Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors.

abstract：OBJECTIVE:To identify and compare health-economic models that were developed to evaluate the cost-effectiveness of treatments for type 2 diabetes mellitus (T2DM), and their use within Health Technology Assessments (HTAs). METHODS:In total, six commonly used databases were searched for articles published between Octobe...

journal_title：Current medical research and opinion

authors： Charokopou M,Sabater FJ,Townsend R,Roudaut M,McEwan P,Verheggen BG

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the safety and clinical efficacy of alcaftadine 0.25% ophthalmic solution, a new topical anti-allergic agent for the prevention of the signs and symptoms of allergic conjunctivitis induced by conjunctival allergen challenge (CAC). STUDY DESIGN AND METHODS:This two-ar...

journal_title：Current medical research and opinion

authors： Torkildsen G,Shedden A

更新日期：2011-03-01 00:00:00

abstract：:Quetiapine fumarate is a novel dibenzothiazepine antipsychotic developed by Zeneca. It is marketed under the trade name 'Seroquel'. Quetiapine is well tolerated and clinically effective in the treatment of schizophrenia. The initial hope of investigators was that quetiapine would have antipsychotic potential and that ...

journal_title：Current medical research and opinion

authors： Green B

更新日期：1999-01-01 00:00:00

abstract：:A trial was carried out in 30 patients to assess the effectiveness of indanyl carbenicillin in acute or chronic urinary tract infections, many of which were complicated by a pathological urological or medical condition. In all patients, infection was due to a single species of pathogen: E. coli (19), Proteus (6), and ...

journal_title：Current medical research and opinion

authors： Giamarellou E,Papazachos G,Piperakis G,Daikos G

更新日期：1976-01-01 00:00:00

abstract：:Effective management of influenza depends on early recognition of influenza in the community and on rapid diagnosis. Early recognition is achieved by integrated clinical and laboratory based surveillance programmes in representative populations. The recent introduction of 'near patient tests' for influenza provide inc...

journal_title：Current medical research and opinion

authors： Fleming D,Wood M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Adequate bowel preparation prior to colonic diagnostic procedures is essential to ensure adequate visualisation. SCOPE:This consensus aims to provide guidance as to the appropriate use of bowel preparation for a range of defined clinical circumstances. A consensus group from across Europe was convened and m...

journal_title：Current medical research and opinion

authors： Mathus-Vliegen E,Pellisé M,Heresbach D,Fischbach W,Dixon T,Belsey J,Parente F,Rio-Tinto R,Brown A,Toth E,Crosta C,Layer P,Epstein O,Boustiere C

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:Patients that undergo total hip replacement (THA) are at risk of revision surgery. This study evaluated the cumulative incidence of revision following a medial collared, triple tapered (MCTT) primary hip stem versus other implants in real-world settings using electronic medical records. METHODS:This was a re...

journal_title：Current medical research and opinion

authors： Chitnis AS,Mantel J,Ruppenkamp J,Bourcet A,Holy CE

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Stroke is a major cause of disability. Certain experimental studies have suggested that a combination of almitrine + raubasine (Duxil) increases the supply of oxygen to cerebral tissues and may be beneficial in post-stroke rehabilitation. This multicentre clinical study was carried out in orde...

journal_title：Current medical research and opinion

authors： Li S,Long J,Ma Z,Xu Z,Li J,Zhang Z

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the relative bioavailability of a new formulation containing 5 mg mosapride and 10 mg rabeprazole (T) and compare it with the branded formulations of both drugs co-administered in separate tablets (R) to meet the regulatory requirements of bioequivalence in Argentina. METHODS:A randomized-sequenc...

journal_title：Current medical research and opinion

authors： Keller GA,Czerniuk P,Bertuola R,de Mena F,Simoni MV,Assefi AR,Di Girolamo G

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age. METHODS:MEDLINE (1950 to November 2008), EMBASE (1980 to November 2008), The Cochrane Library (2007, Issue 3), ACP Journal...

journal_title：Current medical research and opinion

authors： Southey ER,Soares-Weiser K,Kleijnen J

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Persisting pain is demoralising and debilitating for patients and their carers. Most patients with chronic pain do not need the services of a specialised pain clinic and are appropriately managed by their general practitioner (GP). METHOD:Interviewers approached 569 GPs to assess their satisfaction with the...

