The selection of healthy volunteers for clinical investigation: the case for volunteer pools.

abstract：OBJECTIVE:Ramelteon is an MT(1)/MT(2) melatonin receptor agonist indicated for the treatment of insomnia characterized by difficulty with sleep onset. In previous clinical studies, ramelteon reduced latency to persistent sleep (LPS) in subjects with chronic insomnia. The goal of the current analysis was to determine th...

journal_title：Current medical research and opinion

authors： Wang-Weigand S,McCue M,Ogrinc F,Mini L

更新日期：2009-05-01 00:00:00

abstract：:The use of steroid compounds formulated in oil for depot injection can be associated with acute pulmonary reactions characterized primarily by cough, but sometimes with other associated symptoms. The pathophysiology of these reactions remains unclear, although they are reported in the literature as 'POMEs' or pulmonar...

journal_title：Current medical research and opinion

authors： Meyer RJ,Mann M

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To evaluate costs associated with prostaglandin analogs among newly-diagnosed glaucoma patients in a managed-care population. RESEARCH DESIGN AND METHODS:A cost minimization model compared annual costs for patients initiating therapy with one of the three prostaglandin analogs (bimatoprost, latanoprost, trav...

journal_title：Current medical research and opinion

authors： Schmier JK,Covert DW,Robin AL

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To determine resource utilization in controller naïve children diagnosed with asthma receiving initial therapy with fluticasone propionate (FP) and salmeterol (SAL) in a single inhaler (FSC), FP alone, montelukast (MON), inhaled corticosteroid (ICS) + SAL from separate inhalers, or ICS + MON. RESEARCH DESIGN...

journal_title：Current medical research and opinion

authors： Stempel DA,Riedel AA,Carranza Rosenzweig JR

更新日期：2006-03-01 00:00:00

abstract：:The term "mixed pain" is increasingly applied for specific clinical scenarios, such as low back pain, cancer pain and postsurgical pain, in which there "is a complex overlap of the different known pain types (nociceptive, neuropathic, nociplastic) in any combination, acting simultaneously and/or concurrently to cause ...

journal_title：Current medical research and opinion

authors： Freynhagen R,Rey R,Argoff C

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Differences between interferons have been evaluated for over 20 years. While randomized controlled trial (RCT) data is mainly used for assessments and strong data for causal inferences, it does not necessarily reflect everyday practice. Real-world data may provide additional information. PURPOSE:To assess t...

journal_title：Current medical research and opinion

authors： Einarson TR,Bereza BG,Machado M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Untreated and under-treated pain represent one of the most pervasive health problems, which is worsening as the population ages and accrues risk for pain. Multiple treatment options are available, most of which have one mechanism of action, and cannot be prescribed at unlimited doses due to the ceiling of ef...

journal_title：Current medical research and opinion

authors： Varrassi G,Hanna M,Macheras G,Montero A,Montes Perez A,Meissner W,Perrot S,Scarpignato C

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) and fingolimod are approved oral disease-modifying treatments for relapsing-remitting multiple sclerosis. In phase 3 trials, DMF (DEFINE/CONFIRM) and fingolimod (FREEDOMS/FREEDOMS II) resulted in significant reductions in clinical and...

journal_title：Current medical research and opinion

authors： Fox RJ,Chan A,Zhang A,Xiao J,Levison D,Lewin JB,Edwards MR,Marantz JL

更新日期：2017-02-01 00:00:00

abstract：:Although the statistical strength of direct comparative randomized controlled trials is generally acknowledged, the particular demands of therapeutic decision making will often require indirect comparisons to be made, based on pooled data from multiple trials. As for all post-hoc analyses, the process of indirect comp...

journal_title：Current medical research and opinion

authors： Belsey JD

更新日期：2015-02-01 00:00:00

abstract：:A study was carried out in general practice to assess the clinical effectiveness and tolerability of the oral cephalosporin, cefuroxime axetil, in the treatment of 369 patients presenting with acute infections of the upper respiratory tract. The main diagnoses were tonsillitis, pharyngitis, sinusitis and otitis media....

