Appropriate use of information in therapeutic decision-making: reflections on indirect comparisons.

abstract：:A double-blind, crossover study was carried out in 31 patients with rheumatoid arthritis or osteoarthritis who suffered from insomnia which was considered to be caused primarily by their disease. Patients received 7-day courses of 400 mg chlormezanone, 200 mg chlormezanone and placebo in a pre-determined random order....

journal_title：Current medical research and opinion

authors： Wojtulewski JA,Walter J

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treatment of predominantly cystic thyroid nodules. MATERIALS AND METHODS:This prospective study included 111 patients with 122 benign predominantly cystic thyroid nodules inducing pressure symptoms or cosmetic problems. The no...

journal_title：Current medical research and opinion

authors： Gong X,Zhou Q,Chen S,Wang F,Wu W,Chen X

更新日期：2017-08-01 00:00:00

abstract：:A double-blind trial was carried out in 76 patients with active rheumatoid arthritis to compare the analgesic and anti-inflammatory activity of 3 g. alclofenac with 4.8 g. aspirin daily over a 6-week period. All patients selected showed reversible inflammatory swelling of the finger joints. Of the 60 patients successf...

journal_title：Current medical research and opinion

authors： Bedi SS

更新日期：1975-01-01 00:00:00

abstract：:In order to assess the effect of ACTH on the adrenal cortex when used as a therapeutic or diagnostic agent, adrenocortical function was tested before and 2 hours after 0.5 mg tetracosactrin given intramuscularly in 31 healthy children, divided into 4 groups according to age and sex. Mean plasma cortisol levels were sh...

journal_title：Current medical research and opinion

authors： Tsvetkova V

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Severe allergic asthma patients may not be controlled even with guideline recommended care, including inhaled corticosteroids, long-acting beta-2 agonists, theophylline, oral steroids and anti-leukotrienes. They experience exacerbations requiring intensive healthcare use and which may be fatal. Omalizumab, a...

journal_title：Current medical research and opinion

authors： Dewilde S,Turk F,Tambour M,Sandström T

更新日期：2006-09-01 00:00:00

abstract：:Two hundred and sixty male patients with gonorrhoea, allocated to 4 unequal groups, were treated with one single oral dose of: (a) 2 g epicillin plus 1 g probenecid, (b) 2 g epicillin alone, (c) 1 g epicillin, 1 g cephradine plus 1 g probenecid, and (d) 1 g epicillin and 1 g cephradine. The last 3 groups acted as cont...

journal_title：Current medical research and opinion

authors： Theodoridis A,Marcollou-Kindi O,Vagana A,Sivenas C,Capetanakis J

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Epicardial adipose tissue (EAT) serves as a biologically active organ with important endocrine and inflammatory function. Review An accumulating body of evidenc...

journal_title：Current medical research and opinion

authors： Goudis CA,Vasileiadis IE,Liu T

更新日期：2018-11-01 00:00:00

abstract：:In a single-blind study in general practice, 60 patients with anxiety neuroses were randomly allocated to receive either 0.5 mg haloperidol twice daily or 2 mg diazepam 3-times daily for 6 weeks. Eighteen patients (6 on haloperidol and 12 on diazepam) were excluded from the analysis of efficacy. On the Hamilton Rating...

journal_title：Current medical research and opinion

authors： Budden MG

更新日期：1979-01-01 00:00:00

abstract：:A comparative controlled study was carried out in 40 patients suffering from rheumatoid arthritis, osteoarthrosis or ankylosing spondylitis to assess the efficacy of ketoprofen and ibuprofen. Patients were allocated at random to receive either 100 mg ketoprofen twice daily or 400 mg ibuprofen 3-times daily over a peri...

journal_title：Current medical research and opinion

authors： Saxena RP,Saxena U

更新日期：1978-01-01 00:00:00

abstract：:A randomized, double-blind, parallel-group, multi-centre clinical trial was undertaken in 60 patients with dermatophytosis or pityriasis versicolor to compare topical 2% fenticonazole cream with topical 2% miconazole cream. Treatment, by twice-daily application, was for 4 weeks or until earlier complete resolution of ...

