Clinical investigation of a very low dosage oral contraceptive combination: 0-75 mg lynestrenol and 0-0375 mg ethinyl oestradiol.

abstract：OBJECTIVE:The purpose of this study was to evaluate the safety and clinical efficacy of alcaftadine 0.25% ophthalmic solution, a new topical anti-allergic agent for the prevention of the signs and symptoms of allergic conjunctivitis induced by conjunctival allergen challenge (CAC). STUDY DESIGN AND METHODS:This two-ar...

journal_title：Current medical research and opinion

authors： Torkildsen G,Shedden A

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Non-adherence to pain medication is common in chronic pain patients and may result in unfavorable treatment outcomes. Interventions to improve adherence behavior often fail to significantly change medication use. In this report, we describe the application of a theoretical psychological model of behavior chan...

journal_title：Current medical research and opinion

authors： Timmerman L,Stronks DL,Huygen FJPM

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Although beta-blocker therapy has been shown to improve survival in patients with chronic heart failure, this class of drugs tends to be underutilized in diabetic patients due to concerns about adverse metabolic effects, especially on glycemic control. No randomized clinical trial has specifically evaluated ...

journal_title：Current medical research and opinion

authors： Bell DS,Lukas MA,Holdbrook FK,Fowler MB

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Recent survey data have reported the incidence rate of needlestick injuries (NIs) and NIs which draw blood sustained by nurses caring for patients with diabetes in an in-patient hospital setting. The purpose of this study was to deduce the potential short-term annual economic impact resulting from such NI, and ...

journal_title：Current medical research and opinion

authors： Lee WC,Nicklasson L,Cobden D,Chen E,Conway D,Pashos CL

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Most registration studies for new osteoporosis drugs have used a combination of quantitative morphometry (QM) and visual semiquantitative reading (SQ) to define vertebral fractures. However, in the pivotal teriparatide Fracture Prevention Trial (ClinicalTrials.gov Identifier: NCT00670501), vertebral fractures...

journal_title：Current medical research and opinion

authors： Prevrhal S,Krege JH,Chen P,Genant H,Black DM

更新日期：2009-04-01 00:00:00

abstract：:Cardiac arrhythmias are the most common cardiac complication reported in pregnant women with and without structural heart disease (SHD); they are more frequent among women with SHD, such as cardiomyopathy and congenital heart disease (CHD). While older studies had indicated supraventricular tachycardia as the most com...

journal_title：Current medical research and opinion

authors： Manolis TA,Manolis AA,Apostolopoulos EJ,Papatheou D,Melita H,Manolis AS

更新日期：2020-07-01 00:00:00

abstract：:Objectives: The purpose of this study was to assess (1) the trends of and (2) the factors associated with health information technology (HIT) use among older adults in the U.S.Methods: A decade (2009-2018) of data from the U.S. National Health Interview Survey (NHIS) was used. The trends of HIT use among older adults ...

journal_title：Current medical research and opinion

authors： Hung LY,Lyons JG,Wu CH

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Ocular surface disease (OSD) is a common side effect of ophthalmic medications containing the preservative benzalkonium chloride (BAK). Little is known whether and how glaucoma treatment patterns and annual costs vary based on the presence of BAK. The objective of this analysis was to estimate first-year trea...

journal_title：Current medical research and opinion

authors： Schmier JK,Covert DW,Robin AL

更新日期：2010-12-01 00:00:00

abstract：:Objective: Health utility estimates for children and adolescents are critical for cost-utility analyses informing health technology assessment (HTA) authorities' decisions governing access to pediatric treatments. However, in a recent review, only 29% of published pediatric cost-utility models used a utility measure v...

journal_title：Current medical research and opinion

authors： Bégo-Le Bagousse G,Jia X,Wolowacz S,Eckert L,Tavi J,Hudson R

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Severe allergic asthma patients may not be controlled even with guideline recommended care, including inhaled corticosteroids, long-acting beta-2 agonists, theophylline, oral steroids and anti-leukotrienes. They experience exacerbations requiring intensive healthcare use and which may be fatal. Omalizumab, a...

