Pharmacological agents used for the treatment of stress urinary incontinence in women.

abstract：OBJECTIVE:The aim of the study was to evaluate the effect of gliclazide modified release (MR) treatment on adiponectin, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) plasma concentrations in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:24 randomly selected type 2 diabetic patients, aged 61...

journal_title：Current medical research and opinion

authors： Drzewoski J,Zurawska-Klis M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Estimate the proportion of phosphodiesterase type-5 inhibitor (PDE5-I) patients who co-possess nitrates and compare the proportion of tadalafil patients dispensed nitrates to a matched control group. Secondarily, examine the percentage of co-possession of PDE5-Is and nitrates where the products were dispensed...

journal_title：Current medical research and opinion

authors： Chang LL,Ma M,Allmen Hv,Henderson SC,Harper K,Hornbuckle K

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Basal cell carcinoma (BCC) is the most common cancer. Most cases of BCCs are treated with only optimal surgical resection. However, unresectable, locally advanced or metastatic tumors might have potential to progress. In this patient group, there is no standardized treatment approach. Vismodegib is a new sel...

journal_title：Current medical research and opinion

authors： Erdem GU,Sendur MA,Ozdemir NY,Yazıcı O,Zengin N

更新日期：2015-04-01 00:00:00

abstract：:A double-blind trial of methocarbamol versus placebo was carried out in 59 matched pairs of patients suffering from painful muscle spasm. Methocarbamol (1500 mg. q.d.s.) was found to be effective in approximately 60% of patients compared with 30% of patients receiving placebo (p less than 0.01). Side-effects were of a...

journal_title：Current medical research and opinion

authors： Valtonen EJ

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:This study assesses the direct (medical and drugs) and indirect (work loss) annual costs associated with Atrial Fibrillation (AFIB) in a privately insured population. BACKGROUND:AFIB is the most common sustained rhythm disturbance, affecting 2.3 million people in the United States. METHODS:Cost and co-morbi...

journal_title：Current medical research and opinion

authors： Wu EQ,Birnbaum HG,Mareva M,Tuttle E,Castor AR,Jackman W,Ruskin J

更新日期：2005-10-01 00:00:00

abstract：:Sufficient time and effective communication are the main requirements in an ideal asthma consultation. One way of using limited time effectively is for patients to be offered more information prior to the consultation. Physician-patient communication during the consultation may be improved by patients receiving, in ad...

journal_title：Current medical research and opinion

authors： Partridge MR

更新日期：2005-01-01 00:00:00

abstract：:The bioavailability of ofloxacin after a single dose of one of two tablet formulations (200 or 400 mg) or a liquid formulation (1.67 mg/ml) was investigated in 24 healthy male volunteers in an open randomized, crossover design study with a 5-day wash-out period between doses. Plasma concentrations of ofloxacin were de...

journal_title：Current medical research and opinion

authors： Flor S,Beals B

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:The efficacy of antihistamines in perennial allergic rhinitis in children has been evaluated in studies using active comparators, whereas placebo-controlled studies are very few. A randomized, multicenter, double-blind, parallel-group clinical study was carried out to evaluate the dose-response relationship a...

journal_title：Current medical research and opinion

authors： Okubo K,Okuda M,Magara H,Kaneko K

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Breast cancer cells can develop resistance to standard hormonal treatment and chemotherapy with the activation of the mTOR pathway; this is supported by results of preclinical and clinical studies. In clinical trials, the addition of everolimus to hormonal treatment or anti-HER2 treatment improved the outcom...

journal_title：Current medical research and opinion

authors： Sendur MA,Zengin N,Aksoy S,Altundag K

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Data related to the cost effectiveness of surgical interventions and catheter ablation is sparse. This model-based analysis assessed the clinical and economic trade-offs involved in using catheter ablation or the Cox maze procedure in treating patients with atrial fibrillation. METHODS:A deterministic model...

journal_title：Current medical research and opinion

authors： Yang YT,Ortendahl J

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:As of 2012, nearly 10% of Americans had diabetes mellitus. People with diabetes are at approximately double the risk of premature death compared with those in the same age groups without the condition. While the prevalence of diabetes has risen across all racial/ethnic groups over the past 30 years, rates ar...

