Sleep and wake after benzodiazepine hypnotics: a 20-hour EEG comparison of lormetazepam and flunitrazepam.

abstract：OBJECTIVE:To examine outcomes associated with colesevelam treatment among patients with hypercholesterolemia in real-world clinical practice. METHODS:This analysis was conducted as a retrospective, observational cohort study in an ambulatory-care medical network in Northern California. Patients with orders for colesev...

journal_title：Current medical research and opinion

authors： Romanelli RJ,Leahy A,Jukes T,Ye X,Qian C,Ishisaka DY

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:In ST-segment elevation myocardial infarction (STEMI), current guidelines discourage treatment of the non-culprit lesions at the time of the primary intervention. Latest trials have challenged this strategy suggesting benefit of early complete revascularization. We performed a Bayesian multiple treatment net...

journal_title：Current medical research and opinion

authors： Komócsi A,Kehl D,d'Ascenso F,DiNicolantonio J,Vorobcsuk A

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Several different durable or disposable insulin pen delivery devices are currently available, and newer, improved devices are being introduced. One prefilled insulin device, FlexPen (FP), has recently been improved (known as the Next Generation FlexPen (NGFP) in Europe or the improved FlexPen in the United St...

journal_title：Current medical research and opinion

authors： Niskanen L

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:In order to reduce individual cardiovascular risk, many patients require life-long lipid-lowering therapy, often as a drug combination approach. We aimed to describe the usage pattern, effectiveness and tolerability of long-term treatment with lipid-lowering agents, with particular focus on an oral combinati...

journal_title：Current medical research and opinion

authors： Hildemann SK,Barho C,Karmann B,Darius H,Bode C

更新日期：2008-10-01 00:00:00

abstract：:Impaired red cell deformability has been found in patients suffering from chronic peripheral vascular disorders, the implication being that microcirculatory blood flow is hindered and tissue hypoxaemia is aggravated. Measurement of erythrocyte deformability by a standard filtration technique for whole blood was carri...

journal_title：Current medical research and opinion

authors： Angelkort B,Maurin N,Boateng K

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:This study was designed to assess the safety of 25- and 50-mg dosage strengths of zonisamide for initial titration in patients with epilepsy. RESEARCH DESIGN AND METHODS:This phase 3, multicenter, open-label, uncontrolled study conducted at 26 study sites in the United States included male and female patient...

journal_title：Current medical research and opinion

authors： Uthman BM,Miller GS,Montouris G,James SP,Anthony S,Zonisamide 501 Study Group.

更新日期：2004-06-01 00:00:00

abstract：:Hypertension is another predictor of erectile dysfunction (ED). This is further evidence supporting a link between the pathogenesis of atherosclerotic disease and ED. In one study (TOMHS) involving hypertensive patients, the incidence of ED was 14.4%. The drugs used to treat hypertension may cause ED. However, there i...

journal_title：Current medical research and opinion

authors： Mikhailidis DP,Khan MA,Milionis HJ,Morgan RJ

更新日期：2000-01-01 00:00:00

abstract：:An open study was carried out in 37 patients, with chronic, moderate to severe gastric or bilious reflux associated with hiatus hernia or subsequent to gastro-oesophageal surgery, to assess the effectiveness of an alginate/antacid combination product ('Gastrocote'). The overall success rate of treatment was 81% after ...

journal_title：Current medical research and opinion

authors： Hasan SS

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Fibromyalgia (FM) is characterized by persistent and widespread pain and often associated with other symptoms and comorbidities. Thus, FM patients seek care from multiple physician specialties. This study compared prescribing patterns, patient-reported outcomes (PROs), healthcare resource use (HRU), and dire...

journal_title：Current medical research and opinion

authors： McNett M,Goldenberg D,Schaefer C,Hufstader M,Baik R,Chandran A,Zlateva G

更新日期：2011-03-01 00:00:00

abstract：:Objective: To review the mechanism of action, pharmacology, dosing, and complications of tranexamic acid (TXA) and consolidate current evidence for TXA in gynecologic surgery.Methods: A literature search of PubMed, Ovid (MEDLINE), Google Scholar, and Elsevier was performed, in addition to a targeted search of cited re...

