Lipid-lowering therapy: strategies for improving compliance.

abstract：PURPOSE:Tamoxifen, used in breast cancer treatment, may induce hepatic steatosis. It has been suggested that leptin, which has a relationship with body fat stores, may be involved in the pathogenesis of hepatic steatosis. In this study, we compared serum leptin levels in tamoxifen-treated patients with and without hepa...

journal_title：Current medical research and opinion

authors： Günel N,Coşkun U,Toruner FB,Sancak B,Yilmaz E,Cengiz O,Elbeg S,Uner A,Ozkan S

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To explore relationships between beta-cell function and incident cardiovascular events, death, and medical costs among elderly individuals. RESEARCH DESIGN AND METHODS:In a prospective, population-based cohort of 4555 elderly individuals, we examined the effect of beta-cell function on incident cardiovascula...

journal_title：Current medical research and opinion

authors： Curtis LH,Hammill BG,Bethel MA,Anstrom KJ,Liao L,Gottdiener JS,Schulman KA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Pain is usually assessed by spontaneous pain ratings. Time-dependent (brief attacks) or evoked (allodynia) phenomena, common in neuropathic pain, are not captured. To evaluate the overall effectiveness of a treatment, improvement of all sensory symptoms should be measured. Since the pattern of sensory abnorm...

journal_title：Current medical research and opinion

authors： Höper J,Helfert S,Heskamp ML,Maihöfner CG,Baron R

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:The use of embolic protection devices to decrease major adverse cardiac events (MACEs) in patients with saphenous vein graft lesions is considered class I therapy by the recent practice guidelines. However, the benefits of adjunctive protection devices to prevent distal embolization in patients with native co...

journal_title：Current medical research and opinion

authors： Jin B,Dong XH,Zhang C,Li Y,Shi HM

更新日期：2012-06-01 00:00:00

abstract：:The potential advantages of eletriptan lie firstly in its lipophilicity reflected as an increased rate of absorption and Tmax compared to sumatriptan. This is manifested in a modest advantage over sumatriptan in terms of speed of onset, 2 h headache response and 2 h pain free. However, eletriptan has not yet been show...

journal_title：Current medical research and opinion

authors： Giffin N

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:With a growing number of studies and comparators in MRSA skin infections, a unified framework for comparing treatments is needed for health technology assessment (HTA). The objective was to systematically assess the success rates of common antimicrobial agents for the treatment of complicated skin and soft ti...

journal_title：Current medical research and opinion

authors： Logman JF,Stephens J,Heeg B,Haider S,Cappelleri J,Nathwani D,Tice A,van Hout BA

更新日期：2010-07-01 00:00:00

abstract：:Objective: A prior study found that hyaluronic acid (HA) treatment may help reduce pain medication use (such as steroids, non-steroidal anti-inflammatory drugs [NSAIDs] and opioids) among knee osteoarthritis (OA) patients in the real-world setting. This study aims to update the prior study results to include only the ...

journal_title：Current medical research and opinion

authors： Chitnis AS,Etter K,Holy CE,Gray FS,Manalac FJ,Bisson B,Bhattacharyya SK

更新日期：2019-09-01 00:00:00

abstract：:A single-blind, open-label controlled study was carried out in 30 healthy male volunteers to compare gastro-intestinal blood loss before, during and after treatment with a new, sustained-release formulation of the non-steroidal anti-inflammatory agent etodolac (etodolac SR) or with naproxen. Subjects remained at the s...

journal_title：Current medical research and opinion

authors： Leese P

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Thiazide diuretics such as hydrochlorothiazide (HCT) are a widely used first-line treatment for hypertension, but most patients will not achieve blood pressure (BP) control with HCT alone and so will require combination therapy. In this study the efficacy, safety and tolerability of a single-pill combination ...

journal_title：Current medical research and opinion

authors： Blumenstein M,Romaszko J,Calderón A,Andersen K,Ibram G,Liu Z,Zhang J

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVES:The primary objective of this study was to quantify how many publications retracted because of misconduct involved declared medical writers (i.e., not ghostwriters) or declared pharmaceutical industry support. The secondary objective was to investigate factors associated with misconduct retractions. DESIGN:...

