Efficacy and safety of cerivastatin, 0.2 mg and 0.4 mg, in patients with primary hypercholesterolaemia: a multinational, randomised, double-blind study. Cerivastatin Study Group.

abstract：BACKGROUND:Triptans are not identical and migraine sufferers respond differently to different triptans. Few studies have evaluated the efficacy of switching triptans in migraine patients who have shown poor response to another agent. OBJECTIVE:To investigate the efficacy and tolerability of almotriptan 12.5 mg in pati...

journal_title：Current medical research and opinion

authors： Diener HC

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:Tamoxifen, used in breast cancer treatment, may induce hepatic steatosis. It has been suggested that leptin, which has a relationship with body fat stores, may be involved in the pathogenesis of hepatic steatosis. In this study, we compared serum leptin levels in tamoxifen-treated patients with and without hepa...

journal_title：Current medical research and opinion

authors： Günel N,Coşkun U,Toruner FB,Sancak B,Yilmaz E,Cengiz O,Elbeg S,Uner A,Ozkan S

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Heart failure (HF) is a major health problem facing the US and studies suggest that the incidence of this condition will rise significantly over the next 10 years. Limiting the incidence or duration of HF hospitalizations would, therefore, have a major impact on healthcare costs. The purpose of this review is...

journal_title：Current medical research and opinion

authors： Williams RE

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Insulin resistance alone does not result in the development of type 2 diabetes; progressive dysfunction of pancreatic islet alpha and beta cells, which results in inadequate control of hyperglycemia, must be present for the disease to develop. Because of these defects, meal-stimulated insulin secretion from ...

journal_title：Current medical research and opinion

authors： Meece J

更新日期：2007-04-01 00:00:00

abstract：:A double-blind crossover study was carried out in 21 patients with osteoarthrosis of the hip to compare the effectiveness and tolerance of 1200 mg tolmetin sodium daily with 75 mg indomethacin daily. Each drug was given in 3 equally divided doses daily for a period of 2 weeks, both active treatment periods being prece...

journal_title：Current medical research and opinion

authors： Davies J,Dixon AS,Steele CE

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVES:Sulfonylurea therapy among patients with type 2 diabetes mellitus (T2DM) can be disrupted due to adverse events, including hypoglycemia. A retrospective study using the MarketScan claims database quantified the frequency of sulfonylurea discontinuation or down-titration and identified associated risk factors...

journal_title：Current medical research and opinion

authors： Iglay K,Qiu Y,Steve Fan CP,Li Z,Tang J,Laires P

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic condition commonly requiring lifelong care. Both IBD and IBD-related treatments can cause significant morbidity, and it is often difficult to differentiate their relative etiologic contribution to adverse events (AEs). The objectives of this study were to assess ...

journal_title：Current medical research and opinion

authors： McAuliffe ME,Lanes S,Leach T,Parikh A,Faich G,Porter J,Holick C,Esposito D,Zhao Y,Fox I

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To review published evidence on the impact of weight/BMI change on health-related quality of life (HRQoL) in adults from the US with overweight/obesity. METHODS:The systematic review was conducted in accordance with PRISMA guidelines. MEDLINE, Embase, EconLit, and Cochrane Library databases were reviewed usi...

journal_title：Current medical research and opinion

authors： Kroes M,Osei-Assibey G,Baker-Searle R,Huang J

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Vesicoureteral reflux (VUR) occurs in approximately 1% of infants and children and is associated with recurrent urinary tract infections (UTIs). The objective of this paper is to examine the use of endoscopic injection with dextranomer/hyaluronic acid copolymer (Dx/HA) as a curative option and as an alternati...

journal_title：Current medical research and opinion

authors： Elder JS,Shah MB,Batiste LR,Eaddy M

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Aripiprazole differs from other atypical antipsychotics in its pharmacological and clinical profile. SCOPE:As aripiprazole has been available in the USA for bipolar mania since 2004, clinical experience-sharing from clinical and research use of this agent can assist with initiation and administration in pra...

journal_title：Current medical research and opinion

authors： Fagiolini A

更新日期：2008-09-01 00:00:00

abstract：:A double-blind crossover study was carried out in 24 patients with rheumatoid arthritis to investigate the relative efficacy of tolmetin (1600 mg/day) and phenylbutazone (400 mg/day). Each drug was given for 4 weeks, preceded by a 2-week wash-out period during which patients received paracetamol alone for pain relief....

