Abstract:
OBJECTIVE:This study was undertaken to assess the long-term outcome of transcatheter arterial chemoembolization (TACE) after radiofrequency ablation (RFA) combined with a combined therapy for Chinese patients with intermediate (stage B) hepatocellular carcinoma (HCC) of single block type, and evaluate the survival rate for 1, 3, 5, and 7 years. RESEARCH DESIGN AND METHODS:This prospective, single-center study consisted of patients with solitary massive intermediate (stage B) HCC treated by RFA combined with TACE from October 1999 to December 2013. MAIN OUTCOME MEASURES:The survival rate of the patients for 1, 3, 5, and 7 years, and safety of the RFA treatment in the interim, total RFA for each case, and number of TACE cycles were evaluated. RESULTS:Ninety-three patients (aged 54.4 ± 8.0 years) underwent RFA combined with TACE as a combined therapy, and they were analyzed and followed up until December 2013. The mean time for the initial ablation was 1.5-3 h, and, on average, each patient received 1.39 RFA and 1.43 TACE therapies. Overall, complete ablation was achieved in nine patients, and the majority of ablation was seen in 84 patients. The longest survival time was 102 months and, among the survivors the 1, 3, 5, and 7 year survival rate was 94.4%, 52.3%, 26.1%, and 14.1%, respectively. The median survival time was 36 months (95% confidence interval = 32.7-39.3). Serum alpha-fetoprotein (AFP) levels showed significant correlation with tumor size in patients with HCC (r = 0.323, p = 0.0001). There were no major complications related to this therapy. CONCLUSION:This was the first study that performed RFA combined with TACE in Chinese patients with intermediate (stage B) HCC. RFA combined with TACE, as a combined therapy for intermediate (stage B) HCC, seems to be a promising regimen that showed a satisfactory clinical effect, which may become a new therapy mode for HCC. However, a larger cohort and control group(s) reflecting usual standards of care are needed to assess the external validity of these results in a wider population.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Xu RC,Liu HC,Li JL,Li K,Ou SY,Yu ZY,Kong Y,Ma GA,Shao WSdoi
10.1185/03007995.2015.1058249subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1553-60issue
8eissn
0300-7995issn
1473-4877journal_volume
31pub_type
杂志文章abstract:OBJECTIVE:The European Forsteo Observational Study (EFOS) study was primarily designed to assess fracture incidence, degree of pain, health-related quality of life (HRQoL) and compliance in women prescribed teriparatide in a community setting. This report describes the design of the study and characteristics of the pat...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079908x261087
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND SCOPE:Whether generic drug products are truly therapeutically identical and interchangeable with their innovator counterparts is still a matter of debate. This review discusses the controversies related to the criteria for bioequivalence and therapeutic equivalence. These concerns are illustrated by usin...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990903116867
更新日期:2009-09-01 00:00:00
abstract::Zolmitriptan has been developed in an orally disintegrating tablet (ODT) formulation that rapidly dissolves on the tongue and can be taken quickly, conveniently and discreetly without fluid intake. In this 3-month, non-comparative, observational, post-marketing surveillance (PMS) study, 5,570 physicians prescribed the...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X46296
更新日期:2005-01-01 00:00:00
abstract::A double-blind trial was carried out in 37 patients with osteoarthrosis to compare the efficacy and tolerance of 250 mg diflunisal twice daily with that of 400 mg ibuprofen 3-times daily over an 8-week period. Rating scale assessments were made, at the end of a preceding 1-week, wash-out period on placebo and at regul...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007997809109001
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:The objectives of this survey were to understand (1) the effects of overactive bladder (OAB) and urinary incontinence (UI) on women's lives and to understand (2) women's needs and expectations of health care providers and treatment related to these disorders. METHODS:Women (N = 1046) with self-reported sympt...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X59076
更新日期:2005-09-01 00:00:00
abstract::Zolmitriptan is a 5-HT1B/1D receptor agonist for the acute treatment of migraine. This study examined the efficacy of a second dose of zolmitriptan for the treatment of persistent or recurrent headache. Part 1 was a randomised, placebo-controlled, double-blind evaluation of 2.5 mg and 5 mg zolmitriptan for the treatme...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1185/03007999909116498
