Lercanidipine valuable effect on urine protein losses: the RED LEVEL study.

Abstract:

OBJECTIVE:The RED LEVEL study (REnal Disease: LErcanidipine Valuable Effect on urine protein Losses) directly compares, in an explorative fashion, the effects of lercanidipine + enalapril and amlodipine + enalapril combinations on renal parameters in hypertensive subjects. RESEARCH DESIGN AND METHODS:This was a 1 year, prospective, multi-center, randomized, open-label, blinded-endpoint (PROBE) study in hypertensive patients with albuminuria. MAIN OUTCOME MEASURES:Renal function (albuminuria, serum creatinine, creatinine clearance, estimated glomerular filtration rate and proteinuria); blood pressure. RESULTS:Albuminuria was significantly reduced, compared with baseline values, with the lercanidipine + enalapril combination over the entire study period; at month 3, month 6 and month 12, changes from baseline were: -162.5 (p-value = 0.0439), -425.8 (p-value = 0.0010), -329.0 (p-value = 0.0011) mg/24 h), respectively. On the other hand, this improvement was not observed with enalapril + amlodipine. Other parameters of renal function such as serum creatinine, creatinine clearance, estimated glomerular filtration rate and proteinuria did not change over the study. Both lercanidipine + enalapril and amlodipine + enalapril significantly reduced systolic and diastolic blood pressure values from baseline all over the study period with no significant differences between groups. Safety outcomes were comparable between the two groups. CONCLUSIONS:Overall, the results of this explorative study lend support to the anti-albuminuric effect of the lercanidipine + enalapril combination and to the long term renal-protective effects of this combination in patients with hypertension.

journal_name

Curr Med Res Opin

authors

Robles NR,Calvo C,Sobrino J,Espinel E,Esteban R,Mateos L,Macias JF

doi

10.1080/03007995.2016.1218838

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

29-34

issue

sup2

eissn

0300-7995

issn

1473-4877

journal_volume

32

pub_type

杂志文章,多中心研究,随机对照试验
  • The treatment of tennis elbow with triamcinolone acetonide.

    abstract::Twenty-seven patients with tennis elbow were treated with triamcinolone acetonide (40 mg/ml) injected locally into the tender area without local anaesthetic. Reduction of pain or complete relief was achieved in 1 to 72 hours, although in 9 cases exacerbation of pain occurred before relief was given. The recurrence rat...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007998009109477

    authors: Nevelös AB

    更新日期:1980-01-01 00:00:00

  • Conjugated catecholamines and their measurement: some pharmacokinetic aspects.

    abstract::Comparison of the methods of determination of conjugated catecholamines shows that, despite their variable absolute values, the relative proportions of the free and conjugated dopamine, norepinephrine and epinephrine are close (mean of 97.3% of dopamine, 73% of norepinephrine and 84% of epinephrine being conjugated) a...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007998309109831

    authors: Kuchel O,Buu NT

    更新日期:1983-01-01 00:00:00

  • Appropriate use of information in therapeutic decision-making: reflections on indirect comparisons.

    abstract::Although the statistical strength of direct comparative randomized controlled trials is generally acknowledged, the particular demands of therapeutic decision making will often require indirect comparisons to be made, based on pooled data from multiple trials. As for all post-hoc analyses, the process of indirect comp...

    journal_title:Current medical research and opinion

    pub_type: 社论

    doi:10.1185/03007995.2014.1002559

    authors: Belsey JD

    更新日期:2015-02-01 00:00:00

  • From victim to ally: the kidney as an emerging target for the treatment of diabetes mellitus.

    abstract:BACKGROUND:Elevated glucose blood levels are the key criteria for diagnosing diabetes mellitus (DM). Hyperglycaemia contributes to the pathophysiology associated with DM, including microvascular and possibly macrovascular disease. In spite of a wide range of pharmacological options available to reduce hyperglycaemia in...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007990802710422

    authors: Bays H

    更新日期:2009-03-01 00:00:00

  • Safety and efficacy of galcanezumab in Taiwanese patients: a post-hoc analysis of phase 3 studies in episodic and chronic migraine.

    abstract:OBJECTIVE:Migraine is a chronic, disabling neurological disease affecting >1 billion people worldwide. Migraine remains undertreated in Asia, including Taiwan. Galcanezumab is a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide, a peptide firmly established in the pathophysiology of m...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2020.1815181

    authors: Yang CP,Lee CF,Dell'Agnello G,Hundemer HP,Lipsius S,Wang SJ

    更新日期:2020-10-01 00:00:00

  • Effect of gliclazide modified release on adiponectin, interleukin-6, and tumor necrosis factor-alpha plasma levels in individuals with type 2 diabetes mellitus.