journal_title：Current medical research and opinion

authors： Cardoe N,Steele CE

更新日期：1976-01-01 00:00:00

abstract：:A double-blind trial was carried out in 45 anxious out-patients to compare the effectiveness and tolerance of clobazam and diazepam. The severity of each patient's symptoms was assessed before, during and at the end of the trial period using the Hamilton Anxiety Rating Scale, and a note kept of any side-effects. The r...

journal_title：Current medical research and opinion

authors： Botter PA

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:The RED LEVEL study (REnal Disease: LErcanidipine Valuable Effect on urine protein Losses) directly compares, in an explorative fashion, the effects of lercanidipine + enalapril and amlodipine + enalapril combinations on renal parameters in hypertensive subjects. RESEARCH DESIGN AND METHODS:This was a 1 year...

journal_title：Current medical research and opinion

authors： Robles NR,Calvo C,Sobrino J,Espinel E,Esteban R,Mateos L,Macias JF

更新日期：2016-10-01 00:00:00

abstract：:Two hundred and two patients with symptoms, signs and mycological evidence of Candida vaginitis were entered in a single-blind trial comparing 6-day clotrimazole therapy with a control group receiving 6 days' nystatin therapy. Adequate data was collected on 69 clotrimazole and 72 nystatin treated patients for analysis...

journal_title：Current medical research and opinion

authors： Masterton G,Henderson J,Napier IR,Moffet M

更新日期：1975-01-01 00:00:00

abstract：:Acetyl-L-carnitine (ALC) is a compound acting as an intracellular carrier of acetyl groups across inner mitochondrial membranes. It also appears to have neuroprotective properties and it has recently been shown to reduce attention deficits in patients with Alzheimer's disease (AD) after long-term treatment. We perform...

journal_title：Current medical research and opinion

authors： Bianchetti A,Rozzini R,Trabucchi M

更新日期：2003-01-01 00:00:00

abstract：:Background: In routine clinical practice, the implantation of a drug-eluting stent (DES) versus a bare metal stent (BMS) for percutaneous coronary intervention (PCI) has been guided by criteria for appropriate use. The cost-effectiveness (CE) of adopting these guidelines, however, is not clear, and was investigated fr...

journal_title：Current medical research and opinion

authors： Ariyaratne TV,Ademi Z,Ofori-Asenso R,Huq MM,Duffy SJ,Yan BP,Ajani AE,Clark DJ,Billah B,Brennan AL,New G,Andrianopoulos N,Reid CM

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Long-term oral corticosteroid (OCS) therapy and related adverse events are associated with a significant burden on patients and healthcare resources. METHODS:This subgroup analysis of a randomized, open-label, parallel-group study evaluated the OCS-sparing effect of omalizumab (OMA) added to optimized asthm...

journal_title：Current medical research and opinion

authors： Siergiejko Z,Świebocka E,Smith N,Peckitt C,Leo J,Peachey G,Maykut R

更新日期：2011-11-01 00:00:00

abstract：:Abstract A growing body of evidence suggests that targeting low-density lipoprotein cholesterol is not enough and that a substantial residual risk remains despite aggressive statin treatment, particularly in patients with mixed dyslipidemia. Statin plus fibrate combination results in a more effective control of severa...

journal_title：Current medical research and opinion

authors： Athyros VG,Tziomalos K,Karagiannis A,Mikhailidis DP

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the efficacy and safety of doses of fentanyl buccal tablet (FBT) proportional to doses of opioids used for background analgesia versus dose titration starting with the minimal dose for the management of breakthrough cancer pain (BTcP). METHODS:A total of 82 cancer patien...

journal_title：Current medical research and opinion

authors： Mercadante S,Gatti A,Porzio G,Lo Presti C,Aielli F,Adile C,Casuccio A

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether healthy men would prefer either luteinizing hormone releasing hormone analogues (LHRHa) or non-steroidal anti-androgen therapy (NSAA) should they hypothetically develop locally advanced prostate cancer. PARTICIPANTS AND METHODS:A representative sample of 180 men...

journal_title：Current medical research and opinion

authors： Jenkins V,Fallowfield L,Edginton T,Payne H,Hamilton E

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:Healthcare providers managing older patients with type 2 diabetes mellitus (T2DM) face a complex milieu of medical conditions and comorbidities, which increase the risk of unintended treatment consequences. The objective of this study was to understand factors associated with hypoglycemia-related hospitalizat...

