Abstract:
:Neuroprotective agents inhibit reactions in the brain ischaemic injury cascade which lead to neuronal death. Gamma-aminobutyric acid (GABA) is a naturally occurring inhibitory neurotransmitter that increases chloride influx into the neuron and counteracts the toxic effects of glutamate. Clomethiazole is a GABA(A) agonist, which causes membrane hyperpolarization, counteracting depolarization and the subsequent cascade of biochemical events that result in neuronal death. Promising results in animal models resulted in clinical trials conducted in humans. However, large randomized placebo controlled trials in Europe, Canada and North America did not show the superiority of clomethiazole over placebo that was seen in animal models.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Vaishnav A,Lutsep HLdoi
10.1185/030079902125000651keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
s5-8eissn
0300-7995issn
1473-4877journal_volume
18 Suppl 2pub_type
杂志文章,meta分析abstract::A clinical trial was undertaken in 50 patients with osteoarthritis of the knee to assess the therapeutic value of glycosaminoglycan-peptide complex in treatment. The first year consisted of a randomized, double-blind, placebo-controlled, parallel-group trial (25 patients in each group), after which all patients receiv...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998709112416
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:The objectives of this article are to review the pathophysiology of type 2 diabetes mellitus (T2DM), present the rationale for a pathophysiologically based treatment approach for patients with T2DM and discuss the role of the therapeutic combination of pioglitazone and exenatide in the management of T2DM. ME...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990802390795
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic condition commonly requiring lifelong care. Both IBD and IBD-related treatments can cause significant morbidity, and it is often difficult to differentiate their relative etiologic contribution to adverse events (AEs). The objectives of this study were to assess ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2015.1065242
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The pattern of renal transplantation has never been described since the introduction of the technique. The purpose of this study was therefore to characterise the pattern of renal transplantation from 1967 to 2000, focusing on renal graft function as a predictor of survival. METHODS:This study was a retrosp...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X65574
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To evaluate inpatient oral anticoagulant (OAC) treatment, discharge location, and post-discharge OAC treatment for patients hospitalized with non-valvular atrial fibrillation (NVAF). RESEARCH DESIGN AND METHODS:Retrospective study using claims data linked to hospital electronic health records (EHR). Patients...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2017.1417029
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To assess whether maintenance of labor epidural analgesia using programmed intermittent epidural bolus (PIEB) is associated with reduced local anesthetic (LA) consumption, patient-controlled epidural analgesia (PCEA) use, and rescue analgesia requirements compared to continuous epidural infusion (CEI). RESEA...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1181619
更新日期:2016-08-01 00:00:00
abstract::The therapeutic efficacy and tolerability of a new controlled-release 1000 mg tablet of naproxen (naproxen CR) were compared with 200 mg isoxicam in 100 out-patients with osteoarthritis. Medications were administered once daily for 4 weeks in a controlled, randomized, double-blind, parallel trial. Patients were assess...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998809111127
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:The systematic use of 2-octyl cyanoacrylate (2-OCA) became routine in our cardiac unit in 2000. This topical skin adhesive has been used in conjunction with conventional suturing for skin closure and prevention of postoperative wound infections by means of its performance as a microbial barrier to exogenou...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079908x253807
更新日期:2008-01-01 00:00:00
abstract::A single-blind, open-label controlled study was carried out in 30 healthy male volunteers to compare gastro-intestinal blood loss before, during and after treatment with a new, sustained-release formulation of the non-steroidal anti-inflammatory agent etodolac (etodolac SR) or with naproxen. Subjects remained at the s...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007999209115217
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The relationship between chronic pancreatitis (CP) and subsequent pyogenic liver abscess (PLA) is not well understood. METHODS:We investigated the risk of PLA in patients with CP using inpatient claims data from the Taiwan National Health Insurance Program for the period 2000-2010. We identified 17,810 pati...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1266312
更新日期:2017-03-01 00:00:00
abstract::A double-blind study was carried out to investigate the prophylactic use of single-dose cefuroxime in elective abdominal surgery. Twenty-three patients received 1.5 g cefuroxime by intravenous injection immediately prior to induction of anaesthesia; 24 patients received no antibiotics. In the cefuroxime group, there w...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998009109459
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:To determine the extent to which raloxifene can maintain low density lipoprotein cholesterol (LDL-C) levels below 160 mg/dL or reduce elevated LDL-C levels to below lipid-lowering goals in postmenopausal women. PATIENTS AND METHODS:The Multiple Outcomes of Raloxifene Evaluation (MORE) osteoporosis treatment ...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/030079904125004187
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Fasting during the month of Ramadan is practiced by over 1.5 billion Muslims worldwide. It remains unclear, however, how this change in lifestyle affects heart failure, a condition that has reached epidemic dimensions. This study examined the effects of fasting in patients with acute heart failure (AHF) usin...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1080/03007995.2017.1376629
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:There is a general perception that research is underdeveloped in rehabilitation professions. However, a PubMed search found that the growth in publications in the rehabilitation field was twice that of the general medical field. Despite this growth, another study focusing on Europe found that the proportion ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1815685
更新日期:2020-11-01 00:00:00
abstract::Seventy frail elderly patients attending a day hospital were studied to investigate the incidence of postural hypotension in control patients on no diuretic treatment (n = 30), patients on loop diuretics (frusemide) for mild cardiac failure (n = 20) and patients on thiazide diuretics for mild cardiac failure (n = 20)....
