking a stab...

journal_title：Current medical research and opinion

authors： Shepherd J,Packard C,Littlejohn TW 3rd,Walker J,Stein EA,Smith K,Kallend D,Blasetto JW

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Luseogliflozin is a novel sodium glucose cotransporter 2 inhibitor for type 2 diabetes mellitus (T2DM) treatment. An exploratory Phase II study was conducted to assess the efficacy and safety of several doses of luseogliflozin in Japanese T2DM patients. PATIENTS AND METHODS:Japanese T2DM patients aged 20-74 ...

journal_title：Current medical research and opinion

authors： Seino Y,Sasaki T,Fukatsu A,Sakai S,Samukawa Y

更新日期：2014-07-01 00:00:00

abstract：:In a study of 32 patients, there were 29 cases of intra-uterine fetal death and 3 cases of hydatidiform mole. The intravenous administration of either prostaglandin E1, E2 or F2 successfully induced labor in 29 out of the 32 cases. 2 patients delivered following additional intravenous oxytocin and there was 1 failur...

journal_title：Current medical research and opinion

authors： Roberts G

更新日期：1974-01-01 00:00:00

abstract：BACKGROUND:It has been postulated that intraocular pressure, an important glaucoma risk factor, correlates positively with arterial blood pressure (blood pressure). However, results of experimental and clinical studies are often contradictory. It is hypothesized that, in some hypertensive patients, disturbances in intr...

journal_title：Current medical research and opinion

authors： Skrzypecki J,Grabska-Liberek I,Przybek J,Ufnal M

更新日期：2018-03-01 00:00:00

abstract：:In a multi-centre study, the antidepressant efficacy and incidence of on-therapy events of trazodone (100 to 400 mg daily) and mianserin (30 to 120 mg daily) was compared using a double-blind pre-determined randomized parallel group design in depressed patients unresponsive to placebo after a 7-day screening period. O...

journal_title：Current medical research and opinion

authors： Bennie EH,Khan MC,Tyrer SP,Siddiqui U,Ankier SI

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:Bariatric surgery is an effective treatment for the reduction of weight in obese patients (BMI ≥ 40 kg/m(2) or 30 kg/m(2) with ≥1 comorbidities), who are refractory to behavioral and medical therapies. This study examined the effect of the adjustable gastric band (AGB) system on changes in gastroesophageal re...

journal_title：Current medical research and opinion

authors： Woodman G,Cywes R,Billy H,Montgomery K,Cornell C,Okerson T,APEX Study Group.

更新日期：2012-04-01 00:00:00

abstract：:A double-blind trial of methocarbamol versus placebo was carried out in 59 matched pairs of patients suffering from painful muscle spasm. Methocarbamol (1500 mg. q.d.s.) was found to be effective in approximately 60% of patients compared with 30% of patients receiving placebo (p less than 0.01). Side-effects were of a...

journal_title：Current medical research and opinion

authors： Valtonen EJ

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:To investigate the predictive factors associated with physical impairment among older patients with type 2 diabetes mellitus (T2DM) in Japan and to examine the potential impact of physical impairment on patient-reported health outcomes in this population. METHODS:A cross-sectional analysis was conducted usin...

journal_title：Current medical research and opinion

authors： Araki A,Umegaki H,Sakurai T,Mizuno Y,Miyao M,Imori M,Suzuki S,Cambron-Mellott MJ,Yokote K,Onuma T,Yokono K

更新日期：2020-11-23 00:00:00

abstract：:This paper represents a review, by experts, of current opinion and information on intermittent claudication (IC) and the role that cilostazol plays in its treatment. IC is a common and debilitating condition that has a significant adverse impact on health-related quality of life (HR-QoL). It is currently under-recogni...

journal_title：Current medical research and opinion

authors： Barnett AH,Bradbury AW,Brittenden J,Crichton B,Donnelly R,Homer-Vanniasinkam S,Mikhailidis DP,Stansby G

