Abstract：
:Four hundred and twenty-seven hypertensive patients in the United Kingdom have so far been admitted to two on-going open multicentre trials, and have been treated with acebutolol for periods ranging from 1 to 6 months. Oral dosages were within the range of 100 mg to 1200 mg/day in divided doses and were increased or decreased to suit individual requirements. The data on 366 patients completing more than 1 month's treatment were analysed. A high significant reduction in mean diastolic pressure was observed. This reduction was progressive up to 6-month's treatment and was the more marked as pre-treatment values were higher. There was a highly significant correlation between pre-treatment mean diastolic pressure and mean fall of diastolic pressure at 6-months' treatment. There was also a highly sigificant association between initial values and response, and between duration of treatment and response. The higher the pre-treatment value, the less likely was non-response. Response also increased as treatment duration increased. Although asthmatic patients were not excluded, only 2 of the 427 patients included in the present study had to discontinue treatment because of the occurrence of airways obstruction; only 1 of these patients had experienced asthma previously.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Ashton WLdoi
10.1185/03007997609112001keywords:
subject
Has Abstractpub_date
1976-01-01 00:00:00pages
442-54issue
6eissn
0300-7995issn
1473-4877journal_volume
4pub_type
临床试验,杂志文章abstract：:Poor nutritional status may impair well being indirectly as a consequence of increased morbidity and decline in functional status. The aim of this study was to examine the independent effect of body mass index on the well being of older people. Thirty one hospital-based patients over 65 years of age were studied. Well...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:All the components of the kallikrein-kinin system are located in the vascular smooth muscle as well as in the heart. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischaemia, myocardial infarction and left ventricular hypertrophy, have ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007990212500093
更新日期：2002-01-01 00:00:00
abstract：:Oesophageal mucosa has well established protective mechanisms, which operate within pre-epithelial, epithelial and post-epithelial compartments. Since refluxed acid and pepsin always act from the luminal side of the mucosa, protective factors like EGF, operating as a part of pre-epithelial defence, are thought to be p...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007999809113354
更新日期：1998-01-01 00:00:00
abstract：:An open study was carried out in 37 patients, with chronic, moderate to severe gastric or bilious reflux associated with hiatus hernia or subsequent to gastro-oesophageal surgery, to assess the effectiveness of an alginate/antacid combination product ('Gastrocote'). The overall success rate of treatment was 81% after ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007998009110074
更新日期：1980-01-01 00:00:00
abstract：OBJECTIVE:Despite a plethora of published data on levocetirizine, no meta-analyses exist on the effect of study design, and covariates like age, gender, and baseline symptom severity on treatment response. The objective of this study was the efficacy of levocetirizine 5 mg tablets and matching placebo at reducing alle...
journal_title：Current medical research and opinion
pub_type： 杂志文章,meta分析
doi：10.1185/03007995.2010.537319
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:PREDICTIVE is a multi-national, prospective, observational study, assessing the safety and efficacy of insulin detemir in patients with diabetes. RESEARCH DESIGN AND METHODS:The European cohort includes 20,531 patients with diabetes (7420 type 1) from 11 countries. A subgroup of 4782 type 1 patients were tra...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1185/030079908x260835
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:To review the pharmacoeconomic literature evaluating use of antihistamines in treating allergic rhinitis (AR) in the US. METHODS:Three independent reviewers conducted a comprehensive search of the current literature with PubMed. They identified articles describing original research comprising US cost analyse...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007990902875992
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:The injection force and the patient perception of the Next Generation FlexPen (NGFP) with design modifications aimed at reducing injection force was assessed. The accuracy and precision of the NGFP was also tested under standard conditions. RESEARCH DESIGN AND METHODS:Dosing accuracy was tested (according to...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007990802329264
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Untreated and under-treated pain represent one of the most pervasive health problems, which is worsening as the population ages and accrues risk for pain. Multiple treatment options are available, most of which have one mechanism of action, and cannot be prescribed at unlimited doses due to the ceiling of ef...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1080/03007995.2017.1310092
更新日期：2017-06-01 00:00:00
abstract：:This paper represents a review, by experts, of current opinion and information on intermittent claudication (IC) and the role that cilostazol plays in its treatment. IC is a common and debilitating condition that has a significant adverse impact on health-related quality of life (HR-QoL). It is currently under-recogni...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079904X4464
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To develop a patient-completed screening tool to help differentiate nociceptive and neuropathic pain. RESEARCH DESIGN AND METHODS:A multicenter study was performed for item reduction (initial 89-item questionnaire) and model building. Patients (N = 586) with non-headache chronic pain completed the questionna...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
doi：10.1185/030079906X115702
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:Evaluation of the safety and efficacy of insulin detemir (IDet) in the observational and non-interventional PREDICTIVE study. METHODS:A total of 2923 patients with type 1 or 2 diabetes on basal-bolus regimens were followed for 6 months: Group (1) NPH + human insulin (HI) bolus switching to IDet + analogue bo...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007990903262885
更新日期：2009-11-01 00:00:00
abstract：:The sensitivity of a number of beta-lactamase producing strains of Enterobacter aerogenes, Enterobacter cloacae, Enterobacter species, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa and Serratia marcescens to cefamandole, cefoxitin, cefuroxi...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007998109114263
更新日期：1981-01-01 00:00:00
abstract：OBJECTIVES:Data related to the cost effectiveness of surgical interventions and catheter ablation is sparse. This model-based analysis assessed the clinical and economic trade-offs involved in using catheter ablation or the Cox maze procedure in treating patients with atrial fibrillation. METHODS:A deterministic model...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2018.1546681
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to evaluate the effects of losartan +/- hydrochlorothiazide (HCTZ) versus placebo in obese patients with systolic and diastolic hypertension. RESEARCH DESIGN AND METHODS:Randomized patients (n = 261) were non-diabetic with systolic blood pressure (SBP) > or = 140 and < or = 1...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/030079908x280716
更新日期：2008-04-01 00:00:00
abstract：INTRODUCTION:Normoglycaemia in people with diabetes results in improved outcome. Continuous glucose monitoring provides detailed diagnostic information used to optimise therapy with the goal of achieving normoglycaemia. The objective of this study was to review the published literature evaluating the single device avai...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007990903094452
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:It has been acknowledged that patients who receive a beta-blocker or diuretic based regimen are at increased risk of developing new-onset diabetes. Recently, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been shown to decrease patients' odds of developing new-o...
