Recent advances in breast cancer: the 27th ESMO Congress 2002.

abstract：:Studies in several populations have indicated that genetic variation at the apolipoprotein E (apoE) structural locus influences the risk of coronary artery disease (CAD) and myocardial infarction (MI). This study aimed at investigating whether apoE polymorphism has an allelic and/or genotypic impact on the risk of MI ...

journal_title：Current medical research and opinion

authors： Kolovou G,Yiannakouris N,Hatzivassiliou M,Malakos J,Daskalova D,Hatzigeorgiou G,Cariolou MA,Cokkinos DV

更新日期：2002-01-01 00:00:00

abstract：:Twenty patients with mild to moderate hypertension participated in a single-blind crossover comparison of treatment with 25 mg hydrochlorothiazide plus 50 mg triamterene and 50 mg hydrochlorothiazide plus 5 mg amiloride in once-daily dosage regimens. After a 2-week run-in period without treatment, patients were alloca...

journal_title：Current medical research and opinion

authors： Dean S,Spencer-Mills L

更新日期：1984-01-01 00:00:00

abstract：:This study evaluated the prognostic significance of several risk factors on the outcome of coronary heart disease (CHD) in 639 cardiovascular disease-free subjects with heterozygous familial hypercholesterolaemia (FH). During the 15-year follow-up, 53 (18%) men and 34 (9.8%) women had a CHD event (men vs women, p < 0....

journal_title：Current medical research and opinion

authors： Panagiotakos DB,Pitsavos C,Skoumas J,Chrysohoou C,Toutouza M,Stefanadis CI,Toutouzas PK

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Elevated glucose blood levels are the key criteria for diagnosing diabetes mellitus (DM). Hyperglycaemia contributes to the pathophysiology associated with DM, including microvascular and possibly macrovascular disease. In spite of a wide range of pharmacological options available to reduce hyperglycaemia in...

journal_title：Current medical research and opinion

authors： Bays H

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase 4 (DPP4) inhibitors are currently used as glucose-lowering agents in type 2 diabetes, due to their effects on insulin and glucagon secretion. These agents, which are effective in improving glucose control, could also have a beneficial...

journal_title：Current medical research and opinion

authors： Mannucci E,Dicembrini I

更新日期：2012-05-01 00:00:00

abstract：:Lowering cholesterol levels is a primary approach for reducing the risk of coronary heart disease (CHD), yet patients rarely achieve the lipid targets recommended by international guidelines. Although high rates of compliance and achievement of lipid targets have been reported in clinical trials, this situation is inf...

journal_title：Current medical research and opinion

authors： Riesen WF,Darioli R,Noll G

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Ocular surface disease (OSD) is a common side effect of ophthalmic medications containing the preservative benzalkonium chloride (BAK). Little is known whether and how glaucoma treatment patterns and annual costs vary based on the presence of BAK. The objective of this analysis was to estimate first-year trea...

journal_title：Current medical research and opinion

authors： Schmier JK,Covert DW,Robin AL

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Natalizumab is a highly effective treatment for patients with relapsing-remitting multiple sclerosis (RRMS). Treatment with natalizumab has been associated with progressive multifocal leukoencephalopathy (PML), a rare yet serious disease of the brain. Published studies have quantified the PML risk by the pre...

journal_title：Current medical research and opinion

authors： Walker A,Watson C,Alexopoulos ST,Deniz B,Arnold R,Bates D

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:In epidural analgesia, synthetic opioids increase the potency of amide local anesthetics by modifying their analgesic properties. The purpose of this systematic review and meta-analysis is to compare the efficacy and safety of bupivacaine with ropivacaine and levobupivacaine in combination with sufentanil (B...

journal_title：Current medical research and opinion

authors： Lv BS,Wang W,Wang ZQ,Wang XW,Wang JH,Fang F,Mi WD

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:To evaluate posaconazole pharmacokinetics in subjects with different degrees of hepatic impairment compared with matched healthy subjects. RESEARCH DESIGN AND METHODS:A total of 37 subjects were enrolled in this open-label, single-dose, parallel-group study; 19 with hepatic impairment and 18 healthy subjects...