journal_title：Current medical research and opinion

authors： Zakhari A,Sanders AP,Solnik MJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Modern immunology has been extremely successful in elucidating many features of the immune system, but not in stemming pandemics of non-infectious, immune-related disease associated with industrialized populations. These pandemics involve a broad range of allergic, autoimmune, and inflammatory diseases, poten...

journal_title：Current medical research and opinion

authors： Parker W,Perkins SE,Harker M,Muehlenbein MP

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism (PE), is a major cause of morbidity and mortality. VTE is a common disorder, with an estimated annual incidence of approximately 5-12 persons per 10,000. The prognosis for patients who develop VTE is exacerbated by the r...

journal_title：Current medical research and opinion

authors： Ruppert A,Lees M,Steinle T

更新日期：2010-10-01 00:00:00

abstract：:The sensitivity of a number of beta-lactamase producing strains of Enterobacter aerogenes, Enterobacter cloacae, Enterobacter species, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa and Serratia marcescens to cefamandole, cefoxitin, cefuroxi...

journal_title：Current medical research and opinion

authors： Kuipers JS

更新日期：1981-01-01 00:00:00

abstract：:Breast cancer was the focus of several presentations during the 27th European Society of Medical Oncology (ESMO) Congress held in Nice. Fulvestrant seems to be equally effective to tamoxifen as a first-line therapy in hormone-sensitive advanced breast cancer in postmenopausal women. However, it may be more effective t...

journal_title：Current medical research and opinion

authors： Mokbel K

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:The best management of patients with femoropopliteal and infrapopliteal artery occlusion disease is not clear. This study aimed to compare the efficacy of drug-coated balloons (DCBs) and drug-eluting stents (DESs) with percutaneous transluminal angioplasty (PTA) in patients with femoropopliteal or infrapoplit...

journal_title：Current medical research and opinion

authors： Chen X,Li J,Zheng C,He Y,Jia J,Wang X,Li D,Shang T,Li M

更新日期：2018-01-01 00:00:00

abstract：:Normalizing serum thyroid stimulating hormone (TSH) levels by lifelong treatment with levothyroxine (LT4) remains the primary goal of therapy for patients with hypothyroidism. The reference ranges for TSH are derived from populations with (supposedly) normal thyroid function. But, TSH results are affected by a number ...

journal_title：Current medical research and opinion

authors： Razvi S,Hostalek U

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Fasting during the month of Ramadan is practiced by over 1.5 billion Muslims worldwide. It remains unclear, however, how this change in lifestyle affects heart failure, a condition that has reached epidemic dimensions. This study examined the effects of fasting in patients with acute heart failure (AHF) usin...

journal_title：Current medical research and opinion

authors： Salam AM,Sulaiman K,Alsheikh-Ali AA,Singh R,Asaad N,Al-Qahtani A,Salim I,AlHabib KF,Al-Zakwani I,Al-Jarallah M,AlMahmeed W,Bulbanat B,Ridha M,Bazargani N,Amin H,Al-Motarreb A,Al Faleh H,Albackr H,Panduranga P,Shehab

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the positive predictive value of claims-based V85 codes for identifying individuals with varying degrees of BMI relative to their measured BMI obtained from medical record abstraction. METHODS:This was a retrospective validation study utilizing administrative claims and medical chart data from 1 ...

journal_title：Current medical research and opinion

authors： Caplan EO,Kamble PS,Harvey RA,Smolarz BG,Renda A,Bouchard JR,Huang JC

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:A novel preoperative procedure From Home To Operation (FHTO) seeks to combat increasing operation and infection rates. This is the first prospective randomized controlled trial (RCT) comparing the cost-effectiveness and cost-utility of FHTO and conventional ward procedures for standardized Laparoscopic Cholec...

journal_title：Current medical research and opinion

authors： Keränen J,Soini EJ,Ryynänen OP,Hietaniemi K,Keränen U

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Studies have shown that many patients with type 2 diabetes do not achieve optimal glycemic control, and progression of diabetes over time requires more than one pharmacotherapy to achieve glycemic goal. OBJECTIVE:To examine the efficacy and safety of the fixed-dose combination (FDC) of pioglitazone 15 mg an...

