Pharmaceutical industry-authored preprints: scientific and social media impact.

abstract：OBJECTIVES:To compare the efficacy and safety of ciprofloxacin 0.3%/dexamethasone 0.1% (CIP/DEX) otic suspension with that of neomycin 0.35%/polymyxin B 10,000 IU/mL/hydrocortisone 1.0% (N/P/H) otic suspension in patients with acute otitis externa (AOE). STUDY DESIGN:Randomized, observer-masked, parallel-group, multic...

journal_title：Current medical research and opinion

authors： Roland PS,Pien FD,Schultz CC,Henry DC,Conroy PJ,Wall GM,Garadi R,Dupre SJ,Potts SL,Hogg LG,Stroman DW,Ciprodex Otic AOE Study Group.

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Fibromyalgia (FM) is characterized by persistent and widespread pain and often associated with other symptoms and comorbidities. Thus, FM patients seek care from multiple physician specialties. This study compared prescribing patterns, patient-reported outcomes (PROs), healthcare resource use (HRU), and dire...

journal_title：Current medical research and opinion

authors： McNett M,Goldenberg D,Schaefer C,Hufstader M,Baik R,Chandran A,Zlateva G

更新日期：2011-03-01 00:00:00

abstract：:A double-blind crossover study was carried out in 24 patients with rheumatoid arthritis to investigate the relative efficacy of tolmetin (1600 mg/day) and phenylbutazone (400 mg/day). Each drug was given for 4 weeks, preceded by a 2-week wash-out period during which patients received paracetamol alone for pain relief....

journal_title：Current medical research and opinion

authors： Cardoe N,Steele CE

更新日期：1976-01-01 00:00:00

abstract：:A study was carried out in 80 mild to moderately depressed patients seen in general practice to assess the relative effectiveness and tolerance of a single night-time dose compared with the usual divided daily dosage regimen of a chlordiazepoxide (5 mg)/amitriptyline (12.5 mg) combination. Patients were assigned at ra...

journal_title：Current medical research and opinion

authors： James RT,Dean BC

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether gum chewing affects perceived levels of everyday stress among persons who (1) regularly chew gum or (2) do not chew gum on a regular basis. RESEARCH DESIGN AND METHODS:Two Internet-based studies were conducted. Study 1 enrolled participants who chewed gum > or =4 days per week, chewed ...

journal_title：Current medical research and opinion

authors： Zibell S,Madansky E

更新日期：2009-06-01 00:00:00

abstract：:Although the statistical strength of direct comparative randomized controlled trials is generally acknowledged, the particular demands of therapeutic decision making will often require indirect comparisons to be made, based on pooled data from multiple trials. As for all post-hoc analyses, the process of indirect comp...

journal_title：Current medical research and opinion

authors： Belsey JD

更新日期：2015-02-01 00:00:00

abstract：:One hundred and eight patients who had been taking phenytoin for a year or more, either alone or in combination with other drugs, were examined for gum hypertrophy by three observers independently. Approximately 90% of the patients showed either mild or no gum hypertrophy and severe swelling occurred in only 1%. The o...

journal_title：Current medical research and opinion

authors： Grant RH,Parsonage MJ,Barot MH

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To further assess the clinically active dose range of etoricoxib, a COX-2 selective inhibitor, in rheumatoid arthritis (RA). METHODS:RA patients were randomized to etoricoxib 10, 30, 60, or 90 mg or placebo in a double-blind, 12-week study. DMARDs (methotrexate, biologics) or low-dose corticosteroids were al...

journal_title：Current medical research and opinion

authors： Greenwald M,Peloso PM,Mandel D,Soto O,Mehta A,Frontera N,Boice JA,Zhan XJ,Curtis SP

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Osteoporosis is a skeletal disorder characterized by diminished bone strength, which results in an increased risk of fracture. Currently, osteoporosis is a public health priority due to the large number of individuals affected and the detrimental effect on quality of life. Primary osteoporosis, the most commo...

journal_title：Current medical research and opinion

authors： Brandi ML,Minisola S

更新日期：2013-11-01 00:00:00

abstract：:As the emergence of cardiovascular disease (CVD) is linked to modifiable lifestyle and physiological factors, it is increasingly important to concentrate on preventative strategies. For preventative measures to be beneficial it is necessary to clearly identify patients at risk--given that multiple risk factors often c...

