Chewable cimetidine versus chewable antacid in dyspepsia: which provides faster pain relief?

Abstract:

:A randomized double-blind antacid-controlled study was carried out to investigate the speed of onset of relief from dyspeptic pain with a novel, chewable formulation of cimetidine in 80 patients with persistent dyspepsia. Inclusion and exclusion criteria were chosen to identify patients with an acid-related dyspeptic complex. After the ingestion of either 1 chewable cimetidine (200 mg) tablet or a chewable antacid tablet identical in appearance, dyspeptic pain was recorded by each patient every 10 minutes over a 1-hour period. The times for some improvement and for total disappearance of the pain were noted, as was the appearance of the next attack of dyspepsia. For both treatments, the median times for some improvement were less than 20 minutes and for total pain relief were less than 45 minutes. There was no statistically significant difference between treatments. The duration of pain relief was variable, but 13% of patients who had received antacid reported another attack of dyspepsia in less than 5 hours compared to none of the cimetidine-treated patients.

journal_name

Curr Med Res Opin

authors

Parr SN

doi

10.1185/03007998909112672

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

557-66

issue

9

eissn

0300-7995

issn

1473-4877

journal_volume

11

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Co-possession of phosphodiesterase type-5 inhibitors (PDE5-I) with nitrates.

    abstract:OBJECTIVE:Estimate the proportion of phosphodiesterase type-5 inhibitor (PDE5-I) patients who co-possess nitrates and compare the proportion of tadalafil patients dispensed nitrates to a matched control group. Secondarily, examine the percentage of co-possession of PDE5-Is and nitrates where the products were dispensed...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007991003771874

    authors: Chang LL,Ma M,Allmen Hv,Henderson SC,Harper K,Hornbuckle K

    更新日期:2010-06-01 00:00:00

  • A cost-effectiveness analysis of calcipotriol plus betamethasone dipropionate aerosol foam versus gel for the topical treatment of plaque psoriasis.

    abstract:BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD f...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1080/03007995.2018.1428542

    authors: Foley P,Garrett S,Ryttig L

    更新日期:2018-07-01 00:00:00

  • Ibuprofen and diclofenac sodium in the treatment of osteoarthritis: a comparative trial of two once-daily sustained-release NSAID formulations.

    abstract::An investigator-blind, parallel-group, multicentre study was undertaken to compare the efficacy and tolerability of once-daily, sustained-release (s-r) ibuprofen and diclofenac sodium in patients (mean age 59.8 years) suffering from painful osteoarthritis affecting chiefly the knee and/or hip. Patients attending eight...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1185/03007999609115224

    authors: Baumgartner H,Schwarz HA,Blum W,Bruhin A,Gallachi G,Goldinger G,Saxer M,Trost H

    更新日期:1996-01-01 00:00:00

  • Gemfibrozil in hyperlipidaemic patients with peripheral arterial disease: some undiscovered actions.

    abstract::The effects of gemfibrozil were assessed in 27 hyperlipidaemic patients with stable peripheral arterial occlusive disease. Gemfibrozil (600 mg twice daily) was administered for 12 weeks after 2 weeks of placebo medication, thus enabling patients to act as their own controls. Serum cholesterol levels were reduced by a ...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章

    doi:10.1185/03007999009111649

    authors: Stringer MD,Steadman CA,Kakkar VV

    更新日期:1990-01-01 00:00:00

  • Linagliptin improves glycemic control after 1 year as add-on therapy to basal insulin in Asian patients with type 2 diabetes mellitus.

    abstract:OBJECTIVE:To evaluate the efficacy and long-term safety of linagliptin added to basal insulin in Asian patients with type 2 diabetes mellitus (T2DM) inadequately controlled by basal insulin with/without oral agents. RESEARCH DESIGN AND METHODS:This was a post hoc analysis of Asian patients from a global ≥52 week study...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,随机对照试验

    doi:10.1185/03007995.2015.1010638

    authors: Sheu WH,Park SW,Gong Y,Pinnetti S,Bhattacharya S,Patel S,Seck T,Woerle HJ

    更新日期:2015-03-01 00:00:00

  • Effectiveness of perindopril/amlodipine fixed dose combination in everyday clinical practice: results from the EMERALD study.

    abstract:OBJECTIVE:The rates of blood pressure (BP) control worldwide are discouraging. This study had the purpose of assessing the effectiveness of perindopril/amlodipine fixed dose combination on BP-lowering efficacy, and recording adherence, safety and tolerability during a 4 month treatment period. RESEARCH DESIGN AND METH...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究

    doi:10.1080/03007995.2016.1193481

    authors: Vlachopoulos C,Grammatikou V,Kallistratos M,Karagiannis A

    更新日期:2016-09-01 00:00:00

  • Pancreatic beta-cell function as a predictor of cardiovascular outcomes and costs: findings from the Cardiovascular Health Study.