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Mycophenolate mofetil (MMF) is widely and successfully used in immunosuppressive regimens for the prophylaxis of organ rejection following transplantation. Conventionally, it is administered at a fixed dose without serial measurements of plasma concentrations of mycophenolic acid (MPA), the active metabolite...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079906X148481
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:The fentanyl HCl iontophoretic transdermal system (ITS) is a patient-controlled analgesic delivery system that actively administers bolus doses of fentanyl transdermally upon patient activation. OBJECTIVE:To determine the amount of fentanyl absorbed from fentanyl ITS via passive absorption over a 24.5-h per...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802594941
更新日期:2009-02-01 00:00:00
abstract::An open study was carried out in 37 patients, with chronic, moderate to severe gastric or bilious reflux associated with hiatus hernia or subsequent to gastro-oesophageal surgery, to assess the effectiveness of an alginate/antacid combination product ('Gastrocote'). The overall success rate of treatment was 81% after ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998009110074
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to quantify the incidence of thromboembolic events (specifically, deep vein thromboses [DVT] and pulmonary embolism [PE]) in patients with cancer, and to examine the effects of a major clinical trial design and execution factors on those incidence rates. RESEARCH DESIGN AND ME...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析,评审
doi:10.1185/030079908x261050
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Poor quality has been reported for some generics and other copies of original products. We performed a pilot study to compare the disintegration/dissolution profiles of FOSAMAX (alendronate) 70 mg tablets with those of copies of FOSAMAX that were manufactured outside the United States. RESEARCH DESIGN AND ME...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079903125002577
更新日期:2003-01-01 00:00:00
abstract::A comparative controlled study was carried out in 40 patients suffering from rheumatoid arthritis, osteoarthrosis or ankylosing spondylitis to assess the efficacy of ketoprofen and ibuprofen. Patients were allocated at random to receive either 100 mg ketoprofen twice daily or 400 mg ibuprofen 3-times daily over a peri...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007997809111919
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:With a growing number of studies and comparators in MRSA skin infections, a unified framework for comparing treatments is needed for health technology assessment (HTA). The objective was to systematically assess the success rates of common antimicrobial agents for the treatment of complicated skin and soft ti...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析,评审
doi:10.1185/03007995.2010.481251
更新日期:2010-07-01 00:00:00
abstract::The glomerular and tubular function of 7 patients with a spectrum of renal impairment was measured before, during and after 4-days' treatment with cefuroxime and gentamicin. Neither the mean plasma urea nor creatinine concentrations of the group increased after combined treatment, nor was the excretion of cefuroxime s...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998009109458
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Nausea with or without vomiting of pregnancy (NVP) is the most common medical condition in pregnancy. NVP, even with mild symptoms, is associated with costs to society, patients, and the health care system. OBJECTIVE:The main objective of this study was to estimate the total direct and indirect costs per wo...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079907x178739
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:The objectives were to estimate the prevalence of self-treated hypoglycaemia in patients using basal insulin analogues; identify demographic, treatment related and behavioural risk factors; and describe patient and physician responses to these events. RESEARCH DESIGN AND METHODS:The GAPP2 (Global Attitude o...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1185/03007995.2012.743457
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that first-line treatment with atomoxetine provides superior efficacy than placebo for up to 12 weeks in improving the symptoms of Attention Deficit/Hyperactivity Disorder (ADHD). RESEARCH DESIGN AND METHODS:This double-blind, randomized, placebo-controlled, parallel clinical trial inc...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990903316152
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:This meta-analysis compared the median overall survival (mOS) of brentuximab vedotin reported in the pivotal phase 2 study with published results of other therapies for the treatment of relapsed/refractory (R/R) Hodgkin lymphoma (HL) post autologous stem cell transplant (ASCT). RESEARCH DESIGN AND METHODS:A ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/03007995.2015.1048208
更新日期:2015-01-01 00:00:00