journal_title：Current medical research and opinion

authors： De Backer G

更新日期：2007-11-01 00:00:00

abstract：:Thirteen young adult patients suffering from heterozygotic familial hypercholesterolaemia with tendinous xanthomatosis, previously treated with a suitable special diet, were studied to assess the effect of bezafibrate, given for 2 years at a dose of 800 mg/day, on plasma lipid and lipoprotein levels and on changes in ...

journal_title：Current medical research and opinion

authors： Rouffy J,Chanu B,Bakir R,Goy-Loeper J,Djian F,Monsuez JJ,Gomberg R,Laval-Jeantet M

更新日期：1988-01-01 00:00:00

abstract：:Objective: Determine healthcare resource utilization (HCRU) and costs associated with fatigue and stiffness among patients with rheumatoid arthritis (RA).Methods: A retrospective claims analysis compared RA patients with fatigue or stiffness to matched RA control patients with neither. Claims from a large US commercia...

journal_title：Current medical research and opinion

authors： Strand V,Shah R,Atzinger C,Zhou J,Clewell J,Ganguli A,Tundia N

更新日期：2020-01-01 00:00:00

abstract：UNLABELLED:The occurrence of intestinal bacterial overgrowth in patients with Crohn's Disease (CD) has been described and antimicrobial treatment has been shown to be effective in reversing this condition. However, the mechanisms underlying the efficacy of antimicrobial therapy are still only partially known. The aim o...

journal_title：Current medical research and opinion

authors： Biancone L,Vernia P,Agostini D,Ferrieri A,Pallone F

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To evaluate knowledge about risks, prevention and consequences of infection with hepatitis B virus (HBV) among travellers from four low HBV risk, European countries. METHODS:Individuals from an internet panel and based in the Czech Republic, the Netherlands, Spain and Sweden were invited to take part in an o...

journal_title：Current medical research and opinion

authors： Herbinger KH,Nothdurft HD,Prymula R

更新日期：2011-03-01 00:00:00

abstract：:A double-blind, parallel group study was carried out in 50 patients with an anxiety disorder to compare the anxiolytic efficacy and tolerability of a recently developed benzodiazepine, metaclazepam, with that of bromazepam. Patients were allocated at random to receive treatment for 2 weeks with either 15 mg metaclazep...

journal_title：Current medical research and opinion

authors： Marano P,Patti F,Nicoletti F

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To develop a patient-completed screening tool to help differentiate nociceptive and neuropathic pain. RESEARCH DESIGN AND METHODS:A multicenter study was performed for item reduction (initial 89-item questionnaire) and model building. Patients (N = 586) with non-headache chronic pain completed the questionna...

journal_title：Current medical research and opinion

authors： Portenoy R

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:To derive current real-world data on the rates and costs of severe hypoglycemia (SH) for people with type 2 diabetes mellitus (T2D) who have initiated basal insulin therapy and to examine differences in SH rates and costs stratified by history of prior SH events. METHODS:We used a nation-wide electronic hea...

journal_title：Current medical research and opinion

authors： Ganz ML,Wintfeld NS,Li Q,Lee YC,Gatt E,Huang JC

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:This subanalysis compared the efficacy of betahistine plus piracetam dual therapy versus betahistine monotherapy using data from OSVaLD, a 3 month, open-label, observational study conducted in 2272 patients with peripheral vestibular vertigo. Of the 1898 patients included in the original efficacy populatio...

journal_title：Current medical research and opinion

authors： Melnikov OA,Lilenko SV,Nauta J,Ouwens MJ

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The implementation of international pediatric asthma guidelines hinges on the distinction between intermittent and persistent phenotypes and the prescription of recommended phenotype-specific pharmacotherapy. OBJECTIVES:To ascertain key factors associated with specialist-confirmed phenotype and document phy...

journal_title：Current medical research and opinion

authors： Ducharme FM,Morin J,Davis GM,Gingras J,Noya FJ

更新日期：2012-09-01 00:00:00

abstract：:Objectives Real-world patient outcomes data is scarce concerning the high disease burden of IBS-C. The aim of this study was to compare patient-reported symptom control, health-related quality of life (HRQoL), resource utilization, and treatment satisfaction of lubiprostone vs non-lubiprostone treatment for irritable ...

journal_title：Current medical research and opinion

authors： Solem CT,Patel H,Mehta S,Mody R,Macahilig C,Gao X

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:High-sensitivity C-reactive protein (hs-CRP) has been explored for use in predicting cardiovascular risk. The recent Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study found that statin therapy reduced cardiovascular events in those with ...

