A multi-centre general practice trial of a pindolol/clopamide combination ('Viskaldix') in essential hypertension.

abstract：AIMS:The safety and efficacy of exenatide BID (exenatide) and insulin glargine (glargine) have been studied in clinical trials with few elderly patients. This study examined the clinical effectiveness of exenatide compared to glargine in patients 65 years and older with type 2 diabetes mellitus (T2DM). METHODS:A retro...

journal_title：Current medical research and opinion

authors： Pawaskar M,Li Q,Reynolds MW

更新日期：2012-06-01 00:00:00

abstract：:A double-blind, parallel-group study was carried out to compare the efficacy and tolerability of a controlled-release tablet formulation of trazodone with the standard trazodone tablet. Three hundred and forty-seven general practice patients with depressive symptoms were recruited into the trial. Patients were randoml...

journal_title：Current medical research and opinion

authors： Moon CA,Laws D,Stott PC,Hayes G

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Inadequate removal of extracellular volume markedly increases blood pressure and contributes to high morbidity and mortality in hemodialysis patients. Advances in fluid management are needed to improve clinical outcomes. The aim of this quality improvement project was to examine the advantages of using a hem...

journal_title：Current medical research and opinion

authors： Balter P,Ficociello LH,Taylor PB,Usvyat L,Sawin DA,Mullon C,Diaz-Buxo J,Zabetakis P

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To develop a patient-completed screening tool to help differentiate nociceptive and neuropathic pain. RESEARCH DESIGN AND METHODS:A multicenter study was performed for item reduction (initial 89-item questionnaire) and model building. Patients (N = 586) with non-headache chronic pain completed the questionna...

journal_title：Current medical research and opinion

authors： Portenoy R

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Patients receiving levodopa for Parkinson's disease experience motor fluctuations and immobility ('off' episodes) between doses. This study assessed adjunctive Zelapar (selegiline orally disintegrating tablet (ODT)) for managing off episodes and for long-term safety. METHODS:This open-label extension evaluat...

journal_title：Current medical research and opinion

authors： Lew MF,Pahwa R,Leehey M,Bertoni J,Kricorian G,Zydis Selegiline Study Group.

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD f...

journal_title：Current medical research and opinion

authors： Foley P,Garrett S,Ryttig L

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score <19 as a threshold for moderate to severe dry eye disease (DED). METHODS:A phase III, randomized, controlled...

journal_title：Current medical research and opinion

authors： Doan S,Bremond-Gignac D,Chiambaretta F

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:In controlled clinical trials, rabeprazole effectively improves symptoms and heals oesophageal erosions in patients with gastro-oesophageal reflux disease (GORD). AIM:To examine symptom relief during week 1 of rabeprazole therapy, in addition to GORD healing, in a clinical practice setting. METHODS:In this...

journal_title：Current medical research and opinion

authors： Archimandritis AJ,Nikolopoulou V,Kouklakis G,Paraskevas E,Avgerinos A,Tsianos E,Triantafillidis JK,Hellenic Rabeprazole Study Group.

更新日期：2005-04-01 00:00:00

abstract：:An investigator-blind, parallel-group, multicentre study was undertaken to compare the efficacy and tolerability of once-daily, sustained-release (s-r) ibuprofen and diclofenac sodium in patients (mean age 59.8 years) suffering from painful osteoarthritis affecting chiefly the knee and/or hip. Patients attending eight...

journal_title：Current medical research and opinion

authors： Baumgartner H,Schwarz HA,Blum W,Bruhin A,Gallachi G,Goldinger G,Saxer M,Trost H

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Report efficacy findings from three clinical trials (one phase 2 and two phase 3 [OPUS-1, OPUS-2]) of lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease (DED). RESEARCH DESIGN AND METHODS:Three 84-day, randomized, double-masked, placebo-controlled trials. Adults (≥18 years) with DED were r...

journal_title：Current medical research and opinion

authors： Holland EJ,Whitley WO,Sall K,Lane SS,Raychaudhuri A,Zhang SY,Shojaei A

更新日期：2016-10-01 00:00:00

abstract：:An open, parallel-group study was carried out to compare the efficacy and tolerance of a sustained-release capsule formulation of tiaprofenic acid at a dosage of 600 mg once daily with standard 300 mg tiaprofenic acid tablets given twice daily. Four hundred and eighty-five general practice patients with rheumatic dise...

