A double-blind trial of methocarbamol versus placebo in painful muscle spasm.

abstract：OBJECTIVES:Docetaxel and paclitaxel show significant clinical activity in metastatic breast cancer (MBC) and have been approved for MBC by the U.S. Food and Drug Administration, but it is still unclear whether a paclitaxel-based regimen improves outcomes over a docetaxel-based regimen in patients with MBC. We therefore...

journal_title：Current medical research and opinion

authors： Qi WX,Shen Z,Lin F,Sun YJ,Min DL,Tang LN,He AN,Yao Y

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Short-term clinical trials have demonstrated the efficacy and safety of pregabalin in the treatment of generalized anxiety disorder (GAD). This study examined long-term safety and tolerability of pregabalin in patients with GAD, social anxiety disorder (SAD), or panic disorder (PD). RESEARCH DESIGN AND METHO...

journal_title：Current medical research and opinion

authors： Montgomery S,Emir B,Haswell H,Prieto R

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Exenatide, an incretin mimetic for adjunctive treatment of type 2 diabetes (T2DM), reduced hemoglobin A(1c) (A1C) and weight in clinical trials. The objective of this study was to evaluate the effects of > or = 3 years exenatide therapy on glycemic control, body weight, cardiometabolic markers, and safety. ...

journal_title：Current medical research and opinion

authors： Klonoff DC,Buse JB,Nielsen LL,Guan X,Bowlus CL,Holcombe JH,Wintle ME,Maggs DG

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical efficacy and safety of mometasone furoate administered via a dry powder inhaler (MF-DPI) in Japanese patients with intermittent or mild persistent asthma who were not previously receiving inhaled corticosteroids. RESEARCH DESIGN AND METHODS:This was an 8-week open-label study conduct...

journal_title：Current medical research and opinion

authors： Tohda Y,Miyamoto T

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To quantify changes in clinical and cost outcomes associated with increasing levels of body mass index (BMI) in a US setting. RESEARCH METHODS AND PROCEDURES:A semi-Markov model was developed to project and compare life expectancy (LE), quality-adjusted life expectancy (QALE) and direct medical costs associa...

journal_title：Current medical research and opinion

authors： Tucker DM,Palmer AJ,Valentine WJ,Roze S,Ray JA

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND SCOPE:Whether generic drug products are truly therapeutically identical and interchangeable with their innovator counterparts is still a matter of debate. This review discusses the controversies related to the criteria for bioequivalence and therapeutic equivalence. These concerns are illustrated by usin...

journal_title：Current medical research and opinion

authors： Meredith PA

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVES:An economic analysis (based on interim data from a long-term, randomised, multi-centre, controlled, clinical trial) to evaluate chemotherapy with XELOX (capecitabine/oxaliplatin) versus FOLFOX6 (5Fluorouracil/leucovorin/oxaliplatin) as an adjuvant treatment for high risk colorectal cancer patients in Greece....

journal_title：Current medical research and opinion

authors： Maniadakis N,Fragoulakis V,Pectasides D,Fountzilas G

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the effects of losartan +/- hydrochlorothiazide (HCTZ) versus placebo in obese patients with systolic and diastolic hypertension. RESEARCH DESIGN AND METHODS:Randomized patients (n = 261) were non-diabetic with systolic blood pressure (SBP) > or = 140 and < or = 1...

journal_title：Current medical research and opinion

authors： Oparil S,Abate N,Chen E,Creager MA,Galet V,Jia G,Julius S,Lerman A,Lyle PA,Pool J,Tershakovec AM

更新日期：2008-04-01 00:00:00

abstract：:Objective: The aim of this study was to investigate the impact of methodological choices in a meta-analysis of real-world evidence (RWE) comparing three non-vitamin-K antagonist oral anticoagulants with vitamin K antagonists (VKAs) for the treatment of patients with non-valvular atrial fibrillation (NVAF). Methods: Th...

journal_title：Current medical research and opinion

authors： Briere JB,Wu O,Bowrin K,Millier A,Toumi M,Taieb V,Levy P,Coleman CI

更新日期：2019-11-01 00:00:00

abstract：:One hundred adult male volunteers were randomized to receive either Merieux or Wellcome RA27/3 rubella vaccine. Prior to vaccination, 10% of the subjects were seronegative and all of these seroconverted. No significant boosting effect was found in those with a high pre-vaccine titre but some boost was shown in those w...

