Rapid onset of action of oral labetalol in severe hypertension.

abstract：BACKGROUND:Physicians and other health care personnel rely on the peer-reviewed biomedical literature as a key source for making clinical decisions. Thus, ensuring that the nonclinical and clinical findings published in biomedical journals are reported accurately and clearly, without undue influence from commercial int...

journal_title：Current medical research and opinion

authors： Bareket-Samish A,Denny M,Ruzicka B,Bogush M,Flynn K,Glinka K,McMahon-Wise B,Schiller S,Sjostedt P,Matheson N

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of fenofibrate on sleep apnoea indices. METHODS:Proof-of-concept study comprising a placebo run-in period (1 week, 5 weeks if fibrate washout was required) and a 4-week randomized, double-blind treatment period. Thirty-four subjects (mean age 55 years, body mass index 34 kg/m 2 , fa...

journal_title：Current medical research and opinion

authors： Bruckert E,Duchêne E,Bonnefont-Rousselot D,Hansel B,Ansquer JC,Dubois A,Gaymard B

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Statins are hypothesized to have beneficial effects in asthma management through their pleiotropic anti-inflammatory effects. Several studies have examined this relationship, but have yielded conflicting results. This study investigates the effect of statin use on asthma-related hospitalizations and/or emerge...

journal_title：Current medical research and opinion

authors： Tse SM,Charland SL,Stanek E,Herrera V,Goldfarb S,Litonjua AA,Weiss ST,Wu AC

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism (PE), is a major cause of morbidity and mortality. VTE is a common disorder, with an estimated annual incidence of approximately 5-12 persons per 10,000. The prognosis for patients who develop VTE is exacerbated by the r...

journal_title：Current medical research and opinion

authors： Ruppert A,Lees M,Steinle T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The glutathione S-transferases (GST) can metabolise endogenous and exogenous toxins and carcinogens by catalysing the conjugation of diverse electrophiles with reduced glutathione (GSH). Variations of GST enzyme activity could influence the susceptibility of developing cancers in certain areas of the gastroi...

journal_title：Current medical research and opinion

authors： Hoensch H,Peters WH,Roelofs HM,Kirch W

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:Pharmaceutical preparations of human menopausal gonadotrophin (hMG), urine-derived follicle-stimulating hormone (u-FSH) and highly purified u-FSH (u-FSH-HP) have been available since the early 1960s and the mid 1980s and 1990s, respectively. Another commercial preparation of u-FSH-HP, Folyrmon P, was launched...

journal_title：Current medical research and opinion

authors： Bassett R,Ceccarelli D,Crisci C,di Tria AM,Mancinelli M,Martelli F,Mendola D,Pezzotti A

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Inadequate removal of extracellular volume markedly increases blood pressure and contributes to high morbidity and mortality in hemodialysis patients. Advances in fluid management are needed to improve clinical outcomes. The aim of this quality improvement project was to examine the advantages of using a hem...

journal_title：Current medical research and opinion

authors： Balter P,Ficociello LH,Taylor PB,Usvyat L,Sawin DA,Mullon C,Diaz-Buxo J,Zabetakis P

更新日期：2015-01-01 00:00:00

abstract：:Diabetes mellitus ia very common disease with a high cardiovascular morbidity and mortality. This articles reviews the types of lipid disorders that can accompany diabetes mellitus and the evidence that treatment of dyslipidaemia improves primary and secondary endpoints, i.e. lipid levels, cardiovascular events, and m...

journal_title：Current medical research and opinion

authors： Goguen JM,Leiter LA

更新日期：2002-01-01 00:00:00

abstract：:The effect of spironolactone in the alleviation of the symptoms of the premenstrual syndrome was compared with placebo in a double-blind, parallel group controlled study. One tablet daily of 100 mg spironolactone or placebo was given to 63 women from Day 12 of the menstrual cycle until the first day of the next menstr...

journal_title：Current medical research and opinion

authors： Vellacott ID,Shroff NE,Pearce MY,Stratford ME,Akbar FA

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:In clinical practice, persistence with statin therapy is poor. While little is known about relative persistence to specific statins, previous studies have observed greater persistence in patients who achieve greater degrees of lipid lowering. Identification of statin therapies which improve patient persisten...

journal_title：Current medical research and opinion

authors： Foody JM,Joyce AT,Rudolph AE,Liu LZ,Benner JS

更新日期：2008-07-01 00:00:00

abstract：:Stress urinary incontinence (SUI) is the involuntary loss of urine associated with physical activities such as running, jumping, or lifting, or with sneezing and coughing. For many patients it can be a very bothersome symptom, causing social isolation, loss of self-esteem, and increased expenses. Although there is cur...