journal_title：Current medical research and opinion

authors： Athow-Frost TA,Freeman K,Mann TA,Marks R,Vollum D,Warin AP

更新日期：1986-01-01 00:00:00

abstract：:Five-year results are reported of a controlled long-term comparative study to assess the effects of ergoloid mesylates (1.5 mg 3-times daily) and placebo on medical, psychological and electrophysiological variables. Initially, 148 healthy elderly volunteers of both sexes were included. Eighty-nine subjects (48 on ergo...

journal_title：Current medical research and opinion

authors： Huber F,Köberle S,Prestele H,Spiegel R

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Persisting pain is demoralising and debilitating for patients and their carers. Most patients with chronic pain do not need the services of a specialised pain clinic and are appropriately managed by their general practitioner (GP). METHOD:Interviewers approached 569 GPs to assess their satisfaction with the...

journal_title：Current medical research and opinion

authors： Stannard C,Johnson M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Sulfonylurea therapy among patients with type 2 diabetes mellitus (T2DM) can be disrupted due to adverse events, including hypoglycemia. A retrospective study using the MarketScan claims database quantified the frequency of sulfonylurea discontinuation or down-titration and identified associated risk factors...

journal_title：Current medical research and opinion

authors： Iglay K,Qiu Y,Steve Fan CP,Li Z,Tang J,Laires P

更新日期：2016-09-01 00:00:00

abstract：:A study was carried out in general practice to assess the clinical effectiveness and tolerability of the oral cephalosporin, cefuroxime axetil, in the treatment of 369 patients presenting with acute infections of the upper respiratory tract. The main diagnoses were tonsillitis, pharyngitis, sinusitis and otitis media....

journal_title：Current medical research and opinion

authors： Griffiths GK,VandenBurg MJ,Wight LJ,Gudgeon AC,Kelsey M

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Evaluation of the safety and efficacy of insulin detemir (IDet) in the observational and non-interventional PREDICTIVE study. METHODS:A total of 2923 patients with type 1 or 2 diabetes on basal-bolus regimens were followed for 6 months: Group (1) NPH + human insulin (HI) bolus switching to IDet + analogue bo...

journal_title：Current medical research and opinion

authors： Hermansen K,Dornhorst A,Sreenan S

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:Parenteral sodium ferric gluconate in complex (Ferrlecit [branded SFG]) is used to treat patients with iron deficiency anemia undergoing chronic hemodialysis and receiving supplemental epoetin. This comparative pharmacokinetic study (GeneraMedix, Inc., Study 17909) evaluates whether the recently approved gene...

journal_title：Current medical research and opinion

authors： Baribeault D

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Alternaria alternata (AA) sensitisation is a common cause of respiratory allergies such as rhinitis and asthma. So far there are no controlled double-blind trials evaluating the efficacy and safety of specific sublingual immunotherapy (SLIT) in AA allergies. OBJECTIVE:To evaluate the efficacy of SLIT treatm...

journal_title：Current medical research and opinion

authors： Pozzan M,Milani M

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVES:Due to the high cost of nonvalvular atrial fibrillation (NVAF), this condition may be a suitable candidate for condition-specific bundled payments. This paper evaluates the healthcare cost of NVAF and uses common bleeding and stroke risk scores (HAS-BLED and CHA2DS2-VASc) to explore the risk-based healthcare...

journal_title：Current medical research and opinion

authors： Kaatz S,Coleman CI,Bookhart B,Laliberté F,Nelson WW,Brown K,Martin S,Schein J,Lefebvre P

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD f...

journal_title：Current medical research and opinion

authors： Foley P,Garrett S,Ryttig L

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To compare the safety and efficacy of celecoxib versus diclofenac slow release (SR) plus omeprazole in elderly arthritis patients. RESEARCH DESIGN AND METHODS:Patients aged≥65 years, with osteoarthritis and/or rheumatoid arthritis, at high gastrointestinal (GI) risk who participated in the CONDOR trial (Cele...

journal_title：Current medical research and opinion

authors： Kellner HL,Li C,Essex MN

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis (AR) can have substantial negative impact on children. Most notably, it can impede learning during the school-age years. Other consequences include adverse behavioral and psychosocial effects, poor quality of life, and potential impact on serious comorbidities, such as asthma. CONSENSUS PA...

journal_title：Current medical research and opinion

authors： Blaiss MS,Allergic Rhinitis in Schoolchildren Consensus Group.

