Double-blind comparison of zopiclone and flunitrazepam in elderly insomniacs with special focus on residual effects.

abstract：:Three methods for the determination of azapropazone were studied for the analysis of blood plasma samples taken after oral administration of azapropazone. A gas chromatographic method was compared with two simple spectrophotometric assay methods and the effect of metabolites of the drug on each method is described. It...

journal_title：Current medical research and opinion

authors： Leach H

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:As of 2012, nearly 10% of Americans had diabetes mellitus. People with diabetes are at approximately double the risk of premature death compared with those in the same age groups without the condition. While the prevalence of diabetes has risen across all racial/ethnic groups over the past 30 years, rates ar...

journal_title：Current medical research and opinion

authors： Ferdinand KC,Nasser SA

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To determine the effects of long-term atomoxetine treatment on sexual development in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) as compared with placebo and with a national US survey in non-Hispanic white children and adolescents. METHODS:This double-blind, placebo-controll...

journal_title：Current medical research and opinion

authors： Trzepacz PT,Spencer TJ,Zhang S,Bangs ME,Witte MM,Desaiah D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Basal cell carcinoma (BCC) is the most common cancer. Most cases of BCCs are treated with only optimal surgical resection. However, unresectable, locally advanced or metastatic tumors might have potential to progress. In this patient group, there is no standardized treatment approach. Vismodegib is a new sel...

journal_title：Current medical research and opinion

authors： Erdem GU,Sendur MA,Ozdemir NY,Yazıcı O,Zengin N

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To review the evidence evaluating the efficacy of vardenafil in subgroups of hypertensive patients with erectile dysfunction (ED). METHODS:Meta-analysis of randomized, double-blinded, placebo-controlled, flexible-dose vardenafil clinical trials that were >or=12 weeks in duration evaluated men with a >or=6-mo...

journal_title：Current medical research and opinion

authors： Shabsigh R,Duval S,Shah M,Regan TS,Juhasz M,Veltry LG

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To examine the impact of an electronic data capture system on patient satisfaction and patient-physician interactions in a rheumatology clinical setting. STUDY DESIGN:In this multicenter study, 1079 patients with rheumatoid arthritis completed questionnaires quarterly about their health and satisfaction with...

journal_title：Current medical research and opinion

authors： Huffstutter J,Craig WD,Schimizzi G,Harshbarger J,Lisse J,Kasle S,Hymson L,Yocum D,Castro L,Hegedus R,Callegari P,Yeilding N,Gilmer K

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Significant race and ethnic disparities exist in diabetes-related health care. Using a nationally representative database, we sought to determine if use of thiazolidinediones (TZDs) differs by race and ethnicity. As a secondary objective, we sought to determine if race and ethnicity is associated with use of ...

journal_title：Current medical research and opinion

authors： Aquilante CL,Zhang W,McCollum M

更新日期：2007-03-01 00:00:00

abstract：:A double-blind, crossover study was carried out in 31 patients with rheumatoid arthritis or osteoarthritis who suffered from insomnia which was considered to be caused primarily by their disease. Patients received 7-day courses of 400 mg chlormezanone, 200 mg chlormezanone and placebo in a pre-determined random order....

journal_title：Current medical research and opinion

authors： Wojtulewski JA,Walter J

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:The fentanyl HCl iontophoretic transdermal system (ITS) is a patient-controlled analgesic delivery system that actively administers bolus doses of fentanyl transdermally upon patient activation. OBJECTIVE:To determine the amount of fentanyl absorbed from fentanyl ITS via passive absorption over a 24.5-h per...

journal_title：Current medical research and opinion

authors： Sathyan G,Phipps B,Gupta SK

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:Tumor necrosis factor (TNF) antagonists, most frequently prescribed biologics for moderate to severe rheumatoid arthritis (RA), are subject to dose escalation. Even though different methods have been employed to estimate the timing and magnitude of dose escalation, there is no consensus on which method is op...

journal_title：Current medical research and opinion

authors： Huang X,Gu NY,Fox KM,Harrison DJ,Globe D

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Recent survey data have reported the incidence rate of needlestick injuries (NIs) and NIs which draw blood sustained by nurses caring for patients with diabetes in an in-patient hospital setting. The purpose of this study was to deduce the potential short-term annual economic impact resulting from such NI, and ...