journal_title：Current medical research and opinion

authors： Ferdinand KC,Nasser SA

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To evaluate costs associated with prostaglandin analogs among newly-diagnosed glaucoma patients in a managed-care population. RESEARCH DESIGN AND METHODS:A cost minimization model compared annual costs for patients initiating therapy with one of the three prostaglandin analogs (bimatoprost, latanoprost, trav...

journal_title：Current medical research and opinion

authors： Schmier JK,Covert DW,Robin AL

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Decision aids (DAs) are increasingly used to operationalize shared decision-making (SDM) but their development is not often described. Decisions about oral anticoagulants (OACs) for atrial fibrillation (AF) involve a trade-off between lowering stroke risk and increasing OAC-associated bleeding risk, and consi...

journal_title：Current medical research and opinion

authors： Kaiser K,Cheng WY,Jensen S,Clayman ML,Thappa A,Schwiep F,Chawla A,Goldberger JJ,Col N,Schein J

更新日期：2015-12-01 00:00:00

abstract：:The term "mixed pain" is increasingly applied for specific clinical scenarios, such as low back pain, cancer pain and postsurgical pain, in which there "is a complex overlap of the different known pain types (nociceptive, neuropathic, nociplastic) in any combination, acting simultaneously and/or concurrently to cause ...

journal_title：Current medical research and opinion

authors： Freynhagen R,Rey R,Argoff C

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score <19 as a threshold for moderate to severe dry eye disease (DED). METHODS:A phase III, randomized, controlled...

journal_title：Current medical research and opinion

authors： Doan S,Bremond-Gignac D,Chiambaretta F

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of rosuvastatin in postmenopausal women with hypercholesterolemia who are receiving hormone replacement therapy (HRT) in a randomized, double-blind, placebo-controlled trial. METHODS:After a 6-week dietary lead-in period, 135 postmenopausal women who had been taking a stab...

journal_title：Current medical research and opinion

authors： Shepherd J,Packard C,Littlejohn TW 3rd,Walker J,Stein EA,Smith K,Kallend D,Blasetto JW

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:In a 4-week, double-blind, placebo-controlled study, the attention-promoting agent modafinil improved symptoms of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents and was well tolerated. To assess the continued efficacy of modafinil and obtain additional safety data, an 8-week, open...

journal_title：Current medical research and opinion

authors： Boellner SW,Earl CQ,Arora S

更新日期：2006-12-01 00:00:00

abstract：:Data from phase III clinical trials suggest that high dose chemotherapy (HDC) is currently not indicated for any stage of breast cancer. Therefore HDC should only be considered within the context of clinical trials. Furthermore, there is no significant evidence to support the routine use of taxanes in women with metas...

journal_title：Current medical research and opinion

authors： Mokbel K,Elkak A

更新日期：2001-01-01 00:00:00

abstract：:The therapeutic efficacy and tolerability of a new controlled-release 1000 mg tablet of naproxen (naproxen CR) were compared with 200 mg isoxicam in 100 out-patients with osteoarthritis. Medications were administered once daily for 4 weeks in a controlled, randomized, double-blind, parallel trial. Patients were assess...

journal_title：Current medical research and opinion

authors： Frankhof W

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Neurosurgery often requires skull immobilization with a Mayfield clamp, which often causes brief intense nociceptive stimulation, hypertension and tachycardia. Blunting this response may help prevent increased intracranial pressure, cerebral aneurysm or vascular malformation rupture, and/or myocardial stress....

journal_title：Current medical research and opinion

authors： Berger M,Philips-Bute B,Guercio J,Hopkins TJ,James ML,Borel CO,Warner DS,McDonagh DL

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of nebivolol, a third generation beta-blocker, on blood pressure (BP) reduction and polysomnographic parameters in hypertensive patients with mild-to-moderate obstructive sleep apnoea (OSA). METHODS:In this double-blind, parallel group study, patients were randomized to nebivolol 5...