journal_title：Current medical research and opinion

authors： Viktrup L,Bump RC

更新日期：2003-01-01 00:00:00

abstract：:Cholinesterase inhibitors, which act by inhibiting the degradation of acetylcholine in the brain, form the mainstay of therapy for AD. Predominant adverse events are cholinergic in nature, the most frequent being gastrointestinal side effects. Here we present a case series of patients with dementia who were treated wi...

journal_title：Current medical research and opinion

authors： Venkatesh K,Bullock R,Akbaş A

更新日期：2007-01-01 00:00:00

abstract：:Atypical antipsychotics are commonly used off-label to treat behavioural and psychiatric symptoms in dementia (BPSD), particularly in elderly care homes. Much of this use is inappropriate, and trials have shown an increased likelihood of serious cerebrovascular adverse events (CVAEs) such as stroke and transient ische...

journal_title：Current medical research and opinion

authors： Bullock R

更新日期：2005-01-01 00:00:00

abstract：:Objective: To evaluate the risk of chronic kidney disease (CKD), cardiovascular disease (CVD), and osteoporotic fractures in human immunodeficiency virus (HIV) patients utilizing data within the Veteran's Affairs (VA) Administration system.Methods: A retrospective cohort study utilizing VA system claims (January 2000-...

journal_title：Current medical research and opinion

authors： Sutton SS,Magagnoli J,Cummings TH,Hardin JW,Edun B,Beaubrun A

更新日期：2019-01-01 00:00:00

abstract：:A randomized double-blind antacid-controlled study was carried out to investigate the speed of onset of relief from dyspeptic pain with a novel, chewable formulation of cimetidine in 80 patients with persistent dyspepsia. Inclusion and exclusion criteria were chosen to identify patients with an acid-related dyspeptic ...

journal_title：Current medical research and opinion

authors： Parr SN

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:We evaluated the clinical efficacy of sacubitril/valsartan in a group of ambulatory patients with heart failure (HF) with reduced ejection fraction (HFrEF) referred to our HF clinic. METHODS:Patients (n = 29; 72% males; mean age 76 years) with HFrEF in New York Heart Association (NYHA) classes II-III were in...

journal_title：Current medical research and opinion

authors： Cosentino ER,Degli Esposti D,Miceli R,Bentivenga C,Landolfo M,Fg Cicero A,Berardi E,Spinardi L,Magri G,Dugato V,Borghi C

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:As results from an increasing number of clinical trials with disease-modifying drugs (DMDs) in multiple sclerosis (MS) become available, the challenge for the treating neurologist is how to decide on the appropriate therapy for an individual patient. OBJECTIVE:An International Working Group for Treatment Op...

journal_title：Current medical research and opinion

authors： Goodin DS,Biermann LD,Bohlega S,Boiko A,Chofflon M,Gebeily S,Gouider R,Havrdova E,Jakab G,Karabudak R,Karussis D,Miller A,Pakdaman H,Selmaj K,Sharief M,International Working Group for Treatment Optimization in MS.

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To determine the extent to which raloxifene can maintain low density lipoprotein cholesterol (LDL-C) levels below 160 mg/dL or reduce elevated LDL-C levels to below lipid-lowering goals in postmenopausal women. PATIENTS AND METHODS:The Multiple Outcomes of Raloxifene Evaluation (MORE) osteoporosis treatment ...

journal_title：Current medical research and opinion

authors： Cox DA,Sarkar S,Harper K,Barrett-Connor E

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:Tamoxifen, used in breast cancer treatment, may induce hepatic steatosis. It has been suggested that leptin, which has a relationship with body fat stores, may be involved in the pathogenesis of hepatic steatosis. In this study, we compared serum leptin levels in tamoxifen-treated patients with and without hepa...

journal_title：Current medical research and opinion

authors： Günel N,Coşkun U,Toruner FB,Sancak B,Yilmaz E,Cengiz O,Elbeg S,Uner A,Ozkan S

更新日期：2003-01-01 00:00:00

abstract：:The bioavailability of ofloxacin after a single dose of one of two tablet formulations (200 or 400 mg) or a liquid formulation (1.67 mg/ml) was investigated in 24 healthy male volunteers in an open randomized, crossover design study with a 5-day wash-out period between doses. Plasma concentrations of ofloxacin were de...

