Successful treatment of anxiety with a single night-time dose of chlormezanone: double-blind comparison with diazepam.

abstract：:A double-blind, placebo-controlled trial was carried out to assess the effectiveness of a new synthetic bioflavonoid, hidrosmin, in patients with chronic venous insufficiency of the lower limbs. Fifty-seven patients, showing varicose veins and ankle swelling and suffering from local pain and heaviness of the legs, wer...

journal_title：Current medical research and opinion

authors： Domínguez C,Brautigam I,González E,González JA,Nazco J,Valiente R,Boada J

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To review the fatalities among children hospitalized with respiratory syncytial virus (RSV) infection, and identify factors leading to a fatal outcome. RESEARCH DESIGN AND METHODS:Review of literature identified from a structured search of PubMed (1966-2009) using the following Medical Subject Headings: resp...

journal_title：Current medical research and opinion

authors： Welliver RC Sr,Checchia PA,Bauman JH,Fernandes AW,Mahadevia PJ,Hall CB

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:The primary aim of this study was to compare the effect of colesevelam HCl in combination with ezetimibe to ezetimibe monotherapy on low-density lipoprotein cholesterol (LDL-C) levels in subjects with primary hypercholesterolemia. METHODS:Subjects with primary hypercholesterolemia (N = 86) were enrolled in a...

journal_title：Current medical research and opinion

authors： Bays H,Rhyne J,Abby S,Lai YL,Jones M

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Improving health-related quality of life (HRQoL) should be a treatment goal for patients with Generalised Anxiety Disorder (GAD). OBJECTIVES:To assess the impact of treatment with escitalopram on HRQoL as well as the effect of relapse on HRQoL and work productivity. METHODS:This study was conducted alongsi...

journal_title：Current medical research and opinion

authors： Allgulander C,Jørgensen T,Wade A,François C,Despiegel N,Auquier P,Toumi M

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Research indicates that insomnia may contribute significantly to healthcare costs; however, information on the effects of treatments on costs has not been thoroughly published. This study presents predictive models that forecast, from the perspective of commercial managed care, the effects of insomnia medicat...

journal_title：Current medical research and opinion

authors： Jhaveri M,Seal B,Pollack M,Wertz D

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Epicardial adipose tissue (EAT) serves as a biologically active organ with important endocrine and inflammatory function. Review An accumulating body of evidenc...

journal_title：Current medical research and opinion

authors： Goudis CA,Vasileiadis IE,Liu T

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the intraocular pressure lowering effect of the dorzolamide/timolol fixed combination (DTFC) in non-responder glaucoma patients to prostaglandin analogs/prostamides (prostas). PATIENTS AND METHODS:All glaucoma patients treated with DTFC, between June 2003 and December 2005, who were unresponsive ...

journal_title：Current medical research and opinion

authors： Martínez A,Sánchez M

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To compare injection site pain of subcutaneous (sc) epoetin beta and darbepoetin alfa in adult patients with chronic kidney disease. RESEARCH DESIGN AND METHODS:This was a multi-centre, randomised, two-arm, single-blind, cross-over study. Patients were randomised to receive weekly sc darbepoetin alfa 30 mug ...

journal_title：Current medical research and opinion

authors： Roger SD,Suranyi MG,Walker RG,Disney A,Isbel NM,Kairaitis L,Pollock CA,Brown FG,Chow J,Truman MI,Ulyate KA,COMFORT study group.

更新日期：2008-08-01 00:00:00

abstract：:Propranolol has recently been shown to produce some impairment of psychomotor performance in human volunteers. This beta-blocking compound, however, is lipophilic and readily penetrates the blood-brain barrier to gain access to the central nervous system. Acebutolol has a lower lipid solubility. A study was carried ou...

journal_title：Current medical research and opinion

authors： Broadhurst AD

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:Benefits from interferon beta (IFNbeta treatment in patients with multiple sclerosis are affected by many factors, including sustained clinical efficacy, acceptable tolerability, adherence to therapy, and the development of neutralizing antibodies (NAbs). The Prospective and Retrospective Long-Term Observatio...

journal_title：Current medical research and opinion

authors： Minagara A,Murray TJ,PROOF Study Investigators.

