Putting evidence-based medicine into clinical practice: comparing anti-resorptive agents for the treatment of osteoporosis.

abstract：OBJECTIVE:To compare the effectiveness of 20:1 cafedrine/theodrenaline approved for use in Germany to ephedrine in the restoration of arterial blood pressure and on post-operative outcomes in patients with intra-operative arterial hypotension of any origin under standard clinical practice conditions. METHODS AND RESUL...

journal_title：Current medical research and opinion

authors： Eberhart L,Geldner G,Huljic S,Marggraf K,Keller T,Koch T,Kranke P

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To assess the burden of treatment-resistant depression (TRD) among privately insured patients with anxiety disorder and/or substance use disorders (SUD). METHODS:Adults <65 years old were identified in the Optum Health Care Solutions Inc. database (July 2009-March 2017). Among those with major depressive dis...

journal_title：Current medical research and opinion

authors： Zhdanava M,Kuvadia H,Joshi K,Daly E,Pilon D,Rossi C,Morrison L,Lefebvre P,Nelson C

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the positive predictive value of claims-based V85 codes for identifying individuals with varying degrees of BMI relative to their measured BMI obtained from medical record abstraction. METHODS:This was a retrospective validation study utilizing administrative claims and medical chart data from 1 ...

journal_title：Current medical research and opinion

authors： Caplan EO,Kamble PS,Harvey RA,Smolarz BG,Renda A,Bouchard JR,Huang JC

更新日期：2018-01-01 00:00:00

abstract：:An open, multi-centre trial was carried out to assess the efficacy and tolerance of acemetacin in the treatment of patients suffering from various rheumatic diseases. The patients were treated by general practitioners for a maximum period of 6 weeks with a daily dose of 60 mg acemetacin 3-times daily. Assessments were...

journal_title：Current medical research and opinion

authors： Rechziegler H,Zündorf P

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Physicians and other health care personnel rely on the peer-reviewed biomedical literature as a key source for making clinical decisions. Thus, ensuring that the nonclinical and clinical findings published in biomedical journals are reported accurately and clearly, without undue influence from commercial int...

journal_title：Current medical research and opinion

authors： Bareket-Samish A,Denny M,Ruzicka B,Bogush M,Flynn K,Glinka K,McMahon-Wise B,Schiller S,Sjostedt P,Matheson N

更新日期：2009-02-01 00:00:00

abstract：:Hypertension is another predictor of erectile dysfunction (ED). This is further evidence supporting a link between the pathogenesis of atherosclerotic disease and ED. In one study (TOMHS) involving hypertensive patients, the incidence of ED was 14.4%. The drugs used to treat hypertension may cause ED. However, there i...

journal_title：Current medical research and opinion

authors： Mikhailidis DP,Khan MA,Milionis HJ,Morgan RJ

更新日期：2000-01-01 00:00:00

abstract：:The influence of buflomedil on brain circulation was investigated in an open, preliminary trial in 12 patients with dementia caused by multi-cerebral infarcts. Patients were given 150 mg buflomedil 3-times daily for a period of 6 months. Assessments carried out before treatment included regional cerebral blood flow me...

journal_title：Current medical research and opinion

authors： Karoutas G,Milonas I,Artemis N,Karacostas D,Pitas J,Logothetis J

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy of fenofibrate and statin dual therapy versus a double or equivalent dose of statin monotherapy. METHODS:A systematic literature search and meta-analysis was performed for publications before 1 January 2014 in MEDLINE, Embase, and BIOSIS Previews, among others. RESULTS:The difference ...

journal_title：Current medical research and opinion

authors： Ouwens MJ,Nauta J,Ansquer JC,Driessen S

更新日期：2015-12-01 00:00:00

abstract：:Using an equilibrium dialysis method, the competition was investigated between tritated-progesterone and a range of synthetic steroids for binding to 20,000 g. supernatants of human uterine endometrium and myometrium. Both types of uterine tissue showed similar patterns of progestogen binding and probably contain sim...

journal_title：Current medical research and opinion

authors： Briggs MH

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:Ocular surface disease (OSD) is a common side effect of ophthalmic medications containing the preservative benzalkonium chloride (BAK). Little is known whether and how glaucoma treatment patterns and annual costs vary based on the presence of BAK. The objective of this analysis was to estimate first-year trea...