journal_title：Current medical research and opinion

authors： Phillips G,Selfridge DI,Hayes G,Rose CM

更新日期：1987-01-01 00:00:00

abstract：:An open multicentre trial was carried out in 13 hypertensive patients, who had responded satisfactorily to and been stabilized on treatment with 400 mg acebutolol daily in divided doses, to assess the effectiveness and tolerance of the same daily dosage given as a single morning dose. On admission, patients were chang...

journal_title：Current medical research and opinion

authors： Ashton WL

更新日期：1977-01-01 00:00:00

abstract：:In a double-blind investigation in 21 patients undergoing minor plastic surgery the effects of 4 mg lorazepam or a mixture of 20 mg papaveretum/400 mug hyoscine given intramuscularly as premedicants were studied. Lorazepam produced superior preoperative and post-operative anterograde amnesia, with respect to both inci...

journal_title：Current medical research and opinion

authors： Paymaster NJ

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of selective laser trabeculoplasty (SLT) on the intraocular pressure (IOP) of untreated fellow eyes in patients with open-angle glaucoma. STUDY DESIGN:Retrospective chart review. PATIENTS AND METHODS:Charts of all patients who underwent SLT at the University of Texas Southwestern M...

journal_title：Current medical research and opinion

authors： Rhodes KM,Weinstein R,Saltzmann RM,Aggarwal N,Kooner KS,Petroll WM,Whitson JT

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. A high level of low-density lipoprotein cholesterol (LDL-C) is a major CVD risk factor. Guidelines recommend effective cholesterol management and set LDL-C goals, yet deficiencies exist in physician implementation of these recommendati...

journal_title：Current medical research and opinion

authors： Hobbs FD,Erhardt LR,Rycroft C,Heart study investigators.

更新日期：2008-05-01 00:00:00

abstract：:A comparative controlled study was carried out in 40 patients suffering from rheumatoid arthritis, osteoarthrosis or ankylosing spondylitis to assess the efficacy of ketoprofen and ibuprofen. Patients were allocated at random to receive either 100 mg ketoprofen twice daily or 400 mg ibuprofen 3-times daily over a peri...

journal_title：Current medical research and opinion

authors： Saxena RP,Saxena U

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:In contrast to the trial design of acute mania studies, there is no standard design for bipolar maintenance studies. Over the past 15 years, the design of monotherapy maintenance studies in bipolar disorder has evolved significantly, but recent study designs continue to differ in important ways. SCOPE:We re...

journal_title：Current medical research and opinion

authors： Gitlin MJ,Abulseoud O,Frye MA

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Obesity is one of the major problems of health policy in different countries. Pharmacological attempts have been made to help affected people without a definitive solution. Some agents--either with peripheral or central effect--are available in the market. On July 2012, the FDA approved two novel preparation...

journal_title：Current medical research and opinion

authors： Catoira NP,Viale L,Di Girolamo G,Gonzalez C

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Fibromyalgia (FM) is characterized by persistent and widespread pain and often associated with other symptoms and comorbidities. Thus, FM patients seek care from multiple physician specialties. This study compared prescribing patterns, patient-reported outcomes (PROs), healthcare resource use (HRU), and dire...

journal_title：Current medical research and opinion

authors： McNett M,Goldenberg D,Schaefer C,Hufstader M,Baik R,Chandran A,Zlateva G

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines development group examined the properties of oral H(1)-antihistamines and made proposals about an 'optimal' drug. Several criteria should be met by oral H(1)-antihistamines in terms of their pharmacological, and clinical efficacy and safety pro...

journal_title：Current medical research and opinion

authors： Bousquet J,Ansótegui I,Canonica GW,Zuberbier T,Baena-Cagnani CE,Bachert C,Cruz AA,González SN,Kuna P,Morais-Almeida M,Mullol J,Ryan DP,Sánchez-Borges M,Valiente R,Church MK

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of epoetin theta and epoetin beta in anaemic patients with chronic kidney disease, undergoing haemodialysis and previously on stable maintenance therapy with epoetin beta. METHODS:In this multicentre, randomised, controlled, double-blind study 270 haemodialysis patients wer...

