Cross-over trial comparing the antidepressant effects of amineptine and maprotiline.

abstract：OBJECTIVE:To compare the efficacy and safety of epoetin theta and epoetin beta in anaemic patients with chronic kidney disease, undergoing haemodialysis and previously on stable maintenance therapy with epoetin beta. METHODS:In this multicentre, randomised, controlled, double-blind study 270 haemodialysis patients wer...

journal_title：Current medical research and opinion

authors： Gertz B,Kohler E,Kes P,Essaian A,Bias P,Buchner A,Elsässer R

更新日期：2010-10-01 00:00:00

abstract：:Atypical antipsychotics are commonly used off-label to treat behavioural and psychiatric symptoms in dementia (BPSD), particularly in elderly care homes. Much of this use is inappropriate, and trials have shown an increased likelihood of serious cerebrovascular adverse events (CVAEs) such as stroke and transient ische...

journal_title：Current medical research and opinion

authors： Bullock R

更新日期：2005-01-01 00:00:00

abstract：:Twenty-five acutely disturbed psychotic patients were treated in an open study with a single injection of zuclopenthixol acetate 5% in 'Viscoleo, a thin vegetable oil. Patients were assessed post-injection for 3 days using the BPRS, CGI, and a specially designed behaviour/activity scale. Doses of 50 to 150 mg proved e...

journal_title：Current medical research and opinion

authors： Chakravarti SK,Muthu A,Muthu PK,Naik P,Pinto RT

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Epicardial adipose tissue (EAT) serves as a biologically active organ with important endocrine and inflammatory function. Review An accumulating body of evidenc...

journal_title：Current medical research and opinion

authors： Goudis CA,Vasileiadis IE,Liu T

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Osteoporosis is a skeletal disorder characterized by diminished bone strength, which results in an increased risk of fracture. Currently, osteoporosis is a public health priority due to the large number of individuals affected and the detrimental effect on quality of life. Primary osteoporosis, the most commo...

journal_title：Current medical research and opinion

authors： Brandi ML,Minisola S

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism (PE), is a major cause of morbidity and mortality. VTE is a common disorder, with an estimated annual incidence of approximately 5-12 persons per 10,000. The prognosis for patients who develop VTE is exacerbated by the r...

journal_title：Current medical research and opinion

authors： Ruppert A,Lees M,Steinle T

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Most patients with hypertension require antihypertensive combination therapy to achieve BP control. This study investigated the safety and efficacy of the direct renin inhibitor aliskiren combined with the calcium channel blocker amlodipine. METHODS:Overall, 556 patients with hypertension (msDBP > or =95-<11...

journal_title：Current medical research and opinion

authors： Littlejohn TW 3rd,Trenkwalder P,Hollanders G,Zhao Y,Liao W

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:To review the evidence evaluating the efficacy of vardenafil in subgroups of hypertensive patients with erectile dysfunction (ED). METHODS:Meta-analysis of randomized, double-blinded, placebo-controlled, flexible-dose vardenafil clinical trials that were >or=12 weeks in duration evaluated men with a >or=6-mo...

journal_title：Current medical research and opinion

authors： Shabsigh R,Duval S,Shah M,Regan TS,Juhasz M,Veltry LG

更新日期：2007-10-01 00:00:00

abstract：:The pharmacokinetics of Bay g 2821, a new diuretic agent, were studied in dogs, healthy volunteers and in patients with renal insufficiency. The drug was rapidly absorbed after oral administration, peak plasma levels (approx. 0.4 microgram/ml) occurring within 1 hour. Elimination of the unchanged drug from plasma was ...

journal_title：Current medical research and opinion

authors： Ritter W

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:Aliskiren is the first in a new class of orally effective direct renin inhibitors approved for the treatment of hypertension. This multiple-dose study investigated the potential for pharmacokinetic interactions between aliskiren and three drugs, each predominantly eliminated by a different clearance/metabolic...

journal_title：Current medical research and opinion

authors： Ayalasomayajula S,Tchaloyan S,Yeh CM,Bizot MN,Dieterich HA,Howard D,Dole WP

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVES:This study proposed a conception of individualized chemotherapy based on organ selectivity of drug distribution by retrospectively comparing the effect of vinorelbine and capecitabine in patients with metastatic breast cancer. METHODS:Between January 2002 and December 2009, 133 patients with lung metastasis...