journal_title：Current medical research and opinion

authors： Woolley KL,Lew RA,Stretton S,Ely JA,Bramich NJ,Keys JR,Monk JA,Woolley MJ

更新日期：2011-06-01 00:00:00

abstract：:Recombinant human erythropoietin (epoetin) is a highly active molecule and as such is used at very low therapeutic concentrations that require stabilisation. Commercially available epoetins differ in the stabilisers used in their formulations, which result in variations between epoetin preparations in storage and hand...

journal_title：Current medical research and opinion

authors： Haselbeck A

更新日期：2003-01-01 00:00:00

abstract：:Abstract A growing body of evidence suggests that targeting low-density lipoprotein cholesterol is not enough and that a substantial residual risk remains despite aggressive statin treatment, particularly in patients with mixed dyslipidemia. Statin plus fibrate combination results in a more effective control of severa...

journal_title：Current medical research and opinion

authors： Athyros VG,Tziomalos K,Karagiannis A,Mikhailidis DP

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy of fenofibrate and statin dual therapy versus a double or equivalent dose of statin monotherapy. METHODS:A systematic literature search and meta-analysis was performed for publications before 1 January 2014 in MEDLINE, Embase, and BIOSIS Previews, among others. RESULTS:The difference ...

journal_title：Current medical research and opinion

authors： Ouwens MJ,Nauta J,Ansquer JC,Driessen S

更新日期：2015-12-01 00:00:00

abstract：:A double-blind crossover trial was undertaken to compare the efficacy of sustained-release clonidine and long-acting propranolol in the treatment of 20 patients (8 males and 12 females) with sustained hypertension. Each patient was stabilized with metoprolol with or without diuretic therapy prior to admission to the t...

journal_title：Current medical research and opinion

authors： Rodrigues E,Lawson AA

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:The pattern of renal transplantation has never been described since the introduction of the technique. The purpose of this study was therefore to characterise the pattern of renal transplantation from 1967 to 2000, focusing on renal graft function as a predictor of survival. METHODS:This study was a retrosp...

journal_title：Current medical research and opinion

authors： McEwan P,Baboolal K,Dixon S,Conway P,Currie CJ

更新日期：2005-11-01 00:00:00

abstract：:An open multicentre trial was carried out in 13 hypertensive patients, who had responded satisfactorily to and been stabilized on treatment with 400 mg acebutolol daily in divided doses, to assess the effectiveness and tolerance of the same daily dosage given as a single morning dose. On admission, patients were chang...

journal_title：Current medical research and opinion

authors： Ashton WL

更新日期：1977-01-01 00:00:00

abstract：:Comparison of the methods of determination of conjugated catecholamines shows that, despite their variable absolute values, the relative proportions of the free and conjugated dopamine, norepinephrine and epinephrine are close (mean of 97.3% of dopamine, 73% of norepinephrine and 84% of epinephrine being conjugated) a...

journal_title：Current medical research and opinion

authors： Kuchel O,Buu NT

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:As an ever widening array of anti-hyperglycemic agents are now available, the effect of these drugs on lipids is increasingly complex and controversial. The present meta-analysis was designed to clarify the effect of a dual combination of noninsulin anti-hyperglycemic agents on lipids in type 2 diabetes. MET...

journal_title：Current medical research and opinion

authors： Dai X,Wang H,Jing Z,Fu P

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The fentanyl HCl iontophoretic transdermal system (ITS) is a patient-controlled analgesic delivery system that actively administers bolus doses of fentanyl transdermally upon patient activation. OBJECTIVE:To determine the amount of fentanyl absorbed from fentanyl ITS via passive absorption over a 24.5-h per...

journal_title：Current medical research and opinion

authors： Sathyan G,Phipps B,Gupta SK

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:In controlled clinical trials, rabeprazole effectively improves symptoms and heals oesophageal erosions in patients with gastro-oesophageal reflux disease (GORD). AIM:To examine symptom relief during week 1 of rabeprazole therapy, in addition to GORD healing, in a clinical practice setting. METHODS:In this...

journal_title：Current medical research and opinion

authors： Archimandritis AJ,Nikolopoulou V,Kouklakis G,Paraskevas E,Avgerinos A,Tsianos E,Triantafillidis JK,Hellenic Rabeprazole Study Group.