journal_title：Current medical research and opinion

authors： Gertz B,Kohler E,Kes P,Essaian A,Bias P,Buchner A,Elsässer R

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Rhizophora mangle aqueous bark extract (RMABE) (CIKRON-H), has been used as antiseptic and skin wound healing promoter. The present study was a randomised, single-blinded, placebo control trial conducted to asses the efficacy of RMABE in treating oral aphthous ulcers. RESEARCH DESIGN AND METHODS:Patients (n ...

journal_title：Current medical research and opinion

authors： de Armas E,Sarracent Y,Marrero E,Fernández O,Branford-White C

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:The implementation of international pediatric asthma guidelines hinges on the distinction between intermittent and persistent phenotypes and the prescription of recommended phenotype-specific pharmacotherapy. OBJECTIVES:To ascertain key factors associated with specialist-confirmed phenotype and document phy...

journal_title：Current medical research and opinion

authors： Ducharme FM,Morin J,Davis GM,Gingras J,Noya FJ

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To identify and compare health-economic models that were developed to evaluate the cost-effectiveness of treatments for type 2 diabetes mellitus (T2DM), and their use within Health Technology Assessments (HTAs). METHODS:In total, six commonly used databases were searched for articles published between Octobe...

journal_title：Current medical research and opinion

authors： Charokopou M,Sabater FJ,Townsend R,Roudaut M,McEwan P,Verheggen BG

更新日期：2016-01-01 00:00:00

abstract：:Objective To assess the efficacy of a mixed intervention, educational, and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods This was a prospective, longitudinal, multi-center study, carried out in 110 speci...

journal_title：Current medical research and opinion

authors： Márquez-Contreras E,Martell-Claros N,Márquez-Rivero S,Hermida-Campa E,Gracia-Diez C,Sanchez-López E,Gil-Guillén V,Compliance and Inertia Working Group, Spanish Society of Hypertension (SEH-LELHA).

更新日期：2018-07-01 00:00:00

abstract：:In an electropharmacokinetic study, the effects of lormetazepam and flunitrazepam were compared by the means of a sleep EEG and waking EEG during the following daytime. At a 1-week interval, 6 normal subjects received at random either 2 mg lormetazepam or 2 mg flunitrazepam in a double-blind, crossover fashion. Sleep ...

journal_title：Current medical research and opinion

authors： Timsit-Berthier M,de Thier D,Machowsky R,Mantanus H,Rousseau JC

更新日期：1985-01-01 00:00:00

abstract：:An open, multi-centre study was carried out in 804 patients complaining of sleep disorders to assess the effectiveness and acceptance of temazepam as a hypnotic. Patients received between 10 mg and 30 mg (mean 16.4 mg) temazepam each night for a week. Subjective assessments using a self-administered questionnaire were...

journal_title：Current medical research and opinion

authors： Harry TV,Johnson PA

更新日期：1978-01-01 00:00:00

abstract：UNLABELLED:Abstract Background: The Schizophrenia Trial of Aripiprazole (STAR) showed superior efficacy for aripiprazole compared with atypical antipsychotic standard-of-care (SOC) for the community treatment of schizophrenia 1 based on the Investigator Assessment Questionnaire total score. OBJECTIVE:To determine the ...

journal_title：Current medical research and opinion

authors： King D,Knapp M,Thomas P,Razzouk D,Loze JY,Kan HJ,van Baardewijk M

更新日期：2011-02-01 00:00:00

abstract：:A trial was carried out in 3 clinics to test the efficacy of and cycle control obtained with a very low dosage oral contraceptive combination of lynesternol (0.75 mg) and ethinyl oestradiol (0.0375 mg). A total of 134 healthy, fertile women, ages ranging from under 19 years to over 40 years, participated and completed...

journal_title：Current medical research and opinion

authors： Altkemper R,Prinz W,Soergel W

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:To determine the extent to which raloxifene can maintain low density lipoprotein cholesterol (LDL-C) levels below 160 mg/dL or reduce elevated LDL-C levels to below lipid-lowering goals in postmenopausal women. PATIENTS AND METHODS:The Multiple Outcomes of Raloxifene Evaluation (MORE) osteoporosis treatment ...

journal_title：Current medical research and opinion

authors： Cox DA,Sarkar S,Harper K,Barrett-Connor E

更新日期：2004-07-01 00:00:00