Lipids and diabetes mellitus: a review of therapeutic options.

abstract：:Fifty-two patients suffering from presumed viral pharyngeal infection or tonsillitis were treated with either benzydamine or placebo oral rinse as a gargle at 3-hourly intervals in a randomized double-blind study. Patients on the active preparation experienced faster resolution of pain and dysphagia and at 7 days 88% ...

journal_title：Current medical research and opinion

authors： Whiteside MW

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:As results from an increasing number of clinical trials with disease-modifying drugs (DMDs) in multiple sclerosis (MS) become available, the challenge for the treating neurologist is how to decide on the appropriate therapy for an individual patient. OBJECTIVE:An International Working Group for Treatment Op...

journal_title：Current medical research and opinion

authors： Goodin DS,Biermann LD,Bohlega S,Boiko A,Chofflon M,Gebeily S,Gouider R,Havrdova E,Jakab G,Karabudak R,Karussis D,Miller A,Pakdaman H,Selmaj K,Sharief M,International Working Group for Treatment Optimization in MS.

更新日期：2007-11-01 00:00:00

abstract：:Angiotensin converting enzyme (ACE) inhibitors have been avoided as an initial therapeutic option in the treatment of hypertension in African-Americans. A major reason for this has been the widespread perception of clinicians that these agents have poor blood pressure (BP) lowering efficacy in this population. Remarka...

journal_title：Current medical research and opinion

authors： Flack JM,Mensah GA,Ferrario CM

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:Compare costs and healthcare resource utilization (HCRU) among newly-diagnosed non-valvular atrial fibrillation (NVAF) patients newly treated with dabigatran vs apixaban, rivaroxaban, or warfarin. METHODS:Newly-diagnosed adult NVAF patients initiating dabigatran, apixaban, rivaroxaban, or warfarin (index ev...

journal_title：Current medical research and opinion

authors： Gilligan AM,Franchino-Elder J,Song X,Wang C,Henriques C,Sainski-Nguyen A,Wilson K,Smith DM,Sander S

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Report efficacy findings from three clinical trials (one phase 2 and two phase 3 [OPUS-1, OPUS-2]) of lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease (DED). RESEARCH DESIGN AND METHODS:Three 84-day, randomized, double-masked, placebo-controlled trials. Adults (≥18 years) with DED were r...

journal_title：Current medical research and opinion

authors： Holland EJ,Whitley WO,Sall K,Lane SS,Raychaudhuri A,Zhang SY,Shojaei A

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to estimate utility values for hypothetical health states that describe differences in weight and quality of life associated with type 2 diabetes mellitus (DM) from Canadians with type 2 DM. The impact on utility values was examined separately for participants with a body mass ...

journal_title：Current medical research and opinion

authors： Lane S,Levy AR,Mukherjee J,Sambrook J,Tildesley H

更新日期：2014-07-01 00:00:00

abstract：:Objective: Type 2 diabetes (T2D) is a prevalent health problem. Oral agents, with the exception of metformin, are often discontinued with the initiation of insulin. The objective was to understand the proportion of patients discontinuing dipeptidyl peptidase-4 inhibitors (DPP-4is) and the reasons for the decision to d...

journal_title：Current medical research and opinion

authors： Fernandes G,Matos JE,Jaffe DH,Beyer G,Yang L,Iglay K,Gantz I,Rajpathak S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To investigate the predictive factors associated with physical impairment among older patients with type 2 diabetes mellitus (T2DM) in Japan and to examine the potential impact of physical impairment on patient-reported health outcomes in this population. METHODS:A cross-sectional analysis was conducted usin...

journal_title：Current medical research and opinion

authors： Araki A,Umegaki H,Sakurai T,Mizuno Y,Miyao M,Imori M,Suzuki S,Cambron-Mellott MJ,Yokote K,Onuma T,Yokono K

更新日期：2020-11-23 00:00:00

abstract：INTRODUCTION:The systematic use of 2-octyl cyanoacrylate (2-OCA) became routine in our cardiac unit in 2000. This topical skin adhesive has been used in conjunction with conventional suturing for skin closure and prevention of postoperative wound infections by means of its performance as a microbial barrier to exogenou...

