Abstract:
OBJECTIVE:The RED LEVEL study (REnal Disease: LErcanidipine Valuable Effect on urine protein Losses) directly compares, in an explorative fashion, the effects of lercanidipine + enalapril and amlodipine + enalapril combinations on renal parameters in hypertensive subjects. RESEARCH DESIGN AND METHODS:This was a 1 year, prospective, multi-center, randomized, open-label, blinded-endpoint (PROBE) study in hypertensive patients with albuminuria. MAIN OUTCOME MEASURES:Renal function (albuminuria, serum creatinine, creatinine clearance, estimated glomerular filtration rate and proteinuria); blood pressure. RESULTS:Albuminuria was significantly reduced, compared with baseline values, with the lercanidipine + enalapril combination over the entire study period; at month 3, month 6 and month 12, changes from baseline were: -162.5 (p-value = 0.0439), -425.8 (p-value = 0.0010), -329.0 (p-value = 0.0011) mg/24 h), respectively. On the other hand, this improvement was not observed with enalapril + amlodipine. Other parameters of renal function such as serum creatinine, creatinine clearance, estimated glomerular filtration rate and proteinuria did not change over the study. Both lercanidipine + enalapril and amlodipine + enalapril significantly reduced systolic and diastolic blood pressure values from baseline all over the study period with no significant differences between groups. Safety outcomes were comparable between the two groups. CONCLUSIONS:Overall, the results of this explorative study lend support to the anti-albuminuric effect of the lercanidipine + enalapril combination and to the long term renal-protective effects of this combination in patients with hypertension.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Robles NR,Calvo C,Sobrino J,Espinel E,Esteban R,Mateos L,Macias JFdoi
10.1080/03007995.2016.1218838subject
Has Abstractpub_date
2016-10-01 00:00:00pages
29-34issue
sup2eissn
0300-7995issn
1473-4877journal_volume
32pub_type
杂志文章,多中心研究,随机对照试验abstract::Twenty-seven patients with tennis elbow were treated with triamcinolone acetonide (40 mg/ml) injected locally into the tender area without local anaesthetic. Reduction of pain or complete relief was achieved in 1 to 72 hours, although in 9 cases exacerbation of pain occurred before relief was given. The recurrence rat...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998009109477
更新日期:1980-01-01 00:00:00
abstract::Comparison of the methods of determination of conjugated catecholamines shows that, despite their variable absolute values, the relative proportions of the free and conjugated dopamine, norepinephrine and epinephrine are close (mean of 97.3% of dopamine, 73% of norepinephrine and 84% of epinephrine being conjugated) a...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998309109831
更新日期:1983-01-01 00:00:00
abstract::Although the statistical strength of direct comparative randomized controlled trials is generally acknowledged, the particular demands of therapeutic decision making will often require indirect comparisons to be made, based on pooled data from multiple trials. As for all post-hoc analyses, the process of indirect comp...
journal_title:Current medical research and opinion
pub_type: 社论
doi:10.1185/03007995.2014.1002559
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Elevated glucose blood levels are the key criteria for diagnosing diabetes mellitus (DM). Hyperglycaemia contributes to the pathophysiology associated with DM, including microvascular and possibly macrovascular disease. In spite of a wide range of pharmacological options available to reduce hyperglycaemia in...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990802710422
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:Migraine is a chronic, disabling neurological disease affecting >1 billion people worldwide. Migraine remains undertreated in Asia, including Taiwan. Galcanezumab is a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide, a peptide firmly established in the pathophysiology of m...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1815181
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the effect of gliclazide modified release (MR) treatment on adiponectin, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) plasma concentrations in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:24 randomly selected type 2 diabetic patients, aged 61...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/030079906X132424
更新日期:2006-10-01 00:00:00
abstract:UNLABELLED:Abstract Background: The Schizophrenia Trial of Aripiprazole (STAR) showed superior efficacy for aripiprazole compared with atypical antipsychotic standard-of-care (SOC) for the community treatment of schizophrenia 1 based on the Investigator Assessment Questionnaire total score. OBJECTIVE:To determine the ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007995.2010.542745
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:Modern immunology has been extremely successful in elucidating many features of the immune system, but not in stemming pandemics of non-infectious, immune-related disease associated with industrialized populations. These pandemics involve a broad range of allergic, autoimmune, and inflammatory diseases, poten...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2012.695731
更新日期:2012-07-01 00:00:00
abstract::The effects of gemfibrozil were assessed in 27 hyperlipidaemic patients with stable peripheral arterial occlusive disease. Gemfibrozil (600 mg twice daily) was administered for 12 weeks after 2 weeks of placebo medication, thus enabling patients to act as their own controls. Serum cholesterol levels were reduced by a ...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007999009111649
更新日期:1990-01-01 00:00:00
abstract::Objective: The aim of this study was to investigate the impact of methodological choices in a meta-analysis of real-world evidence (RWE) comparing three non-vitamin-K antagonist oral anticoagulants with vitamin K antagonists (VKAs) for the treatment of patients with non-valvular atrial fibrillation (NVAF). Methods: Th...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1080/03007995.2019.1647020
更新日期:2019-11-01 00:00:00
abstract::Abstract A growing body of evidence suggests that targeting low-density lipoprotein cholesterol is not enough and that a substantial residual risk remains despite aggressive statin treatment, particularly in patients with mixed dyslipidemia. Statin plus fibrate combination results in a more effective control of severa...
