The effects of the addition of micronised fenofibrate on uric acid metabolism in patients receiving indapamide.


OBJECTIVE:Hyperuricaemia is associated with indapamide administration. In contrast, micronised fenofibrate can significantly decrease serum uric acid levels. However, there are no data on the effect of combination therapy of indapamide with micronised fenofibrate on uric acid metabolism. METHODS:We studied 20 non-diabetic hypertensive patients with mixed dyslipidaemia in whom serum metabolic parameters, including uric acid levels in serum and urine, were measured before and after eight weeks of indapamide administration (2.5 mg once daily). This study was continued for a further eight weeks, when the indapamide was combined with micronised fenofibrate (200 mg once daily). RESULTS:Indapamide significantly decreased mean systolic and diastolic blood pressure (BP) from 153 +/- 9/97 +/- 8 mmHg to 138 +/- 8/93 +/- 4 mmHg (p< 0.05 for both comparisons). A significant increase in serum uric acid levels occurred after indapamide administration (from a mean value of 5.6 +/- 1.3 mg/dl (0.33 +/- 0.07 mmol/l) to 6.4 +/- 1.1 mg/dl (0.38 +/- 0.06 mmol/l), p < 0.01]. This effect was associated with a decrease in the fractional excretion of uric acid (from a mean value of 9.5 +/- 5% to 7 +/- 5.5%, p < 0.05). The addition of micronised fenofibrate significantly decreased plasma fibrinogen levels as well as total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B (ApoB) and triglycerides, and increased high-density lipoprotein cholesterol and ApoA, levels. Fenofibrate administration was followed by a significant decrease in serum uric acid levels to 4.7 +/- 1.2 mg/dl (0.28 +/- 0.07 mmol/l), p < 0.01, owing to a substantial increase in fractional urate excretion to 11 +/- 3%, p < 0.01. CONCLUSION:The addition of micronised fenofibrate can correct the hyperuricaemic effect of indapamide administration.


Curr Med Res Opin


Achimastos A,Liberopoulos E,Nikas S,Bairaktari E,Miltiadous G,Tsimihodimos V,Elisaf M





Has Abstract


2002-01-01 00:00:00












  • The bioavailability of ofloxacin from several formulations.

    abstract::The bioavailability of ofloxacin after a single dose of one of two tablet formulations (200 or 400 mg) or a liquid formulation (1.67 mg/ml) was investigated in 24 healthy male volunteers in an open randomized, crossover design study with a 5-day wash-out period between doses. Plasma concentrations of ofloxacin were de...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Flor S,Beals B

    更新日期:1991-01-01 00:00:00

  • Successful treatment of anxiety with a single night-time dose of chlormezanone: double-blind comparison with diazepam.

    abstract::A multi-centre, double-blind trial was carried out in general practice in 44 patients with symptoms of neurotic anxiety to compare the effects of treatment with either 400 mg chlormezanone at night or 5 mg diazepam 3-times daily for 4 weeks. The results indicated tht there were similar improvements in anxiety, duratio...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Allin DM

    更新日期:1982-01-01 00:00:00

  • Generic drug approval: a US perspective.

    abstract:OBJECTIVE:Generic drugs are identical or bioequivalent versions of the brand name drugs. They are the economic alternative of the costlier brand name drugs. This article presents a general overview of the procedure and regulatory aspects relating to generic drug approval in the US. METHODS:A computerized search was co...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Nagori BP,Mathur V,Garg S

    更新日期:2011-03-01 00:00:00

  • Efficacy and safety of celecoxib versus diclofenac and omeprazole in elderly arthritis patients: a subgroup analysis of the CONDOR trial.

    abstract:OBJECTIVE:To compare the safety and efficacy of celecoxib versus diclofenac slow release (SR) plus omeprazole in elderly arthritis patients. RESEARCH DESIGN AND METHODS:Patients aged≥65 years, with osteoarthritis and/or rheumatoid arthritis, at high gastrointestinal (GI) risk who participated in the CONDOR trial (Cele...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kellner HL,Li C,Essex MN

    更新日期:2012-09-01 00:00:00

  • Characterization of patients in the European Forsteo Observational Study (EFOS): postmenopausal women entering teriparatide treatment in a community setting.