journal_title：Current medical research and opinion

authors： Schmier JK,Covert DW,Robin AL

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:The prevalence of non-steroidal anti-inflammatory drug (NSAID) and concurrent gastroprotective agent (GPA) use in the US is not known. As such, the prevalence of GPA use among arthritis patients taking NSAIDs was examined. METHODS:Men and women aged ≥ 40 with self-reported arthritis and members of a web-base...

journal_title：Current medical research and opinion

authors： Coyne KS,Margolis MK,Cappelleri JC,Hsieh R,Essex MN,Park PW,Joshi AV

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the efficacy and safety of doses of fentanyl buccal tablet (FBT) proportional to doses of opioids used for background analgesia versus dose titration starting with the minimal dose for the management of breakthrough cancer pain (BTcP). METHODS:A total of 82 cancer patien...

journal_title：Current medical research and opinion

authors： Mercadante S,Gatti A,Porzio G,Lo Presti C,Aielli F,Adile C,Casuccio A

更新日期：2012-06-01 00:00:00

abstract：:A multi-centre trial was carried out in 1629 patients with osteoarthrosis in 233 clinical centres to investigate the therapeutic efficacy and tolerability of indoprofen in this clinical condition. The results from assessments of both subjective and objective variables were comparable to those obtained in Phase 3 studi...

journal_title：Current medical research and opinion

authors： Emanueli A,Mandelli V,Mascellani G,Sacchetti G

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:Bariatric surgery is an effective treatment for the reduction of weight in obese patients (BMI ≥ 40 kg/m(2) or 30 kg/m(2) with ≥1 comorbidities), who are refractory to behavioral and medical therapies. This study examined the effect of the adjustable gastric band (AGB) system on changes in gastroesophageal re...

journal_title：Current medical research and opinion

authors： Woodman G,Cywes R,Billy H,Montgomery K,Cornell C,Okerson T,APEX Study Group.

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:We evaluated the clinical efficacy of sacubitril/valsartan in a group of ambulatory patients with heart failure (HF) with reduced ejection fraction (HFrEF) referred to our HF clinic. METHODS:Patients (n = 29; 72% males; mean age 76 years) with HFrEF in New York Heart Association (NYHA) classes II-III were in...

journal_title：Current medical research and opinion

authors： Cosentino ER,Degli Esposti D,Miceli R,Bentivenga C,Landolfo M,Fg Cicero A,Berardi E,Spinardi L,Magri G,Dugato V,Borghi C

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:In May 2018, the US Food and Drug Administration approved pegvaliase-pqpz (Palynziq*), the first enzyme substitution therapy for the treatment of phenylketonuria (PKU). This article provides an overview of the mechanism of action, pharmacokinetic properties, clinical efficacy, and the safety and tolerability ...

journal_title：Current medical research and opinion

authors： Mahan KC,Gandhi MA,Anand S

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD f...

journal_title：Current medical research and opinion

authors： Foley P,Garrett S,Ryttig L

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the relative bioavailability of a new formulation containing 5 mg mosapride and 10 mg rabeprazole (T) and compare it with the branded formulations of both drugs co-administered in separate tablets (R) to meet the regulatory requirements of bioequivalence in Argentina. METHODS:A randomized-sequenc...

journal_title：Current medical research and opinion

authors： Keller GA,Czerniuk P,Bertuola R,de Mena F,Simoni MV,Assefi AR,Di Girolamo G

更新日期：2011-11-01 00:00:00

abstract：:Objective: To review the mechanism of action, pharmacology, dosing, and complications of tranexamic acid (TXA) and consolidate current evidence for TXA in gynecologic surgery.Methods: A literature search of PubMed, Ovid (MEDLINE), Google Scholar, and Elsevier was performed, in addition to a targeted search of cited re...

journal_title：Current medical research and opinion

authors： Zakhari A,Sanders AP,Solnik MJ

更新日期：2020-03-01 00:00:00

abstract：:As the emergence of cardiovascular disease (CVD) is linked to modifiable lifestyle and physiological factors, it is increasingly important to concentrate on preventative strategies. For preventative measures to be beneficial it is necessary to clearly identify patients at risk--given that multiple risk factors often c...