journal_title：Current medical research and opinion

authors： Lee WC,Nicklasson L,Cobden D,Chen E,Conway D,Pashos CL

更新日期：2005-12-01 00:00:00

abstract：:Sodium meclofenamate (200 to 400 mg daily) was compared with aspirin (2.4 to 4.8 g daily) for the treatment of rheumatoid arthritis in a 6-month, double-blind, multicentre study. Two groups of patients participated, one receiving stabilized doses of concomitant gold or steroid therapy and one not receiving such therap...

journal_title：Current medical research and opinion

authors： Gowans JD

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To describe the impact of migraine on psychological well-being of young women and to evaluate their communication with physicians about migraine. RESEARCH DESIGN AND METHODS:This cross-sectional telephone survey was conducted in Israel and eight European countries (Finland, Germany, Greece, Italy, Norway, Sp...

journal_title：Current medical research and opinion

authors： Dueland AN,Leira R,Cabelli ST

更新日期：2005-08-01 00:00:00

abstract：:Elevated serum cholesterol level is a key risk factor for cardiovascular morbidity and mortality. Cerivastatin is a highly effective lipid-lowering agent currently licensed at doses of 0.1, 0.2, 0.3 and 0.4 mg. This was a multicentre, randomised, double-blind, parallel-group study comparing the efficacy and safety of ...

journal_title：Current medical research and opinion

authors： Ose L,Luurila O,Eriksson J,Olsson A,Lithell H,Widgren B

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:The European Forsteo Observational Study (EFOS) study was primarily designed to assess fracture incidence, degree of pain, health-related quality of life (HRQoL) and compliance in women prescribed teriparatide in a community setting. This report describes the design of the study and characteristics of the pat...

journal_title：Current medical research and opinion

authors： Rajzbaum G,Jakob F,Karras D,Ljunggren O,Lems WF,Langdahl BL,Fahrleitner-Pammer A,Walsh JB,Gibson A,Tynan AJ,Marin F

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:This study assesses the direct (medical and drugs) and indirect (work loss) annual costs associated with Atrial Fibrillation (AFIB) in a privately insured population. BACKGROUND:AFIB is the most common sustained rhythm disturbance, affecting 2.3 million people in the United States. METHODS:Cost and co-morbi...

journal_title：Current medical research and opinion

authors： Wu EQ,Birnbaum HG,Mareva M,Tuttle E,Castor AR,Jackman W,Ruskin J

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Pseudomonas aeruginosa is a difficult-to-treat bacterial pathogen often isolated from patients with serious nosocomial infections. The goal of this analysis is to present the clinical and microbiologic effectiveness of doripenem in the treatment of infections due to P. aeruginosa. RESEARCH DESIGN AND METHODS...

journal_title：Current medical research and opinion

authors： Jenkins SG,Fisher AC,Peterson JA,Nicholson SC,Kaniga K

更新日期：2009-12-01 00:00:00

abstract：:Effective management of influenza depends on early recognition of influenza in the community and on rapid diagnosis. Early recognition is achieved by integrated clinical and laboratory based surveillance programmes in representative populations. The recent introduction of 'near patient tests' for influenza provide inc...

journal_title：Current medical research and opinion

authors： Fleming D,Wood M

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Several different durable or disposable insulin pen delivery devices are currently available, and newer, improved devices are being introduced. One prefilled insulin device, FlexPen (FP), has recently been improved (known as the Next Generation FlexPen (NGFP) in Europe or the improved FlexPen in the United St...

journal_title：Current medical research and opinion

authors： Niskanen L

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treatment of predominantly cystic thyroid nodules. MATERIALS AND METHODS:This prospective study included 111 patients with 122 benign predominantly cystic thyroid nodules inducing pressure symptoms or cosmetic problems. The no...

journal_title：Current medical research and opinion

authors： Gong X,Zhou Q,Chen S,Wang F,Wu W,Chen X

更新日期：2017-08-01 00:00:00

abstract：:A study was carried out to determine the efficacy and long-term safety of dantrolene in treating stroke patients with spasticity limiting rehabilitation. Fifteen of the 18 patients studied experienced reduction in spasticity and clinical improvement after treatment with dantrolene sodium for 6 weeks. Fourteen of these...

