Abstract:
OBJECTIVE:Vesicoureteral reflux (VUR) occurs in approximately 1% of infants and children and is associated with recurrent urinary tract infections (UTIs). The objective of this paper is to examine the use of endoscopic injection with dextranomer/hyaluronic acid copolymer (Dx/HA) as a curative option and as an alternative to antibiotic prophylaxis, as Dx/HA is gaining in popularity in the treatment of VUR. METHODS:The nationally representative PharMetrics Integrated Medical and Pharmaceutical database was used to conduct this retrospective analysis. Patients < 11 years of age who were continuously eligible and had an International Classification of Diseases (ICD-9-CM) code for VUR were identified. Resource utilization and outcome measures were evaluated over a 6-month pre- and 12-month post-index period. Patients diagnosed with neuropathic bladder, posterior urethral valves, bladder exstrophy, ureterocele, or duplication anomaly were excluded. Patients were matched 3 : 1, antibiotic prophylaxis to Dx/HA, by age, gender, urinary tract infections (UTIs) prior to index date, and diagnosing physician specialty. The primary outcome assessed was UTIs. RESULTS:Of the matched patients, 114 received a prescription for antibiotic prophylaxis and 38 underwent endoscopic injection with Dx/HA between January 2000 and December 2004. The average number of UTIs per year was 0.28 in the antibiotic cohort and 0.08 in the Dx/HA cohort, respectively. The incidence rate ratio (IRR) of 4.826 (p = 0.029) revealed that the average number of UTIs was 383% higher for patients receiving antibiotic prophylaxis compared with patients who underwent endoscopic injection. The retrospective nature of the analysis did not allow for treatment randomization. Due to the stringent classification of UTIs, rates of UTIs may be underestimated in both cohorts. CONCLUSIONS:Treatment with endoscopic injection with Dx/HA resulted in significantly fewer UTIs compared with children receiving antibiotic prophylaxis, supporting a role for Dx/HA as a first-line treatment option for patients with VUR.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Elder JS,Shah MB,Batiste LR,Eaddy Mdoi
10.1185/030079907X226230subject
Has Abstractpub_date
2007-09-01 00:00:00pages
S15-20eissn
0300-7995issn
1473-4877journal_volume
23 Suppl 4pub_type
杂志文章,评审abstract::Aims: We sought to investigate the reasons for, and rates of, novel oral anticoagulant (DOAC) therapy discontinuation.Methods: This was an observational cohort study of patients with atrial fibrillation (AF) referred to a regional DOAC outpatient clinic between February 2013 and October 2017. The study population cons...
journal_title:Current medical research and opinion
pub_type: 杂志文章
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abstract::Oxaprozin (4,5-diphenyl-2-oxazolepropionic acid) is a non-steroidal anti-inflammatory drug (NSAID) which is effective in models of inflammation, pain and pyrexia. It is effective and well tolerated in the clinical management of adult rheumatoid arthritis (RA), osteoarthritis (OA), ankylosing spondylitis, soft tissue d...
journal_title:Current medical research and opinion
pub_type: 评论,社论
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abstract:OBJECTIVE:The prevalence of non-steroidal anti-inflammatory drug (NSAID) and concurrent gastroprotective agent (GPA) use in the US is not known. As such, the prevalence of GPA use among arthritis patients taking NSAIDs was examined. METHODS:Men and women aged ≥ 40 with self-reported arthritis and members of a web-base...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
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更新日期:2013-05-01 00:00:00
abstract::Discussions on the healthy volunteer in clinical investigation do not attempt to define normality. In 34 healthy volunteers, 1653 biochemical and haematological tests were performed. The incidence of abnormal results was 11%. Only 4 subjects had all tests within normal limits and when these repeated only 1 subject sti...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997609109302
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abstract:OBJECTIVE:Significant race and ethnic disparities exist in diabetes-related health care. Using a nationally representative database, we sought to determine if use of thiazolidinediones (TZDs) differs by race and ethnicity. As a secondary objective, we sought to determine if race and ethnicity is associated with use of ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079906X167354
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998709112403
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abstract::A study was carried out to compare attitudes, perceptions and experiences of general practitioners and patients who had treated/suffered from herpes zoster, or shingles, in the recent past. Randomized samples of 224 general practitioners and 236 patients were drawn from different locations in Italy, Germany and the Un...
journal_title:Current medical research and opinion
pub_type: 杂志文章
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abstract::Objective: Determine healthcare resource utilization (HCRU) and costs associated with fatigue and stiffness among patients with rheumatoid arthritis (RA).Methods: A retrospective claims analysis compared RA patients with fatigue or stiffness to matched RA control patients with neither. Claims from a large US commercia...
journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
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abstract:OBJECTIVE:To determine the efficacy and safety of lumiracoxib for knee osteoarthritis (OA). METHODS:This was a 13-week, multicentre, randomized, double-blind, double-dummy, placebo-controlled study. Males or females aged >/= 18 years with primary knee OA received lumiracoxib 100 mg od, lumiracoxib 100 mg od with a loa...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1185/030079905x38196
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
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更新日期:1978-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:We recently reported the efficacy of rofecoxib in two randomized controlled trials in chronic low back pain (CLBP). The objectives of this report are to present data regarding the onset of efficacy of rofecoxib from these trials and propose methods for reporting onset. RESEARCH DESIGN AND METHODS:Patients we...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-05-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
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journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-08-01 00:00:00
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更新日期:2020-04-01 00:00:00