Abstract:
BACKGROUND:Studies have shown that many patients with type 2 diabetes do not achieve optimal glycemic control, and progression of diabetes over time requires more than one pharmacotherapy to achieve glycemic goal. OBJECTIVE:To examine the efficacy and safety of the fixed-dose combination (FDC) of pioglitazone 15 mg and metformin 850 mg versus its individual components in a twice-daily regimen over 24 weeks of treatment in type 2 diabetes patients who were currently not receiving antidiabetes therapy. METHODS:This was a double-blind, randomized, parallel-group, controlled study. The primary endpoint was change from baseline in hemoglobin A1c (HbA1c) of pioglitazone/metformin FDC therapy compared with pioglitazone and metformin monotherapy. Secondary endpoints included change from baseline in fasting plasma glucose (FPG), fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR). Safety and tolerability of pioglitazone/metformin FDC therapy and its individual components were also evaluated. Study limitations to be noted include the early stage of diabetes in these patients, which may be more responsive to treatment, and the 6 month treatment period, which does not provide durability data. CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov, NCT00727857. RESULTS:From a baseline HbA1c >8.6%, mean HbA1c decreased the most with pioglitazone/metformin FDC (-1.83%) (P < 0.0001), compared with pioglitazone (-0.96%) and metformin (-0.99%) monotherapy, with 63.8% of FDC patients achieving HbA1c < or = 7% versus 46.9% of pioglitazone- and 38.9% of metformin-treated patients. The decrease from baseline to final visit in FPG was significantly larger in the pioglitazone/metformin FDC group (-39.9 mg/dL) (P < 0.01) compared with either monotherapy; the decrease in mean HOMA-IR was greatest with pioglitazone/metformin FDC. The pioglitazone/metformin FDC was well tolerated with no unexpected findings in adverse events of special interest, including hypoglycemia, bone fractures, peripheral edema, and cardiac failure. CONCLUSIONS:Overall, treatment with pioglitazone/metformin FDC demonstrated greater efficacy than its individual components. The FDC therapy was well tolerated, with reduced or similar adverse event rates compared with each individual monotherapy.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Perez A,Zhao Z,Jacks R,Spanheimer Rdoi
10.1185/03007990903350011subject
Has Abstractpub_date
2009-12-01 00:00:00pages
2915-23issue
12eissn
0300-7995issn
1473-4877journal_volume
25pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:The impact of multiple sclerosis (MS) center type on outcomes has not been investigated. This study aimed to evaluate baseline characteristics and clinical and magnetic resonance imaging (MRI) outcomes in patients with MS receiving fingolimod over 16 months' follow-up at private or academic centers in the USA...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1458708
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To examine medication dosing patterns of duloxetine and pregabalin among patients with fibromyalgia. METHODS:From a large US administrative claims database, commercially insured fibromyalgia patients aged 18-64 who initiated duloxetine or pregabalin in 2006 were selected. Initiation was defined as a 90-day m...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2011.605113
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:A double-blind randomized trial evaluated the efficacy and tolerability of rivastigmine and donepezil in patients with Alzheimer's disease (AD) over 2 years. Baseline data indicated that some patients had symptoms suggestive of concomitant Lewy body disease. This retrospective analysis investigated whether A...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/030079906x80279
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether once daily biphasic insulin aspart 30 (BIAsp 30) is noninferior to once daily insulin glargine (IGlar) among Chinese and Japanese insulin-naïve subjects with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS:This was a 24 week treat-to-target trial (NCT01123980) that include...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007995.2013.838155
更新日期:2013-12-01 00:00:00
abstract::Forty-two patients with a radiologically confirmed diagnosis of chronic pyelonephritis were treated with 1 g carindacillin every 6 hours over a period of 6 weeks. An underlying urological disease was present in 84% of the 38 patients for whom sufficient data were available for evaluation. The results of carindacillin ...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007997809111904
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVES:High-sensitivity C-reactive protein (hs-CRP) has been explored for use in predicting cardiovascular risk. The recent Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study found that statin therapy reduced cardiovascular events in those with ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2010.516994
