Abstract：
BACKGROUND:Proton pump inhibitors (PPIs) are the most commonly used pharmacological treatment for gastroesophageal reflux disease (GERD). OBJECTIVE:To examine the utilization patterns of PPIs and other GERD-related medications, satisfaction with PPI treatment and presence of GERD symptoms. PATIENTS AND METHODS:GERD patients using prescription PPIs were identified from a mixed-model HMO health plan. Utilization patterns of PPIs and other GERD medications, satisfaction with PPI treatment and presence of GERD symptoms were assessed using questionnaires. RESULTS:Among the 617 patients who completed the survey, 71.0% used PPIs once a day (QD), 22.2% used twice a day (BID) and 6.8% more than twice a day or on an as-needed basis. Approximately 42.1% of all patients supplemented their prescription PPIs with other GERD medications, including over-the-counter medications and H(2)-receptor antagonists. Over 85% of the patients still experienced GERD symptoms and 82.7% nighttime symptoms. Overall, 72.8% of all patients were satisfied or very satisfied with their PPI treatment. LIMITATIONS:The study used self-reported data which may have been subject to recall bias. As the study was conducted in a specific region of the US, the results may have limited generalizability to other US regions or countries. CONCLUSIONS:Patients on PPI treatment often experience GERD symptoms and supplement their prescription PPIs with other GERD medications. A substantial proportion of GERD patients receiving PPI treatment are on a BID regimen. Furthermore, more than a quarter of the patients are not completely satisfied with their PPI treatment.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Chey WD,Mody RR,Wu EQ,Chen L,Kothari S,Persson B,Beaulieu N,Lu Mdoi
10.1185/03007990903035745subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1869-78issue
8eissn
0300-7995issn
1473-4877journal_volume
25pub_type
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journal_title：Current medical research and opinion
pub_type： 评论,社论
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journal_title：Current medical research and opinion
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journal_title：Current medical research and opinion
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journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
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journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title：Current medical research and opinion
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journal_title：Current medical research and opinion
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journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Current medical research and opinion
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journal_title：Current medical research and opinion
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journal_title：Current medical research and opinion
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journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Current medical research and opinion
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