journal_title：Current medical research and opinion

authors： Souza EC,Fitaroni RB,Januzelli DM,Macruz HM,Camacho JC,Souza MR

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Docetaxel and paclitaxel show significant clinical activity in metastatic breast cancer (MBC) and have been approved for MBC by the U.S. Food and Drug Administration, but it is still unclear whether a paclitaxel-based regimen improves outcomes over a docetaxel-based regimen in patients with MBC. We therefore...

journal_title：Current medical research and opinion

authors： Qi WX,Shen Z,Lin F,Sun YJ,Min DL,Tang LN,He AN,Yao Y

更新日期：2013-02-01 00:00:00

abstract：:Seventy frail elderly patients attending a day hospital were studied to investigate the incidence of postural hypotension in control patients on no diuretic treatment (n = 30), patients on loop diuretics (frusemide) for mild cardiac failure (n = 20) and patients on thiazide diuretics for mild cardiac failure (n = 20)....

journal_title：Current medical research and opinion

authors： Heseltine D,Bramble MG

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Although beta-blocker therapy has been shown to improve survival in patients with chronic heart failure, this class of drugs tends to be underutilized in diabetic patients due to concerns about adverse metabolic effects, especially on glycemic control. No randomized clinical trial has specifically evaluated ...

journal_title：Current medical research and opinion

authors： Bell DS,Lukas MA,Holdbrook FK,Fowler MB

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To review clinical trial evidence supporting treatment of patients to a near-normal HbA(1c) target level and outline therapeutic strategies that optimize glycemic control. RESEARCH DESIGN AND METHODS:The current MEDLINE database and bibliographies were searched for literature relevant to diabetic complicatio...

journal_title：Current medical research and opinion

authors： Davidson JA

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:Health economic analysis from a healthcare and societal point of view was conducted to assess the cost-effectiveness of insulin degludec (IDeg) after switching from other basal insulins in people with type 1 diabetes. MATERIAL AND METHODS:This was a prospective, open-label, single arm, observational follow-...

journal_title：Current medical research and opinion

authors： Landstedt-Hallin L,Gundgaard J,Ericsson Å,Ellfors-Zetterlund S

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Obesity is one of the major problems of health policy in different countries. Pharmacological attempts have been made to help affected people without a definitive solution. Some agents--either with peripheral or central effect--are available in the market. On July 2012, the FDA approved two novel preparation...

journal_title：Current medical research and opinion

authors： Catoira NP,Viale L,Di Girolamo G,Gonzalez C

更新日期：2014-06-01 00:00:00

abstract：:In a double-blind, partial cross-over study of 141 patients with mild to moderate hypertension, chlorthalidone 50 mg was compared with chlorthalidone 50 mg/triamterene 50 mg combination treatment. The study assessed clinical efficacy in the reduction of blood pressure, and safety with regard to serum potassium concent...

journal_title：Current medical research and opinion

authors： Spiers DR,Wade RC

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:In addition to direct weight reduction, there may be other benefits of obesity treatment including improved insulin sensitivity. The purpose of this study was to characterise concomitant diabetes drug use and the related costs in patients with diabetes treated with orlistat (Xenical) in the first 6 months of ...

journal_title：Current medical research and opinion

authors： Rowe R,Cowx M,Poole C,McEwan P,Morgan C,Walker M

更新日期：2005-11-01 00:00:00

abstract：:One hundred adult male volunteers were randomized to receive either Merieux or Wellcome RA27/3 rubella vaccine. Prior to vaccination, 10% of the subjects were seronegative and all of these seroconverted. No significant boosting effect was found in those with a high pre-vaccine titre but some boost was shown in those w...

journal_title：Current medical research and opinion

authors： Harcus AW,Ward AE,Bryett KA

更新日期：1986-01-01 00:00:00

abstract：:The efficacy of trimetazidine, an anti-ischaemic agent, has been largely assessed and presented in the international literature through its metabolic effects, selective and specific fatty acid oxidation inhibition and lack of haemodynamic effects in stable angina pectoris. As such, trimetazidine has opened up a new cl...

journal_title：Current medical research and opinion

authors： Marzilli M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To evaluate knowledge about risks, prevention and consequences of infection with hepatitis B virus (HBV) among travellers from four low HBV risk, European countries. METHODS:Individuals from an internet panel and based in the Czech Republic, the Netherlands, Spain and Sweden were invited to take part in an o...