    abstract:OBJECTIVE:The European Forsteo Observational Study (EFOS) study was primarily designed to assess fracture incidence, degree of pain, health-related quality of life (HRQoL) and compliance in women prescribed teriparatide in a community setting. This report describes the design of the study and characteristics of the pat...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Rajzbaum G,Jakob F,Karras D,Ljunggren O,Lems WF,Langdahl BL,Fahrleitner-Pammer A,Walsh JB,Gibson A,Tynan AJ,Marin F

    更新日期:2008-02-01 00:00:00

  • Postoperative injection of phenylbutazone does not influence fibrinolytic shutdown.

    abstract::Twenty-nine patients undergoing cholecystectomy because of chronic calculous cholecystitis were randomised to receive phenylbutazone 10 mg/kg intramuscularly or a control injection (vehicle-containing local anaesthetic) immediately after completion of surgery. Fibrinogen and plasminogen concentrations in plasma, plasm...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Szczepański M,Kubiak J,Lembas L

    更新日期:1998-01-01 00:00:00

  • Physical activity, screen time, and school absenteeism: self-reports from NHANES 2005-2008.

    abstract:OBJECTIVE:The purpose of this study was to examine how lifestyle behaviors in the context of physical activity levels and screen time are associated with school absenteeism. METHODS:We analyzed 2005-2008 NHANES data of proxy interviews for 1048 children aged 6-11 years and in-person self-reports of 1117 adolescents ag...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Hansen AR,Pritchard T,Melnic I,Zhang J

    更新日期:2016-01-01 00:00:00

  • Six-day clotrimazole therapy in vaginal candidosis.

    abstract::Two hundred and two patients with symptoms, signs and mycological evidence of Candida vaginitis were entered in a single-blind trial comparing 6-day clotrimazole therapy with a control group receiving 6 days' nystatin therapy. Adequate data was collected on 69 clotrimazole and 72 nystatin treated patients for analysis...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Masterton G,Henderson J,Napier IR,Moffet M

    更新日期:1975-01-01 00:00:00

  • Efficacy of econazole ('Gyno-Pevaryl' 150) in vaginal candidosis during pregnancy.

    abstract::An open, multi-centre study was carried out in 117 pregnant women presenting with vaginal candidosis to assess the effectiveness of econazole in providing mycological control and symptom relief, and in preventing, as far as possible, the risk of contamination of the newborn: nearly 50% of the patients were in the last...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章


    authors: Goormans E,Beek JM,Declercq JA,Loendersloot EW,Roelofs HJ,van Zanten A

    更新日期:1985-01-01 00:00:00

  • Initiative for a new diabetes therapeutic approach in a Mediterranean country: the INDEED study.

    abstract:AIM:To assess the efficacy of a strategy to improve vascular risk management in patients with type 2 diabetes mellitus (T2DM). METHODS:This was a pilot best practice implementation enhancement programme that enrolled 578 patients with T2DM. A baseline visit was followed by a concerted effort from previously trained ph...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Athyros VG,Hatzitolios A,Karagiannis A,Didangelos TP,Iliadis F,Dolgyras S,Vosnakidis T,Vasiliadis P,Malias I,Tziomalos K,Samouilidou M,Mikhailidis DP,INDEED Collaborative Group.

    更新日期:2009-08-01 00:00:00

  • Iron supplementation in the non-dialysis chronic kidney disease (ND-CKD) patient: oral or intravenous?

    abstract:BACKGROUND:The management of iron-deficiency anaemia in patients with non-dialysis chronic kidney disease (ND-CKD) remains controversial, particularly regarding the use of oral versus intravenous iron supplementation. METHODS:A PubMed search from 1970 to February 2009 was conducted to identify relevant research articl...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Macdougall IC

    更新日期:2010-02-01 00:00:00

  • Modelling the cost-effectiveness of tofacitinib for the treatment of rheumatoid arthritis in the United States.

    abstract:BACKGROUND AND OBJECTIVES:Rheumatoid arthritis (RA) is a chronic, debilitating disease affecting an estimated 1.5 million patients in the US. The condition is associated with a substantial health and economic burden. An economic model was developed to evaluate the cost-effectiveness of tofacitinib (a novel oral Janus k...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Claxton L,Taylor M,Gerber RA,Gruben D,Moynagh D,Singh A,Wallenstein GV

    更新日期:2018-11-01 00:00:00

  • Influenza vaccine: the effects of the 1986/1987 viral strains.

