Abstract:
OBJECTIVE:We sought to evaluate the relationship between different levels of medication possession ratio (MPR) attained and achievement of clinically meaningful reductions in lipid levels. RESEARCH DESIGN AND METHODS:This was a retrospective cohort study of 4691 new statin users from the Department of Veteran Affairs (VA). Subjects were required to be eligible for VA medical and pharmacy services throughout the 1 year study period from index date and to have complete data for exposure, outcome, and adjustment variables. MPR was defined as number of days supplied with prescription medication divided by days of observation. MAIN OUTCOME MEASURES:Achieving 25% or greater reduction from baseline in lipid levels for three lipid outcomes: non-high-density lipoprotein (non-HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and total cholesterol (TC). RESULTS:We observed a statistically significant trend of an increasing proportion of study subjects achieving a 25% reduction or more for all three lipid outcomes (p-values <0.001 for each of the three outcomes using the Cochran-Armitage trend test). Using multiple logistic regression, odds ratios (ORs) for each of the three outcomes were at a maximum for the 0.9-1.0 MPR category with ORs of 12.90 (95% confidence interval (CI), 9.60, 17.35) for the non-HDL cholesterol outcome; 11.29 (95% CI, 8.61, 14.80) for the LDL cholesterol outcome; and 9.11 (95% CI, 6.62, 12.53) for the TC outcome. Direct comparison of the 0.9-1.0 MPR category versus the 0.8-0.89 MPR category demonstrated an increase in odds of achieving 25% or more reduction for all three lipid outcomes. CONCLUSIONS:We conclude that significant improvements in outcomes are achieved with higher MPR thresholds than commonly targeted. The authors propose consideration of an MPR-adherence threshold of 0.9 MPR. Limitations include the possible modification of study findings in non-VA settings. MPR is a secondary adherence measure based on refill frequency.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Watanabe JH,Bounthavong M,Chen Tdoi
10.1185/03007995.2013.766164subject
Has Abstractpub_date
2013-03-01 00:00:00pages
175-80issue
3eissn
0300-7995issn
1473-4877journal_volume
29pub_type
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Current medical research and opinion
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abstract:OBJECTIVE:To assess the safety, tolerability and pharmacokinetics of an interleukin (IL)-12/23 monoclonal antibody (mAb) in subjects with a relapsing form of multiple sclerosis (MS). METHODS:A phase I, double-blind, placebo-controlled, sequential dose escalation study was conducted in 20 subjects with MS. Subjects wer...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:OBJECTIVES:Docetaxel and paclitaxel show significant clinical activity in metastatic breast cancer (MBC) and have been approved for MBC by the U.S. Food and Drug Administration, but it is still unclear whether a paclitaxel-based regimen improves outcomes over a docetaxel-based regimen in patients with MBC. We therefore...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析,评审
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2012.688737
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abstract::Cholinesterase inhibitors, which act by inhibiting the degradation of acetylcholine in the brain, form the mainstay of therapy for AD. Predominant adverse events are cholinergic in nature, the most frequent being gastrointestinal side effects. Here we present a case series of patients with dementia who were treated wi...
journal_title:Current medical research and opinion
pub_type: 信件
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079906X167282
更新日期:2007-02-01 00:00:00
abstract::Two hundred and two patients with symptoms, signs and mycological evidence of Candida vaginitis were entered in a single-blind trial comparing 6-day clotrimazole therapy with a control group receiving 6 days' nystatin therapy. Adequate data was collected on 69 clotrimazole and 72 nystatin treated patients for analysis...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079906X132523
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
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abstract:OBJECTIVES:To report on the results of a recent large-scale, internet-based survey of the population, prevalence and attributes of pain experience in the United Kingdom (UK), France, Spain, Germany and Italy. METHODS:The results reported here are taken from the internet-based, 2008 National Health and Wellness Survey ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2010.542136
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079906x167336
更新日期:2007-04-01 00:00:00
abstract::A multi-centre, double-blind trial was carried out in general practice in 44 patients with symptoms of neurotic anxiety to compare the effects of treatment with either 400 mg chlormezanone at night or 5 mg diazepam 3-times daily for 4 weeks. The results indicated tht there were similar improvements in anxiety, duratio...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1982-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X65286
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
abstract::An open study was carried out in 37 patients, with chronic, moderate to severe gastric or bilious reflux associated with hiatus hernia or subsequent to gastro-oesophageal surgery, to assess the effectiveness of an alginate/antacid combination product ('Gastrocote'). The overall success rate of treatment was 81% after ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:Since many patients with COPD in the US are managed by primary care physicians, we evaluated adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines in a primary care setting. METHODS:A cross-sectional study was conducted using a random sample of patients (n=50-150 per site)...
journal_title:Current medical research and opinion
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To better understand depression's impact on family functioning from the perspectives of patients with major depressive disorder (MDD) and their partners; to develop and test patient and partner versions of a new self-reported measure, the Depression and Family Functioning Scale (DFFS), for use in clinical tri...
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pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00