journal_title：Current medical research and opinion

authors： Herbinger KH,Nothdurft HD,Prymula R

更新日期：2011-03-01 00:00:00

abstract：:Zolmitriptan has been developed in an orally disintegrating tablet (ODT) formulation that rapidly dissolves on the tongue and can be taken quickly, conveniently and discreetly without fluid intake. In this 3-month, non-comparative, observational, post-marketing surveillance (PMS) study, 5,570 physicians prescribed the...

journal_title：Current medical research and opinion

authors： Diener HC,Gendolla A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Implantation of bone marrow mononuclear cells (BM-MNCs), including endothelial progenitor cells, into ischemic lower limbs has been shown to improve symptoms in patients with peripheral arterial diseases (PAD). This study investigated whether BM-MNC implantation (BMI) is also effective for the ischemic hands ...

journal_title：Current medical research and opinion

authors： Koshikawa M,Shimodaira S,Yoshioka T,Kasai H,Watanabe N,Wada Y,Seto T,Fukui D,Amano J,Ikeda U

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:The use of embolic protection devices to decrease major adverse cardiac events (MACEs) in patients with saphenous vein graft lesions is considered class I therapy by the recent practice guidelines. However, the benefits of adjunctive protection devices to prevent distal embolization in patients with native co...

journal_title：Current medical research and opinion

authors： Jin B,Dong XH,Zhang C,Li Y,Shi HM

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:As an ever widening array of anti-hyperglycemic agents are now available, the effect of these drugs on lipids is increasingly complex and controversial. The present meta-analysis was designed to clarify the effect of a dual combination of noninsulin anti-hyperglycemic agents on lipids in type 2 diabetes. MET...

journal_title：Current medical research and opinion

authors： Dai X,Wang H,Jing Z,Fu P

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism (PE), is a major cause of morbidity and mortality. VTE is a common disorder, with an estimated annual incidence of approximately 5-12 persons per 10,000. The prognosis for patients who develop VTE is exacerbated by the r...

journal_title：Current medical research and opinion

authors： Ruppert A,Lees M,Steinle T

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:In a 4-week, double-blind, placebo-controlled study, the attention-promoting agent modafinil improved symptoms of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents and was well tolerated. To assess the continued efficacy of modafinil and obtain additional safety data, an 8-week, open...

journal_title：Current medical research and opinion

authors： Boellner SW,Earl CQ,Arora S

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:In the four SMILE (Survival of Myocardial Infarction Long-Term Evaluation) studies, early administration of zofenopril in acute myocardial infarction (AMI) showed beneficial effects as compared to placebo and other angiotensin converting enzyme inhibitors (ACEIs). This study investigated whether the concomita...

journal_title：Current medical research and opinion

authors： Borghi C,Omboni S,Reggiardo G,Bacchelli S,Degli Esposti D,Ambrosioni E,SMILE (Survival of Myocardial Infarction Long-Term Evaluation) Working Project.

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF)-based regimens have been associated with impaired kidney function and loss of bone mineral density among patients living with HIV (PLWH). We assess the association between TDF exposure and the odds of chronic kidney disease (CKD) and osteoporotic fracture in HIV patients. ...

journal_title：Current medical research and opinion

authors： Sutton SS,Magagnoli J,Hardin JW,Hsu LI,Beaubrun A,Majethia S,Cummings TH

更新日期：2020-10-01 00:00:00

abstract：:A study was carried out to compare attitudes, perceptions and experiences of general practitioners and patients who had treated/suffered from herpes zoster, or shingles, in the recent past. Randomized samples of 224 general practitioners and 236 patients were drawn from different locations in Italy, Germany and the Un...

journal_title：Current medical research and opinion

authors： Henry T

更新日期：1994-01-01 00:00:00

abstract：:In gouty patients, urate lowering therapies (ULTs) are recommended to bring serum uric acid (SUA) levels below 6.0 mg/dL, with the aim of dissolving urate depositions, thereby reducing disease impact. However, patients with hyperuricemia often present with other conditions associated with cardiovascular (CV) risk, suc...

journal_title：Current medical research and opinion

authors： Johnson RJ

更新日期：2015-01-01 00:00:00