journal_title：Current medical research and opinion

authors： De Backer G

更新日期：2007-11-01 00:00:00

abstract：:During the past decades several epidemiological studies have provided a 'portrait' of the potential candidate for cardiovascular disease, introducing many emerging life-style risk factors such as obesity, unhealthy diet, exposure to passive smoking, lack of exercise, psychosocial stress, and depression, as well as ele...

journal_title：Current medical research and opinion

authors： Pitsavos CE,Toutouzas PK

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Chronic respiratory failure (CRF) is a syndrome defined by certain disturbances in arterial blood gases. Non-invasive mechanical ventilation (NIMV) is an increasingly used treatment modality in respiratory failure. The aim of this study was to investigate the long-term effects of NIMV on pulmonary function an...

journal_title：Current medical research and opinion

authors： Dogan OT,Turkyilmaz S,Berk S,Epozturk K,Akkurt I

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To estimate the proportion of patients with moderate to severe chronic kidney disease (CKD) whose initial dipeptidyl-peptidase-4 inhibitor (DPP4-i) dosage was concordant with prescribing information (label) recommendations in the United States. METHODS:Adult patients with type 2 diabetes mellitus (T2DM) who ...

journal_title：Current medical research and opinion

authors： Huang H,Shetty S,Bauer E,Lang K

更新日期：2018-06-01 00:00:00

abstract：:Acetyl-L-carnitine (ALC) is a compound acting as an intracellular carrier of acetyl groups across inner mitochondrial membranes. It also appears to have neuroprotective properties and it has recently been shown to reduce attention deficits in patients with Alzheimer's disease (AD) after long-term treatment. We perform...

journal_title：Current medical research and opinion

authors： Bianchetti A,Rozzini R,Trabucchi M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To determine the effects of long-term atomoxetine treatment on sexual development in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) as compared with placebo and with a national US survey in non-Hispanic white children and adolescents. METHODS:This double-blind, placebo-controll...

journal_title：Current medical research and opinion

authors： Trzepacz PT,Spencer TJ,Zhang S,Bangs ME,Witte MM,Desaiah D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The epidemiology and outcome of people hospitalised with a primary diagnosis of psoriasis has never been characterised previously in the United Kingdom. The aim of the study was to characterise the epidemiology of people admitted to hospital with a primary diagnosis of psoriasis. METHODS:Routine hospital da...

journal_title：Current medical research and opinion

authors： Conway P,Currie CJ

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The implementation of international pediatric asthma guidelines hinges on the distinction between intermittent and persistent phenotypes and the prescription of recommended phenotype-specific pharmacotherapy. OBJECTIVES:To ascertain key factors associated with specialist-confirmed phenotype and document phy...

journal_title：Current medical research and opinion

authors： Ducharme FM,Morin J,Davis GM,Gingras J,Noya FJ

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score <19 as a threshold for moderate to severe dry eye disease (DED). METHODS:A phase III, randomized, controlled...

journal_title：Current medical research and opinion

authors： Doan S,Bremond-Gignac D,Chiambaretta F

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:GOLD guideline recommendations are currently the "gold standard" for the treatment of COPD patients. OBJECTIVES:The objective of this analysis was to evaluate compliance with GOLD guidelines in managing COPD patients' treatment by general practitioners (GPs) and pulmonologists. Since inhaled corticosteroi...

journal_title：Current medical research and opinion

authors： Visentin E,Nieri D,Vagaggini B,Peruzzi E,Paggiaro P

更新日期：2016-09-01 00:00:00

abstract：:In this narrative review, we will discuss some of the significant risks and dramatic consequences that are associated with epilepsy: depression, suicide, seizure-related injuries, and mortality, both in adults and in children. Considering the high prevalence of depression among people with epilepsy (PWE), routine and ...

journal_title：Current medical research and opinion

authors： Mesraoua B,Deleu D,Hassan AH,Gayane M,Lubna A,Ali MA,Tomson T,Khalil BA,Cross JH,Asadi-Pooya AA

更新日期：2020-09-01 00:00:00