Abstract:
OBJECTIVES:To derive current real-world data on the rates and costs of severe hypoglycemia (SH) for people with type 2 diabetes mellitus (T2D) who have initiated basal insulin therapy and to examine differences in SH rates and costs stratified by history of prior SH events. METHODS:We used a nation-wide electronic health records database that included encounter and laboratory data, as well as clinical notes, to estimate the rates and costs of SH events among adults with T2D who initiated basal insulin between 2008 and 2011. Unadjusted and regression-adjusted rates and quarterly costs were calculated for all patients as well as stratified by history of a SH event before starting basal insulin and history of a SH event during the basal insulin titration period. RESULTS:We identified 7235 incident cases of basal insulin use among patients with T2D who did not use insulin during the previous 12 months. Regression-adjusted incidence and total event rates were 10.36 and 11.21 per 100 patient-years, respectively. A history of SH events during the pre-index baseline and post-index titration periods were statistically significantly associated with both the incidence and total event rates (p < 0.01). Regression-adjusted total healthcare and diabetes-related costs were statistically significantly (p < 0.01) higher in those quarters when a SH event occurred than in those quarters without any SH events ($3591 vs. $487 and $3311 vs. $406, respectively). A history of previous SH or SH events during the titration period were not statistically significantly associated with costs. CONCLUSIONS:These results suggest that the real-world burden of SH is high among people with T2D who start using basal insulin and that history of previous SH events, both before starting insulin and during the insulin titration period, influences future SH. These results can also provide insights into interventions that can prevent or delay SH. These results should, however, be interpreted in light of the key limitations of our study: not all SH events may have been captured or coded in the database, data on filled prescriptions were not available, and the post-titration follow-up period could have been divided into time units other than quarters (3 month blocks) resulting in potentially different conclusions. Further real-world studies on the frequency and costs of SH, using methods to identify as many SH events as possible, can allow healthcare providers to make more informed decisions on the risks and benefits of basal insulin therapy in T2D patients.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Ganz ML,Wintfeld NS,Li Q,Lee YC,Gatt E,Huang JCdoi
10.1185/03007995.2014.936930subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1991-2000issue
10eissn
0300-7995issn
1473-4877journal_volume
30pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to ascertain the factors associated with non-achievement of triglyceride (TG) goals in a cohort of hypertriglyceridemic patients attending the lipid clinics of the Spanish Arteriosclerosis Society (LC-SAS). METHODS:Patients with high TG levels (>2.2 mmol/L; 200 mg/dL) were included...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007995.2013.850069
更新日期:2014-01-01 00:00:00
abstract::An open, multi-centre study was carried out in 117 pregnant women presenting with vaginal candidosis to assess the effectiveness of econazole in providing mycological control and symptom relief, and in preventing, as far as possible, the risk of contamination of the newborn: nearly 50% of the patients were in the last...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007998509109606
更新日期:1985-01-01 00:00:00
abstract::Objectives: Asthma/chronic obstructive pulmonary disease (COPD) overlap (ACO) is a recently described phenomenon defined as the coexistence of both asthma and COPD. Both asthma and COPD are known to result in increased emergency department (ED) visits and hospitalizations, but it is unclear how the ACO population util...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2019.1565531
更新日期:2019-07-01 00:00:00
abstract::An open, multi-centre study was carried out in 804 patients complaining of sleep disorders to assess the effectiveness and acceptance of temazepam as a hypnotic. Patients received between 10 mg and 30 mg (mean 16.4 mg) temazepam each night for a week. Subjective assessments using a self-administered questionnaire were...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997809111918
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:Evaluation of the safety and efficacy of insulin detemir (IDet) in the observational and non-interventional PREDICTIVE study. METHODS:A total of 2923 patients with type 1 or 2 diabetes on basal-bolus regimens were followed for 6 months: Group (1) NPH + human insulin (HI) bolus switching to IDet + analogue bo...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990903262885
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:These studies evaluated the safety and efficacy of enteric-coated budesonide for the induction and maintenance of remission of mild-to-moderate Crohn's disease (CD) in children. METHODS:The consecutive, multicenter, open-label, non-comparative studies enrolled patients aged 6-17 years. In the induction study...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1080/03007995.2017.1313213
更新日期:2017-07-01 00:00:00