journal_title：Current medical research and opinion

authors： Ketel WB,Kolb ME

更新日期：1984-01-01 00:00:00

abstract：:A double-blind trial was carried out in 37 patients with osteoarthrosis to compare the efficacy and tolerance of 250 mg diflunisal twice daily with that of 400 mg ibuprofen 3-times daily over an 8-week period. Rating scale assessments were made, at the end of a preceding 1-week, wash-out period on placebo and at regul...

journal_title：Current medical research and opinion

authors： Bresnihan B,Hughes G,Essigman WK

更新日期：1978-01-01 00:00:00

abstract：OBJECTIVE:To compare glycemic goal achievement (HbA(1c) < 7%) in type 2 diabetes patients receiving initial metformin plus pioglitazone combination therapy and initial metformin monotherapy augmented with pioglitazone in a cohort follow-up study. RESEARCH DESIGN AND METHODS:Adult patients were identified from the Inge...

journal_title：Current medical research and opinion

authors： Pandya BJ,Bron M,McCall T,Yu AP,Chen KS,Mattson ME,Wu EQ

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To evaluate inpatient oral anticoagulant (OAC) treatment, discharge location, and post-discharge OAC treatment for patients hospitalized with non-valvular atrial fibrillation (NVAF). RESEARCH DESIGN AND METHODS:Retrospective study using claims data linked to hospital electronic health records (EHR). Patients...

journal_title：Current medical research and opinion

authors： Henk HJ,Cao F,Tuell K,Price K,Singh P,Mardekian J,Odell K,Patel C,Tan W,Sands GH,Singhal S,Trocio J,Vo L

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score <19 as a threshold for moderate to severe dry eye disease (DED). METHODS:A phase III, randomized, controlled...

journal_title：Current medical research and opinion

authors： Doan S,Bremond-Gignac D,Chiambaretta F

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age. METHODS:MEDLINE (1950 to November 2008), EMBASE (1980 to November 2008), The Cochrane Library (2007, Issue 3), ACP Journal...

journal_title：Current medical research and opinion

authors： Southey ER,Soares-Weiser K,Kleijnen J

更新日期：2009-09-01 00:00:00

abstract：:The efficacy of etodolac (600 mg/day) and placebo were compared in a 4-week double-blind, parallel-group study involving 104 patients with osteoarthritis of the knee and 106 with osteoarthritis of the hip. Most patients had improvement of their symptoms during the study, but significantly more improvement was seen in ...

journal_title：Current medical research and opinion

authors： Williams PI,Hosie J,Scott DL

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Compare migraine duration with frovatriptan (versus baseline) in migraineurs reporting long- (24-72 h) or short-duration (<24 h) migraines at baseline. METHODS:Post hoc analysis of two postmarketing surveillance studies of migraineurs in German primary care clinics using frovatriptan (2.5 mg) to treat a sin...

journal_title：Current medical research and opinion

authors： Kelman L,Harper SQ,Hu X,Campbell JC

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Corticotropin-releasing hormone (CRH) is one of the most potent vasodilatory factors in the human feto-placental circulation. The expression of CRH was significantly down-regulated in patients with intrahepatic cholestasis of pregnancy (ICP). METHODS:One hundred pregnant women diagnosed with ICP at 34-34(+6)...

journal_title：Current medical research and opinion

authors： Zhou F,Zhang L,He MM,Liu ZF,Gao BX,Wang XD

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the effects of losartan +/- hydrochlorothiazide (HCTZ) versus placebo in obese patients with systolic and diastolic hypertension. RESEARCH DESIGN AND METHODS:Randomized patients (n = 261) were non-diabetic with systolic blood pressure (SBP) > or = 140 and < or = 1...

journal_title：Current medical research and opinion

authors： Oparil S,Abate N,Chen E,Creager MA,Galet V,Jia G,Julius S,Lerman A,Lyle PA,Pool J,Tershakovec AM

更新日期：2008-04-01 00:00:00