Abstract:
:Two clinical trials were carried out in order to study adrenal suppression in 6 patients with psoriatic erythroderma and in 28 patients with psoriasis treated with topical glucocorticosteroids. Betamethasone-17-valerate (0.1%), betamethasone-17,21-dipropionate (0.05%) and budesonide (0.025%) ointments were studied in erythroderma; betamethasone-17,21-dipropionate and budesonide in psoriasis. The erythroderma study was an open, crossover experiment; the psoriasis study was a double-blind, group-comparative study. Adrenal suppression was measured as plasma cortisol concentrations with and without ACTH stimulation. The depressive activity on the HPA-axis in increasing order was budesonide, betamethasone-17-valerate and betamethasone-17,21-dipropionate. The differences, however, did not reach statistically significant levels.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Salde L,Lassus Adoi
10.1185/03007998309109785subject
Has Abstractpub_date
1983-01-01 00:00:00pages
475-80issue
7eissn
0300-7995issn
1473-4877journal_volume
8pub_type
临床试验,杂志文章abstract::Seventy frail elderly patients attending a day hospital were studied to investigate the incidence of postural hypotension in control patients on no diuretic treatment (n = 30), patients on loop diuretics (frusemide) for mild cardiac failure (n = 20) and patients on thiazide diuretics for mild cardiac failure (n = 20)....
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998809114241
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:In the four SMILE (Survival of Myocardial Infarction Long-Term Evaluation) studies, early administration of zofenopril in acute myocardial infarction (AMI) showed beneficial effects as compared to placebo and other angiotensin converting enzyme inhibitors (ACEIs). This study investigated whether the concomita...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1080/03007995.2018.1496076
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stroke is a major cause of disability. Certain experimental studies have suggested that a combination of almitrine + raubasine (Duxil) increases the supply of oxygen to cerebral tissues and may be beneficial in post-stroke rehabilitation. This multicentre clinical study was carried out in orde...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1185/030079904125003080
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Fasting during the month of Ramadan is practiced by over 1.5 billion Muslims worldwide. It remains unclear, however, how this change in lifestyle affects heart failure, a condition that has reached epidemic dimensions. This study examined the effects of fasting in patients with acute heart failure (AHF) usin...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1080/03007995.2017.1376629
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Bariatric surgery is an effective treatment for the reduction of weight in obese patients (BMI ≥ 40 kg/m(2) or 30 kg/m(2) with ≥1 comorbidities), who are refractory to behavioral and medical therapies. This study examined the effect of the adjustable gastric band (AGB) system on changes in gastroesophageal re...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,meta分析
doi:10.1185/03007995.2012.666962
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:These studies evaluated the safety and efficacy of enteric-coated budesonide for the induction and maintenance of remission of mild-to-moderate Crohn's disease (CD) in children. METHODS:The consecutive, multicenter, open-label, non-comparative studies enrolled patients aged 6-17 years. In the induction study...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1080/03007995.2017.1313213
更新日期:2017-07-01 00:00:00
abstract::In a single-blind study in general practice, 60 patients with anxiety neuroses were randomly allocated to receive either 0.5 mg haloperidol twice daily or 2 mg diazepam 3-times daily for 6 weeks. Eighteen patients (6 on haloperidol and 12 on diazepam) were excluded from the analysis of efficacy. On the Hamilton Rating...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007997909109010
更新日期:1979-01-01 00:00:00
abstract::The therapeutic efficacy and tolerability of a new controlled-release 1000 mg tablet of naproxen (naproxen CR) were compared with 200 mg isoxicam in 100 out-patients with osteoarthritis. Medications were administered once daily for 4 weeks in a controlled, randomized, double-blind, parallel trial. Patients were assess...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998809111127
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To review published evidence on the impact of weight/BMI change on health-related quality of life (HRQoL) in adults from the US with overweight/obesity. METHODS:The systematic review was conducted in accordance with PRISMA guidelines. MEDLINE, Embase, EconLit, and Cochrane Library databases were reviewed usi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2015.1128403
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Severe allergic asthma patients may not be controlled even with guideline recommended care, including inhaled corticosteroids, long-acting beta-2 agonists, theophylline, oral steroids and anti-leukotrienes. They experience exacerbations requiring intensive healthcare use and which may be fatal. Omalizumab, a...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1185/030079906X132389
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:To compare the efficacy and safety of the concomitant administration of travoprost 0.004% once daily and brinzolamide 0.1% twice daily with those of a fixed combination of latanoprost 0.005%/timolol 0.5% once daily. RESEARCH, DESIGN AND METHODS:Forty-four patients with primary open-angle glaucoma or ocular hyp...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/030079904125004529
更新日期:2004-09-01 00:00:00
abstract::Migraine is a very common disorder, affecting about 11% of adult populations in Western countries. Prevalence is highest during the peak productive years--between the ages of 25 and 55. The prevalence is higher in females than males at all post-pubertal ages, but the sex ratio varies with age. In the United States, mi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/0300799039117005
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:It is unclear how well different outcome measures in randomized controlled trials (RCTs) perform in predicting real-world cancer survival. We assess the ability of RCT overall survival (OS) and surrogate endpoints - progression-free survival (PFS) and time to progression (TTP) - to predict real-world OS acros...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2016.1140027
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Postpartum depression (PPD) is the most common medical complication of childbirth. PPD can be disabling, with potential negative effects on maternal health-related quality-of-life (HRQoL) as well as on children and partners. The objective of this study was to systematically review and summarize recently publi...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1552039