journal_title：Current medical research and opinion

authors： Moton A,Krishna G,Ma L,O'Mara E,Prasad P,McLeod J,Preston RA

更新日期：2010-01-01 00:00:00

abstract：:Objectives: To evaluate central foveal thickness (CFT) variability and accompanying changes in visual acuity (VA) 12 months before and after treatment with the 190 mcg fluocinolone acetonide (FAc) intravitreal implant for diabetic macular edema (DME).Methods: The Iluvien Clinical Evidence cohort study in the United Ki...

journal_title：Current medical research and opinion

authors： Holden SE,Habib M,Currie CJ

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:Health economic analysis from a healthcare and societal point of view was conducted to assess the cost-effectiveness of insulin degludec (IDeg) after switching from other basal insulins in people with type 1 diabetes. MATERIAL AND METHODS:This was a prospective, open-label, single arm, observational follow-...

journal_title：Current medical research and opinion

authors： Landstedt-Hallin L,Gundgaard J,Ericsson Å,Ellfors-Zetterlund S

更新日期：2017-04-01 00:00:00

abstract：:Neuroprotective agents inhibit reactions in the brain ischaemic injury cascade which lead to neuronal death. Gamma-aminobutyric acid (GABA) is a naturally occurring inhibitory neurotransmitter that increases chloride influx into the neuron and counteracts the toxic effects of glutamate. Clomethiazole is a GABA(A) agon...

journal_title：Current medical research and opinion

authors： Vaishnav A,Lutsep HL

更新日期：2002-01-01 00:00:00

abstract：:An open clinical evaluation was carried out in 736 African out-patients suffering from rheumatic and inflammatory disorders to assess the efficacy and tolerability of tenoxicam in relieving the signs and symptoms of their condition. On entry, all previous treatment was discontinued and patients received a simple daily...

journal_title：Current medical research and opinion

authors： Ibrahima K,Kodjo G,Issa S,Seye L,Cisse F,Eassey G,Rietiker S

更新日期：1991-01-01 00:00:00

abstract：:A multi-centre trial was carried out in 1629 patients with osteoarthrosis in 233 clinical centres to investigate the therapeutic efficacy and tolerability of indoprofen in this clinical condition. The results from assessments of both subjective and objective variables were comparable to those obtained in Phase 3 studi...

journal_title：Current medical research and opinion

authors： Emanueli A,Mandelli V,Mascellani G,Sacchetti G

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:The Physician Payments Sunshine Act, enacted in 2010, is intended to increase the transparency of relationships between US physicians and teaching hospitals and manufacturers of drugs, biologics, and medical devices. We examined current opinion regarding the impact of the Sunshine Act on peer-reviewed medical...

journal_title：Current medical research and opinion

authors： Toroser D,Robinson M,Gegner J,Smith G,Nilsen J,Hyatt L,Johnson T,Hassan A,Gatchalian C

更新日期：2016-01-01 00:00:00

abstract：:Normalizing serum thyroid stimulating hormone (TSH) levels by lifelong treatment with levothyroxine (LT4) remains the primary goal of therapy for patients with hypothyroidism. The reference ranges for TSH are derived from populations with (supposedly) normal thyroid function. But, TSH results are affected by a number ...

journal_title：Current medical research and opinion

authors： Razvi S,Hostalek U

更新日期：2019-07-01 00:00:00

abstract：:Objective: To review the mechanism of action, pharmacology, dosing, and complications of tranexamic acid (TXA) and consolidate current evidence for TXA in gynecologic surgery.Methods: A literature search of PubMed, Ovid (MEDLINE), Google Scholar, and Elsevier was performed, in addition to a targeted search of cited re...

journal_title：Current medical research and opinion

authors： Zakhari A,Sanders AP,Solnik MJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:As an ever widening array of anti-hyperglycemic agents are now available, the effect of these drugs on lipids is increasingly complex and controversial. The present meta-analysis was designed to clarify the effect of a dual combination of noninsulin anti-hyperglycemic agents on lipids in type 2 diabetes. MET...

journal_title：Current medical research and opinion

authors： Dai X,Wang H,Jing Z,Fu P

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:To evaluate effectiveness and safety information of transdermal fentanyl (TDF) (Duragesic/Durogesic) and sustained-release oral morphine (SRM) in cancer pain (CP) and chronic non-cancer pain (NCP), a pooled analysis was conducted on datasets of published, open label, uncontrolled (no comparator group) and rando...