journal_title：Current medical research and opinion

authors： Harcus AW,Ward AE,Bryett KA

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF) is widely and successfully used in immunosuppressive regimens for the prophylaxis of organ rejection following transplantation. Conventionally, it is administered at a fixed dose without serial measurements of plasma concentrations of mycophenolic acid (MPA), the active metabolite...

journal_title：Current medical research and opinion

authors： Kaplan B

更新日期：2006-12-01 00:00:00

abstract：INTRODUCTION:This brief review describes conservative treatment methods for pelvic venous congestion. Therapy options: The authors present an analysis of the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs), ergot alkaloid derivatives, hormonal agents, venoprotective agents, and compression therapy in the trea...

journal_title：Current medical research and opinion

authors： Gavrilov SG,Turischeva OO

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the positive predictive value of claims-based V85 codes for identifying individuals with varying degrees of BMI relative to their measured BMI obtained from medical record abstraction. METHODS:This was a retrospective validation study utilizing administrative claims and medical chart data from 1 ...

journal_title：Current medical research and opinion

authors： Caplan EO,Kamble PS,Harvey RA,Smolarz BG,Renda A,Bouchard JR,Huang JC

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD f...

journal_title：Current medical research and opinion

authors： Foley P,Garrett S,Ryttig L

更新日期：2018-07-01 00:00:00

abstract：:Background: In routine clinical practice, the implantation of a drug-eluting stent (DES) versus a bare metal stent (BMS) for percutaneous coronary intervention (PCI) has been guided by criteria for appropriate use. The cost-effectiveness (CE) of adopting these guidelines, however, is not clear, and was investigated fr...

journal_title：Current medical research and opinion

authors： Ariyaratne TV,Ademi Z,Ofori-Asenso R,Huq MM,Duffy SJ,Yan BP,Ajani AE,Clark DJ,Billah B,Brennan AL,New G,Andrianopoulos N,Reid CM

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Although risk factors for MI have been described in the general population, there is a lack of data on the assessment of risk factors associated with MI in venous thromboembolism (VTE) patients. OBJECTIVE:The purpose of this study was to identify risk factors associated with MI in VTE patients. PATIENTS AN...

journal_title：Current medical research and opinion

authors： Laliberté F,Nutescu EA,Lefebvre P,Rondeau-Leclaire J,Bookhart BK,LaMori JC,Damaraju CV,Schein J,Kaatz S

更新日期：2014-01-01 00:00:00

abstract：:A double-blind crossover study was carried out in 21 patients with osteoarthrosis of the hip to compare the effectiveness and tolerance of 1200 mg tolmetin sodium daily with 75 mg indomethacin daily. Each drug was given in 3 equally divided doses daily for a period of 2 weeks, both active treatment periods being prece...

journal_title：Current medical research and opinion

authors： Davies J,Dixon AS,Steele CE

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:Chronic respiratory failure (CRF) is a syndrome defined by certain disturbances in arterial blood gases. Non-invasive mechanical ventilation (NIMV) is an increasingly used treatment modality in respiratory failure. The aim of this study was to investigate the long-term effects of NIMV on pulmonary function an...

journal_title：Current medical research and opinion

authors： Dogan OT,Turkyilmaz S,Berk S,Epozturk K,Akkurt I

更新日期：2010-09-01 00:00:00

abstract：:Atypical antipsychotics are commonly used off-label to treat behavioural and psychiatric symptoms in dementia (BPSD), particularly in elderly care homes. Much of this use is inappropriate, and trials have shown an increased likelihood of serious cerebrovascular adverse events (CVAEs) such as stroke and transient ische...

journal_title：Current medical research and opinion

authors： Bullock R

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Despite a plethora of published data on levocetirizine, no meta-analyses exist on the effect of study design, and covariates like age, gender, and baseline symptom severity on treatment response. The objective of this study was the efficacy of levocetirizine 5  mg tablets and matching placebo at reducing alle...

journal_title：Current medical research and opinion

authors： Boev R,Song D,Bedenbaugh A,Haeusler JM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:While arterial wall imaging has been used to characterize progression of atherosclerosis, there remain limitations to this approach. SCOPE:A selective overview of emerging modalities to image the artery wall and highlight how they may be used to evaluate emerging anti-atherosclerotic agents. FINDINGS:Ongoi...