journal_title：Current medical research and opinion

authors： Stannard C,Johnson M

更新日期：2003-01-01 00:00:00

abstract：:An acute and chronic dosing pharmacokinetic study of the calcium antagonist nitrendipine was carried out in 8 normotensive volunteers (mean age 80.1 +/- 3.4 years) to investigate if drug accumulation occurred in the elderly. Subjects received 10 mg nitrendipine once daily by mouth for 8 days. Plasma nitrendipine conce...

journal_title：Current medical research and opinion

authors： Crome P,Baksi A,Edwards J,Marley J

更新日期：1989-01-01 00:00:00

abstract：:Faecal blood loss arising from tenoxicam at a dose of 20 mg/day was compared to that arising from piroxicam at a dose of 20 mg/day in a double-blind, parallel comparative study in 12 healthy male volunteers. Faecal blood loss was measured for a 1-week run-in on placebo, during 4 weeks of treatment and for a 2-week pos...

journal_title：Current medical research and opinion

authors： Bird HA,Hill J,Haw WM,Dixon JS,Harris PA,Wright V

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To develop a patient-completed screening tool to help differentiate nociceptive and neuropathic pain. RESEARCH DESIGN AND METHODS:A multicenter study was performed for item reduction (initial 89-item questionnaire) and model building. Patients (N = 586) with non-headache chronic pain completed the questionna...

journal_title：Current medical research and opinion

authors： Portenoy R

更新日期：2006-08-01 00:00:00

abstract：:Objective: A prior study found that hyaluronic acid (HA) treatment may help reduce pain medication use (such as steroids, non-steroidal anti-inflammatory drugs [NSAIDs] and opioids) among knee osteoarthritis (OA) patients in the real-world setting. This study aims to update the prior study results to include only the ...

journal_title：Current medical research and opinion

authors： Chitnis AS,Etter K,Holy CE,Gray FS,Manalac FJ,Bisson B,Bhattacharyya SK

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Bariatric surgery is an effective treatment for the reduction of weight in obese patients (BMI ≥ 40 kg/m(2) or 30 kg/m(2) with ≥1 comorbidities), who are refractory to behavioral and medical therapies. This study examined the effect of the adjustable gastric band (AGB) system on changes in gastroesophageal re...

journal_title：Current medical research and opinion

authors： Woodman G,Cywes R,Billy H,Montgomery K,Cornell C,Okerson T,APEX Study Group.

更新日期：2012-04-01 00:00:00

abstract：:Thirteen young adult patients suffering from heterozygotic familial hypercholesterolaemia with tendinous xanthomatosis, previously treated with a suitable special diet, were studied to assess the effect of bezafibrate, given for 2 years at a dose of 800 mg/day, on plasma lipid and lipoprotein levels and on changes in ...

journal_title：Current medical research and opinion

authors： Rouffy J,Chanu B,Bakir R,Goy-Loeper J,Djian F,Monsuez JJ,Gomberg R,Laval-Jeantet M

更新日期：1988-01-01 00:00:00

abstract：:An open study was carried out in 37 patients, with chronic, moderate to severe gastric or bilious reflux associated with hiatus hernia or subsequent to gastro-oesophageal surgery, to assess the effectiveness of an alginate/antacid combination product ('Gastrocote'). The overall success rate of treatment was 81% after ...

journal_title：Current medical research and opinion

authors： Hasan SS

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:We sought to evaluate the relationship between different levels of medication possession ratio (MPR) attained and achievement of clinically meaningful reductions in lipid levels. RESEARCH DESIGN AND METHODS:This was a retrospective cohort study of 4691 new statin users from the Department of Veteran Affairs ...

journal_title：Current medical research and opinion

authors： Watanabe JH,Bounthavong M,Chen T

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Natalizumab is a highly effective treatment for patients with relapsing-remitting multiple sclerosis (RRMS). Treatment with natalizumab has been associated with progressive multifocal leukoencephalopathy (PML), a rare yet serious disease of the brain. Published studies have quantified the PML risk by the pre...

journal_title：Current medical research and opinion

authors： Walker A,Watson C,Alexopoulos ST,Deniz B,Arnold R,Bates D

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:The primary aim of this study was to compare the effect of colesevelam HCl in combination with ezetimibe to ezetimibe monotherapy on low-density lipoprotein cholesterol (LDL-C) levels in subjects with primary hypercholesterolemia. METHODS:Subjects with primary hypercholesterolemia (N = 86) were enrolled in a...