journal_title：Current medical research and opinion

authors： Liu XH,Man YN,Cao R,Liu C,Wu XZ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Adequate bowel preparation prior to colonic diagnostic procedures is essential to ensure adequate visualisation. SCOPE:This consensus aims to provide guidance as to the appropriate use of bowel preparation for a range of defined clinical circumstances. A consensus group from across Europe was convened and m...

journal_title：Current medical research and opinion

authors： Mathus-Vliegen E,Pellisé M,Heresbach D,Fischbach W,Dixon T,Belsey J,Parente F,Rio-Tinto R,Brown A,Toth E,Crosta C,Layer P,Epstein O,Boustiere C

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The management of iron-deficiency anaemia in patients with non-dialysis chronic kidney disease (ND-CKD) remains controversial, particularly regarding the use of oral versus intravenous iron supplementation. METHODS:A PubMed search from 1970 to February 2009 was conducted to identify relevant research articl...

journal_title：Current medical research and opinion

authors： Macdougall IC

更新日期：2010-02-01 00:00:00

abstract：:Twenty-seven patients with tennis elbow were treated with triamcinolone acetonide (40 mg/ml) injected locally into the tender area without local anaesthetic. Reduction of pain or complete relief was achieved in 1 to 72 hours, although in 9 cases exacerbation of pain occurred before relief was given. The recurrence rat...

journal_title：Current medical research and opinion

authors： Nevelös AB

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The validity of opinions expressed in questionnaire surveys diminishes with lower response rates. Recent research suggests that general practitioners (GPs) are more likely to respond to questionnaire surveys if they are motivated to do so because the subject of the survey is perceived as relevant to the prac...

journal_title：Current medical research and opinion

authors： Jiwa M,Coker AE,Bagley J,Freeman J,Coleman M

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Undetected/uncontrolled diabetes is associated with substantial morbidity and mortality and consequent costs. Early detection through screening identifies patients at risk, allowing for earlier treatment initiation. OBJECTIVES:To determine the economic impact of screening for type 2 diabetes (T2DM). DATA S...

journal_title：Current medical research and opinion

authors： Einarson TR,Bereza BG,Acs A,Jensen R

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To compare real-world adherence to and persistence with deferasirox film-coated tablets (DFX-FCT) and deferasirox dispersible tablets (DFX-DT) among patients who switched from DFX-DT to DFX-FCT, overall and by disease type (sickle cell disease [SCD], thalassemia, and myelodysplastic syndrome [MDS]). METHODS:...

journal_title：Current medical research and opinion

authors： Cheng WY,Said Q,Hao Y,Xiao Y,Vekeman F,Bobbili P,Duh MS,Nandal S,Blinder M

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To determine whether a new category of artificial tear product, carboxymethylcellulose 0.5% with compatible solutes (CMC-solutes) (Optive, Allergan, Inc., Irvine, California) improves clinical outcomes when used adjunctively with topical cyclosporine 0.05% (Restasis, Allergan, Inc., Irvine, California) for the ...

journal_title：Current medical research and opinion

authors： Hardten DR,Brown MJ,Pham-Vang S

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Pseudomonas aeruginosa is a difficult-to-treat bacterial pathogen often isolated from patients with serious nosocomial infections. The goal of this analysis is to present the clinical and microbiologic effectiveness of doripenem in the treatment of infections due to P. aeruginosa. RESEARCH DESIGN AND METHODS...

journal_title：Current medical research and opinion

authors： Jenkins SG,Fisher AC,Peterson JA,Nicholson SC,Kaniga K

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:To evaluate knowledge about risks, prevention and consequences of infection with hepatitis B virus (HBV) among travellers from four low HBV risk, European countries. METHODS:Individuals from an internet panel and based in the Czech Republic, the Netherlands, Spain and Sweden were invited to take part in an o...

journal_title：Current medical research and opinion

authors： Herbinger KH,Nothdurft HD,Prymula R

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To assess whether maintenance of labor epidural analgesia using programmed intermittent epidural bolus (PIEB) is associated with reduced local anesthetic (LA) consumption, patient-controlled epidural analgesia (PCEA) use, and rescue analgesia requirements compared to continuous epidural infusion (CEI). RESEA...