journal_title：Current medical research and opinion

authors： Perez A,Zhao Z,Jacks R,Spanheimer R

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:Eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, has been shown to increase platelet counts in adults with chronic immune thrombocytopenia and chronic hepatitis C. This multicenter phase 2 study assessed the efficacy and safety of eltrombopag in patients receiving first-line carboplatin/pacl...

journal_title：Current medical research and opinion

authors： Kellum A,Jagiello-Gruszfeld A,Bondarenko IN,Patwardhan R,Messam C,Mostafa Kamel Y

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:The primary objective of the study was to compare the percentage of men with mean serum total T (C(ave(0-24))) within normal range during the 24-h pharmacokinetic (PK) sampling period on Days 14 and 15. METHODS:Treatment with a new testosterone (T) buccal system, (Striant), 30 mg twice daily was compared to ...

journal_title：Current medical research and opinion

authors： Dobs AS,Matsumoto AM,Wang C,Kipnes MS

更新日期：2004-05-01 00:00:00

abstract：:A study was carried out to compare the efficacy and tolerability of etodolac and piroxicam in patients with rheumatoid arthritis. Sixty patients entered this double-blind, parallel study and after a wash-out period of up to 2 weeks were randomly assigned to receive 200 mg etodolac twice daily or 20 mg piroxicam once d...

journal_title：Current medical research and opinion

authors： Schattenkirchner M

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Over the last two decades the development and analysis of a number of registries have enhanced the knowledge of the epidemiology, presentation, natural history, and pathophysiology of pulmonary arterial hypertension (PAH). The understanding of the effectiveness of available treatments has also been greatly i...

journal_title：Current medical research and opinion

authors： Poscia R,Ghio S,D'Alto M,Vitulo P,Mulè M,Albera C,Parisi F,Badagliacca R,Fedele F,Vizza CD

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To estimate the costs and consequences of using pamidronate compared to zoledronic acid in the prophylactic management of skeletal morbidity among breast cancer patients in the UK. DESIGN AND SETTING:This was a modelling study performed from the perspective of the UK's National Health Service (NHS). METHODS...

journal_title：Current medical research and opinion

authors： Guest JF,Clegg JP,Davie AM,McCloskey E

更新日期：2005-05-01 00:00:00

abstract：INTRODUCTION:GOLD guideline recommendations are currently the "gold standard" for the treatment of COPD patients. OBJECTIVES:The objective of this analysis was to evaluate compliance with GOLD guidelines in managing COPD patients' treatment by general practitioners (GPs) and pulmonologists. Since inhaled corticosteroi...

journal_title：Current medical research and opinion

authors： Visentin E,Nieri D,Vagaggini B,Peruzzi E,Paggiaro P

更新日期：2016-09-01 00:00:00

abstract：:A double-blind, crossover study was carried out in 31 patients with rheumatoid arthritis or osteoarthritis who suffered from insomnia which was considered to be caused primarily by their disease. Patients received 7-day courses of 400 mg chlormezanone, 200 mg chlormezanone and placebo in a pre-determined random order....

journal_title：Current medical research and opinion

authors： Wojtulewski JA,Walter J

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:The objectives of this survey were to understand (1) the effects of overactive bladder (OAB) and urinary incontinence (UI) on women's lives and to understand (2) women's needs and expectations of health care providers and treatment related to these disorders. METHODS:Women (N = 1046) with self-reported sympt...

journal_title：Current medical research and opinion

authors： MacDiarmid S,Rosenberg M

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:We sought to evaluate the relationship between different levels of medication possession ratio (MPR) attained and achievement of clinically meaningful reductions in lipid levels. RESEARCH DESIGN AND METHODS:This was a retrospective cohort study of 4691 new statin users from the Department of Veteran Affairs ...

journal_title：Current medical research and opinion

authors： Watanabe JH,Bounthavong M,Chen T

更新日期：2013-03-01 00:00:00

abstract：:In a double-blind, partial cross-over study of 141 patients with mild to moderate hypertension, chlorthalidone 50 mg was compared with chlorthalidone 50 mg/triamterene 50 mg combination treatment. The study assessed clinical efficacy in the reduction of blood pressure, and safety with regard to serum potassium concent...

journal_title：Current medical research and opinion

authors： Spiers DR,Wade RC

更新日期：1996-01-01 00:00:00