Is initial dose titration of amlodipine worthwhile in patients with mild to moderate hypertension?

abstract：OBJECTIVE:The efficacy of antihistamines in perennial allergic rhinitis in children has been evaluated in studies using active comparators, whereas placebo-controlled studies are very few. A randomized, multicenter, double-blind, parallel-group clinical study was carried out to evaluate the dose-response relationship a...

journal_title：Current medical research and opinion

authors： Okubo K,Okuda M,Magara H,Kaneko K

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of rosuvastatin in postmenopausal women with hypercholesterolemia who are receiving hormone replacement therapy (HRT) in a randomized, double-blind, placebo-controlled trial. METHODS:After a 6-week dietary lead-in period, 135 postmenopausal women who had been taking a stab...

journal_title：Current medical research and opinion

authors： Shepherd J,Packard C,Littlejohn TW 3rd,Walker J,Stein EA,Smith K,Kallend D,Blasetto JW

更新日期：2004-10-01 00:00:00

abstract：:Forty-nine patients participated in a randomized double-blind, parallel group comparison of beclomethasone dipropionate aqueous nasal spray with terfenadine tablets in the treatment of hay fever. Symptom scores for nasal and ocular symptoms as well as grass pollen counts were registered daily for at least 1 month. Eva...

journal_title：Current medical research and opinion

authors： Beswick KB,Kenyon GS,Cherry JR

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Patients with hypereosinophilic syndrome (HES) vary considerably in their clinical presentation with regard to the severity and pattern of end-organ involvement. Clinical manifestations range from nonspecific symptoms to life-threatening, multisystem damage caused by eosinophil infiltration and local release...

journal_title：Current medical research and opinion

authors： Schwartz LB,Sheikh J,Singh A

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVE:The management of hyponatremia has evolved in recent years, particularly with the introduction of tolvaptan for hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This commentary presents a summary of recent international recommendations in the for...

journal_title：Current medical research and opinion

authors： Aylwin S,Burst V,Peri A,Runkle I,Thatcher N

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To describe dosing patterns of etanercept, adalimumab, and infliximab in rheumatoid arthritis (RA) patients in US managed care. METHODS:This retrospective analysis included adult (18-64 years) RA patients in the HealthCore Integrated Research Database with ≥ 1 claim for etanercept, adalimumab, or infliximab ...

journal_title：Current medical research and opinion

authors： Fisher MD,Watson C,Fox KM,Chen YW,Gandra SR

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To identify and compare health-economic models that were developed to evaluate the cost-effectiveness of treatments for type 2 diabetes mellitus (T2DM), and their use within Health Technology Assessments (HTAs). METHODS:In total, six commonly used databases were searched for articles published between Octobe...

journal_title：Current medical research and opinion

authors： Charokopou M,Sabater FJ,Townsend R,Roudaut M,McEwan P,Verheggen BG

更新日期：2016-01-01 00:00:00

abstract：:A double-blind controlled, cross-over trial was carried out in 70 depressed patients to compare the effectiveness and tolerability of amineptine with that of maprotiline. Patients were allocated at random to receive treatment with either 150 mg amineptine or 75 mg maprotiline daily for 6 weeks before being treated for...

journal_title：Current medical research and opinion

authors： Bornstein S

更新日期：1979-01-01 00:00:00

abstract：:A single-blind, open-label controlled study was carried out in 30 healthy male volunteers to compare gastro-intestinal blood loss before, during and after treatment with a new, sustained-release formulation of the non-steroidal anti-inflammatory agent etodolac (etodolac SR) or with naproxen. Subjects remained at the s...

journal_title：Current medical research and opinion

authors： Leese P

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To better understand depression's impact on family functioning from the perspectives of patients with major depressive disorder (MDD) and their partners; to develop and test patient and partner versions of a new self-reported measure, the Depression and Family Functioning Scale (DFFS), for use in clinical tri...

journal_title：Current medical research and opinion

authors： DiBenedetti DB,Danchenko N,François C,Lewis S,Davis KH,Fehnel SE

更新日期：2012-03-01 00:00:00

abstract：:Objective: A prior study found that hyaluronic acid (HA) treatment may help reduce pain medication use (such as steroids, non-steroidal anti-inflammatory drugs [NSAIDs] and opioids) among knee osteoarthritis (OA) patients in the real-world setting. This study aims to update the prior study results to include only the ...