更新日期：2004-12-01 00:00:00

abstract：:For over a century, there has been considerable interest in the management of regional lymph node metastasis in patients with primary breast cancer. Since the advent of sentinel lymph node biopsies, there has been renewed interest in the management of patients with metastasis to the internal mammary nodes. The appropr...

journal_title：Current medical research and opinion

authors： Jatoi I

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To systematically identify and assess current quality measures for anticoagulation in atrial fibrillation (AF), venous thromboembolism (VTE) treatment and surgical VTE prophylaxis. RESEARCH DESIGN AND METHODS:Fifteen quality measure websites were searched as were bibliographic databases (January 2000-Februar...

journal_title：Current medical research and opinion

authors： Sobieraj DM,White CM,Parker M,Bookhart BK,Coleman CI

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Estimate the proportion of phosphodiesterase type-5 inhibitor (PDE5-I) patients who co-possess nitrates and compare the proportion of tadalafil patients dispensed nitrates to a matched control group. Secondarily, examine the percentage of co-possession of PDE5-Is and nitrates where the products were dispensed...

journal_title：Current medical research and opinion

authors： Chang LL,Ma M,Allmen Hv,Henderson SC,Harper K,Hornbuckle K

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To analyze the effect of brexpiprazole on metabolic parameters and body weight in adults with schizophrenia, including clinically relevant sub-groups of patients, based on data from two pivotal phase 3 studies (NCT01393613; NCT01396421) and a long-term extension study (NCT01397786). METHODS:The short-term st...

journal_title：Current medical research and opinion

authors： Newcomer JW,Eriksson H,Zhang P,Weiller E,Weiss C

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. A high level of low-density lipoprotein cholesterol (LDL-C) is a major CVD risk factor. Guidelines recommend effective cholesterol management and set LDL-C goals, yet deficiencies exist in physician implementation of these recommendati...

journal_title：Current medical research and opinion

authors： Hobbs FD,Erhardt LR,Rycroft C,Heart study investigators.

更新日期：2008-05-01 00:00:00

abstract：:Control of hypertension is hindered by the incidence of adverse events associated with therapy, which can result in low patient compliance. Specific angiotensin II receptor subtype AT1 blockers offer an alternative to the angiotensin converting enzyme inhibitors in the treatment of hypertension, as the incidence of si...

journal_title：Current medical research and opinion

authors： Levine B

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of epoetin theta and epoetin beta in anaemic patients with chronic kidney disease, undergoing haemodialysis and previously on stable maintenance therapy with epoetin beta. METHODS:In this multicentre, randomised, controlled, double-blind study 270 haemodialysis patients wer...

journal_title：Current medical research and opinion

authors： Gertz B,Kohler E,Kes P,Essaian A,Bias P,Buchner A,Elsässer R

更新日期：2010-10-01 00:00:00

abstract：:A double-blind, parallel group study was carried out in 50 patients with an anxiety disorder to compare the anxiolytic efficacy and tolerability of a recently developed benzodiazepine, metaclazepam, with that of bromazepam. Patients were allocated at random to receive treatment for 2 weeks with either 15 mg metaclazep...

journal_title：Current medical research and opinion

authors： Marano P,Patti F,Nicoletti F

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy of the cholesterol absorption inhibitor ezetimibe in patients with refractory familial hyperlipidaemia or intolerant to statin therapy. METHODS:This prospective study assessed the safety and efficacy of ezetimibe in 200 patients with refractory familial hyperlipidaemias not achiev...

journal_title：Current medical research and opinion

authors： Wierzbicki AS,Doherty E,Lumb PJ,Chik G,Crook MA

更新日期：2005-03-01 00:00:00