journal_title：Current medical research and opinion

authors： Clark AJ,Ahmedzai SH,Allan LG,Camacho F,Horbay GL,Richarz U,Simpson K

更新日期：2004-09-01 00:00:00

abstract：:A single-blind, open-label controlled study was carried out in 30 healthy male volunteers to compare gastro-intestinal blood loss before, during and after treatment with a new, sustained-release formulation of the non-steroidal anti-inflammatory agent etodolac (etodolac SR) or with naproxen. Subjects remained at the s...

journal_title：Current medical research and opinion

authors： Leese P

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To compare the safety and efficacy of celecoxib versus diclofenac slow release (SR) plus omeprazole in elderly arthritis patients. RESEARCH DESIGN AND METHODS:Patients aged≥65 years, with osteoarthritis and/or rheumatoid arthritis, at high gastrointestinal (GI) risk who participated in the CONDOR trial (Cele...

journal_title：Current medical research and opinion

authors： Kellner HL,Li C,Essex MN

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Although beta-blocker therapy has been shown to improve survival in patients with chronic heart failure, this class of drugs tends to be underutilized in diabetic patients due to concerns about adverse metabolic effects, especially on glycemic control. No randomized clinical trial has specifically evaluated ...

journal_title：Current medical research and opinion

authors： Bell DS,Lukas MA,Holdbrook FK,Fowler MB

更新日期：2006-02-01 00:00:00

abstract：:A study was carried out to compare a new, unique chemical strip test for the measurement of urine specific gravity with the traditional methods of hydrometry and refractometry, during water concentration/dilution tests in 12 normal subjects. The pattern of specific gravity results during these serial measurements was ...

journal_title：Current medical research and opinion

authors： Gounden D,Newall RG

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:In TRITON-TIMI 38, patients with acute coronary syndromes were treated with prasugrel or clopidogrel, with aspirin, for a median of 14.5 (maximum of 15) months. Based on this trial, the EU label for prasugrel recommends treatment for up to 12 months and excludes patients with prior stroke/transient ischemic ...

journal_title：Current medical research and opinion

authors： Wilcox R,Iqbal K,Costigan T,Lopez-Sendon J,Ramos Y,Widimsky P

更新日期：2014-11-01 00:00:00

abstract：:A double-blind crossover trial was undertaken to compare the efficacy of sustained-release clonidine and long-acting propranolol in the treatment of 20 patients (8 males and 12 females) with sustained hypertension. Each patient was stabilized with metoprolol with or without diuretic therapy prior to admission to the t...

journal_title：Current medical research and opinion

authors： Rodrigues E,Lawson AA

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:A recent retrospective meta-analysis of cardiovascular events from long-term studies with acarbose in type 2 diabetes showed that treatment was associated with a significant reduction in the risk of cardiovascular events, supporting the hypothesis that postprandial hyperglycemia is a risk factor for cardiovas...

journal_title：Current medical research and opinion

authors： Roze S,Valentine WJ,Evers T,Palmer AJ

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Low back pain in general and specifically chronic low back pain forms a major burden for the patient and society. Recently studies demonstrated that up to 65% of patients evolve to chronic pain as opposed to the previously accepted 8%. As low back pain patients present first with their general practitioner, ...

journal_title：Current medical research and opinion

authors： Itz C,Huygen F,Kleef MV

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Migraine is a chronic, disabling neurological disease affecting >1 billion people worldwide. Migraine remains undertreated in Asia, including Taiwan. Galcanezumab is a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide, a peptide firmly established in the pathophysiology of m...

journal_title：Current medical research and opinion

authors： Yang CP,Lee CF,Dell'Agnello G,Hundemer HP,Lipsius S,Wang SJ

更新日期：2020-10-01 00:00:00

abstract：:Two clinical trials were carried out in order to study adrenal suppression in 6 patients with psoriatic erythroderma and in 28 patients with psoriasis treated with topical glucocorticosteroids. Betamethasone-17-valerate (0.1%), betamethasone-17,21-dipropionate (0.05%) and budesonide (0.025%) ointments were studied in ...

journal_title：Current medical research and opinion

authors： Salde L,Lassus A

更新日期：1983-01-01 00:00:00