journal_title：Current medical research and opinion

authors： Chitnis AS,Etter K,Holy CE,Gray FS,Manalac FJ,Bisson B,Bhattacharyya SK

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To evaluate costs associated with prostaglandin analogs among newly-diagnosed glaucoma patients in a managed-care population. RESEARCH DESIGN AND METHODS:A cost minimization model compared annual costs for patients initiating therapy with one of the three prostaglandin analogs (bimatoprost, latanoprost, trav...

journal_title：Current medical research and opinion

authors： Schmier JK,Covert DW,Robin AL

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Resistance to endocrine treatment generally occurs over time, especially in the metastatic stage. In this paper, we aimed to review the mechanisms of cyclin-dependent kinase (CDK) 4/6 inhibition and clinical usage of new agents in the light of recent literature updates. SCOPE:A literature search was carried...

journal_title：Current medical research and opinion

authors： Bilgin B,Sendur MAN,Şener Dede D,Akıncı MB,Yalçın B

更新日期：2017-09-01 00:00:00

abstract：:Anaemia is an important factor in the fatigue experienced by many patients receiving chemotherapy. A recent large-scale, randomised, placebo-controlled trial has shown that treatment with epoetin alfa raises haemoglobin levels, reduces fatigue and improves overall quality of life (QoL). In order to examine the relatio...

journal_title：Current medical research and opinion

authors：

更新日期：2005-01-01 00:00:00

abstract：:Objective: Determine healthcare resource utilization (HCRU) and costs associated with fatigue and stiffness among patients with rheumatoid arthritis (RA).Methods: A retrospective claims analysis compared RA patients with fatigue or stiffness to matched RA control patients with neither. Claims from a large US commercia...

journal_title：Current medical research and opinion

authors： Strand V,Shah R,Atzinger C,Zhou J,Clewell J,Ganguli A,Tundia N

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Schizophrenia is one of the most debilitating diseases in the United Arab Emirates. Oral antipsychotics (OA) are commonly used in terms of pharmacotherapy; however, these treatments can be rendered ineffective by poor patient adherence. Paliperidone palmitate once monthly (PP1M) is a long acting antipsychotic...

journal_title：Current medical research and opinion

authors： Nuhoho S,Saad A,Saumell G,Ribes D,El Khoury AC

更新日期：2018-04-01 00:00:00

abstract：:A double-blind crossover study was carried out in 24 patients with rheumatoid arthritis to investigate the relative efficacy of tolmetin (1600 mg/day) and phenylbutazone (400 mg/day). Each drug was given for 4 weeks, preceded by a 2-week wash-out period during which patients received paracetamol alone for pain relief....

journal_title：Current medical research and opinion

authors： Cardoe N,Steele CE

更新日期：1976-01-01 00:00:00

abstract：:Objective: The purpose of this study was to examine surgical and survival outcomes in the elderly (65-79 years of age) and the very elderly (≥80 years of age) who received surgery for gastric cancer.Methods: This study retrospectively reviewed the records of patients ≥65 years old who received a gastrectomy for gastri...

journal_title：Current medical research and opinion

authors： Wong JU,Tai FC,Huang CC

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:To determine whether a new category of artificial tear product, carboxymethylcellulose 0.5% with compatible solutes (CMC-solutes) (Optive, Allergan, Inc., Irvine, California) improves clinical outcomes when used adjunctively with topical cyclosporine 0.05% (Restasis, Allergan, Inc., Irvine, California) for the ...

journal_title：Current medical research and opinion

authors： Hardten DR,Brown MJ,Pham-Vang S

更新日期：2007-09-01 00:00:00

abstract：:Lowering cholesterol levels is a primary approach for reducing the risk of coronary heart disease (CHD), yet patients rarely achieve the lipid targets recommended by international guidelines. Although high rates of compliance and achievement of lipid targets have been reported in clinical trials, this situation is inf...

