Phenytoin-induced gum hypertrophy in patients with epilepsy.

abstract：OBJECTIVE:To compare hypoglycemia event rates in patients initiated on long-acting insulin analog (glargine) or intermediate-acting insulin (NPH) and to analyze the associated cost-consequence from a managed care perspective. STUDY DESIGN:A retrospective analysis of pharmacy and medical claims and electronic laborator...

journal_title：Current medical research and opinion

authors： Bullano MF,Al-Zakwani IS,Fisher MD,Menditto L,Willey VJ

更新日期：2005-02-01 00:00:00

abstract：:Abstract Recent guidelines recommend strict goals for low-density lipoprotein cholesterol (LDL-C) (1.8-2.6 mmol/L; 70-100 mg/dL). However, these goals are not always met and many primary and secondary prevention patients are not optimally controlled. Both the under-prescription of lipid-lowering medication and lack of...

journal_title：Current medical research and opinion

authors： Daskalopoulou SS,Doonan RJ,Mikhailidis DP

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVES:Eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, has been shown to increase platelet counts in adults with chronic immune thrombocytopenia and chronic hepatitis C. This multicenter phase 2 study assessed the efficacy and safety of eltrombopag in patients receiving first-line carboplatin/pacl...

journal_title：Current medical research and opinion

authors： Kellum A,Jagiello-Gruszfeld A,Bondarenko IN,Patwardhan R,Messam C,Mostafa Kamel Y

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Small cell lung cancer (SCLC) patients, who have achieved complete or partial response after chemotherapy, should be followed with prophylactic cranial irradiation (PCI). PCI for extrapulmonary small cell carcinoma (EPSCC) is not routinely recommended. The purpose of this review is to discuss all aspects of ...

journal_title：Current medical research and opinion

authors： Yazıcı O,Ozdemir NY,Sendur MA,Aksoy S,Zengin N

更新日期：2014-07-01 00:00:00

abstract：:The most common side-effect of statins, mainly during dose titration, is liver toxicity, In these cases, sufficient control of low density lipoprotein cholesterol (LDL-C) in patients with heterozygous familial hypercholesterolaemia (HFH) becomes problematical. In patients with intolerance to resins as well, especially...

journal_title：Current medical research and opinion

authors： Athyros VG,Papageorgiou AA,Demitriadis DS,Kontopoulos AG

更新日期：2001-01-01 00:00:00

abstract：:A double-blind, parallel group trial of a 1 mg sodium cromoglycate metered dose inhaler, a 5 mg formulation and a placebo aerosol was undertaken in 139 asthmatic patients with extrinsic allergic asthma. None of the patients had previously been treated with sodium cromoglycate and few (15%) were familiar with the use o...

journal_title：Current medical research and opinion

authors： Carrasco E,Sepulveda R

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:High-sensitivity C-reactive protein (hs-CRP) has been explored for use in predicting cardiovascular risk. The recent Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study found that statin therapy reduced cardiovascular events in those with ...

journal_title：Current medical research and opinion

authors： Slejko JF,Page RL 2nd,Sullivan PW

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Adequate vitamin D and calcium nutrition play a critical role in the maintenance of musculoskeletal health and are considered the first step in osteoporosis treatment. ROUNDTABLE DISCUSSION:In February 2008 Merck Sharp & Dohme sponsored a 2-day, evidence-based expert panel on the benefits of vitamin D for t...

journal_title：Current medical research and opinion

authors： Roux C,Bischoff-Ferrari HA,Papapoulos SE,de Papp AE,West JA,Bouillon R

更新日期：2008-05-01 00:00:00

abstract：:A randomized study was performed on 24 patients with ankylosing spondylitis to compare the efficacy and tolerability of 20 mg tenoxicam daily with 50 mg diclofenac twice daily. There were 6 withdrawals from the group taking tenoxicam and 4 from the diclofenac group. Depression in 1 patient taking tenoxicam was the onl...

journal_title：Current medical research and opinion

authors： Schwarzer AC,Cohen M,Arnold MH,Kelly D,McNaught P,Brooks PM

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of intranasal fentanyl spray (INFS), oral transmucosal fentanyl citrate (OTFC), fentanyl buccal tablet (FBT) and oral morphine (OM) for the treatment of breakthrough cancer pain (BTCP). METHODS:A systematic literature review (Medline, EMBASE, BIOSIS; 1996-2007) identified six randomis...

journal_title：Current medical research and opinion

authors： Vissers D,Stam W,Nolte T,Lenre M,Jansen J

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the positive predictive value of claims-based V85 codes for identifying individuals with varying degrees of BMI relative to their measured BMI obtained from medical record abstraction. METHODS:This was a retrospective validation study utilizing administrative claims and medical chart data from 1 ...