journal_title：Current medical research and opinion

authors： Heitmann J,Greulich T,Reinke C,Koehler U,Vogelmeier C,Becker HF,Schmidt AC,Canisius S

更新日期：2010-08-01 00:00:00

abstract：:A multi-centre trial was carried out in 1629 patients with osteoarthrosis in 233 clinical centres to investigate the therapeutic efficacy and tolerability of indoprofen in this clinical condition. The results from assessments of both subjective and objective variables were comparable to those obtained in Phase 3 studi...

journal_title：Current medical research and opinion

authors： Emanueli A,Mandelli V,Mascellani G,Sacchetti G

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVES:Eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, has been shown to increase platelet counts in adults with chronic immune thrombocytopenia and chronic hepatitis C. This multicenter phase 2 study assessed the efficacy and safety of eltrombopag in patients receiving first-line carboplatin/pacl...

journal_title：Current medical research and opinion

authors： Kellum A,Jagiello-Gruszfeld A,Bondarenko IN,Patwardhan R,Messam C,Mostafa Kamel Y

更新日期：2010-10-01 00:00:00

abstract：:Twenty-seven patients with tennis elbow were treated with triamcinolone acetonide (40 mg/ml) injected locally into the tender area without local anaesthetic. Reduction of pain or complete relief was achieved in 1 to 72 hours, although in 9 cases exacerbation of pain occurred before relief was given. The recurrence rat...

journal_title：Current medical research and opinion

authors： Nevelös AB

更新日期：1980-01-01 00:00:00

abstract：:Neuroprotective agents inhibit reactions in the brain ischaemic injury cascade which lead to neuronal death. Gamma-aminobutyric acid (GABA) is a naturally occurring inhibitory neurotransmitter that increases chloride influx into the neuron and counteracts the toxic effects of glutamate. Clomethiazole is a GABA(A) agon...

journal_title：Current medical research and opinion

authors： Vaishnav A,Lutsep HL

更新日期：2002-01-01 00:00:00

abstract：:A double-blind study was carried out to investigate the prophylactic use of single-dose cefuroxime in elective abdominal surgery. Twenty-three patients received 1.5 g cefuroxime by intravenous injection immediately prior to induction of anaesthesia; 24 patients received no antibiotics. In the cefuroxime group, there w...

journal_title：Current medical research and opinion

authors： Lambert WG,Mullinger BM

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Alternaria alternata (AA) sensitisation is a common cause of respiratory allergies such as rhinitis and asthma. So far there are no controlled double-blind trials evaluating the efficacy and safety of specific sublingual immunotherapy (SLIT) in AA allergies. OBJECTIVE:To evaluate the efficacy of SLIT treatm...

journal_title：Current medical research and opinion

authors： Pozzan M,Milani M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines development group examined the properties of oral H(1)-antihistamines and made proposals about an 'optimal' drug. Several criteria should be met by oral H(1)-antihistamines in terms of their pharmacological, and clinical efficacy and safety pro...

journal_title：Current medical research and opinion

authors： Bousquet J,Ansótegui I,Canonica GW,Zuberbier T,Baena-Cagnani CE,Bachert C,Cruz AA,González SN,Kuna P,Morais-Almeida M,Mullol J,Ryan DP,Sánchez-Borges M,Valiente R,Church MK

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Migraine is frequently under-treated. The 4-item Migraine Assessment of Current Therapy (Migraine-ACT) questionnaire is a simple, patient-friendly tool to identify patients requiring change in acute migraine treatment. OBJECTIVE:To establish a predictive model for the Migraine-ACT questionnaire in primary c...

journal_title：Current medical research and opinion

authors： Pascual J,Láinez MJ,Baos V,García ML,López-Gil A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Healthcare organizations must evaluate the cost effectiveness of the alternative therapies that are available to treat anemia and improve quality of life (QoL) of patients with cancer, that is, erythropoietic protein therapy and blood transfusion. METHODS:Pharmacoeconomic studies that evaluated the cost of ...

journal_title：Current medical research and opinion

authors： Cornes P,Coiffier B,Zambrowski JJ

更新日期：2007-02-01 00:00:00