更新日期：2008-04-01 00:00:00

abstract：:Acetyl-L-carnitine (ALC) is a compound acting as an intracellular carrier of acetyl groups across inner mitochondrial membranes. It also appears to have neuroprotective properties and it has recently been shown to reduce attention deficits in patients with Alzheimer's disease (AD) after long-term treatment. We perform...

journal_title：Current medical research and opinion

authors： Bianchetti A,Rozzini R,Trabucchi M

更新日期：2003-01-01 00:00:00

abstract：:Quetiapine fumarate is a novel dibenzothiazepine antipsychotic developed by Zeneca. It is marketed under the trade name 'Seroquel'. Quetiapine is well tolerated and clinically effective in the treatment of schizophrenia. The initial hope of investigators was that quetiapine would have antipsychotic potential and that ...

journal_title：Current medical research and opinion

authors： Green B

更新日期：1999-01-01 00:00:00

abstract：:Four hundred and twenty-seven hypertensive patients in the United Kingdom have so far been admitted to two on-going open multicentre trials, and have been treated with acebutolol for periods ranging from 1 to 6 months. Oral dosages were within the range of 100 mg to 1200 mg/day in divided doses and were increased or d...

journal_title：Current medical research and opinion

authors： Ashton WL

更新日期：1976-01-01 00:00:00

abstract：INTRODUCTION:Tumor hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression are important factors influencing treatment response and selection in patients with metastatic breast cancer (mBC). Using the LifeLink Oncology Analyzer Database, we classified mBC patients by combined HR and HER2 st...

journal_title：Current medical research and opinion

authors： Gao S,Barber B,Schabert V,Ferrufino C

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to provide a comprehensive estimate of the cost of ADHD by consider ing the healthcare and work loss costs of persons with ADHD, as well as those costs imposed on their family members. METHODS:Excess per capita healthcare (medical and prescription drug) and work loss (disabilit...

journal_title：Current medical research and opinion

authors： Birnbaum HG,Kessler RC,Lowe SW,Secnik K,Greenberg PE,Leong SA,Swensen AR

更新日期：2005-02-01 00:00:00

abstract：:Two hundred and two patients with symptoms, signs and mycological evidence of Candida vaginitis were entered in a single-blind trial comparing 6-day clotrimazole therapy with a control group receiving 6 days' nystatin therapy. Adequate data was collected on 69 clotrimazole and 72 nystatin treated patients for analysis...

journal_title：Current medical research and opinion

authors： Masterton G,Henderson J,Napier IR,Moffet M

更新日期：1975-01-01 00:00:00

abstract：:The effect of spironolactone in the alleviation of the symptoms of the premenstrual syndrome was compared with placebo in a double-blind, parallel group controlled study. One tablet daily of 100 mg spironolactone or placebo was given to 63 women from Day 12 of the menstrual cycle until the first day of the next menstr...

journal_title：Current medical research and opinion

authors： Vellacott ID,Shroff NE,Pearce MY,Stratford ME,Akbar FA

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Resistance to endocrine treatment generally occurs over time, especially in the metastatic stage. In this paper, we aimed to review the mechanisms of cyclin-dependent kinase (CDK) 4/6 inhibition and clinical usage of new agents in the light of recent literature updates. SCOPE:A literature search was carried...

journal_title：Current medical research and opinion

authors： Bilgin B,Sendur MAN,Şener Dede D,Akıncı MB,Yalçın B

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:The systematic use of 2-octyl cyanoacrylate (2-OCA) became routine in our cardiac unit in 2000. This topical skin adhesive has been used in conjunction with conventional suturing for skin closure and prevention of postoperative wound infections by means of its performance as a microbial barrier to exogenou...

journal_title：Current medical research and opinion

authors： Souza EC,Fitaroni RB,Januzelli DM,Macruz HM,Camacho JC,Souza MR

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Obesity is one of the major problems of health policy in different countries. Pharmacological attempts have been made to help affected people without a definitive solution. Some agents--either with peripheral or central effect--are available in the market. On July 2012, the FDA approved two novel preparation...

journal_title：Current medical research and opinion

authors： Catoira NP,Viale L,Di Girolamo G,Gonzalez C

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to analyze the characteristics and costs of exogenous endoscopy-related infections, pseudo-infections, and toxic reactions in the US. METHODS:A systematic review of the scientific literature published between 1966 and 2005 was conducted in Medline. Data collection was based o...