journal_title：Current medical research and opinion

authors： Caplan EO,Kamble PS,Harvey RA,Smolarz BG,Renda A,Bouchard JR,Huang JC

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:The stratum corneum (SC) pharmacokinetics of terbinafine following single-dose administration of a novel cutaneous solution (film-forming solution, FFS) containing terbinafine hydrochloride and a film-forming agent, was investigated in three studies. Terbinafine 1% cream (Lamisil) was included as a benchmark ...

journal_title：Current medical research and opinion

authors： Kienzler JL,Queille-Roussel C,Mugglestone C,Ortonne JP,Larnier C

更新日期：2007-06-01 00:00:00

abstract：:Objective: A prior study found that hyaluronic acid (HA) treatment may help reduce pain medication use (such as steroids, non-steroidal anti-inflammatory drugs [NSAIDs] and opioids) among knee osteoarthritis (OA) patients in the real-world setting. This study aims to update the prior study results to include only the ...

journal_title：Current medical research and opinion

authors： Chitnis AS,Etter K,Holy CE,Gray FS,Manalac FJ,Bisson B,Bhattacharyya SK

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:In this study, we explored the analgesic and antihyperalgesic properties of a synthetic cannabinoid (nabilone) on experimental heat pain in men and women, as well as its effects on descending pain inhibitory systems. RESEARCH DESIGN AND METHODS:A double-blind, placebo controlled, crossover study of nabilone ...

journal_title：Current medical research and opinion

authors： Redmond WJ,Goffaux P,Potvin S,Marchand S

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the efficacy and safety of doses of fentanyl buccal tablet (FBT) proportional to doses of opioids used for background analgesia versus dose titration starting with the minimal dose for the management of breakthrough cancer pain (BTcP). METHODS:A total of 82 cancer patien...

journal_title：Current medical research and opinion

authors： Mercadante S,Gatti A,Porzio G,Lo Presti C,Aielli F,Adile C,Casuccio A

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To compare real-world adherence to and persistence with deferasirox film-coated tablets (DFX-FCT) and deferasirox dispersible tablets (DFX-DT) among patients who switched from DFX-DT to DFX-FCT, overall and by disease type (sickle cell disease [SCD], thalassemia, and myelodysplastic syndrome [MDS]). METHODS:...

journal_title：Current medical research and opinion

authors： Cheng WY,Said Q,Hao Y,Xiao Y,Vekeman F,Bobbili P,Duh MS,Nandal S,Blinder M

更新日期：2018-11-01 00:00:00

abstract：:The efficacy and side-effect profiles of two formulations of indomethacin were compared in a multi-centre, double-blind, crossover study in 77 patients with osteoarthritis. Patients were allocated at random to receive 75 mg indomethacin per day either as 1 controlled-release tablet at night or as 1 immediate-release c...

journal_title：Current medical research and opinion

authors： Bacon P,Luqmani RA,Bossingham DH,Daymond TJ,Grahame R,West J,Hazleman BL,Adebajo AO,Hughes GR,Abdullah M

更新日期：1990-01-01 00:00:00

abstract：:Objectives: Atopic dermatitis (AD) is a chronic, relapsing skin condition, with signs and symptoms that impact patients' lives and are best measured from the patient perspective. Therefore, there is a need for AD-specific questionnaires that are consistent with Food and Drug Administration guidance and best measuremen...

journal_title：Current medical research and opinion

authors： Foley C,Tundia N,Simpson E,Teixeira HD,Litcher-Kelly L,Bodhani A

更新日期：2019-07-01 00:00:00

abstract：:Propranolol has recently been shown to produce some impairment of psychomotor performance in human volunteers. This beta-blocking compound, however, is lipophilic and readily penetrates the blood-brain barrier to gain access to the central nervous system. Acebutolol has a lower lipid solubility. A study was carried ou...

journal_title：Current medical research and opinion

authors： Broadhurst AD

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether gum chewing affects perceived levels of everyday stress among persons who (1) regularly chew gum or (2) do not chew gum on a regular basis. RESEARCH DESIGN AND METHODS:Two Internet-based studies were conducted. Study 1 enrolled participants who chewed gum > or =4 days per week, chewed ...

journal_title：Current medical research and opinion

authors： Zibell S,Madansky E

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:The objective of this project was to determine pharmacy cost savings and improvement in adherence based on a combinatorial pharmacogenomic test (CPGx ) in patients who had switched or added a new psychiatric medication after having failed monotherapy for their psychiatric disorder. RESEARCH DESIGN AND METHO...