journal_title:Current medical research and opinion
pub_type: 评论,社论
doi:10.1185/03007995.2010.505463
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Statins are hypothesized to have beneficial effects in asthma management through their pleiotropic anti-inflammatory effects. Several studies have examined this relationship, but have yielded conflicting results. This study investigates the effect of statin use on asthma-related hospitalizations and/or emerge...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2013.865599
更新日期:2014-04-01 00:00:00
abstract::Objective: The purpose of this study was to examine surgical and survival outcomes in the elderly (65-79 years of age) and the very elderly (≥80 years of age) who received surgery for gastric cancer.Methods: This study retrospectively reviewed the records of patients ≥65 years old who received a gastrectomy for gastri...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1520083
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:In order to reduce individual cardiovascular risk, many patients require life-long lipid-lowering therapy, often as a drug combination approach. We aimed to describe the usage pattern, effectiveness and tolerability of long-term treatment with lipid-lowering agents, with particular focus on an oral combinati...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1185/03007990802381406
更新日期:2008-10-01 00:00:00
abstract::Forty-nine patients participated in a randomized double-blind, parallel group comparison of beclomethasone dipropionate aqueous nasal spray with terfenadine tablets in the treatment of hay fever. Symptom scores for nasal and ocular symptoms as well as grass pollen counts were registered daily for at least 1 month. Eva...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998509109635
更新日期:1985-01-01 00:00:00
abstract:AIMS:Disease management programs (DMP) for diabetes mellitus (DM) or coronary heart disease (CHD) address the treatment of lipid disorders. The current registry aimed to compare drug utilization, lipid lowering effects and further outcomes of outpatients at high cardiovascular risk in DMP for DM or CHD compared to pati...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2015.1120715
更新日期:2016-01-01 00:00:00
abstract::Faecal blood loss arising from tenoxicam at a dose of 20 mg/day was compared to that arising from piroxicam at a dose of 20 mg/day in a double-blind, parallel comparative study in 12 healthy male volunteers. Faecal blood loss was measured for a 1-week run-in on placebo, during 4 weeks of treatment and for a 2-week pos...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines development group examined the properties of oral H(1)-antihistamines and made proposals about an 'optimal' drug. Several criteria should be met by oral H(1)-antihistamines in terms of their pharmacological, and clinical efficacy and safety pro...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2011.648263
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abstract:BACKGROUND:Control of arterial hypertension in obese or overweight patients is complicated since obesity directly contributes to increased blood pressure, requiring new, highly effective antihypertensive drugs. This study evaluates the efficacy of azilsartan medoxomil in real clinical practice. METHODS:An internationa...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1844647
更新日期:2020-12-07 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2012.678940
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journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
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更新日期:2010-06-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1257983
更新日期:2017-02-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998409109590
更新日期:1984-01-01 00:00:00
abstract::Compatibility of two types of needles with a variety of durable and prefilled injection pens for diabetes medication was tested by attaching the needles according to ISO 11608-2 and verifying penetration into the cartridge using air shots and two-dimensional X-rays. NovoFine* and NovoFine Autocover† attached correctly...
journal_title:Current medical research and opinion
pub_type: 信件
doi:10.1185/03007995.2010.547574
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:In ST-segment elevation myocardial infarction (STEMI), current guidelines discourage treatment of the non-culprit lesions at the time of the primary intervention. Latest trials have challenged this strategy suggesting benefit of early complete revascularization. We performed a Bayesian multiple treatment net...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1260534
更新日期:2017-03-01 00:00:00
abstract::A double-blind study was carried out to investigate the prophylactic use of single-dose cefuroxime in elective abdominal surgery. Twenty-three patients received 1.5 g cefuroxime by intravenous injection immediately prior to induction of anaesthesia; 24 patients received no antibiotics. In the cefuroxime group, there w...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998009109459
更新日期:1980-01-01 00:00:00
abstract::The effect of spironolactone in the alleviation of the symptoms of the premenstrual syndrome was compared with placebo in a double-blind, parallel group controlled study. One tablet daily of 100 mg spironolactone or placebo was given to 63 women from Day 12 of the menstrual cycle until the first day of the next menstr...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998709112403
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Based on the clear neuroanatomical delineation of many neuropathic pain (NP) symptoms, a simple tool for performing a short structured clinical encounter based on the IASP diagnostic criteria was developed to identify NP. This study evaluated its accuracy and usefulness. METHODS:A case-control study was perf...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1465905
更新日期:2018-08-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/030079906X148436
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Thymectomy is a standard treatment of myasthenia gravis (MG). Immunomodulating agents are frequently given during the post-thymectomy latency period until complete remission is fully consolidated, but serious side effects is a relevant clinical problem for patients on long-term immunomodulating treatment. O...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/030079906X104650
更新日期:2006-05-01 00:00:00