journal_title：Current medical research and opinion

authors： Bays H,Rhyne J,Abby S,Lai YL,Jones M

更新日期：2006-11-01 00:00:00

abstract：:Twenty-nine patients undergoing cholecystectomy because of chronic calculous cholecystitis were randomised to receive phenylbutazone 10 mg/kg intramuscularly or a control injection (vehicle-containing local anaesthetic) immediately after completion of surgery. Fibrinogen and plasminogen concentrations in plasma, plasm...

journal_title：Current medical research and opinion

authors： Szczepański M,Kubiak J,Lembas L

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:To compare the efficacy and safety of the concomitant administration of travoprost 0.004% once daily and brinzolamide 0.1% twice daily with those of a fixed combination of latanoprost 0.005%/timolol 0.5% once daily. RESEARCH, DESIGN AND METHODS:Forty-four patients with primary open-angle glaucoma or ocular hyp...

journal_title：Current medical research and opinion

authors： Martinez-de-la-Casa JM,Castillo A,Garcia-Feijoo J,Mendez-Hernandez C,Fernandez-Vidal A,Garcia-Sanchez J

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:Neurosurgery often requires skull immobilization with a Mayfield clamp, which often causes brief intense nociceptive stimulation, hypertension and tachycardia. Blunting this response may help prevent increased intracranial pressure, cerebral aneurysm or vascular malformation rupture, and/or myocardial stress....

journal_title：Current medical research and opinion

authors： Berger M,Philips-Bute B,Guercio J,Hopkins TJ,James ML,Borel CO,Warner DS,McDonagh DL

更新日期：2014-02-01 00:00:00

abstract：:A double-blind trial was carried out in 37 patients with osteoarthrosis to compare the efficacy and tolerance of 250 mg diflunisal twice daily with that of 400 mg ibuprofen 3-times daily over an 8-week period. Rating scale assessments were made, at the end of a preceding 1-week, wash-out period on placebo and at regul...

journal_title：Current medical research and opinion

authors： Bresnihan B,Hughes G,Essigman WK

更新日期：1978-01-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy of the cholesterol absorption inhibitor ezetimibe in patients with refractory familial hyperlipidaemia or intolerant to statin therapy. METHODS:This prospective study assessed the safety and efficacy of ezetimibe in 200 patients with refractory familial hyperlipidaemias not achiev...

journal_title：Current medical research and opinion

authors： Wierzbicki AS,Doherty E,Lumb PJ,Chik G,Crook MA

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To identify determinants of non-compliance with bisphosphonates in women with postmenopausal osteoporosis. By considering the year of the introduction of weekly bisphosphonates important additional information is obtained. METHODS:New female users of daily or weekly alendronate or risedronate between 1999 an...

journal_title：Current medical research and opinion

authors： Penning-van Beest FJ,Erkens JA,Olson M,Herings RM

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that first-line treatment with atomoxetine provides superior efficacy than placebo for up to 12 weeks in improving the symptoms of Attention Deficit/Hyperactivity Disorder (ADHD). RESEARCH DESIGN AND METHODS:This double-blind, randomized, placebo-controlled, parallel clinical trial inc...

journal_title：Current medical research and opinion

authors： Montoya A,Hervas A,Cardo E,Artigas J,Mardomingo MJ,Alda JA,Gastaminza X,García-Polavieja MJ,Gilaberte I,Escobar R

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:Compare costs and healthcare resource utilization (HCRU) among newly-diagnosed non-valvular atrial fibrillation (NVAF) patients newly treated with dabigatran vs apixaban, rivaroxaban, or warfarin. METHODS:Newly-diagnosed adult NVAF patients initiating dabigatran, apixaban, rivaroxaban, or warfarin (index ev...

journal_title：Current medical research and opinion

authors： Gilligan AM,Franchino-Elder J,Song X,Wang C,Henriques C,Sainski-Nguyen A,Wilson K,Smith DM,Sander S

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Tobacco smoking is a major risk factor for cardiovascular disease, respiratory disease and cancer and, for current smokers, smoking cessation is one of the most effective therapeutic interventions for reducing the risk of all-cause morbidity and mortality. However, smoking cessation causes nicotine withdrawa...

journal_title：Current medical research and opinion

authors： Aubin HJ

更新日期：2009-02-01 00:00:00