journal_title：Current medical research and opinion

authors： Riesen WF,Darioli R,Noll G

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Insulin resistance alone does not result in the development of type 2 diabetes; progressive dysfunction of pancreatic islet alpha and beta cells, which results in inadequate control of hyperglycemia, must be present for the disease to develop. Because of these defects, meal-stimulated insulin secretion from ...

journal_title：Current medical research and opinion

authors： Meece J

更新日期：2007-04-01 00:00:00

abstract：:A double-blind trial of methocarbamol versus placebo was carried out in 59 matched pairs of patients suffering from painful muscle spasm. Methocarbamol (1500 mg. q.d.s.) was found to be effective in approximately 60% of patients compared with 30% of patients receiving placebo (p less than 0.01). Side-effects were of a...

journal_title：Current medical research and opinion

authors： Valtonen EJ

更新日期：1975-01-01 00:00:00

abstract：:Sodium meclofenamate (200 to 400 mg daily) was compared with aspirin (2.4 to 4.8 g daily) for the treatment of rheumatoid arthritis in a 6-month, double-blind, multicentre study. Two groups of patients participated, one receiving stabilized doses of concomitant gold or steroid therapy and one not receiving such therap...

journal_title：Current medical research and opinion

authors： Gowans JD

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:A novel preoperative procedure From Home To Operation (FHTO) seeks to combat increasing operation and infection rates. This is the first prospective randomized controlled trial (RCT) comparing the cost-effectiveness and cost-utility of FHTO and conventional ward procedures for standardized Laparoscopic Cholec...

journal_title：Current medical research and opinion

authors： Keränen J,Soini EJ,Ryynänen OP,Hietaniemi K,Keränen U

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and long-term safety of linagliptin added to basal insulin in Asian patients with type 2 diabetes mellitus (T2DM) inadequately controlled by basal insulin with/without oral agents. RESEARCH DESIGN AND METHODS:This was a post hoc analysis of Asian patients from a global ≥52 week study...

journal_title：Current medical research and opinion

authors： Sheu WH,Park SW,Gong Y,Pinnetti S,Bhattacharya S,Patel S,Seck T,Woerle HJ

更新日期：2015-03-01 00:00:00

abstract：:An open, multi-centre study was carried out in 117 pregnant women presenting with vaginal candidosis to assess the effectiveness of econazole in providing mycological control and symptom relief, and in preventing, as far as possible, the risk of contamination of the newborn: nearly 50% of the patients were in the last...

journal_title：Current medical research and opinion

authors： Goormans E,Beek JM,Declercq JA,Loendersloot EW,Roelofs HJ,van Zanten A

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:To compare the efficacy and safety of the concomitant administration of travoprost 0.004% once daily and brinzolamide 0.1% twice daily with those of a fixed combination of latanoprost 0.005%/timolol 0.5% once daily. RESEARCH, DESIGN AND METHODS:Forty-four patients with primary open-angle glaucoma or ocular hyp...

journal_title：Current medical research and opinion

authors： Martinez-de-la-Casa JM,Castillo A,Garcia-Feijoo J,Mendez-Hernandez C,Fernandez-Vidal A,Garcia-Sanchez J

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of antiresorptive agents in reducing the risk of vertebral and non-vertebral fractures using data from published meta-analyses and the technique of adjusted indirect comparisons. RESEARCH DESIGN AND METHODS:Pairs of agents were compared by adjusted indirect comparison of 0.56 [0....

journal_title：Current medical research and opinion

authors： Wehren LE,Hosking D,Hochberg MC

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:The literature on nonfulfillment of prescription medications spans over three decades of work. There is a wide variation in reported nonfulfillment rates, but no previous study has systematically reviewed this literature to explore the reasons behind this variation. OBJECTIVE:The objective of this study was...

journal_title：Current medical research and opinion

authors： Gadkari AS,McHorney CA

更新日期：2010-03-01 00:00:00

abstract：UNLABELLED:Therapeutic interventions that block the renin-angiotensin-aldosterone system (RAAS) have an important role in slowing the progression of cardiovascular risk actors to established cardiovascular diseases. In recent years, angiotensin receptor blockers (ARBs) have emerged as effective and well-tolerated alter...

journal_title：Current medical research and opinion

authors： Meredith PA

更新日期：2007-07-01 00:00:00