journal_title：Current medical research and opinion

authors： Tien M,Allen TK,Mauritz A,Habib AS

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age. METHODS:MEDLINE (1950 to November 2008), EMBASE (1980 to November 2008), The Cochrane Library (2007, Issue 3), ACP Journal...

journal_title：Current medical research and opinion

authors： Southey ER,Soares-Weiser K,Kleijnen J

更新日期：2009-09-01 00:00:00

abstract：:A study was carried out in 80 mild to moderately depressed patients seen in general practice to assess the relative effectiveness and tolerance of a single night-time dose compared with the usual divided daily dosage regimen of a chlordiazepoxide (5 mg)/amitriptyline (12.5 mg) combination. Patients were assigned at ra...

journal_title：Current medical research and opinion

authors： James RT,Dean BC

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Reducing low-density lipoprotein cholesterol (LDL-C) levels to National Cholesterol Expert Panel (NCEP) goal is recommended. However, sex-specific effects may influence benefit. METHODS AND RESULTS:In this post hoc analysis of the GREek Atorvastatin and Coronary heart disease (CHD) Evaluation [GREACE] study...

journal_title：Current medical research and opinion

authors： Athyros VG,Kakafika AI,Papageorgiou AA,Paraskevas KI,Tziomalos K,Anagnostis P,Pagourelias E,Koumaras C,Karagiannis A,Mikhailidis DP

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Control of arterial hypertension in obese or overweight patients is complicated since obesity directly contributes to increased blood pressure, requiring new, highly effective antihypertensive drugs. This study evaluates the efficacy of azilsartan medoxomil in real clinical practice. METHODS:An internationa...

journal_title：Current medical research and opinion

authors： Chazova IE,Zhernakova YV

更新日期：2020-12-07 00:00:00

abstract：:Oesophageal mucosa has well established protective mechanisms, which operate within pre-epithelial, epithelial and post-epithelial compartments. Since refluxed acid and pepsin always act from the luminal side of the mucosa, protective factors like EGF, operating as a part of pre-epithelial defence, are thought to be p...

journal_title：Current medical research and opinion

authors： Marcinkiewicz M,Grabowska SZ,Czyzewska E

更新日期：1998-01-01 00:00:00

abstract：:Objective: To examine the potential sociodemographic disparities in type 2 diabetes (T2D) management and care among US adult individuals, after controlling for clinical and behavioral factors.Methods: This was a retrospective cohort study of individuals with T2D (N = 4552) from a linked database of the National Health...

journal_title：Current medical research and opinion

authors： Tan X,Lee LK,Huynh S,Pawaskar M,Rajpathak S

更新日期：2020-06-01 00:00:00

abstract：AIMS:The safety and efficacy of exenatide BID (exenatide) and insulin glargine (glargine) have been studied in clinical trials with few elderly patients. This study examined the clinical effectiveness of exenatide compared to glargine in patients 65 years and older with type 2 diabetes mellitus (T2DM). METHODS:A retro...

journal_title：Current medical research and opinion

authors： Pawaskar M,Li Q,Reynolds MW

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the effects of losartan +/- hydrochlorothiazide (HCTZ) versus placebo in obese patients with systolic and diastolic hypertension. RESEARCH DESIGN AND METHODS:Randomized patients (n = 261) were non-diabetic with systolic blood pressure (SBP) > or = 140 and < or = 1...

journal_title：Current medical research and opinion

authors： Oparil S,Abate N,Chen E,Creager MA,Galet V,Jia G,Julius S,Lerman A,Lyle PA,Pool J,Tershakovec AM

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Vildagliptin is a potent and selective dipeptidyl peptidase-IV (DPP-4) inhibitor that improves glycemic control in patients with type 2 diabetes by increasing alpha and beta-cell responsiveness to glucose. This study assessed the effect of multiple doses of vildagliptin 100 mg once daily on warfarin pharmacok...

journal_title：Current medical research and opinion

authors： He YL,Sabo R,Riviere GJ,Sunkara G,Leon S,Ligueros-Saylan M,Rosenberg M,Dole WP,Howard D

更新日期：2007-05-01 00:00:00