journal_title：Current medical research and opinion

authors： Griffiths GK,VandenBurg MJ,Wight LJ,Gudgeon AC,Kelsey M

更新日期：1987-01-01 00:00:00

abstract：:Objective: The aim of this study was to provide recommendations for improving the design of subsequent studies through analysis of the registered coronavirus disease 2019 (COVID-19) clinical trials.Methods: A retrospective analysis of 189 trial retrievals achieved on 20 February 2020.Results: A total of 189 trials are...

journal_title：Current medical research and opinion

authors： Wang B,Lai J,Yan X,Jin F,Yao C

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Persisting pain is demoralising and debilitating for patients and their carers. Most patients with chronic pain do not need the services of a specialised pain clinic and are appropriately managed by their general practitioner (GP). METHOD:Interviewers approached 569 GPs to assess their satisfaction with the...

journal_title：Current medical research and opinion

authors： Stannard C,Johnson M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis is one of the most common forms of arthritis seen in primary care. Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in the management of osteoarthritis. However, gastrointestinal (GI) side effects limit their use. Cyclooxygenase-2 (COX-2) selective inhibitors exhibit better...

journal_title：Current medical research and opinion

authors： Pareek A,Chandanwale AS,Oak J,Jain UK,Kapoor S

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Consensus health panels, including the Joint British Societies (JBS), have established increasingly stringent cholesterol goals. However, in clinical settings, most patients do not achieve even the less stringent goals. OBJECTIVE:To provide descriptive data on the proportion of patients in the United Kingdo...

journal_title：Current medical research and opinion

authors： Rajagopalan S,Alemao E,Finch L,Yin D

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:The Exenatide BID Observational Study (ExOS) was designed to evaluate the clinical effectiveness of exenatide BID use in patients with type 2 diabetes (T2D) in a real-world clinical practice setting in the United States. METHODS:Patients were enrolled from 74 practice sites from 9/2007 through 1/2009 and fol...

journal_title：Current medical research and opinion

authors： Bergenstal RM,Garrison LP Jr,Miller LA,Hou L,Blickensderfer A,Zagar A,Stanley S,Bhargava A,Wade R,Herman WH

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To determine the effects of long-term atomoxetine treatment on sexual development in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) as compared with placebo and with a national US survey in non-Hispanic white children and adolescents. METHODS:This double-blind, placebo-controll...

journal_title：Current medical research and opinion

authors： Trzepacz PT,Spencer TJ,Zhang S,Bangs ME,Witte MM,Desaiah D

更新日期：2011-01-01 00:00:00

abstract：:Oesophageal mucosa has well established protective mechanisms, which operate within pre-epithelial, epithelial and post-epithelial compartments. Since refluxed acid and pepsin always act from the luminal side of the mucosa, protective factors like EGF, operating as a part of pre-epithelial defence, are thought to be p...

journal_title：Current medical research and opinion

authors： Marcinkiewicz M,Grabowska SZ,Czyzewska E

更新日期：1998-01-01 00:00:00

abstract：:Evidence is needed to guide therapeutic decisions on patients who had ischaemic cerebral events. The recently published European/Australasian Stroke Prevention in Reversible Ischaemia Trial (ESPRIT), an open-label randomised controlled study, compared long-term treatment of patients randomised to aspirin 30-325 mg dai...

journal_title：Current medical research and opinion

authors： Einhäupl K

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical efficacy and safety of mometasone furoate administered via a dry powder inhaler (MF-DPI) in Japanese patients with intermittent or mild persistent asthma who were not previously receiving inhaled corticosteroids. RESEARCH DESIGN AND METHODS:This was an 8-week open-label study conduct...

journal_title：Current medical research and opinion

authors： Tohda Y,Miyamoto T

更新日期：2010-01-01 00:00:00

abstract：:The glomerular and tubular function of 7 patients with a spectrum of renal impairment was measured before, during and after 4-days' treatment with cefuroxime and gentamicin. Neither the mean plasma urea nor creatinine concentrations of the group increased after combined treatment, nor was the excretion of cefuroxime s...

