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Risk factors associated with myocardial infarction in venous thromboembolism patients.

Abstract：

BACKGROUND:Although risk factors for MI have been described in the general population, there is a lack of data on the assessment of risk factors associated with MI in venous thromboembolism (VTE) patients. OBJECTIVE:The purpose of this study was to identify risk factors associated with MI in VTE patients. PATIENTS AND METHODS:Health insurance claims between January 2004 and September 2008 from the Ingenix IMPACT database were analyzed. Patients aged ≥18 years were identified as of the date of their first VTE diagnosis with ≥1 year of continuous insurance coverage before the index VTE. The risk of MI for VTE patients with 1, 2, and ≥3 major risk factors as identified by published guidelines was calculated. Multivariate Cox proportional hazard models were conducted to identify the most predictive risk factors associated with MI. RESULTS:A total of 177,885 VTE patients were identified; 4412 (2.5%) developed an MI during a mean follow-up period of 1.3 years. Previous MI, age (≥65 years), and coronary artery disease were the most predictive risk factors of MI with adjusted hazard ratios (HRs; 95% CI) of 5.47 (5.01-5.97), 1.78 (1.66-1.91), and 1.60 (1.48-1.74), respectively. Adjusted HRs (95% CI) for VTE patients with 1, 2, and ≥3 major risk factors relative to no major risk factor were 2.34 (1.94-2.81), 3.21 (2.67-3.85), and 6.93 (5.85-8.22), respectively. LIMITATIONS:These included possible inaccuracies or omissions in diagnoses, classification bias such as the identification of false-positive MI events, and the likely undercoding of some risk factors such as social issues. CONCLUSIONS:Traditional major cardiovascular risk factors are also predictive of MI in VTE patients. Having multiple major risk factors significantly increases the probability of developing MI events in VTE patients.

journal_name

Curr Med Res Opin

journal_title

Current medical research and opinion

authors

Laliberté F,Nutescu EA,Lefebvre P,Rondeau-Leclaire J,Bookhart BK,LaMori JC,Damaraju CV,Schein J,Kaatz S

doi

10.1185/03007995.2013.852525

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

27-35

issue

eissn

0300-7995

issn

1473-4877

journal_volume

pub_type

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Risk factors associated with myocardial infarction in venous thromboembolism patients.