更新日期：2004-10-01 00:00:00

abstract：:Two hundred and two patients with symptoms, signs and mycological evidence of Candida vaginitis were entered in a single-blind trial comparing 6-day clotrimazole therapy with a control group receiving 6 days' nystatin therapy. Adequate data was collected on 69 clotrimazole and 72 nystatin treated patients for analysis...

journal_title：Current medical research and opinion

authors： Masterton G,Henderson J,Napier IR,Moffet M

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:Patients with type 2 diabetes (T2DM) often have multiple comorbidities which may impact the selection of antihyperglycemic therapies. The purpose of this study was to quantify the prevalence and co-prevalence of common comorbidities. RESEARCH DESIGN AND METHODS:A retrospective study was conducted using the Q...

journal_title：Current medical research and opinion

authors： Iglay K,Hannachi H,Joseph Howie P,Xu J,Li X,Engel SS,Moore LM,Rajpathak S

更新日期：2016-07-01 00:00:00

abstract：:The position statement on the management of hyperglycemia in patients with type 2 diabetes mellitus issued in 2012 by the American Diabetes Association and the European Association for the Study of Diabetes contains significant improvements over the 2009 version, including an emphasis on patient-centered care, enhance...

journal_title：Current medical research and opinion

authors： Schwartz SS

更新日期：2013-07-01 00:00:00

abstract：:Twenty-nine patients undergoing cholecystectomy because of chronic calculous cholecystitis were randomised to receive phenylbutazone 10 mg/kg intramuscularly or a control injection (vehicle-containing local anaesthetic) immediately after completion of surgery. Fibrinogen and plasminogen concentrations in plasma, plasm...

journal_title：Current medical research and opinion

authors： Szczepański M,Kubiak J,Lembas L

更新日期：1998-01-01 00:00:00

abstract：:A clinical study was carried out to evaluate the usefulness of intravenous lorazepam, given for sedation instead of opiate narcotics or diazepam, in 25 seriously-ill patients being treated in a respiratory and intensive care unit. All but 3 patients were on assisted ventilation. Standard doses of 4 mg lorazepam were g...

journal_title：Current medical research and opinion

authors： Dundee JW,Johnston HM,Gray RC

更新日期：1976-01-01 00:00:00

abstract：:Objective: To assess real-world costs for patients with hemophilia A treated with bypassing agents versus factor VIII (FVIII) replacement. Methods: Claims data from a large US health insurer during 1 January 2006-30 September 2014 were used for analysis. Treated patients with hemophilia A were identified based on ≥1 m...

journal_title：Current medical research and opinion

authors： Swindle JP,Xu Y,Mu Y,Solari PG

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To compare injection site pain of subcutaneous (sc) epoetin beta and darbepoetin alfa in adult patients with chronic kidney disease. RESEARCH DESIGN AND METHODS:This was a multi-centre, randomised, two-arm, single-blind, cross-over study. Patients were randomised to receive weekly sc darbepoetin alfa 30 mug ...

journal_title：Current medical research and opinion

authors： Roger SD,Suranyi MG,Walker RG,Disney A,Isbel NM,Kairaitis L,Pollock CA,Brown FG,Chow J,Truman MI,Ulyate KA,COMFORT study group.

更新日期：2008-08-01 00:00:00

abstract：:Aims: We sought to investigate the reasons for, and rates of, novel oral anticoagulant (DOAC) therapy discontinuation.Methods: This was an observational cohort study of patients with atrial fibrillation (AF) referred to a regional DOAC outpatient clinic between February 2013 and October 2017. The study population cons...

journal_title：Current medical research and opinion

authors： Mitrovic D,Folkeringa R,Veeger N,van Roon E

更新日期：2020-04-01 00:00:00

abstract：: Background & aims: Vitamin D deficiency is widespread worldwide. In this study, we aimed to evaluate the effect of a nano encapsulated form of vitamin D used for fortifying low-fat dairy products (milk and yogurt) on anthropometric indices, glycemic status, and lipid profi...