更新日期:2019-03-01 00:00:00
abstract::A long-term follow-up study was carried out in 44 Type II diabetic patients to confirm the lack of effect of gliclazide on body weight as well as its hypoglycaemic efficacy and tolerance. Patients were assessed for up to 51 months. The results showed no overall significant change in body weight, 21 patients gaining we...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998409109552
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:Luseogliflozin is a novel sodium glucose cotransporter 2 inhibitor for type 2 diabetes mellitus (T2DM) treatment. An exploratory Phase II study was conducted to assess the efficacy and safety of several doses of luseogliflozin in Japanese T2DM patients. PATIENTS AND METHODS:Japanese T2DM patients aged 20-74 ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007995.2014.901943
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the positive predictive value of claims-based V85 codes for identifying individuals with varying degrees of BMI relative to their measured BMI obtained from medical record abstraction. METHODS:This was a retrospective validation study utilizing administrative claims and medical chart data from 1 ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2017.1366302
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Most registration studies for new osteoporosis drugs have used a combination of quantitative morphometry (QM) and visual semiquantitative reading (SQ) to define vertebral fractures. However, in the pivotal teriparatide Fracture Prevention Trial (ClinicalTrials.gov Identifier: NCT00670501), vertebral fractures...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990902790993
更新日期:2009-04-01 00:00:00
abstract::A trial was carried out in 30 patients to assess the effectiveness of indanyl carbenicillin in acute or chronic urinary tract infections, many of which were complicated by a pathological urological or medical condition. In all patients, infection was due to a single species of pathogen: E. coli (19), Proteus (6), and ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997609109298
更新日期:1976-01-01 00:00:00
abstract::An open study was carried out in 41 children with mild to moderate psoriasis to assess the effectiveness and tolerance of treatment with a 0.1% dithranol plus 17% urea preparation applied twice daily. Thirty-four patients completed 6-weeks' treatment and 8 of them continued for a further 4 to 6 weeks. The results show...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007998309111752
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Tenofovir disoproxil fumarate (TDF)-based regimens have been associated with impaired kidney function and loss of bone mineral density among patients living with HIV (PLWH). We assess the association between TDF exposure and the odds of chronic kidney disease (CKD) and osteoporotic fracture in HIV patients. ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1816538
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To compare glycemic goal achievement (HbA(1c) < 7%) in type 2 diabetes patients receiving initial metformin plus pioglitazone combination therapy and initial metformin monotherapy augmented with pioglitazone in a cohort follow-up study. RESEARCH DESIGN AND METHODS:Adult patients were identified from the Inge...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2010.536755
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:This study evaluated the long-term cost-effectiveness of atorvastatin 20 mg, rosuvastatin 10 mg and simvastatin 40 mg in primary and secondary prevention of CHD in Finland. RESEARCH DESIGN AND METHODS:The effect of statin therapy on the incidence of CHD and the expected total costs of the disease were descri...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802144705
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:The use of embolic protection devices to decrease major adverse cardiac events (MACEs) in patients with saphenous vein graft lesions is considered class I therapy by the recent practice guidelines. However, the benefits of adjunctive protection devices to prevent distal embolization in patients with native co...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/03007995.2012.686445
更新日期:2012-06-01 00:00:00
abstract::Twenty-nine patients undergoing cholecystectomy because of chronic calculous cholecystitis were randomised to receive phenylbutazone 10 mg/kg intramuscularly or a control injection (vehicle-containing local anaesthetic) immediately after completion of surgery. Fibrinogen and plasminogen concentrations in plasma, plasm...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007999809113349
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Report efficacy findings from three clinical trials (one phase 2 and two phase 3 [OPUS-1, OPUS-2]) of lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease (DED). RESEARCH DESIGN AND METHODS:Three 84-day, randomized, double-masked, placebo-controlled trials. Adults (≥18 years) with DED were r...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1210107
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To examine medication dosing patterns of duloxetine and pregabalin among patients with fibromyalgia. METHODS:From a large US administrative claims database, commercially insured fibromyalgia patients aged 18-64 who initiated duloxetine or pregabalin in 2006 were selected. Initiation was defined as a 90-day m...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2011.605113
更新日期:2011-09-01 00:00:00
abstract::Doxofylline (7-(1,3-dioxalan-2-ylmethyl) theophylline) is a novel xanthine bronchodilator which differs from theophylline in that it contains a dioxalane group in position 7. Similarly to theophylline, its mechanism of action is related to the inhibition of phosphodiesterase activities, but in contrast it appears to h...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079901750120196
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Studies have shown that many patients with type 2 diabetes do not achieve optimal glycemic control, and progression of diabetes over time requires more than one pharmacotherapy to achieve glycemic goal. OBJECTIVE:To examine the efficacy and safety of the fixed-dose combination (FDC) of pioglitazone 15 mg an...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990903350011
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:This retrospective study assessed the incidence and timing of adverse events (AEs) among patients prescribed varying dose levels of corticosteroids in the US. METHODS:Patients with selected autoimmune or inflammatory disease diagnoses between 2006 and 2015 were identified from a privately insured administrat...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1474090
更新日期:2018-08-01 00:00:00