    abstract:OBJECTIVE:The aim of the study was to evaluate the effect of gliclazide modified release (MR) treatment on adiponectin, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) plasma concentrations in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:24 randomly selected type 2 diabetic patients, aged 61...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章

    doi:10.1185/030079906X132424

    authors: Drzewoski J,Zurawska-Klis M

    更新日期:2006-10-01 00:00:00

  • Cost-effectiveness analysis of aripiprazole vs standard-of-care in the management of community-treated patients with schizophrenia: STAR study.

    abstract:UNLABELLED:Abstract Background: The Schizophrenia Trial of Aripiprazole (STAR) showed superior efficacy for aripiprazole compared with atypical antipsychotic standard-of-care (SOC) for the community treatment of schizophrenia 1 based on the Investigator Assessment Questionnaire total score. OBJECTIVE:To determine the ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1185/03007995.2010.542745

    authors: King D,Knapp M,Thomas P,Razzouk D,Loze JY,Kan HJ,van Baardewijk M

    更新日期:2011-02-01 00:00:00

  • A prescription for clinical immunology: the pills are available and ready for testing. A review.

    abstract:OBJECTIVE:Modern immunology has been extremely successful in elucidating many features of the immune system, but not in stemming pandemics of non-infectious, immune-related disease associated with industrialized populations. These pandemics involve a broad range of allergic, autoimmune, and inflammatory diseases, poten...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007995.2012.695731

    authors: Parker W,Perkins SE,Harker M,Muehlenbein MP

    更新日期:2012-07-01 00:00:00

  • Gemfibrozil in hyperlipidaemic patients with peripheral arterial disease: some undiscovered actions.

    abstract::The effects of gemfibrozil were assessed in 27 hyperlipidaemic patients with stable peripheral arterial occlusive disease. Gemfibrozil (600 mg twice daily) was administered for 12 weeks after 2 weeks of placebo medication, thus enabling patients to act as their own controls. Serum cholesterol levels were reduced by a ...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章

    doi:10.1185/03007999009111649

    authors: Stringer MD,Steadman CA,Kakkar VV

    更新日期:1990-01-01 00:00:00

  • Impact of methodological choices on a meta-analysis of real-world evidence comparing non-vitamin-K antagonist oral anticoagulants with vitamin K antagonists for the treatment of patients with non-valvular atrial fibrillation.

    abstract::Objective: The aim of this study was to investigate the impact of methodological choices in a meta-analysis of real-world evidence (RWE) comparing three non-vitamin-K antagonist oral anticoagulants with vitamin K antagonists (VKAs) for the treatment of patients with non-valvular atrial fibrillation (NVAF). Methods: Th...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,meta分析

    doi:10.1080/03007995.2019.1647020

    authors: Briere JB,Wu O,Bowrin K,Millier A,Toumi M,Taieb V,Levy P,Coleman CI

    更新日期:2019-11-01 00:00:00

  • Statin-fibrate combination for mixed dyslipidaemia: a limited option?

    abstract::Abstract A growing body of evidence suggests that targeting low-density lipoprotein cholesterol is not enough and that a substantial residual risk remains despite aggressive statin treatment, particularly in patients with mixed dyslipidemia. Statin plus fibrate combination results in a more effective control of severa...

    journal_title:Current medical research and opinion

    pub_type: 评论,社论

    doi:10.1185/03007995.2010.505463

    authors: Athyros VG,Tziomalos K,Karagiannis A,Mikhailidis DP

    更新日期:2010-09-01 00:00:00

  • Statin use in asthmatics on inhaled corticosteroids is associated with decreased risk of emergency department visits.

    abstract:OBJECTIVE:Statins are hypothesized to have beneficial effects in asthma management through their pleiotropic anti-inflammatory effects. Several studies have examined this relationship, but have yielded conflicting results. This study investigates the effect of statin use on asthma-related hospitalizations and/or emerge...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007995.2013.865599

    authors: Tse SM,Charland SL,Stanek E,Herrera V,Goldfarb S,Litonjua AA,Weiss ST,Wu AC

    更新日期:2014-04-01 00:00:00

  • An examination of surgical and survival outcomes in the elderly (65-79 years of age) and the very elderly (≥80 years of age) who received surgery for gastric cancer.

    abstract::Objective: The purpose of this study was to examine surgical and survival outcomes in the elderly (65-79 years of age) and the very elderly (≥80 years of age) who received surgery for gastric cancer.Methods: This study retrospectively reviewed the records of patients ≥65 years old who received a gastrectomy for gastri...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2018.1520083

    authors: Wong JU,Tai FC,Huang CC

    更新日期:2020-02-01 00:00:00

  • Sustained effects in hypercholesterolaemic patients on combined simvastatin/ezetimibe treatment: observational cohort study in clinical practice.