journal_title：Current medical research and opinion

authors： Seoane-Vazquez E,Rodriguez-Monguio R,Visaria J,Carlson A

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase 4 (DPP4) inhibitors are currently used as glucose-lowering agents in type 2 diabetes, due to their effects on insulin and glucagon secretion. These agents, which are effective in improving glucose control, could also have a beneficial...

journal_title：Current medical research and opinion

authors： Mannucci E,Dicembrini I

更新日期：2012-05-01 00:00:00

abstract：:A single-blind, between-patient comparative study was carried out in general practice to assess the effectiveness of antacid plus antispasmodic combination tablets (240 mg dried aluminium hydroxide B.P., 144 mg magnesium hydroxide B.P.C., and 5 mg dicyclomine hydrochloride B.P.) and aluminium hydroxide B.P. tablets (5...

journal_title：Current medical research and opinion

authors： Kagan G,Rose R

更新日期：1977-01-01 00:00:00

abstract：:Sodium meclofenamate (200 to 400 mg daily) was compared with aspirin (2.4 to 4.8 g daily) for the treatment of rheumatoid arthritis in a 6-month, double-blind, multicentre study. Two groups of patients participated, one receiving stabilized doses of concomitant gold or steroid therapy and one not receiving such therap...

journal_title：Current medical research and opinion

authors： Gowans JD

更新日期：1981-01-01 00:00:00

abstract：:In a general practice survey of the use of Temazepam 'Planpak' ('Planpak'), 31 participating doctors completed questionnaires on 250 patients. Of these, 228 patients had been taking a variety of 8 benzodiazepine hypnotics prior to 'Planpak' therapy while 22 (8.8%) patients received 'Planpak' as a short course, without...

journal_title：Current medical research and opinion

authors： Drake J

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:This meta-analysis compared the median overall survival (mOS) of brentuximab vedotin reported in the pivotal phase 2 study with published results of other therapies for the treatment of relapsed/refractory (R/R) Hodgkin lymphoma (HL) post autologous stem cell transplant (ASCT). RESEARCH DESIGN AND METHODS:A ...

journal_title：Current medical research and opinion

authors： Bonthapally V,Yang H,Ayyagari R,Tan RD,Cai S,Wu E,Gautam A,Chi A,Huebner D

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Evaluation of the safety and efficacy of insulin detemir (IDet) in the observational and non-interventional PREDICTIVE study. METHODS:A total of 2923 patients with type 1 or 2 diabetes on basal-bolus regimens were followed for 6 months: Group (1) NPH + human insulin (HI) bolus switching to IDet + analogue bo...

journal_title：Current medical research and opinion

authors： Hermansen K,Dornhorst A,Sreenan S

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:To investigate the associations between obesity and any significant improvements in glycemic control, blood pressure, and lipid targets in Chinese patients with concomitant type 2 diabetes mellitus (T2DM) and hypertension. METHODS AND RESULTS:A total of 3041 dyslipidemia patients with an average age of 65.7 ...

journal_title：Current medical research and opinion

authors： Li P,Chen K,Nie Y,Guo LL,Wang HB,Wang SS,Wang AP,Hu DY,Mu YM,Li JH,DYSIS-China Study Investigators.

更新日期：2015-01-01 00:00:00

abstract：:The manifestation of pain in any individual patient may result from a variety of underlying mechanisms that also may vary from one disease state to another. Global measures of pain intensity and relief are inadequate for characterizing specific pain qualities or identifying the unique effects of pain treatments on dif...

journal_title：Current medical research and opinion

authors： Jensen MP

更新日期：2004-01-01 00:00:00

abstract：:A double-blind, parallel group trial of a 1 mg sodium cromoglycate metered dose inhaler, a 5 mg formulation and a placebo aerosol was undertaken in 139 asthmatic patients with extrinsic allergic asthma. None of the patients had previously been treated with sodium cromoglycate and few (15%) were familiar with the use o...

journal_title：Current medical research and opinion

authors： Carrasco E,Sepulveda R

更新日期：1989-01-01 00:00:00