journal_title：Current medical research and opinion

authors： Cockram CS,Richards P,Bax RP

更新日期：1980-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia seen in clinical practice and has attracted much attention due to its association with a substantial mortality and morbidity, particularly from stroke, thromboembolism and heart failure. This Editorial Commentary provides a brief overview of the ...

journal_title：Current medical research and opinion

authors： Khoo CW,Lip GY

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Patients with type 2 diabetes (T2DM) often have multiple comorbidities which may impact the selection of antihyperglycemic therapies. The purpose of this study was to quantify the prevalence and co-prevalence of common comorbidities. RESEARCH DESIGN AND METHODS:A retrospective study was conducted using the Q...

journal_title：Current medical research and opinion

authors： Iglay K,Hannachi H,Joseph Howie P,Xu J,Li X,Engel SS,Moore LM,Rajpathak S

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:A proactive, multifactorial intervention strategy incorporating single-pill amlodipine/atorvastatin (SPAA) (5-10/10 mg up-titrated to 5-10/20 mg, where approved) is more effective than physician's usual care (UC) for reducing calculated 10 year coronary heart disease (CHD) risk, in patients with hypertension ...

journal_title：Current medical research and opinion

authors： Hradec J,Zamorano J,Sutradhar S

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:To compare 1-year direct healthcare costs and utilization among children and adolescents initiating non-stimulant medications atomoxetine (ATX) or extended-release guanfacine (GXR). METHODS:In this retrospective, observational cohort study, children and adolescents aged 6-17 years with attention deficit/hyp...

journal_title：Current medical research and opinion

authors： Molife C,Haynes VS,Nyhuis A,Faries DE,Gelwicks S,Kelsey DK,Alatorre CI

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To provide clinically relevant information on tadalafil 2.5 or 5 mg once daily for the treatment of erectile dysfunction (ED), by reviewing safety and efficacy study findings. Findings from an integrated analysis of trials of tadalafil 10 and 20 mg as needed are presented to provide context for the daily dosi...

journal_title：Current medical research and opinion

authors： Donatucci CF,Wong DG,Giuliano F,Glina S,Dowsett SA,Watts S,Sorsaburu S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Over the last two decades the development and analysis of a number of registries have enhanced the knowledge of the epidemiology, presentation, natural history, and pathophysiology of pulmonary arterial hypertension (PAH). The understanding of the effectiveness of available treatments has also been greatly i...

journal_title：Current medical research and opinion

authors： Poscia R,Ghio S,D'Alto M,Vitulo P,Mulè M,Albera C,Parisi F,Badagliacca R,Fedele F,Vizza CD

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To investigate whether gum chewing affects perceived levels of everyday stress among persons who (1) regularly chew gum or (2) do not chew gum on a regular basis. RESEARCH DESIGN AND METHODS:Two Internet-based studies were conducted. Study 1 enrolled participants who chewed gum > or =4 days per week, chewed ...

journal_title：Current medical research and opinion

authors： Zibell S,Madansky E

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:A double-blind randomized trial evaluated the efficacy and tolerability of rivastigmine and donepezil in patients with Alzheimer's disease (AD) over 2 years. Baseline data indicated that some patients had symptoms suggestive of concomitant Lewy body disease. This retrospective analysis investigated whether A...

journal_title：Current medical research and opinion

authors： Touchon J,Bergman H,Bullock R,Rapatz G,Nagel J,Lane R

更新日期：2006-01-01 00:00:00

abstract：:A double-blind trial was carried out in 45 anxious out-patients to compare the effectiveness and tolerance of clobazam and diazepam. The severity of each patient's symptoms was assessed before, during and at the end of the trial period using the Hamilton Anxiety Rating Scale, and a note kept of any side-effects. The r...

journal_title：Current medical research and opinion

authors： Botter PA

更新日期：1980-01-01 00:00:00

abstract：:A multi-centre, double-blind trial was carried out in general practice in 44 patients with symptoms of neurotic anxiety to compare the effects of treatment with either 400 mg chlormezanone at night or 5 mg diazepam 3-times daily for 4 weeks. The results indicated tht there were similar improvements in anxiety, duratio...

journal_title：Current medical research and opinion

authors： Allin DM

更新日期：1982-01-01 00:00:00