journal_title：Current medical research and opinion

authors： Fu H,Xie W,Curtis B,Schuster D

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The goals of diabetes management have evolved over the past decade to become the attainment of near-normal glucose and cardiovascular risk factor levels. Improved metabolic control is achieved through optimized medication regimens, but costs specifically associated with such optimization have not been examin...

journal_title：Current medical research and opinion

authors： Crivera C,Suh DC,Huang ES,Cagliero E,Grant RW,Vo L,Shin HC,Meigs JB

更新日期：2006-11-01 00:00:00

abstract：:Filgrastim prophylaxis, both primary and secondary, was rapidly incorporated into clinical practice in the 1990s. When pegfilgrastim became available in 2002, it quickly replaced filgrastim as the colony-stimulating factor (CSF) of choice for prophylaxis. Use of prophylaxis increased markedly in the first decade of th...

journal_title：Current medical research and opinion

authors： Edelsberg J,Weycker D,Bensink M,Bowers C,Lyman GH

更新日期：2020-03-01 00:00:00

abstract：:Forty-two patients with a radiologically confirmed diagnosis of chronic pyelonephritis were treated with 1 g carindacillin every 6 hours over a period of 6 weeks. An underlying urological disease was present in 84% of the 38 patients for whom sufficient data were available for evaluation. The results of carindacillin ...

journal_title：Current medical research and opinion

authors： Michiels HG,Debruyne FM,Moonen WA

更新日期：1978-01-01 00:00:00

abstract：:The efficacy of parenteral mecillinam was evaluated in 105 elderly patients with lower respiratory tract infections or urinary tract infections. Another antibiotic, usually amoxycillin, was given concurrently in cases of respiratory infection. An adequate response was note in 86% of chest infections and in all of the ...

journal_title：Current medical research and opinion

authors： Pines A,Raafat H,Khorasani MH,Sharma JC,Menday AP

更新日期：1981-01-01 00:00:00

abstract：:Background: Actinic keratosis (AK) is considered an "in situ" non-melanoma skin cancer induced by ultraviolet chronic exposure. Sunscreen and topical anti-inflammatory agents like diclofenac could improve the evolution of this kind of lesions. A topical product containing piroxicam 0.8% and sun filters (50 SPF) (ACTX)...

journal_title：Current medical research and opinion

authors： Agozzino M,Russo T,Franceschini C,Mazzilli S,Garofalo V,Campione E,Bianchi L,Milani M,Argenziano G

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of epoetin theta and epoetin beta in anaemic patients with chronic kidney disease, undergoing haemodialysis and previously on stable maintenance therapy with epoetin beta. METHODS:In this multicentre, randomised, controlled, double-blind study 270 haemodialysis patients wer...

journal_title：Current medical research and opinion

authors： Gertz B,Kohler E,Kes P,Essaian A,Bias P,Buchner A,Elsässer R

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:Due to the high cost of nonvalvular atrial fibrillation (NVAF), this condition may be a suitable candidate for condition-specific bundled payments. This paper evaluates the healthcare cost of NVAF and uses common bleeding and stroke risk scores (HAS-BLED and CHA2DS2-VASc) to explore the risk-based healthcare...

journal_title：Current medical research and opinion

authors： Kaatz S,Coleman CI,Bookhart B,Laliberté F,Nelson WW,Brown K,Martin S,Schein J,Lefebvre P

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy of the cholesterol absorption inhibitor ezetimibe in patients with refractory familial hyperlipidaemia or intolerant to statin therapy. METHODS:This prospective study assessed the safety and efficacy of ezetimibe in 200 patients with refractory familial hyperlipidaemias not achiev...

journal_title：Current medical research and opinion

authors： Wierzbicki AS,Doherty E,Lumb PJ,Chik G,Crook MA

更新日期：2005-03-01 00:00:00

abstract：:Comparison of the methods of determination of conjugated catecholamines shows that, despite their variable absolute values, the relative proportions of the free and conjugated dopamine, norepinephrine and epinephrine are close (mean of 97.3% of dopamine, 73% of norepinephrine and 84% of epinephrine being conjugated) a...

journal_title：Current medical research and opinion

authors： Kuchel O,Buu NT

更新日期：1983-01-01 00:00:00