A current and comprehensive review of cyclin-dependent kinase inhibitors for the treatment of metastatic breast cancer.

abstract：OBJECTIVE:Generic drugs are identical or bioequivalent versions of the brand name drugs. They are the economic alternative of the costlier brand name drugs. This article presents a general overview of the procedure and regulatory aspects relating to generic drug approval in the US. METHODS:A computerized search was co...

journal_title：Current medical research and opinion

authors： Nagori BP,Mathur V,Garg S

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:PREDICTIVE is a multi-national, prospective, observational study, assessing the safety and efficacy of insulin detemir in patients with diabetes. RESEARCH DESIGN AND METHODS:The European cohort includes 20,531 patients with diabetes (7420 type 1) from 11 countries. A subgroup of 4782 type 1 patients were tra...

journal_title：Current medical research and opinion

authors： Dornhorst A,Lüddeke HJ,Honka M,Ackermann RW,Meriläinen M,Gallwitz B,Sreenan S,PREDICTIVE Study Group.

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:The objectives of this survey were to understand (1) the effects of overactive bladder (OAB) and urinary incontinence (UI) on women's lives and to understand (2) women's needs and expectations of health care providers and treatment related to these disorders. METHODS:Women (N = 1046) with self-reported sympt...

journal_title：Current medical research and opinion

authors： MacDiarmid S,Rosenberg M

更新日期：2005-09-01 00:00:00

abstract：:Filgrastim prophylaxis, both primary and secondary, was rapidly incorporated into clinical practice in the 1990s. When pegfilgrastim became available in 2002, it quickly replaced filgrastim as the colony-stimulating factor (CSF) of choice for prophylaxis. Use of prophylaxis increased markedly in the first decade of th...

journal_title：Current medical research and opinion

authors： Edelsberg J,Weycker D,Bensink M,Bowers C,Lyman GH

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:This study evaluated the long-term cost-effectiveness of atorvastatin 20 mg, rosuvastatin 10 mg and simvastatin 40 mg in primary and secondary prevention of CHD in Finland. RESEARCH DESIGN AND METHODS:The effect of statin therapy on the incidence of CHD and the expected total costs of the disease were descri...

journal_title：Current medical research and opinion

authors： Peura P,Martikainen J,Soini E,Hallinen T,Niskanen L

更新日期：2008-06-01 00:00:00

abstract：:In gouty patients, urate lowering therapies (ULTs) are recommended to bring serum uric acid (SUA) levels below 6.0 mg/dL, with the aim of dissolving urate depositions, thereby reducing disease impact. However, patients with hyperuricemia often present with other conditions associated with cardiovascular (CV) risk, suc...

journal_title：Current medical research and opinion

authors： Johnson RJ

更新日期：2015-01-01 00:00:00

abstract：:Forty-nine patients participated in a randomized double-blind, parallel group comparison of beclomethasone dipropionate aqueous nasal spray with terfenadine tablets in the treatment of hay fever. Symptom scores for nasal and ocular symptoms as well as grass pollen counts were registered daily for at least 1 month. Eva...

journal_title：Current medical research and opinion

authors： Beswick KB,Kenyon GS,Cherry JR

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:The rates of blood pressure (BP) control worldwide are discouraging. This study had the purpose of assessing the effectiveness of perindopril/amlodipine fixed dose combination on BP-lowering efficacy, and recording adherence, safety and tolerability during a 4 month treatment period. RESEARCH DESIGN AND METH...

journal_title：Current medical research and opinion

authors： Vlachopoulos C,Grammatikou V,Kallistratos M,Karagiannis A

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To compare the efficacy and safety of the concomitant administration of travoprost 0.004% once daily and brinzolamide 0.1% twice daily with those of a fixed combination of latanoprost 0.005%/timolol 0.5% once daily. RESEARCH, DESIGN AND METHODS:Forty-four patients with primary open-angle glaucoma or ocular hyp...

journal_title：Current medical research and opinion

authors： Martinez-de-la-Casa JM,Castillo A,Garcia-Feijoo J,Mendez-Hernandez C,Fernandez-Vidal A,Garcia-Sanchez J

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:There is a general perception that research is underdeveloped in rehabilitation professions. However, a PubMed search found that the growth in publications in the rehabilitation field was twice that of the general medical field. Despite this growth, another study focusing on Europe found that the proportion ...

