Cardiovascular properties of the kallikrein-kinin system.

Abstract:

:All the components of the kallikrein-kinin system are located in the vascular smooth muscle as well as in the heart. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischaemia, myocardial infarction and left ventricular hypertrophy, have suggested that the reduced activity of the local kallikrein-kinin system may be instrumental in the induction of cardiovascular-related diseases. The ability of kallikrein gene delivery to produce a wide spectrum of beneficial effects makes it an excellent candidate in treating hypertension, and cardiovascular and renal diseases. In addition, stable kinin agonists may also be available in the future as therapeutic agents for cardiovascular and renal disorders.

journal_name

Curr Med Res Opin

authors

Sharma JN,Sharma J

doi

10.1185/03007990212500093

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

10-7

issue

1

eissn

0300-7995

issn

1473-4877

journal_volume

18

pub_type

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