journal_title：Current medical research and opinion

authors： Slejko JF,Page RL 2nd,Sullivan PW

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to ascertain the factors associated with non-achievement of triglyceride (TG) goals in a cohort of hypertriglyceridemic patients attending the lipid clinics of the Spanish Arteriosclerosis Society (LC-SAS). METHODS:Patients with high TG levels (>2.2 mmol/L; 200 mg/dL) were included...

journal_title：Current medical research and opinion

authors： Pintó X,Valdivielso P,Perez de Juan JM,Plana N,Garcia-Arias C,Fuentes FJ,Hernández-Mijares A,Mostaza JM,Spanish Registry of Hypertriglyceridemia (Spanish Society of Arteriosclerosis, SAS).

更新日期：2014-01-01 00:00:00

abstract：:Control of hypertension is hindered by the incidence of adverse events associated with therapy, which can result in low patient compliance. Specific angiotensin II receptor subtype AT1 blockers offer an alternative to the angiotensin converting enzyme inhibitors in the treatment of hypertension, as the incidence of si...

journal_title：Current medical research and opinion

authors： Levine B

更新日期：2001-01-01 00:00:00

abstract：:This study evaluated the prognostic significance of several risk factors on the outcome of coronary heart disease (CHD) in 639 cardiovascular disease-free subjects with heterozygous familial hypercholesterolaemia (FH). During the 15-year follow-up, 53 (18%) men and 34 (9.8%) women had a CHD event (men vs women, p < 0....

journal_title：Current medical research and opinion

authors： Panagiotakos DB,Pitsavos C,Skoumas J,Chrysohoou C,Toutouza M,Stefanadis CI,Toutouzas PK

更新日期：2003-01-01 00:00:00

abstract：:During the past decades several epidemiological studies have provided a 'portrait' of the potential candidate for cardiovascular disease, introducing many emerging life-style risk factors such as obesity, unhealthy diet, exposure to passive smoking, lack of exercise, psychosocial stress, and depression, as well as ele...

journal_title：Current medical research and opinion

authors： Pitsavos CE,Toutouzas PK

更新日期：2002-01-01 00:00:00

abstract：:An investigator-blind, parallel-group, multicentre study was undertaken to compare the efficacy and tolerability of once-daily, sustained-release (s-r) ibuprofen and diclofenac sodium in patients (mean age 59.8 years) suffering from painful osteoarthritis affecting chiefly the knee and/or hip. Patients attending eight...

journal_title：Current medical research and opinion

authors： Baumgartner H,Schwarz HA,Blum W,Bruhin A,Gallachi G,Goldinger G,Saxer M,Trost H

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:We sought to evaluate the relationship between different levels of medication possession ratio (MPR) attained and achievement of clinically meaningful reductions in lipid levels. RESEARCH DESIGN AND METHODS:This was a retrospective cohort study of 4691 new statin users from the Department of Veteran Affairs ...

journal_title：Current medical research and opinion

authors： Watanabe JH,Bounthavong M,Chen T

更新日期：2013-03-01 00:00:00

abstract：:The efficacy and safety of etodolac (Ultradol) and acetaminophen plus codeine [A + C (Tylenol #3)] in controlling post-surgical pain were compared in an open-label, randomized, parallel-group outpatient study. Patients who were voluntarily having a vasectomy performed for sterilization were assigned to receive either ...

journal_title：Current medical research and opinion

authors： Casey R,Zadra J,Khonsari H

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To describe dosing patterns of etanercept, adalimumab, and infliximab in rheumatoid arthritis (RA) patients in US managed care. METHODS:This retrospective analysis included adult (18-64 years) RA patients in the HealthCore Integrated Research Database with ≥ 1 claim for etanercept, adalimumab, or infliximab ...

journal_title：Current medical research and opinion

authors： Fisher MD,Watson C,Fox KM,Chen YW,Gandra SR

更新日期：2013-05-01 00:00:00

abstract：:Twenty-seven patients with tennis elbow were treated with triamcinolone acetonide (40 mg/ml) injected locally into the tender area without local anaesthetic. Reduction of pain or complete relief was achieved in 1 to 72 hours, although in 9 cases exacerbation of pain occurred before relief was given. The recurrence rat...

journal_title：Current medical research and opinion

authors： Nevelös AB

更新日期：1980-01-01 00:00:00