    abstract:OBJECTIVE:To explore relationships between beta-cell function and incident cardiovascular events, death, and medical costs among elderly individuals. RESEARCH DESIGN AND METHODS:In a prospective, population-based cohort of 4555 elderly individuals, we examined the effect of beta-cell function on incident cardiovascula...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究

    doi:10.1185/030079908x253573

    authors: Curtis LH,Hammill BG,Bethel MA,Anstrom KJ,Liao L,Gottdiener JS,Schulman KA

    更新日期:2008-01-01 00:00:00

  • Experience with starting tacrolimus postoperatively after transsternal extended thymectomy in patients with myasthenia gravis.

    abstract:BACKGROUND:Thymectomy is a standard treatment of myasthenia gravis (MG). Immunomodulating agents are frequently given during the post-thymectomy latency period until complete remission is fully consolidated, but serious side effects is a relevant clinical problem for patients on long-term immunomodulating treatment. O...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章

    doi:10.1185/030079906X104650

    authors: Ponseti JM,Azem J,Fort JM,López-Cano M,Vilallonga R,Gamez J,Armengol M

    更新日期:2006-05-01 00:00:00

  • Long-term outcome of transcatheter arterial chemoembolization after radiofrequency ablation as a combined therapy for Chinese patients with hepatocellular carcinoma.

    abstract:OBJECTIVE:This study was undertaken to assess the long-term outcome of transcatheter arterial chemoembolization (TACE) after radiofrequency ablation (RFA) combined with a combined therapy for Chinese patients with intermediate (stage B) hepatocellular carcinoma (HCC) of single block type, and evaluate the survival rate...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007995.2015.1058249

    authors: Xu RC,Liu HC,Li JL,Li K,Ou SY,Yu ZY,Kong Y,Ma GA,Shao WS

    更新日期:2015-08-01 00:00:00

  • Efficacy, safety, and tolerability of mometasone furoate in adult Japanese patients with mild asthma: open-label clinical trial findings.

    abstract:OBJECTIVE:To evaluate the clinical efficacy and safety of mometasone furoate administered via a dry powder inhaler (MF-DPI) in Japanese patients with intermittent or mild persistent asthma who were not previously receiving inhaled corticosteroids. RESEARCH DESIGN AND METHODS:This was an 8-week open-label study conduct...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007990903422380

    authors: Tohda Y,Miyamoto T

    更新日期:2010-01-01 00:00:00

  • A double-blind, placebo-controlled evaluation of spironolactone in the premenstrual syndrome.

    abstract::The effect of spironolactone in the alleviation of the symptoms of the premenstrual syndrome was compared with placebo in a double-blind, parallel group controlled study. One tablet daily of 100 mg spironolactone or placebo was given to 63 women from Day 12 of the menstrual cycle until the first day of the next menstr...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007998709112403

    authors: Vellacott ID,Shroff NE,Pearce MY,Stratford ME,Akbar FA

    更新日期:1987-01-01 00:00:00

  • Cost-effectiveness of statin therapy for vascular event prevention in adults with elevated C-reactive protein: implications of JUPITER.

    abstract:OBJECTIVES:High-sensitivity C-reactive protein (hs-CRP) has been explored for use in predicting cardiovascular risk. The recent Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study found that statin therapy reduced cardiovascular events in those with ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007995.2010.516994

    authors: Slejko JF,Page RL 2nd,Sullivan PW

    更新日期:2010-10-01 00:00:00

  • Pioglitazone versus rosiglitazone treatment in patients with type 2 diabetes and dyslipidemia: cost-effectiveness in the US.

    abstract:OBJECTIVES:Pioglitazone hydrochloride (Actos † ) and rosiglitazone maleate (Avandia ‡ ) are members of the thiazolidinedione (TZD) class of oral anti-diabetic drugs (OADs) and are used to treat type 2 diabetes mellitus (T2DM). Greater beneficial effects on lipids have been demonstrated with pioglitazone, however. Study...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007990802434874

    authors: Tunis SL,Minshall ME,St Charles M,Pandya BJ,Baran RW

    更新日期:2008-11-01 00:00:00

  • Current approaches for prophylactic cranial irradiation in extrapulmonary small cell carcinoma.

