Diflunisal in the treatment of osteoarthrosis: a double-blind study comparing diflunisal with ibuprofen.

abstract：:In addition to their beneficial effects in reducing platelet responsiveness, it has been a matter of controversy whether polyunsaturated fatty acids impair the fibrinolytic system or not. In a double-blind, parallel clinical trial, 40 subjects were randomized to treatment with 6 g/day of corn oil, or to 6 g/day of a f...

journal_title：Current medical research and opinion

authors： Hellsten G,Boman K,Saarem K,Hallmans G,Nilsson TK

更新日期：1993-01-01 00:00:00

abstract：:A double-blind crossover study was carried out in 24 patients with rheumatoid arthritis to investigate the relative efficacy of tolmetin (1600 mg/day) and phenylbutazone (400 mg/day). Each drug was given for 4 weeks, preceded by a 2-week wash-out period during which patients received paracetamol alone for pain relief....

journal_title：Current medical research and opinion

authors： Cardoe N,Steele CE

更新日期：1976-01-01 00:00:00

abstract：:A double-blind, multi-centre trial was carried out in 191 patients with acute musculoskeletal conditions to compare the efficacy of naproxen and indomethacin. Patients were randomly allocated to receive either 250 mg naproxen or 50 mg indomethacin twice daily. Treatment was for 7 or 14 days. The results, assessed by t...

journal_title：Current medical research and opinion

authors： Jaffé G

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:Gastro-oesophageal reflux disease (GORD) is a recurring condition with many patients requiring long-term maintenance therapy. Therefore initial choice of treatment has long-term cost implications. The aim was to compare the costs and effectiveness of treatment of GORD the (unconfirmed by endoscopy) with seven...

journal_title：Current medical research and opinion

authors： Remák E,Brown RE,Yuen C,Robinson A

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Schizophrenia is one of the most debilitating diseases in the United Arab Emirates. Oral antipsychotics (OA) are commonly used in terms of pharmacotherapy; however, these treatments can be rendered ineffective by poor patient adherence. Paliperidone palmitate once monthly (PP1M) is a long acting antipsychotic...

journal_title：Current medical research and opinion

authors： Nuhoho S,Saad A,Saumell G,Ribes D,El Khoury AC

更新日期：2018-04-01 00:00:00

abstract：:Objective To assess the efficacy of a mixed intervention, educational, and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods This was a prospective, longitudinal, multi-center study, carried out in 110 speci...

journal_title：Current medical research and opinion

authors： Márquez-Contreras E,Martell-Claros N,Márquez-Rivero S,Hermida-Campa E,Gracia-Diez C,Sanchez-López E,Gil-Guillén V,Compliance and Inertia Working Group, Spanish Society of Hypertension (SEH-LELHA).

更新日期：2018-07-01 00:00:00

abstract：:A randomized, double-blind study was carried out in 24 patients with stable angina pectoris to compare the efficacy of nadolol, a new beta-adrenoceptor antagonist, and propranolol. After a period on placebo, 14 patients received nadolol once daily and 10 patients propranolol 4-times daily over a 10-week dose-ranging p...

journal_title：Current medical research and opinion

authors： Furberg B,Dahlqvist A,Raak A,Wrege U

更新日期：1978-01-01 00:00:00

abstract：:Six patients suffering from rheumatoid arthritis with massive knee joint effusions were treated with single daily doses of 600 mg pirazolac, a novel non-steroidal anti-inflammatory drug, for 3 days. Before the first dose, 3 hours after the second and the third dose, specimens of plasma and synovial fluid were drawn si...

journal_title：Current medical research and opinion

authors： Kurowski M,Dunky A,Geddawi M

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:This survey assessed the impact of symptoms of COPD on patients' ability to perform activities throughout the day and the extent to which physicians provided advice including how medications may help maintain quality of life. METHODS:The survey had three inclusion criteria--physician's diagnosis of COPD, ag...

journal_title：Current medical research and opinion

authors： O'Hagan P,Chavannes NH

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:We sought to evaluate the relationship between different levels of medication possession ratio (MPR) attained and achievement of clinically meaningful reductions in lipid levels. RESEARCH DESIGN AND METHODS:This was a retrospective cohort study of 4691 new statin users from the Department of Veteran Affairs ...