abstract::The effects of flurbiprofen on various coagulation and haemostasis parameters were studied in 19 patients adequately anticoagulated on a fixed dose of phenprocoumon. Laboratory controls were performed 5 times at weekly intervals. Flurbiprofen 50 mg 3-times daily was given for 2 weeks after an initial control period of...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997709108972
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Over the last two decades the development and analysis of a number of registries have enhanced the knowledge of the epidemiology, presentation, natural history, and pathophysiology of pulmonary arterial hypertension (PAH). The understanding of the effectiveness of available treatments has also been greatly i...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2014.960514
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To conduct a preliminary evaluation of a new oral formulation of controlled-release (CR) oxybutynin tablet taken once-daily in patients with urinary urge incontinence. RESEARCH DESIGN AND METHODS:A single-centre, open-label, 8-week study was conducted. Patients with urodynamically-confirmed detrusor instabil...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/030079903125002955
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:To report on the results of a recent large-scale, internet-based survey of the population, prevalence and attributes of pain experience in the United Kingdom (UK), France, Spain, Germany and Italy. METHODS:The results reported here are taken from the internet-based, 2008 National Health and Wellness Survey ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2010.542136
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Long-term oral corticosteroid (OCS) therapy and related adverse events are associated with a significant burden on patients and healthcare resources. METHODS:This subgroup analysis of a randomized, open-label, parallel-group study evaluated the OCS-sparing effect of omalizumab (OMA) added to optimized asthm...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/03007995.2011.620950
更新日期:2011-11-01 00:00:00
abstract::Women who are diagnosed with early breast cancer remain at considerable risk of recurrence over the next several decades, even if their tumors were small and lymph nodes were negative, and despite receiving standard adjuvant therapy. A majority of breast cancers are hormone (estrogen) receptor-positive and amenable to...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079905X65619
更新日期:2005-12-01 00:00:00
abstract::An open study was carried out in 41 children with mild to moderate psoriasis to assess the effectiveness and tolerance of treatment with a 0.1% dithranol plus 17% urea preparation applied twice daily. Thirty-four patients completed 6-weeks' treatment and 8 of them continued for a further 4 to 6 weeks. The results show...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007998309111752
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:Evaluation of the safety and efficacy of insulin detemir (IDet) in the observational and non-interventional PREDICTIVE study. METHODS:A total of 2923 patients with type 1 or 2 diabetes on basal-bolus regimens were followed for 6 months: Group (1) NPH + human insulin (HI) bolus switching to IDet + analogue bo...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990903262885
更新日期:2009-11-01 00:00:00
abstract::The sensitivity of a number of beta-lactamase producing strains of Enterobacter aerogenes, Enterobacter cloacae, Enterobacter species, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa and Serratia marcescens to cefamandole, cefoxitin, cefuroxi...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998109114263
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:Sulfonylurea therapy among patients with type 2 diabetes mellitus (T2DM) can be disrupted due to adverse events, including hypoglycemia. A retrospective study using the MarketScan claims database quantified the frequency of sulfonylurea discontinuation or down-titration and identified associated risk factors...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1190325
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:Despite a plethora of published data on levocetirizine, no meta-analyses exist on the effect of study design, and covariates like age, gender, and baseline symptom severity on treatment response. The objective of this study was the efficacy of levocetirizine 5 mg tablets and matching placebo at reducing alle...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/03007995.2010.537319
更新日期:2011-01-01 00:00:00
abstract::Abstract A growing body of evidence suggests that targeting low-density lipoprotein cholesterol is not enough and that a substantial residual risk remains despite aggressive statin treatment, particularly in patients with mixed dyslipidemia. Statin plus fibrate combination results in a more effective control of severa...
journal_title:Current medical research and opinion
pub_type: 评论,社论
doi:10.1185/03007995.2010.505463
更新日期:2010-09-01 00:00:00