    abstract:BACKGROUND:In order to reduce individual cardiovascular risk, many patients require life-long lipid-lowering therapy, often as a drug combination approach. We aimed to describe the usage pattern, effectiveness and tolerability of long-term treatment with lipid-lowering agents, with particular focus on an oral combinati...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1185/03007990802381406

    authors: Hildemann SK,Barho C,Karmann B,Darius H,Bode C

    更新日期:2008-10-01 00:00:00

  • A comparative study of beclomethasone dipropionate aqueous nasal spray with terfenadine tablets in seasonal allergic rhinitis.

    abstract::Forty-nine patients participated in a randomized double-blind, parallel group comparison of beclomethasone dipropionate aqueous nasal spray with terfenadine tablets in the treatment of hay fever. Symptom scores for nasal and ocular symptoms as well as grass pollen counts were registered daily for at least 1 month. Eva...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007998509109635

    authors: Beswick KB,Kenyon GS,Cherry JR

    更新日期:1985-01-01 00:00:00

  • Better lipid target achievement for secondary prevention through disease management programs for diabetes mellitus and coronary heart disease in clinical practice in Germany.

    abstract:AIMS:Disease management programs (DMP) for diabetes mellitus (DM) or coronary heart disease (CHD) address the treatment of lipid disorders. The current registry aimed to compare drug utilization, lipid lowering effects and further outcomes of outpatients at high cardiovascular risk in DMP for DM or CHD compared to pati...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007995.2015.1120715

    authors: Gitt AK,Sonntag F,Jannowitz C,Weizel A,Karmann B,Schaefer JR,Pittrow D,Hildemann SK

    更新日期:2016-01-01 00:00:00

  • A comparison of faecal blood loss caused by tenoxicam and piroxicam in normal healthy male volunteers.

    abstract::Faecal blood loss arising from tenoxicam at a dose of 20 mg/day was compared to that arising from piroxicam at a dose of 20 mg/day in a double-blind, parallel comparative study in 12 healthy male volunteers. Faecal blood loss was measured for a 1-week run-in on placebo, during 4 weeks of treatment and for a 2-week pos...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007998509109629

    authors: Bird HA,Hill J,Haw WM,Dixon JS,Harris PA,Wright V

    更新日期:1985-01-01 00:00:00

  • Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review.

    abstract:BACKGROUND:The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines development group examined the properties of oral H(1)-antihistamines and made proposals about an 'optimal' drug. Several criteria should be met by oral H(1)-antihistamines in terms of their pharmacological, and clinical efficacy and safety pro...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007995.2011.648263

    authors: Bousquet J,Ansótegui I,Canonica GW,Zuberbier T,Baena-Cagnani CE,Bachert C,Cruz AA,González SN,Kuna P,Morais-Almeida M,Mullol J,Ryan DP,Sánchez-Borges M,Valiente R,Church MK

    更新日期:2012-01-01 00:00:00

  • An international multicenter observational non-interventional prospective study of the efficacy of azilsartan medoxomil in overweight or obese patients with arterial hypertension (CONSTANT).

    abstract:BACKGROUND:Control of arterial hypertension in obese or overweight patients is complicated since obesity directly contributes to increased blood pressure, requiring new, highly effective antihypertensive drugs. This study evaluates the efficacy of azilsartan medoxomil in real clinical practice. METHODS:An internationa...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2020.1844647

    authors: Chazova IE,Zhernakova YV

    更新日期:2020-12-07 00:00:00

  • Incretin-based therapies and cardiovascular risk.

    abstract:BACKGROUND:Glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase 4 (DPP4) inhibitors are currently used as glucose-lowering agents in type 2 diabetes, due to their effects on insulin and glucagon secretion. These agents, which are effective in improving glucose control, could also have a beneficial...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007995.2012.678940

    authors: Mannucci E,Dicembrini I

    更新日期:2012-05-01 00:00:00

  • Omalizumab in children with inadequately controlled severe allergic (IgE-mediated) asthma.

    abstract:BACKGROUND:Many children with severe persistent allergic (IgE-mediated) asthma remain inadequately controlled despite treatment with high-dose inhaled corticosteroids (ICS) plus a long-acting beta(2)-agonist (LABA). RESEARCH AND DESIGN METHODS:This pre-specified analysis of a randomized, double-blind, placebo-controll...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,随机对照试验

    doi:10.1185/03007991003771338

    authors: Kulus M,Hébert J,Garcia E,Fowler Taylor A,Fernandez Vidaurre C,Blogg M

    更新日期:2010-06-01 00:00:00

  • Comparison of health utility weights among elderly patients receiving breast-conserving surgery plus hormonal therapy with or without radiotherapy.