abstract::Migraine is a very common disorder, affecting about 11% of adult populations in Western countries. Prevalence is highest during the peak productive years--between the ages of 25 and 55. The prevalence is higher in females than males at all post-pubertal ages, but the sex ratio varies with age. In the United States, mi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/0300799039117005
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:There is growing evidence describing DNA repair genes polymorphisms are related to increased cancer risk including colorectal cancer (CRC). The aim of this study was to investigate the associations between the APE1 Asp148Glu, hOGG1 Ser326Cys, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His po...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2011.573544
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the safety and clinical efficacy of alcaftadine 0.25% ophthalmic solution, a new topical anti-allergic agent for the prevention of the signs and symptoms of allergic conjunctivitis induced by conjunctival allergen challenge (CAC). STUDY DESIGN AND METHODS:This two-ar...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007995.2010.548797
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The implementation of international pediatric asthma guidelines hinges on the distinction between intermittent and persistent phenotypes and the prescription of recommended phenotype-specific pharmacotherapy. OBJECTIVES:To ascertain key factors associated with specialist-confirmed phenotype and document phy...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2012.716031
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:In order to reduce individual cardiovascular risk, many patients require life-long lipid-lowering therapy, often as a drug combination approach. We aimed to describe the usage pattern, effectiveness and tolerability of long-term treatment with lipid-lowering agents, with particular focus on an oral combinati...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1185/03007990802381406
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:This study was designed to assess the safety of 25- and 50-mg dosage strengths of zonisamide for initial titration in patients with epilepsy. RESEARCH DESIGN AND METHODS:This phase 3, multicenter, open-label, uncontrolled study conducted at 26 study sites in the United States included male and female patient...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1185/030079904125003629
更新日期:2004-06-01 00:00:00
abstract::In addition to their beneficial effects in reducing platelet responsiveness, it has been a matter of controversy whether polyunsaturated fatty acids impair the fibrinolytic system or not. In a double-blind, parallel clinical trial, 40 subjects were randomized to treatment with 6 g/day of corn oil, or to 6 g/day of a f...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007999309111542
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:The impact of multiple sclerosis (MS) center type on outcomes has not been investigated. This study aimed to evaluate baseline characteristics and clinical and magnetic resonance imaging (MRI) outcomes in patients with MS receiving fingolimod over 16 months' follow-up at private or academic centers in the USA...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1458708
更新日期:2018-08-01 00:00:00
abstract::An open study was carried out in 40 elderly patients suffering from osteoarthrosis of the hip to assess the effectiveness of 200 mg flurbiprofen daily, fiven either in tablet or liquid suspension form, over a period of 4 weeks. Statistical evaluation of the results in the 19 patients admitted to analysis showed that f...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007997709108988
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVES:Docetaxel and paclitaxel show significant clinical activity in metastatic breast cancer (MBC) and have been approved for MBC by the U.S. Food and Drug Administration, but it is still unclear whether a paclitaxel-based regimen improves outcomes over a docetaxel-based regimen in patients with MBC. We therefore...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析,评审
doi:10.1185/03007995.2012.756393
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:The injection force and the patient perception of the Next Generation FlexPen (NGFP) with design modifications aimed at reducing injection force was assessed. The accuracy and precision of the NGFP was also tested under standard conditions. RESEARCH DESIGN AND METHODS:Dosing accuracy was tested (according to...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802329264
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Although risk factors for MI have been described in the general population, there is a lack of data on the assessment of risk factors associated with MI in venous thromboembolism (VTE) patients. OBJECTIVE:The purpose of this study was to identify risk factors associated with MI in VTE patients. PATIENTS AN...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2013.852525
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Using a Delphi Consultation process, a group of medical writers established by the European Medical Writers Association (EMWA) set out to determine the current thinking on the problems of ghostwriting in medical publications and what should be done about them. In this context, ghostwriting is where a professi...