journal_title：Current medical research and opinion

authors： Flor S,Beals B

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Transient ischemic attack (TIA) is a serious condition which should be considered on the same spectrum as other conditions involving brain ischemia. Efficient management of these patients is therefore critical. The aim of this research was to gain insights into 'real-world' global trends of the current manage...

journal_title：Current medical research and opinion

authors： Jäkel A,Plested M,Chapman AM,Jackson D,Purroy F

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:To examine the impact of an electronic data capture system on patient satisfaction and patient-physician interactions in a rheumatology clinical setting. STUDY DESIGN:In this multicenter study, 1079 patients with rheumatoid arthritis completed questionnaires quarterly about their health and satisfaction with...

journal_title：Current medical research and opinion

authors： Huffstutter J,Craig WD,Schimizzi G,Harshbarger J,Lisse J,Kasle S,Hymson L,Yocum D,Castro L,Hegedus R,Callegari P,Yeilding N,Gilmer K

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the effect of gliclazide modified release (MR) treatment on adiponectin, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) plasma concentrations in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:24 randomly selected type 2 diabetic patients, aged 61...

journal_title：Current medical research and opinion

authors： Drzewoski J,Zurawska-Klis M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of antiresorptive agents in reducing the risk of vertebral and non-vertebral fractures using data from published meta-analyses and the technique of adjusted indirect comparisons. RESEARCH DESIGN AND METHODS:Pairs of agents were compared by adjusted indirect comparison of 0.56 [0....

journal_title：Current medical research and opinion

authors： Wehren LE,Hosking D,Hochberg MC

更新日期：2004-04-01 00:00:00

abstract：:Objective: The aim of this study was to investigate the impact of methodological choices in a meta-analysis of real-world evidence (RWE) comparing three non-vitamin-K antagonist oral anticoagulants with vitamin K antagonists (VKAs) for the treatment of patients with non-valvular atrial fibrillation (NVAF). Methods: Th...

journal_title：Current medical research and opinion

authors： Briere JB,Wu O,Bowrin K,Millier A,Toumi M,Taieb V,Levy P,Coleman CI

更新日期：2019-11-01 00:00:00

abstract：:An open, multi-centre trial was carried out to assess the efficacy and tolerance of acemetacin in the treatment of patients suffering from various rheumatic diseases. The patients were treated by general practitioners for a maximum period of 6 weeks with a daily dose of 60 mg acemetacin 3-times daily. Assessments were...

journal_title：Current medical research and opinion

authors： Rechziegler H,Zündorf P

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the positive predictive value of claims-based V85 codes for identifying individuals with varying degrees of BMI relative to their measured BMI obtained from medical record abstraction. METHODS:This was a retrospective validation study utilizing administrative claims and medical chart data from 1 ...

journal_title：Current medical research and opinion

authors： Caplan EO,Kamble PS,Harvey RA,Smolarz BG,Renda A,Bouchard JR,Huang JC

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:A proactive, multifactorial intervention strategy incorporating single-pill amlodipine/atorvastatin (SPAA) (5-10/10 mg up-titrated to 5-10/20 mg, where approved) is more effective than physician's usual care (UC) for reducing calculated 10 year coronary heart disease (CHD) risk, in patients with hypertension ...

journal_title：Current medical research and opinion

authors： Hradec J,Zamorano J,Sutradhar S

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy and safety of ciprofloxacin 0.3%/dexamethasone 0.1% (CIP/DEX) otic suspension with that of neomycin 0.35%/polymyxin B 10,000 IU/mL/hydrocortisone 1.0% (N/P/H) otic suspension in patients with acute otitis externa (AOE). STUDY DESIGN:Randomized, observer-masked, parallel-group, multic...

journal_title：Current medical research and opinion

authors： Roland PS,Pien FD,Schultz CC,Henry DC,Conroy PJ,Wall GM,Garadi R,Dupre SJ,Potts SL,Hogg LG,Stroman DW,Ciprodex Otic AOE Study Group.

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:The clinical relevance of pro- and hyperalgesic effects of opioids is still a matter of debate. Particularly for remifentanil, an increased postoperative need for analgesics has been demonstrated suggesting opioid-induced hyperalgesia as a possible cause. The aim of the study was therefore to investigate the ...

journal_title：Current medical research and opinion

authors： Ohnesorge H,Alpes A,Baron R,Gierthmühlen J

更新日期：2016-11-01 00:00:00