    abstract::One hundred and twenty healthy volunteers were recruited for a study to evaluate the reactogenicity and serological response of differing doses of the 1986/87 World Health Organization-recommended influenza viral strains. Each vaccine was prepared by Institut Merieux and contained A/Mississippi/1/85, A/Chile/1/83 and ...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ward AE,Harcus AW,Bryett KA,Moore RA

    更新日期:1987-01-01 00:00:00

  • Lercanidipine valuable effect on urine protein losses: the RED LEVEL study.

    abstract:OBJECTIVE:The RED LEVEL study (REnal Disease: LErcanidipine Valuable Effect on urine protein Losses) directly compares, in an explorative fashion, the effects of lercanidipine + enalapril and amlodipine + enalapril combinations on renal parameters in hypertensive subjects. RESEARCH DESIGN AND METHODS:This was a 1 year...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Robles NR,Calvo C,Sobrino J,Espinel E,Esteban R,Mateos L,Macias JF

    更新日期:2016-10-01 00:00:00

  • Lack of involvement of medical writers and the pharmaceutical industry in publications retracted for misconduct: a systematic, controlled, retrospective study.

    abstract:OBJECTIVES:The primary objective of this study was to quantify how many publications retracted because of misconduct involved declared medical writers (i.e., not ghostwriters) or declared pharmaceutical industry support. The secondary objective was to investigate factors associated with misconduct retractions. DESIGN:...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Woolley KL,Lew RA,Stretton S,Ely JA,Bramich NJ,Keys JR,Monk JA,Woolley MJ

    更新日期:2011-06-01 00:00:00

  • Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).

    abstract:INTRODUCTION:Detection of β-thalassemia trait or carriers (β-TT) depends significantly on an increase in Hemoglobin A2 (HbA2) levels, which is found at low levels (<3%) in normal healthy individuals and elevated levels (≥3.5%) in β-TT individuals. The study was designed to evaluate the reliability of the diagnostic par...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Al-Amodi AM,Ghanem NZ,Aldakeel SA,Ibrahim Al Asoom L,Rafique Ahmed N,Almandil NB,Naserullah ZA,Al-Jarrash S,Shakil Akhtar M,AbdulAzeez S,Al-Ali AK,Borgio JF

    更新日期:2018-05-01 00:00:00

  • Efficacy of Rhizophora mangle aqueous bark extract (RMABE) in the treatment of aphthous ulcers: a pilot study.

    abstract:OBJECTIVE:Rhizophora mangle aqueous bark extract (RMABE) (CIKRON-H), has been used as antiseptic and skin wound healing promoter. The present study was a randomised, single-blinded, placebo control trial conducted to asses the efficacy of RMABE in treating oral aphthous ulcers. RESEARCH DESIGN AND METHODS:Patients (n ...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Armas E,Sarracent Y,Marrero E,Fernández O,Branford-White C

    更新日期:2005-11-01 00:00:00

  • Undertreatment of hypercholesterolemia.

    abstract::Abstract Recent guidelines recommend strict goals for low-density lipoprotein cholesterol (LDL-C) (1.8-2.6 mmol/L; 70-100 mg/dL). However, these goals are not always met and many primary and secondary prevention patients are not optimally controlled. Both the under-prescription of lipid-lowering medication and lack of...

    journal_title:Current medical research and opinion

    pub_type: 评论,社论


    authors: Daskalopoulou SS,Doonan RJ,Mikhailidis DP

    更新日期:2010-02-01 00:00:00

  • High physician adherence to phenotype-specific asthma guidelines, but large variability in phenotype assessment in children.

    abstract:BACKGROUND:The implementation of international pediatric asthma guidelines hinges on the distinction between intermittent and persistent phenotypes and the prescription of recommended phenotype-specific pharmacotherapy. OBJECTIVES:To ascertain key factors associated with specialist-confirmed phenotype and document phy...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Ducharme FM,Morin J,Davis GM,Gingras J,Noya FJ

    更新日期:2012-09-01 00:00:00

  • Conservative treatment of pelvic congestion syndrome: indications and opportunities.

    abstract:INTRODUCTION:This brief review describes conservative treatment methods for pelvic venous congestion. Therapy options: The authors present an analysis of the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs), ergot alkaloid derivatives, hormonal agents, venoprotective agents, and compression therapy in the trea...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Gavrilov SG,Turischeva OO

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  • Systemic side-effects of three topical steroids in diseased skin.