journal_title:Current medical research and opinion
pub_type: 指南,杂志文章
doi:10.1185/030079905x25569
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:Clinical evidence supports the use of cardiac resynchronization therapy (CRT) in advanced heart failure, but its cost-effectiveness is still unclear. This analysis assessed the economic and health consequences in the UK of implanting a CRT in patients with NYHA class III-IV heart failure. METHODS:A discrete ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079906X112516
更新日期:2006-06-01 00:00:00
abstract:UNLABELLED:The occurrence of intestinal bacterial overgrowth in patients with Crohn's Disease (CD) has been described and antimicrobial treatment has been shown to be effective in reversing this condition. However, the mechanisms underlying the efficacy of antimicrobial therapy are still only partially known. The aim o...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/0300799009117003
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To evaluate intraocular pressure (IOP)-lowering efficacy, tolerability, and safety of the fixed combination of bimatoprost 0.03% and timolol 0.5% (Ganfort) among German patients. METHODS:Multicenter, observational, open-label study of patients with primary open angle glaucoma or ocular hypertension (n = 606)...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007990902816947
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To determine the characteristics of asthma (A) and allergic rhinitis (AR) among asthma patients in primary care practice. RESEARCH DESIGN AND METHODS:Primary care physicians, pulmonologists, and allergologists were asked to recruit consecutive asthma patients with or without allergic rhinitis from their dail...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990902820733
更新日期:2009-05-01 00:00:00
abstract::An open, controlled study was carried out in 30 in-patients with low arterial pressure syndrome to compare the effectiveness and tolerance of dimetophrine and midodrine in restoring blood pressure to normal levels and relieving symptoms. Patients were allocated at random to receive treatment for 15 days with either 10...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998409109590
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Untreated and under-treated pain represent one of the most pervasive health problems, which is worsening as the population ages and accrues risk for pain. Multiple treatment options are available, most of which have one mechanism of action, and cannot be prescribed at unlimited doses due to the ceiling of ef...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1080/03007995.2017.1310092
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of selective laser trabeculoplasty (SLT) on the intraocular pressure (IOP) of untreated fellow eyes in patients with open-angle glaucoma. STUDY DESIGN:Retrospective chart review. PATIENTS AND METHODS:Charts of all patients who underwent SLT at the University of Texas Southwestern M...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990902728316
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:Aliskiren is the first in a new class of orally effective direct renin inhibitors approved for the treatment of hypertension. This multiple-dose study investigated the potential for pharmacokinetic interactions between aliskiren and three drugs, each predominantly eliminated by a different clearance/metabolic...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/030079908X260934
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To assess the impact of the decision by Kela (The Social Insurance Institution) to adopt guidelines for the management of food allergies in children, developed by the Finnish Medical Society Duodecim, as the basis for reimbursing clinical nutrition preparations for the treatment of cow milk allergy (CMA) in F...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079908x280455
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:This study assesses the direct (medical and drugs) and indirect (work loss) annual costs associated with Atrial Fibrillation (AFIB) in a privately insured population. BACKGROUND:AFIB is the most common sustained rhythm disturbance, affecting 2.3 million people in the United States. METHODS:Cost and co-morbi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/030079905X65475
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To review published evidence on the impact of weight/BMI change on health-related quality of life (HRQoL) in adults from the US with overweight/obesity. METHODS:The systematic review was conducted in accordance with PRISMA guidelines. MEDLINE, Embase, EconLit, and Cochrane Library databases were reviewed usi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2015.1128403
更新日期:2016-01-01 00:00:00