journal_title：Current medical research and opinion

authors： Decullier E,Tourmente B,Dessez B,Guilhot N,Witko A

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of fenofibrate on sleep apnoea indices. METHODS:Proof-of-concept study comprising a placebo run-in period (1 week, 5 weeks if fibrate washout was required) and a 4-week randomized, double-blind treatment period. Thirty-four subjects (mean age 55 years, body mass index 34 kg/m 2 , fa...

journal_title：Current medical research and opinion

authors： Bruckert E,Duchêne E,Bonnefont-Rousselot D,Hansel B,Ansquer JC,Dubois A,Gaymard B

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Although a reduced aflibercept (2.0 mg) injection frequency relative to the approved dosing posology is included in national treatment guidelines for wet age-related macular degeneration (AMD), there is limited evidence of its comparative efficacy. The objective was to compare the efficacy and safety of reduc...

journal_title：Current medical research and opinion

authors： Szabo SM,Hedegaard M,Chan K,Thorlund K,Christensen R,Vorum H,Jansen JP

更新日期：2015-11-01 00:00:00

abstract：:A study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. The results showed that oral administration of a combination of two amino acids (1200 mg 1-lysine plus 1200 mg 1-arginine) provoked a release of pituitary somatotropin and ...

journal_title：Current medical research and opinion

authors： Isidori A,Lo Monaco A,Cappa M

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To review the fatalities among children hospitalized with respiratory syncytial virus (RSV) infection, and identify factors leading to a fatal outcome. RESEARCH DESIGN AND METHODS:Review of literature identified from a structured search of PubMed (1966-2009) using the following Medical Subject Headings: resp...

journal_title：Current medical research and opinion

authors： Welliver RC Sr,Checchia PA,Bauman JH,Fernandes AW,Mahadevia PJ,Hall CB

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To compare clinical characteristics, statin treatment patterns and adherence among patients at different risk for coronary heart disease (CHD) as defined by National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines. METHODS:Patients ≥ 18 years old with ≥ 1 claim for dyslipidemi...

journal_title：Current medical research and opinion

authors： Kern DM,Balu S,Tunceli O,Anzalone D

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Inadequate treatment by non-specialty primary care physicians (PCPs) has been a concern in improving osteoporosis care. An increase in outpatient visits by older patients seeking osteoporosis care has been reported. But what percentages of these visits are made to PCPs are unknown. We investigated recent tre...

journal_title：Current medical research and opinion

authors： Rianon N,Anand D,Rasu R

更新日期：2013-08-01 00:00:00

abstract：:Compatibility of two types of needles with a variety of durable and prefilled injection pens for diabetes medication was tested by attaching the needles according to ISO 11608-2 and verifying penetration into the cartridge using air shots and two-dimensional X-rays. NovoFine* and NovoFine Autocover† attached correctly...

journal_title：Current medical research and opinion

authors： Buus P,Lilleøre SK,Larsen K

更新日期：2011-03-01 00:00:00

abstract：:Discussions on the healthy volunteer in clinical investigation do not attempt to define normality. In 34 healthy volunteers, 1653 biochemical and haematological tests were performed. The incidence of abnormal results was 11%. Only 4 subjects had all tests within normal limits and when these repeated only 1 subject sti...

journal_title：Current medical research and opinion

authors： Joubert P,Pannall P

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:Bariatric surgery is an effective treatment for the reduction of weight in obese patients (BMI ≥ 40 kg/m(2) or 30 kg/m(2) with ≥1 comorbidities), who are refractory to behavioral and medical therapies. This study examined the effect of the adjustable gastric band (AGB) system on changes in gastroesophageal re...

journal_title：Current medical research and opinion

authors： Woodman G,Cywes R,Billy H,Montgomery K,Cornell C,Okerson T,APEX Study Group.