    abstract::Two clinical trials were carried out in order to study adrenal suppression in 6 patients with psoriatic erythroderma and in 28 patients with psoriasis treated with topical glucocorticosteroids. Betamethasone-17-valerate (0.1%), betamethasone-17,21-dipropionate (0.05%) and budesonide (0.025%) ointments were studied in ...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章


    authors: Salde L,Lassus A

    更新日期:1983-01-01 00:00:00

  • A practice-based approach to the 2012 position statement of the American Diabetes Association and the European Association for the Study of Diabetes.

    abstract::The position statement on the management of hyperglycemia in patients with type 2 diabetes mellitus issued in 2012 by the American Diabetes Association and the European Association for the Study of Diabetes contains significant improvements over the 2009 version, including an emphasis on patient-centered care, enhance...

    journal_title:Current medical research and opinion

    pub_type: 评论,杂志文章


    authors: Schwartz SS

    更新日期:2013-07-01 00:00:00

  • A novel application for bolus remifentanil: blunting the hemodynamic response to Mayfield skull clamp placement.

    abstract:OBJECTIVE:Neurosurgery often requires skull immobilization with a Mayfield clamp, which often causes brief intense nociceptive stimulation, hypertension and tachycardia. Blunting this response may help prevent increased intracranial pressure, cerebral aneurysm or vascular malformation rupture, and/or myocardial stress....

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Berger M,Philips-Bute B,Guercio J,Hopkins TJ,James ML,Borel CO,Warner DS,McDonagh DL

    更新日期:2014-02-01 00:00:00

  • Comparison of the effects of etodolac SR and naproxen on gastro-intestinal blood loss.

    abstract::A single-blind, open-label controlled study was carried out in 30 healthy male volunteers to compare gastro-intestinal blood loss before, during and after treatment with a new, sustained-release formulation of the non-steroidal anti-inflammatory agent etodolac (etodolac SR) or with naproxen. Subjects remained at the s...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Leese P

    更新日期:1992-01-01 00:00:00

  • Verteporfin therapy in combination with triamcinolone: published studies investigating a potential synergistic effect.

    abstract::Evidence from randomized, placebo-controlled, double-masked studies has demonstrated that verteporfin (Visudyne) therapy is effective in reducing the risk of visual acuity loss in selected groups of patients with choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). Pilot studies of intravi...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Kaiser PK

    更新日期:2005-05-01 00:00:00

  • Efficacy and safety of topical ciprofloxacin/dexamethasone versus neomycin/polymyxin B/hydrocortisone for otitis externa.

    abstract:OBJECTIVES:To compare the efficacy and safety of ciprofloxacin 0.3%/dexamethasone 0.1% (CIP/DEX) otic suspension with that of neomycin 0.35%/polymyxin B 10,000 IU/mL/hydrocortisone 1.0% (N/P/H) otic suspension in patients with acute otitis externa (AOE). STUDY DESIGN:Randomized, observer-masked, parallel-group, multic...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Roland PS,Pien FD,Schultz CC,Henry DC,Conroy PJ,Wall GM,Garadi R,Dupre SJ,Potts SL,Hogg LG,Stroman DW,Ciprodex Otic AOE Study Group.

    更新日期:2004-08-01 00:00:00

  • Real-world treatment patterns, comorbidities, and disease-related complications in patients with multiple myeloma in the United States.

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    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Song X,Cong Z,Wilson K

    更新日期:2016-01-01 00:00:00

  • Appropriate use of information in therapeutic decision-making: reflections on indirect comparisons.

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    journal_title:Current medical research and opinion

    pub_type: 社论


    authors: Belsey JD

    更新日期:2015-02-01 00:00:00

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    journal_title:Current medical research and opinion

    pub_type: 杂志文章,随机对照试验


    authors: Einhäupl K

    更新日期:2007-02-01 00:00:00

  • Zolmitriptan is effective for the treatment of persistent and recurrent migraine headache.

    abstract::Zolmitriptan is a 5-HT1B/1D receptor agonist for the acute treatment of migraine. This study examined the efficacy of a second dose of zolmitriptan for the treatment of persistent or recurrent headache. Part 1 was a randomised, placebo-controlled, double-blind evaluation of 2.5 mg and 5 mg zolmitriptan for the treatme...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Mauskop A,Farkkila M,Hering-Hanit R,Rapoport A,Warner J

    更新日期:1999-01-01 00:00:00