    abstract:BACKGROUND:Small cell lung cancer (SCLC) patients, who have achieved complete or partial response after chemotherapy, should be followed with prophylactic cranial irradiation (PCI). PCI for extrapulmonary small cell carcinoma (EPSCC) is not routinely recommended. The purpose of this review is to discuss all aspects of ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/03007995.2014.904771

    authors: Yazıcı O,Ozdemir NY,Sendur MA,Aksoy S,Zengin N

    更新日期:2014-07-01 00:00:00

  • Strategies to prevent type 2 diabetes.

    abstract::Type 2 diabetes mellitus is a public health problem of epidemic proportions and its prevalence is on the rise. The typical American born today has a one in three chance of developing type 2 diabetes. This diagnosis is associated with an adverse cardiovascular prognosis and is considered the risk equivalent of establis...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,meta分析,评审

    doi:10.1185/030079905X50606

    authors: Abuissa H,Bel DS,O'keefe JH Jr

    更新日期:2005-07-01 00:00:00

  • Cost-effectiveness analysis of aripiprazole vs standard-of-care in the management of community-treated patients with schizophrenia: STAR study.

    abstract:UNLABELLED:Abstract Background: The Schizophrenia Trial of Aripiprazole (STAR) showed superior efficacy for aripiprazole compared with atypical antipsychotic standard-of-care (SOC) for the community treatment of schizophrenia 1 based on the Investigator Assessment Questionnaire total score. OBJECTIVE:To determine the ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1185/03007995.2010.542745

    authors: King D,Knapp M,Thomas P,Razzouk D,Loze JY,Kan HJ,van Baardewijk M

    更新日期:2011-02-01 00:00:00

  • Comparison of 1 mg and 5 mg sodium cromoglycate metered dose inhalers in the treatment of asthma: a 12-week double-blind, parallel group trial.

    abstract::A double-blind, parallel group trial of a 1 mg sodium cromoglycate metered dose inhaler, a 5 mg formulation and a placebo aerosol was undertaken in 139 asthmatic patients with extrinsic allergic asthma. None of the patients had previously been treated with sodium cromoglycate and few (15%) were familiar with the use o...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007998909110134

    authors: Carrasco E,Sepulveda R

    更新日期:1989-01-01 00:00:00

  • Surveying general practitioners: a new avenue.

    abstract:BACKGROUND:The validity of opinions expressed in questionnaire surveys diminishes with lower response rates. Recent research suggests that general practitioners (GPs) are more likely to respond to questionnaire surveys if they are motivated to do so because the subject of the survey is perceived as relevant to the prac...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/030079903125002900

    authors: Jiwa M,Coker AE,Bagley J,Freeman J,Coleman M

    更新日期:2004-03-01 00:00:00

  • Characterizing and understanding body weight patterns in patients treated with pregabalin.

    abstract:OBJECTIVE:We examined patterns of weight change among patients treated with pregabalin for up to 1 year. METHODS:Patients with ≥1 pre-treatment weight measurement, ≥2 measurements in Period 1 (day 2-56), and ≥2 during Period 2 (day 57-356) were identified from pooled data of 106 studies including 43,525 patients. Seve...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,meta分析

    doi:10.1185/03007995.2012.684044

    authors: Cabrera J,Emir B,Dills D,Murphy TK,Whalen E,Clair A

    更新日期:2012-06-01 00:00:00

  • Comparison of the effects of etodolac SR and naproxen on gastro-intestinal blood loss.

    abstract::A single-blind, open-label controlled study was carried out in 30 healthy male volunteers to compare gastro-intestinal blood loss before, during and after treatment with a new, sustained-release formulation of the non-steroidal anti-inflammatory agent etodolac (etodolac SR) or with naproxen. Subjects remained at the s...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1185/03007999209115217

    authors: Leese P

    更新日期:1992-01-01 00:00:00

  • Validation of a questionnaire to assess niacin-induced cutaneous flushing.

    abstract:BACKGROUND:Niacin is currently the most effective approved agent for raising high-density lipoprotein cholesterol. However, niacin-induced cutaneous flushing (redness, warmth, tingling and/or itching) significantly limits patient acceptance. To further characterize flushing, a patient-reported Flushing Symptom Question...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,随机对照试验

    doi:10.1185/030079907x199637

    authors: Norquist JM,Watson DJ,Yu Q,Paolini JF,McQuarrie K,Santanello NC

    更新日期:2007-07-01 00:00:00

  • Clinical investigation of a very low dosage oral contraceptive combination: 0-75 mg lynestrenol and 0-0375 mg ethinyl oestradiol.