journal_title：Current medical research and opinion

authors： Dewilde S,Turk F,Tambour M,Sandström T

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:A recent retrospective meta-analysis of cardiovascular events from long-term studies with acarbose in type 2 diabetes showed that treatment was associated with a significant reduction in the risk of cardiovascular events, supporting the hypothesis that postprandial hyperglycemia is a risk factor for cardiovas...

journal_title：Current medical research and opinion

authors： Roze S,Valentine WJ,Evers T,Palmer AJ

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:Ramelteon is an MT(1)/MT(2) melatonin receptor agonist indicated for the treatment of insomnia characterized by difficulty with sleep onset. In previous clinical studies, ramelteon reduced latency to persistent sleep (LPS) in subjects with chronic insomnia. The goal of the current analysis was to determine th...

journal_title：Current medical research and opinion

authors： Wang-Weigand S,McCue M,Ogrinc F,Mini L

更新日期：2009-05-01 00:00:00

abstract：:An open, multi-centre study was carried out in 804 patients complaining of sleep disorders to assess the effectiveness and acceptance of temazepam as a hypnotic. Patients received between 10 mg and 30 mg (mean 16.4 mg) temazepam each night for a week. Subjective assessments using a self-administered questionnaire were...

journal_title：Current medical research and opinion

authors： Harry TV,Johnson PA

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) are the most commonly used pharmacological treatment for gastroesophageal reflux disease (GERD). OBJECTIVE:To examine the utilization patterns of PPIs and other GERD-related medications, satisfaction with PPI treatment and presence of GERD symptoms. PATIENTS AND METHODS:GERD p...

journal_title：Current medical research and opinion

authors： Chey WD,Mody RR,Wu EQ,Chen L,Kothari S,Persson B,Beaulieu N,Lu M

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:To describe the epidemiology and trends in pediatric gastrointestinal (GI) bleeding associated emergency department (ED) visits in the US. METHODS:Estimates of GI bleeding associated ED visits were calculated in children from birth to 19 years of age using the Nationwide Emergency Department Sample (NEDS). ...

journal_title：Current medical research and opinion

authors： Pant C,Olyaee M,Sferra TJ,Gilroy R,Almadhoun O,Deshpande A

更新日期：2015-02-01 00:00:00

abstract：:A randomized, double-blind study was carried out in 24 patients with stable angina pectoris to compare the efficacy of nadolol, a new beta-adrenoceptor antagonist, and propranolol. After a period on placebo, 14 patients received nadolol once daily and 10 patients propranolol 4-times daily over a 10-week dose-ranging p...

journal_title：Current medical research and opinion

authors： Furberg B,Dahlqvist A,Raak A,Wrege U

更新日期：1978-01-01 00:00:00

abstract：AIM:To assess the efficacy of a strategy to improve vascular risk management in patients with type 2 diabetes mellitus (T2DM). METHODS:This was a pilot best practice implementation enhancement programme that enrolled 578 patients with T2DM. A baseline visit was followed by a concerted effort from previously trained ph...

journal_title：Current medical research and opinion

authors： Athyros VG,Hatzitolios A,Karagiannis A,Didangelos TP,Iliadis F,Dolgyras S,Vosnakidis T,Vasiliadis P,Malias I,Tziomalos K,Samouilidou M,Mikhailidis DP,INDEED Collaborative Group.

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The selection of the most appropriate treatment combinations requires the balancing of benefits and harms of these treatment options as well as the patients' preferences for the resulting outcomes. OBJECTIVE:This research aimed at estimating and comparing the utility weights between elderly women with early...

journal_title：Current medical research and opinion

authors： Ali AA,Xiao H,Tawk R,Campbell E,Semykina A,Montero AJ,Diaby V

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:GOAL (Gauging Osteoarthritis [OA] with Limbrel*), an open-label, post-marketing study was performed to determine the overall efficacy and gastrointestinal (GI) tolerability of flavocoxid, a novel, plant-based, anti-inflammatory medication, in a 'real world' clinical practice setting. To this end, the study e...

journal_title：Current medical research and opinion

authors： Pillai L,Burnett BP,Levy RM,GOAL Study Cooperative Group.