journal_title：Current medical research and opinion

authors： Watanabe JH,Bounthavong M,Chen T

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:Estimate the proportion of phosphodiesterase type-5 inhibitor (PDE5-I) patients who co-possess nitrates and compare the proportion of tadalafil patients dispensed nitrates to a matched control group. Secondarily, examine the percentage of co-possession of PDE5-Is and nitrates where the products were dispensed...

journal_title：Current medical research and opinion

authors： Chang LL,Ma M,Allmen Hv,Henderson SC,Harper K,Hornbuckle K

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Healthcare providers managing older patients with type 2 diabetes mellitus (T2DM) face a complex milieu of medical conditions and comorbidities, which increase the risk of unintended treatment consequences. The objective of this study was to understand factors associated with hypoglycemia-related hospitalizat...

journal_title：Current medical research and opinion

authors： Fu H,Xie W,Curtis B,Schuster D

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Niacin is currently the most effective approved agent for raising high-density lipoprotein cholesterol. However, niacin-induced cutaneous flushing (redness, warmth, tingling and/or itching) significantly limits patient acceptance. To further characterize flushing, a patient-reported Flushing Symptom Question...

journal_title：Current medical research and opinion

authors： Norquist JM,Watson DJ,Yu Q,Paolini JF,McQuarrie K,Santanello NC

更新日期：2007-07-01 00:00:00

abstract：:Background: Actinic keratosis (AK) is considered an "in situ" non-melanoma skin cancer induced by ultraviolet chronic exposure. Sunscreen and topical anti-inflammatory agents like diclofenac could improve the evolution of this kind of lesions. A topical product containing piroxicam 0.8% and sun filters (50 SPF) (ACTX)...

journal_title：Current medical research and opinion

authors： Agozzino M,Russo T,Franceschini C,Mazzilli S,Garofalo V,Campione E,Bianchi L,Milani M,Argenziano G

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To assess the safety, tolerability and pharmacokinetics of an interleukin (IL)-12/23 monoclonal antibody (mAb) in subjects with a relapsing form of multiple sclerosis (MS). METHODS:A phase I, double-blind, placebo-controlled, sequential dose escalation study was conducted in 20 subjects with MS. Subjects wer...

journal_title：Current medical research and opinion

authors： Kasper LH,Everitt D,Leist TP,Ryan KA,Mascelli MA,Johnson K,Raychaudhuri A,Vollmer T,Multiple Sclerosis Investigators.

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Most patients with hypertension require more than one drug to attain recommended blood pressure (BP) targets. Initiating therapy with two agents is recommended for patients at high risk of a cardiovascular event or with a BP > 20/10 mmHg above goal. Combination therapy is effective when comprised of agents w...

journal_title：Current medical research and opinion

authors： Ram CV

更新日期：2009-01-01 00:00:00

abstract：:Thirteen young adult patients suffering from heterozygotic familial hypercholesterolaemia with tendinous xanthomatosis, previously treated with a suitable special diet, were studied to assess the effect of bezafibrate, given for 2 years at a dose of 800 mg/day, on plasma lipid and lipoprotein levels and on changes in ...

journal_title：Current medical research and opinion

authors： Rouffy J,Chanu B,Bakir R,Goy-Loeper J,Djian F,Monsuez JJ,Gomberg R,Laval-Jeantet M

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Physicians and other health care personnel rely on the peer-reviewed biomedical literature as a key source for making clinical decisions. Thus, ensuring that the nonclinical and clinical findings published in biomedical journals are reported accurately and clearly, without undue influence from commercial int...

journal_title：Current medical research and opinion

authors： Bareket-Samish A,Denny M,Ruzicka B,Bogush M,Flynn K,Glinka K,McMahon-Wise B,Schiller S,Sjostedt P,Matheson N

更新日期：2009-02-01 00:00:00

abstract：:Migraine is a very common disorder, affecting about 11% of adult populations in Western countries. Prevalence is highest during the peak productive years--between the ages of 25 and 55. The prevalence is higher in females than males at all post-pubertal ages, but the sex ratio varies with age. In the United States, mi...

journal_title：Current medical research and opinion

authors： Lipton RB,Stewart WF,Scher AI

更新日期：2001-01-01 00:00:00

abstract：:A double-blind crossover study was carried out in 21 patients with osteoarthrosis of the hip to compare the effectiveness and tolerance of 1200 mg tolmetin sodium daily with 75 mg indomethacin daily. Each drug was given in 3 equally divided doses daily for a period of 2 weeks, both active treatment periods being prece...