journal_title：Current medical research and opinion

authors： Bayturan O,Uno K,Lavoie A,Nicholls SJ

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:In ST-segment elevation myocardial infarction (STEMI), current guidelines discourage treatment of the non-culprit lesions at the time of the primary intervention. Latest trials have challenged this strategy suggesting benefit of early complete revascularization. We performed a Bayesian multiple treatment net...

journal_title：Current medical research and opinion

authors： Komócsi A,Kehl D,d'Ascenso F,DiNicolantonio J,Vorobcsuk A

更新日期：2017-03-01 00:00:00

abstract：:Four hundred and twenty-seven hypertensive patients in the United Kingdom have so far been admitted to two on-going open multicentre trials, and have been treated with acebutolol for periods ranging from 1 to 6 months. Oral dosages were within the range of 100 mg to 1200 mg/day in divided doses and were increased or d...

journal_title：Current medical research and opinion

authors： Ashton WL

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Natalizumab is a highly effective treatment for patients with relapsing-remitting multiple sclerosis (RRMS). Treatment with natalizumab has been associated with progressive multifocal leukoencephalopathy (PML), a rare yet serious disease of the brain. Published studies have quantified the PML risk by the pre...

journal_title：Current medical research and opinion

authors： Walker A,Watson C,Alexopoulos ST,Deniz B,Arnold R,Bates D

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To evaluate posaconazole pharmacokinetics in subjects with different degrees of hepatic impairment compared with matched healthy subjects. RESEARCH DESIGN AND METHODS:A total of 37 subjects were enrolled in this open-label, single-dose, parallel-group study; 19 with hepatic impairment and 18 healthy subjects...

journal_title：Current medical research and opinion

authors： Moton A,Krishna G,Ma L,O'Mara E,Prasad P,McLeod J,Preston RA

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To evaluate costs associated with prostaglandin analogs among newly-diagnosed glaucoma patients in a managed-care population. RESEARCH DESIGN AND METHODS:A cost minimization model compared annual costs for patients initiating therapy with one of the three prostaglandin analogs (bimatoprost, latanoprost, trav...

journal_title：Current medical research and opinion

authors： Schmier JK,Covert DW,Robin AL

更新日期：2007-11-01 00:00:00

abstract：:Abstract A growing body of evidence suggests that targeting low-density lipoprotein cholesterol is not enough and that a substantial residual risk remains despite aggressive statin treatment, particularly in patients with mixed dyslipidemia. Statin plus fibrate combination results in a more effective control of severa...

journal_title：Current medical research and opinion

authors： Athyros VG,Tziomalos K,Karagiannis A,Mikhailidis DP

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to ascertain the factors associated with non-achievement of triglyceride (TG) goals in a cohort of hypertriglyceridemic patients attending the lipid clinics of the Spanish Arteriosclerosis Society (LC-SAS). METHODS:Patients with high TG levels (>2.2 mmol/L; 200 mg/dL) were included...

journal_title：Current medical research and opinion

authors： Pintó X,Valdivielso P,Perez de Juan JM,Plana N,Garcia-Arias C,Fuentes FJ,Hernández-Mijares A,Mostaza JM,Spanish Registry of Hypertriglyceridemia (Spanish Society of Arteriosclerosis, SAS).

更新日期：2014-01-01 00:00:00

abstract：:Objective: This economic evaluation aims to provide a preliminary assessment of the cost-effectiveness of radiofrequency ablation (RFA) compared with argon plasma coagulation (APC) when used to treat APC-refractory gastric antral vascular ectasia (GAVE) in symptomatic patients.Methods: A Markov model was constructed t...

journal_title：Current medical research and opinion

authors： Magee C,Graham D,Leonard C,McMaster J,Davies H,Skotchko M,Lovat L,Murray C,Mealing S,Smart H,Haidry R

更新日期：2020-06-01 00:00:00

abstract：:Objective: To evaluate the risk of chronic kidney disease (CKD), cardiovascular disease (CVD), and osteoporotic fractures in human immunodeficiency virus (HIV) patients utilizing data within the Veteran's Affairs (VA) Administration system.Methods: A retrospective cohort study utilizing VA system claims (January 2000-...

journal_title：Current medical research and opinion

authors： Sutton SS,Magagnoli J,Cummings TH,Hardin JW,Edun B,Beaubrun A

更新日期：2019-01-01 00:00:00