journal_title：Current medical research and opinion

authors： Winner JG,Carhart JM,Altar CA,Goldfarb S,Allen JD,Lavezzari G,Parsons KK,Marshak AG,Garavaglia S,Dechairo BM

更新日期：2015-01-01 00:00:00

abstract：:A comparative controlled study was carried out in 40 patients suffering from rheumatoid arthritis, osteoarthrosis or ankylosing spondylitis to assess the efficacy of ketoprofen and ibuprofen. Patients were allocated at random to receive either 100 mg ketoprofen twice daily or 400 mg ibuprofen 3-times daily over a peri...

journal_title：Current medical research and opinion

authors： Saxena RP,Saxena U

更新日期：1978-01-01 00:00:00

abstract：:An open, multi-centre study was carried out in 117 pregnant women presenting with vaginal candidosis to assess the effectiveness of econazole in providing mycological control and symptom relief, and in preventing, as far as possible, the risk of contamination of the newborn: nearly 50% of the patients were in the last...

journal_title：Current medical research and opinion

authors： Goormans E,Beek JM,Declercq JA,Loendersloot EW,Roelofs HJ,van Zanten A

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To examine the impact of an electronic data capture system on patient satisfaction and patient-physician interactions in a rheumatology clinical setting. STUDY DESIGN:In this multicenter study, 1079 patients with rheumatoid arthritis completed questionnaires quarterly about their health and satisfaction with...

journal_title：Current medical research and opinion

authors： Huffstutter J,Craig WD,Schimizzi G,Harshbarger J,Lisse J,Kasle S,Hymson L,Yocum D,Castro L,Hegedus R,Callegari P,Yeilding N,Gilmer K

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:Pioglitazone hydrochloride (Actos † ) and rosiglitazone maleate (Avandia ‡ ) are members of the thiazolidinedione (TZD) class of oral anti-diabetic drugs (OADs) and are used to treat type 2 diabetes mellitus (T2DM). Greater beneficial effects on lipids have been demonstrated with pioglitazone, however. Study...

journal_title：Current medical research and opinion

authors： Tunis SL,Minshall ME,St Charles M,Pandya BJ,Baran RW

更新日期：2008-11-01 00:00:00

abstract：:A randomized, double-blind, parallel-group, multi-centre clinical trial was undertaken in 60 patients with dermatophytosis or pityriasis versicolor to compare topical 2% fenticonazole cream with topical 2% miconazole cream. Treatment, by twice-daily application, was for 4 weeks or until earlier complete resolution of ...

journal_title：Current medical research and opinion

authors： Athow-Frost TA,Freeman K,Mann TA,Marks R,Vollum D,Warin AP

更新日期：1986-01-01 00:00:00

abstract：:A double-blind, parallel group study was carried out in 50 patients with an anxiety disorder to compare the anxiolytic efficacy and tolerability of a recently developed benzodiazepine, metaclazepam, with that of bromazepam. Patients were allocated at random to receive treatment for 2 weeks with either 15 mg metaclazep...

journal_title：Current medical research and opinion

authors： Marano P,Patti F,Nicoletti F

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The best management of patients with femoropopliteal and infrapopliteal artery occlusion disease is not clear. This study aimed to compare the efficacy of drug-coated balloons (DCBs) and drug-eluting stents (DESs) with percutaneous transluminal angioplasty (PTA) in patients with femoropopliteal or infrapoplit...

journal_title：Current medical research and opinion

authors： Chen X,Li J,Zheng C,He Y,Jia J,Wang X,Li D,Shang T,Li M

更新日期：2018-01-01 00:00:00

abstract：:The term "mixed pain" is increasingly applied for specific clinical scenarios, such as low back pain, cancer pain and postsurgical pain, in which there "is a complex overlap of the different known pain types (nociceptive, neuropathic, nociplastic) in any combination, acting simultaneously and/or concurrently to cause ...

journal_title：Current medical research and opinion

authors： Freynhagen R,Rey R,Argoff C

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To perform an open, non-controlled, multiple-dose, international, multicentre, phase III study to evaluate epoetin zeta, a biosimilar epoetin referenced to epoetin alfa, for the treatment of chemotherapy-induced anaemia in patients with cancer. METHODS:Safety, tolerability and efficacy of subcutaneously admi...

journal_title：Current medical research and opinion

authors： Tzekova V,Mihaylov G,Elezovic I,Koytchev R,Epoetin Zeta Oncology Study Group.

更新日期：2009-07-01 00:00:00