journal_title：Current medical research and opinion

authors： Davies J,Dixon AS,Steele CE

更新日期：1980-01-01 00:00:00

abstract：:A large, open, multi-centre study was carried out in general practice to evaluate the effectiveness and tolerance of a combination of 10 mg pindolol plus 5 mg clopamide, in single tablet form, in the treatment of patients with essential hypertension. Computer analysis of the records of 8989 patients who completed the ...

journal_title：Current medical research and opinion

authors： Crowder D,Cameron EG

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVES:Due to the high cost of nonvalvular atrial fibrillation (NVAF), this condition may be a suitable candidate for condition-specific bundled payments. This paper evaluates the healthcare cost of NVAF and uses common bleeding and stroke risk scores (HAS-BLED and CHA2DS2-VASc) to explore the risk-based healthcare...

journal_title：Current medical research and opinion

authors： Kaatz S,Coleman CI,Bookhart B,Laliberté F,Nelson WW,Brown K,Martin S,Schein J,Lefebvre P

更新日期：2018-02-01 00:00:00

abstract：:The sensitivity of a number of beta-lactamase producing strains of Enterobacter aerogenes, Enterobacter cloacae, Enterobacter species, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa and Serratia marcescens to cefamandole, cefoxitin, cefuroxi...

journal_title：Current medical research and opinion

authors： Kuipers JS

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) and its long-term secondary complications are major health problems associated with high rates of morbidity and mortality and considerable costs for healthcare systems. Many patients receive suboptimal therapy, despite the availability of established and effective agents (includi...

journal_title：Current medical research and opinion

authors： Cohen AT

更新日期：2012-06-01 00:00:00

abstract：GOALS OF THE WORK:This open compassionate-use prospective registration study evaluated the tolerability, ease of use and applied doses of transdermal (TTS) fentanyl in adult patients with cancer-related pain requiring strong opioid analgesia. Elderly patients were particularly focussed on. PATIENTS AND METHODS:Previou...

journal_title：Current medical research and opinion

authors： Menten J,Desmedt M,Lossignol D,Mullie A

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To provide a commentary on recent studies with the new IOP-lowering fixed-combination product brinzolamide 1%/timolol 0.5%. METHODS:Medline was searched for brinzolamide/timolol fixed-combination clinical literature (up to May 18, 2010) and the current comprehensive brinzolamide/timolol literature was review...

journal_title：Current medical research and opinion

authors： Januleviciene I

更新日期：2010-11-01 00:00:00

abstract：:Understanding of the damaging effects of significance testing has steadily grown. Reporting p values without dichotomizing the result to be significant or not, is not the solution. Confidence intervals are better, but are troubled by a non-intuitive interpretation, and are often misused just to see whether the null va...

journal_title：Current medical research and opinion

authors： The B

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of selective laser trabeculoplasty (SLT) on the intraocular pressure (IOP) of untreated fellow eyes in patients with open-angle glaucoma. STUDY DESIGN:Retrospective chart review. PATIENTS AND METHODS:Charts of all patients who underwent SLT at the University of Texas Southwestern M...

journal_title：Current medical research and opinion

authors： Rhodes KM,Weinstein R,Saltzmann RM,Aggarwal N,Kooner KS,Petroll WM,Whitson JT

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To provide clinically relevant information on tadalafil 2.5 or 5 mg once daily for the treatment of erectile dysfunction (ED), by reviewing safety and efficacy study findings. Findings from an integrated analysis of trials of tadalafil 10 and 20 mg as needed are presented to provide context for the daily dosi...

journal_title：Current medical research and opinion

authors： Donatucci CF,Wong DG,Giuliano F,Glina S,Dowsett SA,Watts S,Sorsaburu S

更新日期：2008-12-01 00:00:00

abstract：:A double-blind, randomized study was carried out in 43 women, who had undergone spontaneous menopause at least 6 months earlier, to compare the effectiveness and tolerance of veralipride with that of a conjugated oestrogens preparation in the control of hot flushes. Twenty-one women received 100 mg veralipride per day...

journal_title：Current medical research and opinion

authors： Wesel S,Bourguignon RP,Bosuma WB

更新日期：1984-01-01 00:00:00