journal_title：Current medical research and opinion

authors： Sharifan P,Ziaee A,Darroudi S,Rezaie M,Safarian M,Eslami S,Khadem-Rezaiyan M,Tayefi M,Mohammadi M,Ghazizadeh H,Khorasanchi Z,Bagherniya M,Sardar MA,Ferns G,Vatanparast H,Ghayour Mobarhan M

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Differences between interferons have been evaluated for over 20 years. While randomized controlled trial (RCT) data is mainly used for assessments and strong data for causal inferences, it does not necessarily reflect everyday practice. Real-world data may provide additional information. PURPOSE:To assess t...

journal_title：Current medical research and opinion

authors： Einarson TR,Bereza BG,Machado M

更新日期：2017-03-01 00:00:00

abstract：AIM:Non-peer-reviewed manuscripts posted as preprints can be cited in peer-reviewed articles, which has both merits and demerits. International Committee of Medical Journal Editors guidelines mandate authors to declare preprints at the time of manuscript submission. We evaluated the trends in pharma-authored research p...

journal_title：Current medical research and opinion

authors： Subramanian K,Nalli A,Senthil V,Bhat A

更新日期：2020-12-09 00:00:00

abstract：:Sodium meclofenamate (200 to 400 mg daily) was compared with aspirin (2.4 to 4.8 g daily) for the treatment of rheumatoid arthritis in a 6-month, double-blind, multicentre study. Two groups of patients participated, one receiving stabilized doses of concomitant gold or steroid therapy and one not receiving such therap...

journal_title：Current medical research and opinion

authors： Gowans JD

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To determine the effects of long-term atomoxetine treatment on sexual development in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) as compared with placebo and with a national US survey in non-Hispanic white children and adolescents. METHODS:This double-blind, placebo-controll...

journal_title：Current medical research and opinion

authors： Trzepacz PT,Spencer TJ,Zhang S,Bangs ME,Witte MM,Desaiah D

更新日期：2011-01-01 00:00:00

abstract：:An open, controlled study was carried out in 30 in-patients with low arterial pressure syndrome to compare the effectiveness and tolerance of dimetophrine and midodrine in restoring blood pressure to normal levels and relieving symptoms. Patients were allocated at random to receive treatment for 15 days with either 10...

journal_title：Current medical research and opinion

authors： Marini U,Cecchi A,Venturini M

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:Ocular surface disease (OSD) is a common side effect of ophthalmic medications containing the preservative benzalkonium chloride (BAK). Little is known whether and how glaucoma treatment patterns and annual costs vary based on the presence of BAK. The objective of this analysis was to estimate first-year trea...

journal_title：Current medical research and opinion

authors： Schmier JK,Covert DW,Robin AL

更新日期：2010-12-01 00:00:00

abstract：:In a double-blind, partial cross-over study of 141 patients with mild to moderate hypertension, chlorthalidone 50 mg was compared with chlorthalidone 50 mg/triamterene 50 mg combination treatment. The study assessed clinical efficacy in the reduction of blood pressure, and safety with regard to serum potassium concent...

journal_title：Current medical research and opinion

authors： Spiers DR,Wade RC

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:This study was undertaken to assess the long-term outcome of transcatheter arterial chemoembolization (TACE) after radiofrequency ablation (RFA) combined with a combined therapy for Chinese patients with intermediate (stage B) hepatocellular carcinoma (HCC) of single block type, and evaluate the survival rate...

journal_title：Current medical research and opinion

authors： Xu RC,Liu HC,Li JL,Li K,Ou SY,Yu ZY,Kong Y,Ma GA,Shao WS

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Abuse and misuse of prescription opioids is a significant public health concern. This review examines the strategies used to confer abuse-deterrent properties on opioid abuse-deterrent formulations (ADFs), the characteristics and supporting data for each of the available ADFs, and the role of opioid ADFs as p...

journal_title：Current medical research and opinion

authors： Pergolizzi JV Jr,Raffa RB,Taylor R Jr,Vacalis S

更新日期：2018-04-01 00:00:00