更新日期：2012-04-01 00:00:00

abstract：:Anaemia is an important factor in the fatigue experienced by many patients receiving chemotherapy. A recent large-scale, randomised, placebo-controlled trial has shown that treatment with epoetin alfa raises haemoglobin levels, reduces fatigue and improves overall quality of life (QoL). In order to examine the relatio...

journal_title：Current medical research and opinion

authors：

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:There are contrasting positions concerning the benefit-risk ratio of acetaminophen use for osteoarthritis (OA)-related pain. To clarify the effectiveness of acetaminophen or acetaminophen-codeine combinations according to their regimen of use, we evaluated whether being a regular user (adherent) of these medi...

journal_title：Current medical research and opinion

authors： Vannacci A,Lombardi N,Simonetti M,Fornasari D,Fanelli A,Cricelli I,Cricelli C,Lora Aprile P,Lapi F

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Development of a second primary malignancy (SPM) after an index esophageal cancer is fairly rare, primarily due to decreased survival in patients with esophageal cancer. However, with advances in early detection and therapy, the number of long-term survivors is increasing, as is the incidence of SPMs in this...

journal_title：Current medical research and opinion

authors： Nandy N,Dasanu CA

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:Tumor necrosis factor (TNF) antagonists, most frequently prescribed biologics for moderate to severe rheumatoid arthritis (RA), are subject to dose escalation. Even though different methods have been employed to estimate the timing and magnitude of dose escalation, there is no consensus on which method is op...

journal_title：Current medical research and opinion

authors： Huang X,Gu NY,Fox KM,Harrison DJ,Globe D

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Adequate bowel preparation prior to colonic diagnostic procedures is essential to ensure adequate visualisation. SCOPE:This consensus aims to provide guidance as to the appropriate use of bowel preparation for a range of defined clinical circumstances. A consensus group from across Europe was convened and m...

journal_title：Current medical research and opinion

authors： Mathus-Vliegen E,Pellisé M,Heresbach D,Fischbach W,Dixon T,Belsey J,Parente F,Rio-Tinto R,Brown A,Toth E,Crosta C,Layer P,Epstein O,Boustiere C

更新日期：2013-08-01 00:00:00

abstract：:A double-blind crossover study was carried out in 24 patients with rheumatoid arthritis to investigate the relative efficacy of tolmetin (1600 mg/day) and phenylbutazone (400 mg/day). Each drug was given for 4 weeks, preceded by a 2-week wash-out period during which patients received paracetamol alone for pain relief....

journal_title：Current medical research and opinion

authors： Cardoe N,Steele CE

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:Benefits from interferon beta (IFNbeta treatment in patients with multiple sclerosis are affected by many factors, including sustained clinical efficacy, acceptable tolerability, adherence to therapy, and the development of neutralizing antibodies (NAbs). The Prospective and Retrospective Long-Term Observatio...

journal_title：Current medical research and opinion

authors： Minagara A,Murray TJ,PROOF Study Investigators.

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Thymectomy is a standard treatment of myasthenia gravis (MG). Immunomodulating agents are frequently given during the post-thymectomy latency period until complete remission is fully consolidated, but serious side effects is a relevant clinical problem for patients on long-term immunomodulating treatment. O...

journal_title：Current medical research and opinion

authors： Ponseti JM,Azem J,Fort JM,López-Cano M,Vilallonga R,Gamez J,Armengol M

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To estimate the costs and consequences of using pamidronate compared to zoledronic acid in the prophylactic management of skeletal morbidity among breast cancer patients in the UK. DESIGN AND SETTING:This was a modelling study performed from the perspective of the UK's National Health Service (NHS). METHODS...

journal_title：Current medical research and opinion

authors： Guest JF,Clegg JP,Davie AM,McCloskey E

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:The European Forsteo Observational Study (EFOS) study was primarily designed to assess fracture incidence, degree of pain, health-related quality of life (HRQoL) and compliance in women prescribed teriparatide in a community setting. This report describes the design of the study and characteristics of the pat...

journal_title：Current medical research and opinion

authors： Rajzbaum G,Jakob F,Karras D,Ljunggren O,Lems WF,Langdahl BL,Fahrleitner-Pammer A,Walsh JB,Gibson A,Tynan AJ,Marin F

更新日期：2008-02-01 00:00:00

abstract：:A study was carried out in 21 patients with Type IIb or Type IV hyperlipoproteinaemia to evaluate the effect of treatment with 600 mg bezafibrate per day over a period of 3 months. The results of the lipid parameters studied showed that there were significant reductions after 1 and 3-months' treatment, respectively, o...

journal_title：Current medical research and opinion

authors： Neuman MP,Kurlat MI,Neuman J

更新日期：1983-01-01 00:00:00