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To evaluate inpatient oral anticoagulant (OAC) treatment, discharge location, and post-discharge OAC treatment for patients hospitalized with non-valvular atrial fibrillation (NVAF). RESEARCH DESIGN AND METHODS:Retrospective study using claims data linked to hospital electronic health records (EHR). Patients...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2017.1417029
更新日期:2018-03-01 00:00:00
abstract::The effects of flurbiprofen on various coagulation and haemostasis parameters were studied in 19 patients adequately anticoagulated on a fixed dose of phenprocoumon. Laboratory controls were performed 5 times at weekly intervals. Flurbiprofen 50 mg 3-times daily was given for 2 weeks after an initial control period of...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997709108972
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:To assess the burden of treatment-resistant depression (TRD) among privately insured patients with anxiety disorder and/or substance use disorders (SUD). METHODS:Adults <65 years old were identified in the Optum Health Care Solutions Inc. database (July 2009-March 2017). Among those with major depressive dis...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1844645
更新日期:2021-01-01 00:00:00
abstract::Cholinesterase inhibitors, which act by inhibiting the degradation of acetylcholine in the brain, form the mainstay of therapy for AD. Predominant adverse events are cholinergic in nature, the most frequent being gastrointestinal side effects. Here we present a case series of patients with dementia who were treated wi...
journal_title:Current medical research and opinion
pub_type: 信件
doi:10.1185/030079906X162791
更新日期:2007-01-01 00:00:00
abstract::This commentary critically evaluates the limitations of genetic risk predictions in multifactorial disease, with specific reference to age-related macular degeneration (AMD). AMD is a common blinding disease with 33 million people worldwide experiencing vision impairment. Although gene polymorphism combinations infer ...
journal_title:Current medical research and opinion
pub_type: 社论
doi:10.1185/03007995.2011.603301
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:This study assesses the direct (medical and drugs) and indirect (work loss) annual costs associated with Atrial Fibrillation (AFIB) in a privately insured population. BACKGROUND:AFIB is the most common sustained rhythm disturbance, affecting 2.3 million people in the United States. METHODS:Cost and co-morbi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/030079905X65475
更新日期:2005-10-01 00:00:00
abstract::A double-blind trial was carried out in 76 patients with active rheumatoid arthritis to compare the analgesic and anti-inflammatory activity of 3 g. alclofenac with 4.8 g. aspirin daily over a 6-week period. All patients selected showed reversible inflammatory swelling of the finger joints. Of the 60 patients successf...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007997509114781
更新日期:1975-01-01 00:00:00
abstract::An open study was carried out in 37 patients, with chronic, moderate to severe gastric or bilious reflux associated with hiatus hernia or subsequent to gastro-oesophageal surgery, to assess the effectiveness of an alginate/antacid combination product ('Gastrocote'). The overall success rate of treatment was 81% after ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998009110074
更新日期:1980-01-01 00:00:00
abstract::In a double-blind investigation in 21 patients undergoing minor plastic surgery the effects of 4 mg lorazepam or a mixture of 20 mg papaveretum/400 mug hyoscine given intramuscularly as premedicants were studied. Lorazepam produced superior preoperative and post-operative anterograde amnesia, with respect to both inci...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007997609111993
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:The Physician Payments Sunshine Act, enacted in 2010, is intended to increase the transparency of relationships between US physicians and teaching hospitals and manufacturers of drugs, biologics, and medical devices. We examined current opinion regarding the impact of the Sunshine Act on peer-reviewed medical...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2015.1131151
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To review the fatalities among children hospitalized with respiratory syncytial virus (RSV) infection, and identify factors leading to a fatal outcome. RESEARCH DESIGN AND METHODS:Review of literature identified from a structured search of PubMed (1966-2009) using the following Medical Subject Headings: resp...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2010.505126
更新日期:2010-09-01 00:00:00
abstract::Doxofylline (7-(1,3-dioxalan-2-ylmethyl) theophylline) is a novel xanthine bronchodilator which differs from theophylline in that it contains a dioxalane group in position 7. Similarly to theophylline, its mechanism of action is related to the inhibition of phosphodiesterase activities, but in contrast it appears to h...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079901750120196