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether healthy men would prefer either luteinizing hormone releasing hormone analogues (LHRHa) or non-steroidal anti-androgen therapy (NSAA) should they hypothetically develop locally advanced prostate cancer. PARTICIPANTS AND METHODS:A representative sample of 180 men...

journal_title：Current medical research and opinion

authors： Jenkins V,Fallowfield L,Edginton T,Payne H,Hamilton E

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To determine the characteristics of asthma (A) and allergic rhinitis (AR) among asthma patients in primary care practice. RESEARCH DESIGN AND METHODS:Primary care physicians, pulmonologists, and allergologists were asked to recruit consecutive asthma patients with or without allergic rhinitis from their dail...

journal_title：Current medical research and opinion

authors： Taegtmeyer AB,Steurer-Stey C,Spertini F,Bircher A,Helbling A,Miedinger D,Schafroth S,Scherer K,Leuppi JD

更新日期：2009-05-01 00:00:00

abstract：:A double-blind crossover study was carried out in 24 patients with rheumatoid arthritis to investigate the relative efficacy of tolmetin (1600 mg/day) and phenylbutazone (400 mg/day). Each drug was given for 4 weeks, preceded by a 2-week wash-out period during which patients received paracetamol alone for pain relief....

journal_title：Current medical research and opinion

authors： Cardoe N,Steele CE

更新日期：1976-01-01 00:00:00

abstract：:The glomerular and tubular function of 7 patients with a spectrum of renal impairment was measured before, during and after 4-days' treatment with cefuroxime and gentamicin. Neither the mean plasma urea nor creatinine concentrations of the group increased after combined treatment, nor was the excretion of cefuroxime s...

journal_title：Current medical research and opinion

authors： Cockram CS,Richards P,Bax RP

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:Non-adherence to pain medication is common in chronic pain patients and may result in unfavorable treatment outcomes. Interventions to improve adherence behavior often fail to significantly change medication use. In this report, we describe the application of a theoretical psychological model of behavior chan...

journal_title：Current medical research and opinion

authors： Timmerman L,Stronks DL,Huygen FJPM

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The presence of midline shift on neuroradiologic studies in brain tumor patients represents mass effect from the tumor and surrounding edema. We hypothesized that baseline cerebral edema as measured by midline shift would increase postoperative nausea (PON). We studied the incidence of PON in brain tumor pat...

journal_title：Current medical research and opinion

authors： Ouyang MW,McDonagh DL,Phillips-Bute B,James ML,Friedman AH,Gan TJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) are the most commonly used pharmacological treatment for gastroesophageal reflux disease (GERD). OBJECTIVE:To examine the utilization patterns of PPIs and other GERD-related medications, satisfaction with PPI treatment and presence of GERD symptoms. PATIENTS AND METHODS:GERD p...

journal_title：Current medical research and opinion

authors： Chey WD,Mody RR,Wu EQ,Chen L,Kothari S,Persson B,Beaulieu N,Lu M

更新日期：2009-08-01 00:00:00

abstract：:Compatibility of two types of needles with a variety of durable and prefilled injection pens for diabetes medication was tested by attaching the needles according to ISO 11608-2 and verifying penetration into the cartridge using air shots and two-dimensional X-rays. NovoFine* and NovoFine Autocover† attached correctly...

journal_title：Current medical research and opinion

authors： Buus P,Lilleøre SK,Larsen K

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Neurosurgery often requires skull immobilization with a Mayfield clamp, which often causes brief intense nociceptive stimulation, hypertension and tachycardia. Blunting this response may help prevent increased intracranial pressure, cerebral aneurysm or vascular malformation rupture, and/or myocardial stress....

journal_title：Current medical research and opinion

authors： Berger M,Philips-Bute B,Guercio J,Hopkins TJ,James ML,Borel CO,Warner DS,McDonagh DL

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:In contrast to the trial design of acute mania studies, there is no standard design for bipolar maintenance studies. Over the past 15 years, the design of monotherapy maintenance studies in bipolar disorder has evolved significantly, but recent study designs continue to differ in important ways. SCOPE:We re...

journal_title：Current medical research and opinion

authors： Gitlin MJ,Abulseoud O,Frye MA

更新日期：2010-08-01 00:00:00