    abstract:BACKGROUND:The selection of the most appropriate treatment combinations requires the balancing of benefits and harms of these treatment options as well as the patients' preferences for the resulting outcomes. OBJECTIVE:This research aimed at estimating and comparing the utility weights between elderly women with early...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2016.1257983

    authors: Ali AA,Xiao H,Tawk R,Campbell E,Semykina A,Montero AJ,Diaby V

    更新日期:2017-02-01 00:00:00

  • Controlled clinical investigation of dimetophrine versus midodrine in the management of moderately decreased arterial blood pressure.

    abstract::An open, controlled study was carried out in 30 in-patients with low arterial pressure syndrome to compare the effectiveness and tolerance of dimetophrine and midodrine in restoring blood pressure to normal levels and relieving symptoms. Patients were allocated at random to receive treatment for 15 days with either 10...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007998409109590

    authors: Marini U,Cecchi A,Venturini M

    更新日期:1984-01-01 00:00:00

  • Compatibility testing of two types of pen needles with a range of injection pens for diabetes medication.

    abstract::Compatibility of two types of needles with a variety of durable and prefilled injection pens for diabetes medication was tested by attaching the needles according to ISO 11608-2 and verifying penetration into the cartridge using air shots and two-dimensional X-rays. NovoFine* and NovoFine Autocover† attached correctly...

    journal_title:Current medical research and opinion

    pub_type: 信件

    doi:10.1185/03007995.2010.547574

    authors: Buus P,Lilleøre SK,Larsen K

    更新日期:2011-03-01 00:00:00

  • Pathfinding to an optimal strategy of revascularization in primary coronary intervention in patients with multivessel disease: a network meta-analysis of randomized trials.

    abstract:OBJECTIVES:In ST-segment elevation myocardial infarction (STEMI), current guidelines discourage treatment of the non-culprit lesions at the time of the primary intervention. Latest trials have challenged this strategy suggesting benefit of early complete revascularization. We performed a Bayesian multiple treatment net...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2016.1260534

    authors: Komócsi A,Kehl D,d'Ascenso F,DiNicolantonio J,Vorobcsuk A

    更新日期:2017-03-01 00:00:00

  • Single-dose cefuroxime in the prophylaxis of abdominal wound sepsis.

    abstract::A double-blind study was carried out to investigate the prophylactic use of single-dose cefuroxime in elective abdominal surgery. Twenty-three patients received 1.5 g cefuroxime by intravenous injection immediately prior to induction of anaesthesia; 24 patients received no antibiotics. In the cefuroxime group, there w...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007998009109459

    authors: Lambert WG,Mullinger BM

    更新日期:1980-01-01 00:00:00

  • A double-blind, placebo-controlled evaluation of spironolactone in the premenstrual syndrome.

    abstract::The effect of spironolactone in the alleviation of the symptoms of the premenstrual syndrome was compared with placebo in a double-blind, parallel group controlled study. One tablet daily of 100 mg spironolactone or placebo was given to 63 women from Day 12 of the menstrual cycle until the first day of the next menstr...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007998709112403

    authors: Vellacott ID,Shroff NE,Pearce MY,Stratford ME,Akbar FA

    更新日期:1987-01-01 00:00:00

  • Diagnostic accuracy of an identification tool for localized neuropathic pain based on the IASP criteria.

    abstract:OBJECTIVE:Based on the clear neuroanatomical delineation of many neuropathic pain (NP) symptoms, a simple tool for performing a short structured clinical encounter based on the IASP diagnostic criteria was developed to identify NP. This study evaluated its accuracy and usefulness. METHODS:A case-control study was perf...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2018.1465905

    authors: Mayoral V,Pérez-Hernández C,Muro I,Leal A,Villoria J,Esquivias A

    更新日期:2018-08-01 00:00:00

  • Lipid-lowering effects of colesevelam HCl in combination with ezetimibe.

    abstract:OBJECTIVE:The primary aim of this study was to compare the effect of colesevelam HCl in combination with ezetimibe to ezetimibe monotherapy on low-density lipoprotein cholesterol (LDL-C) levels in subjects with primary hypercholesterolemia. METHODS:Subjects with primary hypercholesterolemia (N = 86) were enrolled in a...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1185/030079906X148436

    authors: Bays H,Rhyne J,Abby S,Lai YL,Jones M

    更新日期:2006-11-01 00:00:00

  • Experience with starting tacrolimus postoperatively after transsternal extended thymectomy in patients with myasthenia gravis.

    abstract:BACKGROUND:Thymectomy is a standard treatment of myasthenia gravis (MG). Immunomodulating agents are frequently given during the post-thymectomy latency period until complete remission is fully consolidated, but serious side effects is a relevant clinical problem for patients on long-term immunomodulating treatment. O...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章

    doi:10.1185/030079906X104650

    authors: Ponseti JM,Azem J,Fort JM,López-Cano M,Vilallonga R,Gamez J,Armengol M

    更新日期:2006-05-01 00:00:00