    abstract::A trial was carried out in 3 clinics to test the efficacy of and cycle control obtained with a very low dosage oral contraceptive combination of lynesternol (0.75 mg) and ethinyl oestradiol (0.0375 mg). A total of 134 healthy, fertile women, ages ranging from under 19 years to over 40 years, participated and completed...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007997609109328

    authors: Altkemper R,Prinz W,Soergel W

    更新日期:1976-01-01 00:00:00

  • The treatment of chronic pyelonephritis with carindacillin.

    abstract::Forty-two patients with a radiologically confirmed diagnosis of chronic pyelonephritis were treated with 1 g carindacillin every 6 hours over a period of 6 weeks. An underlying urological disease was present in 84% of the 38 patients for whom sufficient data were available for evaluation. The results of carindacillin ...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章

    doi:10.1185/03007997809111904

    authors: Michiels HG,Debruyne FM,Moonen WA

    更新日期:1978-01-01 00:00:00

  • Characterization of patients in the European Forsteo Observational Study (EFOS): postmenopausal women entering teriparatide treatment in a community setting.

    abstract:OBJECTIVE:The European Forsteo Observational Study (EFOS) study was primarily designed to assess fracture incidence, degree of pain, health-related quality of life (HRQoL) and compliance in women prescribed teriparatide in a community setting. This report describes the design of the study and characteristics of the pat...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/030079908x261087

    authors: Rajzbaum G,Jakob F,Karras D,Ljunggren O,Lems WF,Langdahl BL,Fahrleitner-Pammer A,Walsh JB,Gibson A,Tynan AJ,Marin F

    更新日期:2008-02-01 00:00:00

  • Acemetacin in the treatment of rheumatic diseases: an open, multi-centre trial.

    abstract::An open, multi-centre trial was carried out to assess the efficacy and tolerance of acemetacin in the treatment of patients suffering from various rheumatic diseases. The patients were treated by general practitioners for a maximum period of 6 weeks with a daily dose of 60 mg acemetacin 3-times daily. Assessments were...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章

    doi:10.1185/03007998509109654

    authors: Rechziegler H,Zündorf P

    更新日期:1985-01-01 00:00:00

  • The effects of the addition of micronised fenofibrate on uric acid metabolism in patients receiving indapamide.

    abstract:OBJECTIVE:Hyperuricaemia is associated with indapamide administration. In contrast, micronised fenofibrate can significantly decrease serum uric acid levels. However, there are no data on the effect of combination therapy of indapamide with micronised fenofibrate on uric acid metabolism. METHODS:We studied 20 non-diab...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/030079902125000273

    authors: Achimastos A,Liberopoulos E,Nikas S,Bairaktari E,Miltiadous G,Tsimihodimos V,Elisaf M

    更新日期:2002-01-01 00:00:00

  • Systematic literature review of the health economic implications of early detection by screening populations at risk for type 2 diabetes.

    abstract:BACKGROUND:Undetected/uncontrolled diabetes is associated with substantial morbidity and mortality and consequent costs. Early detection through screening identifies patients at risk, allowing for earlier treatment initiation. OBJECTIVES:To determine the economic impact of screening for type 2 diabetes (T2DM). DATA S...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1080/03007995.2016.1257977

    authors: Einarson TR,Bereza BG,Acs A,Jensen R

    更新日期:2017-02-01 00:00:00

  • Spironolactone in the long-term management of patients with congestive heart failure.

    abstract::The therapeutic efficacy of 100 mg spironolactone once daily in patients with congestive heart failure was evaluated in a multi-centre study in general practice. One hundred and fifteen patients were admitted to the study. Clinical and haemotological assessments were made at entry and at regular intervals throughout t...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007998009112040

    authors: Smith AG

    更新日期:1980-01-01 00:00:00

  • Eletriptan: pharmacological differences and clinical results.

    abstract::The potential advantages of eletriptan lie firstly in its lipophilicity reflected as an increased rate of absorption and Tmax compared to sumatriptan. This is manifested in a modest advantage over sumatriptan in terms of speed of onset, 2 h headache response and 2 h pain free. However, eletriptan has not yet been show...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审

    doi:10.1185/0300799039117004

    authors: Giffin N

    更新日期:2001-01-01 00:00:00

  • Passive absorption of fentanyl from the fentanyl HCl iontophoretic transdermal system.

    abstract:BACKGROUND:The fentanyl HCl iontophoretic transdermal system (ITS) is a patient-controlled analgesic delivery system that actively administers bolus doses of fentanyl transdermally upon patient activation. OBJECTIVE:To determine the amount of fentanyl absorbed from fentanyl ITS via passive absorption over a 24.5-h per...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章

    doi:10.1185/03007990802594941

    authors: Sathyan G,Phipps B,Gupta SK

    更新日期:2009-02-01 00:00:00