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:As an ever widening array of anti-hyperglycemic agents are now available, the effect of these drugs on lipids is increasingly complex and controversial. The present meta-analysis was designed to clarify the effect of a dual combination of noninsulin anti-hyperglycemic agents on lipids in type 2 diabetes. MET...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析,评审
doi:10.1185/03007995.2014.921608
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:Recent survey data have reported the incidence rate of needlestick injuries (NIs) and NIs which draw blood sustained by nurses caring for patients with diabetes in an in-patient hospital setting. The purpose of this study was to deduce the potential short-term annual economic impact resulting from such NI, and ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X65286
更新日期:2005-12-01 00:00:00
abstract::Objective: Hypertension is a serious health problem in Egypt, with prevalence rate of 17% as reported in 2015. Despite receiving treatment, many do not achieve blood pressure (BP) control. The current study aimed to evaluate the efficacy and tolerability of amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ) singl...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1719394
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Inadequate removal of extracellular volume markedly increases blood pressure and contributes to high morbidity and mortality in hemodialysis patients. Advances in fluid management are needed to improve clinical outcomes. The aim of this quality improvement project was to examine the advantages of using a hem...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2015.1047746
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To develop a patient-completed screening tool to help differentiate nociceptive and neuropathic pain. RESEARCH DESIGN AND METHODS:A multicenter study was performed for item reduction (initial 89-item questionnaire) and model building. Patients (N = 586) with non-headache chronic pain completed the questionna...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/030079906X115702
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Long-term oral corticosteroid (OCS) therapy and related adverse events are associated with a significant burden on patients and healthcare resources. METHODS:This subgroup analysis of a randomized, open-label, parallel-group study evaluated the OCS-sparing effect of omalizumab (OMA) added to optimized asthm...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/03007995.2011.620950
更新日期:2011-11-01 00:00:00
abstract::An open clinical evaluation was carried out in 736 African out-patients suffering from rheumatic and inflammatory disorders to assess the efficacy and tolerability of tenoxicam in relieving the signs and symptoms of their condition. On entry, all previous treatment was discontinued and patients received a simple daily...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1185/03007999109111519
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Reduction in total cholesterol (TC) and LDL-cholesterol (LDL-C) forms one of the principal objectives of most cardiovascular secondary prevention strategies. Many patients being treated with statins, however, have significant residual dyslipidaemia, with many having suboptimal HDL-cholesterol ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802374633
更新日期:2008-09-01 00:00:00
abstract:AIM:Non-peer-reviewed manuscripts posted as preprints can be cited in peer-reviewed articles, which has both merits and demerits. International Committee of Medical Journal Editors guidelines mandate authors to declare preprints at the time of manuscript submission. We evaluated the trends in pharma-authored research p...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1853083
更新日期:2020-12-09 00:00:00
abstract::The pharmacokinetics of Bay g 2821, a new diuretic agent, were studied in dogs, healthy volunteers and in patients with renal insufficiency. The drug was rapidly absorbed after oral administration, peak plasma levels (approx. 0.4 microgram/ml) occurring within 1 hour. Elimination of the unchanged drug from plasma was ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997709115271
更新日期:1977-01-01 00:00:00
abstract::One hundred adult male volunteers were randomized to receive either Merieux or Wellcome RA27/3 rubella vaccine. Prior to vaccination, 10% of the subjects were seronegative and all of these seroconverted. No significant boosting effect was found in those with a high pre-vaccine titre but some boost was shown in those w...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998609111093
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:Pioglitazone hydrochloride (Actos † ) and rosiglitazone maleate (Avandia ‡ ) are members of the thiazolidinedione (TZD) class of oral anti-diabetic drugs (OADs) and are used to treat type 2 diabetes mellitus (T2DM). Greater beneficial effects on lipids have been demonstrated with pioglitazone, however. Study...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802434874
更新日期:2008-11-01 00:00:00