journal_title：Current medical research and opinion
pub_type： 杂志文章,meta分析
doi：10.1185/030079907X188044
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:Hyperuricaemia is associated with indapamide administration. In contrast, micronised fenofibrate can significantly decrease serum uric acid levels. However, there are no data on the effect of combination therapy of indapamide with micronised fenofibrate on uric acid metabolism. METHODS:We studied 20 non-diab...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079902125000273
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:Since many patients with COPD in the US are managed by primary care physicians, we evaluated adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines in a primary care setting. METHODS:A cross-sectional study was conducted using a random sample of patients (n=50-150 per site)...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2013.803957
更新日期：2013-08-01 00:00:00
abstract：:Amlodipine, a dihydropyrimidine calcium antagonist, is effective in the treatment of patients with mild to moderate hypertension at doses of 5-10 mg daily. The aim of the study reported here was to determine whether an early increase in dosage of amlodipine provided an advantage in terms of antihypertensive effect. Th...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/03007999909115172
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVES:We conducted an adjusted comparison of progression-free survival (PFS) and overall survival (OS) for daratumumab monotherapy versus standard of care, as observed in a real-world historical cohort of heavily pretreated multiple myeloma patients from Czech Republic. METHODS:Using longitudinal chart data from ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2017.1410121
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:Generic drugs are identical or bioequivalent versions of the brand name drugs. They are the economic alternative of the costlier brand name drugs. This article presents a general overview of the procedure and regulatory aspects relating to generic drug approval in the US. METHODS:A computerized search was co...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2010.548374
更新日期：2011-03-01 00:00:00
abstract：:One hundred adult male volunteers were randomized to receive either Merieux or Wellcome RA27/3 rubella vaccine. Prior to vaccination, 10% of the subjects were seronegative and all of these seroconverted. No significant boosting effect was found in those with a high pre-vaccine titre but some boost was shown in those w...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007998609111093
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Physicians and other health care personnel rely on the peer-reviewed biomedical literature as a key source for making clinical decisions. Thus, ensuring that the nonclinical and clinical findings published in biomedical journals are reported accurately and clearly, without undue influence from commercial int...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007990802646584
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:This observational study was conducted to document the safety of capecitabine-based adjuvant therapy in patients with resected colon cancer under routine clinical conditions. RESEARCH AND DESIGN METHODS:ML20431 was a prospective, multicenter, non-interventional, observational study. It was designed to answer...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
doi：10.1185/03007995.2015.1014030
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND AND SCOPE:Whether generic drug products are truly therapeutically identical and interchangeable with their innovator counterparts is still a matter of debate. This review discusses the controversies related to the criteria for bioequivalence and therapeutic equivalence. These concerns are illustrated by usin...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007990903116867
更新日期：2009-09-01 00:00:00
abstract：:An open, multi-centre, non-comparative study was carried out in general practice to assess the efficacy and tolerance of piroxicam in 159 patients with osteoarthritis and 27 patients with rheumatoid arthritis. Initial dosage ranged from 10 to 40 mg piroxicam and all but a few patients continued treatment with 20 mg on...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007998309109807
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to estimate utility values for hypothetical health states that describe differences in weight and quality of life associated with type 2 diabetes mellitus (DM) from Canadians with type 2 DM. The impact on utility values was examined separately for participants with a body mass ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2014.899207
更新日期：2014-07-01 00:00:00
abstract：:A clinical evaluation was carried out in 19 patients with lichen ruber planus to assess the effectiveness of 0.05% betamethasone-17,21-dipropionate ointment in the treatment of patients whose lesions had developed resistance to prolonged treatment with 0.1% betamethasone-17-valerate ointment. The new steroid ointment ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007997609109305
更新日期：1976-01-01 00:00:00
abstract：:A large, open, multi-centre study was carried out in general practice to evaluate the effectiveness and tolerance of a combination of 10 mg pindolol plus 5 mg clopamide, in single tablet form, in the treatment of patients with essential hypertension. Computer analysis of the records of 8989 patients who completed the ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007997909109449
更新日期：1979-01-01 00:00:00