更新日期：2010-05-01 00:00:00

abstract：:A study was carried out to compare the efficacy and tolerability of etodolac and piroxicam in patients with rheumatoid arthritis. Sixty patients entered this double-blind, parallel study and after a wash-out period of up to 2 weeks were randomly assigned to receive 200 mg etodolac twice daily or 20 mg piroxicam once d...

journal_title：Current medical research and opinion

authors： Schattenkirchner M

更新日期：1991-01-01 00:00:00

abstract：UNLABELLED:The occurrence of intestinal bacterial overgrowth in patients with Crohn's Disease (CD) has been described and antimicrobial treatment has been shown to be effective in reversing this condition. However, the mechanisms underlying the efficacy of antimicrobial therapy are still only partially known. The aim o...

journal_title：Current medical research and opinion

authors： Biancone L,Vernia P,Agostini D,Ferrieri A,Pallone F

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical efficacy and safety of mometasone furoate administered via a dry powder inhaler (MF-DPI) in Japanese patients with intermittent or mild persistent asthma who were not previously receiving inhaled corticosteroids. RESEARCH DESIGN AND METHODS:This was an 8-week open-label study conduct...

journal_title：Current medical research and opinion

authors： Tohda Y,Miyamoto T

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Patients with type 2 diabetes (T2DM) often have multiple comorbidities which may impact the selection of antihyperglycemic therapies. The purpose of this study was to quantify the prevalence and co-prevalence of common comorbidities. RESEARCH DESIGN AND METHODS:A retrospective study was conducted using the Q...

journal_title：Current medical research and opinion

authors： Iglay K,Hannachi H,Joseph Howie P,Xu J,Li X,Engel SS,Moore LM,Rajpathak S

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:To look into current evidence exploring the added value of rLH supplementation to rFSH in GnRH analogues cycles, to identify groups of women that still have no evidence for adjuvant rLH therapy and to discuss ways that may advance research on this topic. METHODS:Eight systematic reviews and meta-analyses exp...

journal_title：Current medical research and opinion

authors： Younis JS,Laufer N

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:High-sensitivity C-reactive protein (hs-CRP) has been explored for use in predicting cardiovascular risk. The recent Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study found that statin therapy reduced cardiovascular events in those with ...

journal_title：Current medical research and opinion

authors： Slejko JF,Page RL 2nd,Sullivan PW

更新日期：2010-10-01 00:00:00

abstract：:The effect of spironolactone in the alleviation of the symptoms of the premenstrual syndrome was compared with placebo in a double-blind, parallel group controlled study. One tablet daily of 100 mg spironolactone or placebo was given to 63 women from Day 12 of the menstrual cycle until the first day of the next menstr...

journal_title：Current medical research and opinion

authors： Vellacott ID,Shroff NE,Pearce MY,Stratford ME,Akbar FA

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Statin dose, adherence, and cardiovascular (CV) outcomes are important factors when considering switching statin therapies. The objective of the study was to compare CV event rates and risk in managed care patients receiving atorvastatin versus those switched to simvastatin from atorvastatin. METHODS:Patient...

journal_title：Current medical research and opinion

authors： Jacobson TA,Wertz DA,Kuznik A,Cziraky M

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Since many patients with COPD in the US are managed by primary care physicians, we evaluated adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines in a primary care setting. METHODS:A cross-sectional study was conducted using a random sample of patients (n=50-150 per site)...

journal_title：Current medical research and opinion

authors： Belletti D,Liu J,Zacker C,Wogen J

更新日期：2013-08-01 00:00:00

abstract：:The effects of gemfibrozil were assessed in 27 hyperlipidaemic patients with stable peripheral arterial occlusive disease. Gemfibrozil (600 mg twice daily) was administered for 12 weeks after 2 weeks of placebo medication, thus enabling patients to act as their own controls. Serum cholesterol levels were reduced by a ...

journal_title：Current medical research and opinion

authors： Stringer MD,Steadman CA,Kakkar VV

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF)-based regimens have been associated with impaired kidney function and loss of bone mineral density among patients living with HIV (PLWH). We assess the association between TDF exposure and the odds of chronic kidney disease (CKD) and osteoporotic fracture in HIV patients. ...

journal_title：Current medical research and opinion

authors： Sutton SS,Magagnoli J,Hardin JW,Hsu LI,Beaubrun A,Majethia S,Cummings TH

更新日期：2020-10-01 00:00:00