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998809114241
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Studies have shown that many patients with type 2 diabetes do not achieve optimal glycemic control, and progression of diabetes over time requires more than one pharmacotherapy to achieve glycemic goal. OBJECTIVE:To examine the efficacy and safety of the fixed-dose combination (FDC) of pioglitazone 15 mg an...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990903350011
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. A high level of low-density lipoprotein cholesterol (LDL-C) is a major CVD risk factor. Guidelines recommend effective cholesterol management and set LDL-C goals, yet deficiencies exist in physician implementation of these recommendati...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079908x280491
更新日期:2008-05-01 00:00:00
abstract:INTRODUCTION:Tumor hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression are important factors influencing treatment response and selection in patients with metastatic breast cancer (mBC). Using the LifeLink Oncology Analyzer Database, we classified mBC patients by combined HR and HER2 st...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2012.694364
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:It has been acknowledged that patients who receive a beta-blocker or diuretic based regimen are at increased risk of developing new-onset diabetes. Recently, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been shown to decrease patients' odds of developing new-o...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/030079907X188044
更新日期:2007-06-01 00:00:00
abstract::Effective management of influenza depends on early recognition of influenza in the community and on rapid diagnosis. Early recognition is achieved by integrated clinical and laboratory based surveillance programmes in representative populations. The recent introduction of 'near patient tests' for influenza provide inc...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079902125000921
更新日期:2002-01-01 00:00:00
abstract::For over a century, there has been considerable interest in the management of regional lymph node metastasis in patients with primary breast cancer. Since the advent of sentinel lymph node biopsies, there has been renewed interest in the management of patients with metastasis to the internal mammary nodes. The appropr...
journal_title:Current medical research and opinion
pub_type: 社论
doi:10.1185/030079903125002207
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Guidelines recommend that women with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer (mBC) initiate hormonal therapy before chemotherapy. This study compared outcomes of women with mBC who received chemotherapy first vs hormonal therapy. METHO...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1178108
更新日期:2016-08-01 00:00:00
abstract::An open, multi-centre study was carried out in 804 patients complaining of sleep disorders to assess the effectiveness and acceptance of temazepam as a hypnotic. Patients received between 10 mg and 30 mg (mean 16.4 mg) temazepam each night for a week. Subjective assessments using a self-administered questionnaire were...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997809111918
更新日期:1978-01-01 00:00:00
abstract::In a multi-centre study, the antidepressant efficacy and incidence of on-therapy events of trazodone (100 to 400 mg daily) and mianserin (30 to 120 mg daily) was compared using a double-blind pre-determined randomized parallel group design in depressed patients unresponsive to placebo after a 7-day screening period. O...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998409109588
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Healthcare organizations must evaluate the cost effectiveness of the alternative therapies that are available to treat anemia and improve quality of life (QoL) of patients with cancer, that is, erythropoietic protein therapy and blood transfusion. METHODS:Pharmacoeconomic studies that evaluated the cost of ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079906X167282
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:The relationship between patient characteristics and posaconazole exposures was evaluated in a population pharmacokinetic (PK) model using trial data from neutropenic patients administered oral posaconazole suspension as antifungal prophylaxis. METHODS:Data were analyzed using nonlinear mixed-effects modelin...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990903485056
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To investigate the use of traditional non-steroidal anti-inflammatory drugs (tNSAIDs) in the management of osteoarthritis (OA) in primary care in Spain and to quantify patient and physician satisfaction with tNSAID therapy. METHODS:A 6-month retrospective, observational study conducted in 29 Spanish primary-...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/030079903125001712
更新日期:2003-01-01 00:00:00
abstract::An open, multi-centre, non-comparative study was carried out in general practice to assess the efficacy and tolerance of piroxicam in 159 patients with osteoarthritis and 27 patients with rheumatoid arthritis. Initial dosage ranged from 10 to 40 mg piroxicam and all but a few patients continued treatment with 20 mg on...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998309109807
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Omega-3 fatty acids from fish and fish oils can protect against coronary heart disease (CHD), which is still the most common cause of death in the Western economies. Evidence from epidemiological and case cohort studies indicate that consumpton of fatty fish and omega-3 fatty acids reduces the risk of cardio...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079904x17956
更新日期:2005-01-01 00:00:00
abstract::Objective: The aim of this study was to provide recommendations for improving the design of subsequent studies through analysis of the registered coronavirus disease 2019 (COVID-19) clinical trials.Methods: A retrospective analysis of 189 trial retrievals achieved on 20 February 2020.Results: A total of 189 trials are...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1771294
更新日期:2020-07-01 00:00:00